Abstract 【Objective】To investigate the effect of tetracaine mucilage combined with etomidate in the removal of double-J tube. 【Methods】A total of 180 patients undergoing cystoscopy-assisted double-J tube removal were randomly divided into tetracaine mucilage group(group A),tetracaine mucilage combined with etomidate group(group B),and fentanyl combined with etomidate group(group C),with 60 cases in each group.The mean arterial pressure(MAP),heart rate(HR),pulse oximetry(SpO2),respiratory rate(RR),and adverse reactions during the operation were compared at each time point of the patients' lithotomy position(T0),2 minutes after administration(T1),after entering the bladder(T2),and after removing the double-J tube(T3). The operation time and postoperative urethral pain stimulation [visual analog scale(VAS)] scores were also compared. The satisfaction of patients,operating physicians,and anesthesiologists was compared. 【Results】The MAP,RR,and HR at T2 and T3 in group A were higher than those in group B and C(P<0.05);the MAP,RR,and SpO2 at T1 in group C were lower than those in group A and B(P<0.05);the incidence of body movement during the operation in group A was higher than that in group B and C,while the incidence of myoclonus was lower than that in group B and C(both P<0.05);the incidence of respiratory depression,dizziness,nausea,and vomiting in group C was higher than that in group A and B(P<0.05);the operation time and VAS scores at 10 minutes and 1 hour after surgery in group A were higher than those in group B and C(P<0.05);the VAS score at 2 hours after surgery in group B was lower than that in group A and C(P<0.05);the satisfaction of patients,operating physicians,and anesthesiologists in group B was higher than that in group A and C(P<0.05). 【Conclosion】The effect of tetracaine mucilage combined with etomidate in the removal of double-J tube is better,with the advantages of short-term analgesia,sedation,and less adverse reactions.
[1] AWAD K,WOODWARD M N,SHALABY M S. Long-term outcome of JJ stent insertion for primary obstructive megaureter in children[J].J Pediatr Urol,2019,15(1):66.e1-66.e5.
[2] 李亚妹,廖国龙,李骏,等.丁卡因胶浆在男性患者全麻术后留置导尿管中应用的前瞻性随机对照研究[J].中华腔镜泌尿外科杂志(电子版),2020,14(4):300-303.
[3] KIM J H,BYUN S,CHOI Y J,et al. Efficacy and safety of etomidate in comparison with propofol or midazolam as sedative for upper gastrointestinal endoscopy[J].Clin Endosc,2020,53(5):555-561.
[4] 李小莉.依托咪酯联合丙泊酚麻醉诱导在老年患者手术中的应用效果[J].当代医学,2020,26(32):75-77.
[5] 罗慧榕,陈晓辉,郑晓春.丙泊酚靶控输注联合依托咪酯在无痛胃肠镜检查中的应用[J].创伤与急诊电子杂志,2021,9(1):19-24.
[6] BOYCE R A,KIRPALANI T,MOHAN N. Updates of topical and local anesthesia agents [J].Dent Clin North Am,2016,60(2):445-471.
[7] KUMAR M,CHAWALA R,GOYAL M. Topical anesthesia[J].Anae Clin Pharm,2015,31(4):450-456.
[8] SONG J C,LU Z J,JIAO Y F,et al. Etomidate anesthesia during ERCP caused more stable haemodynamic responses compared with propofol:a randomized clinical trial[J].Int J Med Sci,2015,12(7):559-565.
[9] 张靖文,李恩有.依托咪酯的应用现状及其衍生物的研究进展[J].安徽医药,2019,23(4):733-737.
[10] ZHU Y,ZHOU C M,HE Q X. Butorphanol effectively prevents etomidate-induced myoclonus:a pooled analysis of 788 patients[J].Int Med Res,2019,47(1):353-360.
[11] RAINES D E. The pharmacology of etomidate and etomidate derivative[J].J Int Anesthesiol Clin,2015,53(2):63-75.
[12] WAZIR A,SHUKLA A,DUTTON R P. Patient satisfaction in anesthesia:implementation,relevance,and identification of meaningful measures[J].Adv Anesth,2018,36(1):23-37.
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(7): 1092-1094.
2023, Vol. 40 
