急性大动脉粥样硬化型脑梗死早期神经功能恶化的影响因素

doi:10.3969/j.issn.1671-7171.2023.11.011

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Abstract 【Objective】To investigate the factors influencing early neurological deterioration(END) in acute large artery atherosclerotic(LAA) stroke. 【Methods】A total of 194 LAA stroke patients admitted to the two hospitals were enrolled in the study. Based on whether END occurred during hospitalization,patients were divided into the END group(n=68) and the non-END group(n=126). Clinical data and relevant laboratory test indicators of both groups were compared between the two groups. Multivariate logistic regression was used to analyze the factors related to END,and the receiver operating characteristic(ROC) curve was applied to evaluate the predictive value of clinical indicators for END. 【Results】The systolic and diastolic blood pressures as well as the National Institutes of Health Stroke Scale(NIHSS) scores upon admission in the END group were significantly higher than those in the non-END group(P<0.05).The low-density lipoprotein cholesterol(LDL-C),glycated hemoglobin(HbA1c),and homocysteine(Hcy) levels in the END group were significantly higher than those in the non-END group(P<0.05).Multivariate logistic regression analysis showed that the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c were correlated with END. Their odds ratios (OR) were 3.22,1.03,1.08 and 1.83,respectively.ROC analysis indicated that the predictive value areas under the curve(AUC) for the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c for END were 0.89,0.76,0.71,and 0.81,respectively. 【Conclusion】Factors influencing END in acute LAA stroke include the NIHSS score upon admission,Hcy,systolic pressure,and HbA1c. These factors possess predictive value for END.

Key words： Brain Infarction Acute Disease Trauma, Nervous System Root Cause Analysis

Received: 06 October 2022

PACS:

R743.33

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	Articles by authors
	WANG Tao
	LIU Huifang
	CHEN Xiaohua

Cite this article:

WANG Tao,LIU Huifang,CHEN Xiaohua. Factors Influencing Early Neurological Deterioration in Acute Large Artery Atherosclerotic Stroke[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1653-1655.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.11.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I11/1653

[1] 晏昆,蒙凌,陈玉芳. DPP-4基因多态性与大动脉粥样硬化型脑梗死患者预后的相关性分析[J].实用医学临床杂志,2019,16(6):24-27.
[2] 中华医学会神经病学分会,中华医学会神经病学分会. 中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.
[3] 武晓玲,郝智军,杨金水,等. 同型半胱氨酸水平与急性脑梗死TOAST分型及颈动脉斑块稳定性的相关性分析[J].中华老年心脑血管病杂志,2019,21(12):1249-1252.
[4] 洪春永,吴欣宇,卢武生,等. Solitaire AB 支架取栓对心源性脑栓塞病人血管再通率、NIHSS 评分、mRS评分和脑出血情况的影响[J].中西医结合心脑血管病杂志,2019,17(17):2697-2699.
[5] 李尽义,贾东佩,任应国,等. ACI患者血清 ox-LDL、PAPP-A、HCY、FMD 的水平变化及与患者NIHSS评分、颈动脉硬化的关系[J].实验与检验医学,2019,37(4):661-666.
[6] 陈永明,王慧玲. 大动脉粥样硬化型脑梗死发病机制、主要危险因素及预后影响因素的研究进展[J].实用心脑肺血管病杂志,2018,26(10):6-9.
[7] 宋博雯,汪旭,杨柳,等. 血栓弹力图在轻中度急性脑梗死患者早期神经功能恶化中的预测作用[J].东南国防医学,2019,21(6):593-597.
[8] 石若南,潘玉君. 急性缺血性脑卒中后早期神经功能恶化的危险因素分析[J].卒中与神经疾病,2019,26(5):603-606.
[9] 庞国勋,许进福,马银玲. 血清Hcy水平与缺血性脑卒中发病及疾病程度的相关性研究[J].解放军医药杂志,2019,31(11):73-75.
[10] 陈刚. 活血通络化痰中药对缺血性脑中风患者临床疗效及血清Hcy、CRP、SOD、MDA 的影响[J].标记免疫分析与临床,2017,24(6):627-630.
[11] 杜鑫. 血清Hcy、SAA、D-D水平与脑梗死神经功能缺损程度及短期预后的关系[J].标记免疫分析与临床,2022,29(1):140-144.
[12] 孔勇,王莹,刘海超,等. 糖化血红蛋白在急性缺血性脑卒中神经功能评定中的价值[J].神经损伤与功能重建,2019,14(8):386-388.