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| Application of ASPECTS Score and CT Perfusion Imaging Parameters in Prognostic Evaluation of Acute Ischemic Stroke Patients |
| CHANG Hufei, JI Wenjun, LI Xue |
| Department of Neurology,The Second Hospital of Yulin City,Yulin Shaanxi 719000 |
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Abstract 【Objective】To explore the value of early CT score(ASPECTS) and CT perfusion imaging parameters(CTP) in the prognosis evaluation of patients with acute ischemic stroke(AIS) in the Alberta Stroke Project. 【Methods】A total of 65 AIS patients were divided into a good prognosis group of 36 cases and a poor prognosis group of 29 cases based on their prognosis. We compared the clinical data, National Institutes of Health Stroke Scale(NIHSS) scores, stroke types, ASPECTS scores, and CTP between two groups of patients, and performed multiple logistic regression analysis on the data with differences between the two groups to identify the factors affecting the prognosis of AIS patients. The value of predicting poor prognosis in AIS patients was predicted by analyzing the receiver operating characteristic(ROC) curve of cerebral blood flow(CBF), cerebral blood volume(CBV), and mean transit time(MTT).【Results】The proportion of patients in the poor prognosis group with NIHSS score>7, multiple stroke, cardioembolic stroke, cerebral arteritis, and ASPECTS score ≤7 was significantly higher than that in the good prognosis group(P<0.05); The CBF, CBV, and MTT of the poor prognosis group were significantly lower than those of the good prognosis group(P<0.05). ROC analysis showed that CBF, CBV, and MTT can all be used for predicting poor prognosis in AIS patients, with areas under the curves of 0.828, 0.992, and 0.754, respectively(all P<0.05). Multivariate logistic regression analysis showed that NIHSS score>7, multiple stroke, cardioembolic stroke, cerebral arteritis, ASPECTS score ≤7, CBF≤12.870 mL/100 g/min, CBV≤8.890 mL/100 g, MTT≤16.425 s were risk factors affecting the prognosis of AIS patients(P<0.05). 【Conclusion】NIHSS score, multiple stroke, cardioembolic stroke, cerebral arteritis, ASPECTS score, and CTP parameters are all factors that affect the prognosis of AIS patients, and should be taken seriously in clinical practice.
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Received: 18 August 2022
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2023, Vol. 40 
