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Efficacy of Huotan Xijing Tang Combined with Thrombolysis on Patients with Acute Cerebral Infarction and Effect on Cerebral Hemodynamics |
WANG Liang, WANG Shenghui |
Department of Internal Medicine Ⅳ,Shangluo Traditional Chinese Medicine Hospital,Shangluo Shaanxi 726000 |
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Abstract 【Objective】To investigate the therapeutic effect of Huotan Xijing Tang combined with thrombolysis on patients with acute cerebral infarction and its impact on cognitive function and cerebral hemodynamics. 【Methods】A total of 108 patients with acute cerebral infarction were randomly divided into an observation group and a control group,with 54 cases in each group. The control group was treated with thrombolysis,while the observation group received Huotan Xijing Tang combined with thrombolysis. The therapeutic effects,adverse reactions,and differences in related indicators before and after treatment were compared between the two groups. 【Results】The overall effectiveness rate of the observation group was 94.44%(51/54),which was significantly higher than the 81.48%(44/54) of the control group,and the difference was statistically significant(P<0.05). After treatment,the scores for Traditional Chinese Medicine(TCM) symptoms such as sudden fainting,hemiplegia,and deviation of the mouth and tongue were lower in both groups compared to before treatment(P<0.05). Moreover,the observation group had a greater reduction in these scores than the control group(P<0.05). After treatment,the National Institutes of Health Stroke Scale(NIHSS) scores in both groups significantly reduced,and the Montreal Cognitive Assessment(MoCA) scores and Activities of Daily Living(ADL) scores increased compared to before treatment(P<0.05). The improvement in scores of the observation group was better than that of the control group(P<0.05). After treatment,the pulsatility index(PI) levels in both groups were lower than before treatment,and the peak flow velocity(VP) and mean flow velocity(Vm) levels of the bilateral middle cerebral artery were higher than before treatment(P<0.05). The improvement in these parameters of the observation group was better than that of the control group(P<0.05). The overall incidence of adverse reactions between the two groups showed no statistically significant difference(P>0.05). 【Conclusion】Huotan Xijing Tang combined with thrombolysis in patients with acute cerebral infarction can significantly improve therapeutic effects,reduce TCM symptom scores,enhance neural function,improve cerebral hemodynamics,and elevate patients' cognitive function and daily living ability with minimal drug adverse reactions.
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Received: 22 October 2022
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[1] WEN H,LV M. Correlation analysis between serum procalcitonin and infarct volume in young patients with acute cerebral infarction[J].Neurol Sci,2021,42(8):3189-3196. [2] SHIBATA K,HASHIMOTO T,MIYAZAKI T,et al. Thrombolytic therapy for acute ischemic stroke:Past and future[J].Curr Pharm Des,2019,25(3):242-250. [3] NOGUEIRA R C,LAM M Y,LLWYD O,et al. Cerebral autoregulation and response to intravenous thrombolysis for acute ischemic stroke[J].Sci Rep,2020,10(1):10554-10555. [4] 曹建,谢海洋,秦延昆,等. 温针灸联合豁痰息痉汤对脑梗死继发癫痫患者生命质量及脑电图的影响[J].世界中医药,2019,14(6):1569-1572. [5] 贾建平.神经病学[M].9版.北京:人民卫生出版社,2018:194. [6] 周仲瑛.中医内科学[M].北京:中国中医药出版社,2017:10. [7] 陈官华. r-tPA动静脉联合溶栓治疗急性脑梗死疗效分析[J].中国急救医学,2017,37(z1):34-35. [8] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国中医药出版社,2002:253-258. [9] 郭文雅,袁铮. 日常生活能力评定量表设计脑卒中患者出院日常生活护嘱单的应用效果[J].浙江临床医学,2017,19(2):356-357. [10] 张婷,袁良津,唐向阳,等. P300和蒙特利尔认知评估量表对帕金森患者早期认知功能的临床研究[J].安徽医药,2016,20(12):2304-2306. [11] VOLNY O,CIMFLOVA P,SZEDER V. Inter-rater reliability for thrombolysis in cerebral infarction with tici 2c category[J].J Stroke Cerebrovasc Dis,2017,26(5):992-994. [12] 张青川. 针刺、豁痰息痉汤联合西药对脑梗死合并癫痫患者神经功能的影响[J].实用临床医药杂志,2016,20(3):25-27. [13] 李安民,陈合成,关文标,等. 阿替普酶溶栓治疗对老年急性脑梗死患者神经功能、颅内血流动力学及生活质量的影响[J].中国老年学杂志,2017,37(19):4786-4788. |
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