尿毒清联合贝前列素治疗慢性肾小球肾炎的疗效及对患者肾功能的影响

doi:10.3969/j.issn.1671-7171.2023.11.004

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Abstract 【Objective】To investigate the efficacy of Niaoduqing combined with beraprost in the treatment of chronic glomerulonephritis(CGN) and its impact on patients' renal function. 【Methods】A total of 80 patients with CGN were randomly divided into two groups,with 40 cases in each group.Under routine intervention,patients in the control group were treated with beraprost,while patients in the observation group were additionally treated with Uremic Clearance,with a course of treatment of 90 days.The clinical efficacy,renal function indicators [24 hour urinary protein quantitation(24hUPro),serum creatinine(Scr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG)] levels,and inflammatory factors [interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)] levels,as well as adverse reactions,were observed and compared between the two groups. 【Results】The total effective rate in the observation group was significantly higher than that in the control group(P<0.05). After treatment,the levels of 24hUPro,Scr,BUN,β2-MG,IL-6,TNF-α,and hs-CRP in both groups decreased compared with those before treatment(P<0.05),and the levels of each index in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】Niaoduqing combined with beraprost has significant efficacy in the treatment of CGN,which can effectively improve patients' renal function and reduce the level of inflammatory factors in the body. At the same time,it has high safety and is worthy of clinical application.

Key words： Glomerulonephritis/ZJ Chronic Disease Epoprostenol/AA Kidney Function Tests

Received: 23 August 2022

PACS:

R692.31

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	ZHU Lihong
	LIU Huamei

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ZHU Lihong,LIU Huamei. The Efficacy of Niaoduqing Combined with Beraprost in the Treatment of Chronic Glomerulonephritis and its Impact on Renal Function[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(11): 1628-1630.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.11.004 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I11/1628

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