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Quick Search     Adv Search 2022 Vol. 39, No. 10 Published: 2022-10-26 Original Articles          Original Articles 1441 Current Status of Inhaled Treatments in Patients with Stable Chronic Obstructive Pulmonary Disease WANG Shao, ZENG Yu-qin, SONG Qing, et al DOI: 10.3969/j.issn.1671-7171.2022.10.001 【Objective】 To investigate the current status of initial treatments in patients with stable chronic obstructive pulmonary disease (COPD). 【Methods】Patients with COPD were enrolled to the Department of Respiratory Disease in 13 hospitals of Hunan and Guangxi from December 2016 to March 2021. Demographic data,pulmonary function,inhaled drug treatment prescriptions,and COPD assessment test (CAT),symptom score and Medical Research Council Dyspnea Scale (mMRC) score were collected. According to the 2017 COPD Global Initiative (GOLD) guidelines,patients were divided into groups A,B,C,and D. Patients' inhaled prescriptions were compared with the recommendations of the Global Initiative for COPD (GOLD,2017) guidelines. Inhaled drug prescriptions that were inconsistent with the 2017 GOLD guidelines are considered inappropriate treatment. The difference of inhalation in patients with COPD before and after January 1,2020 was compared. 【Results】A total of 5434 patients with COPD were analyzed. The most commonly used inhaled bronchodilators were long-acting Anticholinergic (LAMA),triple therapy [inhaled glucocorticoids (ICS) + long-acting β2 receptor agonists (LABA) + LAMA] and LABA/ICS,accounting for 38.7%,36.9% and 12.8%,respectively. We found that 44.4% of patients in the Group A,58.4% in Group B,26.7% in Group C,and 5.97% in Group D received inappropriate treatment,particularly the overuse of ICS. After January 1,2020,the use rate of dual bronchodilators (double bronchodilators) increased (P<0.05),while the proportion of triple drug therapy prescriptions decreased significantly (P<0.001),when compared with before January 1,2020.【Conclusion】In clinical practice,inhaled therapy in patients with stable COPD differs from the GOLD recommendations of 2017,particularly the overuse of ICS. After the launch and application of the double-bronchodilator (LABA/LAMA),the use of ICS has a certain trend of decline,but there is still unreasonable use. 2022 Vol. 39 (10): 1441-1444 [Abstract] ( 116 ) HTML (1 KB)  PDF (1122 KB)  ( 199 ) 1445 Expression and Significance of Natural Killer T Cells, Transcription Factor ROR γt and Foxp3 in Peripheral Blood of Patients with Vitiligo WANG Xiao-yuan, CAO Wei, WANG Ying-juan, et al DOI: 10.3969/j.issn.1671-7171.2022.10.002 【Objective】 To investigate the expression and significance of natural killer T cells (NK-T) , RORγt and Foxp3 in peripheral blood of patients with vitiligo.【Methods】 A total of 89 patients with vitiligo diagnosed and treated in our hospital from April 2019 to May 2021 (observation group) were selected, and 36 healthy volunteers (control group) who were examined in our hospital at the same time were selected. The levels of NK-T, RORγt mRNA and Foxp3 mRNA in peripheral blood of the two groups of subjects were detected and compared ; The levels of peripheral blood NK-T, RORγt mRNA and Foxp3 mRNA of vitiligo patients with different disease stages, disease types and skin lesion areas were compared. Correlation of the skin lesion area, NK-T , RORγt mRNA and Foxp3 mRNA levels were analyzed.【Results】 The level of the peripheral blood of RORγt mRNA in patients the observation group was significantly higher than that of the control group.The levels of NK-T and Foxp3 mRNA were significantly lower than those in the control group,the difference was statistically significant (P<0.05); Compared with the stable period, the level of the RORγt mRNA of patients in the advanced stage is high; The levels of NK-T and Foxp3 mRNA were lower, and the difference was statistically significant (P<0.05); Among patients with vitiligo of different disease types, there was a statistically significant difference between the levels of NK-T, RORγt mRNA and Foxp3 mRNA (P<0.05); Between different lesion areas, there was a statistically significant difference between the levels of NK-T, RORγt mRNA and Foxp3 mRNA (P<0.05). There was a positive correlation between RORγt mRNA and lesion area (rs=0.509, P<0.05). NK-T and Foxp3 mRNA were negatively correlated with lesion area (rs=-0.348,rs=-0.307, P<0.05).【Conclusion】 The abnormal levels of NK-T, RORγt mRNA and Foxp3 mRNA in peripheral blood are closely related to the onset and development of vitiligo, and the skin lesion area of vitiligo is positively correlated with RORγt mRNA, and negatively correlated with NK-T and Foxp3 mRNA. 2022 Vol. 39 (10): 1445-1448 [Abstract] ( 60 ) HTML (1 KB)  PDF (1121 KB)  ( 38 ) 1449 Clinical Efficacy of Core Muscle Group Exercise Combined with Electrical Stimulation Biofeedback for Treating Stress Urinary Incontinence in Middle-aged and Elderly Women WU Fei, LUO Jun, LIU Li, et al DOI: 10.3969/j.issn.1671-7171.2022.10.003 【Objective】To explore the clinical efficacy of core muscle group exercise combined with electrical stimulation biofeedback and Kegel training on stress urinary incontinence (SUI) in middle-aged and elderly women. 【Methods】A total of 120 middle-aged and elderly SUI patients treated in the pelvic floor diagnosis and treatment center of Hunan Maternal and Child Health Hospital from January 2020 to December 2021 were selected in the study and randomly divided into the observation group (60 cases) and the control group (60 cases). Patients in both groups received electrical stimulation biofeedback treatment and Kegel training,while patients in the observation group were also given the core muscle group training simultaneously. The treatment efficiency,urinary incontinence quality of life questionnaire (I-QOL),pelvic floor muscle potential value,and pelvic floor muscle contraction strength were compared in the two groups before and after the treatment. 【Results】The treatment effective rate was 90.00% in the observation group and 75.00% in the control group; and the comparative efficacy differences of the two groups were significant (P<0.05). The muscle strength of class Ⅰ and class Ⅱ muscle fibers in the two groups were significantly improved compared to those before treatment. The I-QOL score was higher after treatment compared with that before treatment,and the value of the observed group was higher than that of the control group (P<0.05). The intensity of pelvic floor muscle contraction in the two group was increased compared to that before treatment,and the observed group was increased higher than that of the control group (P<0.05). 【Conclusion】Core muscle group exercise combined with electrical stimulation biofeedback and Kegel training can effectively improve the clinical efficacy of SUI in middle-aged and elderly women,and the exercise program is simple,practical and easy to promote clinically. 2022 Vol. 39 (10): 1449-1451 [Abstract] ( 38 ) HTML (1 KB)  PDF (1099 KB)  ( 61 ) 1452 Value of DAO, D-LA, APACHE Ⅱ and GCSI-R Scores in Evaluating the Severity and Prognosis of Acute Pancreatitis FAN Bo, YAN Run-sheng DOI: 10.3969/j.issn.1671-7171.2022.10.004 【Objective】 To study the value of diamine oxidase (DAO), D-lactic acid (D-LA), acute physiology and chronic health Ⅱ (APACHE Ⅱ) score, and revised major symptom index of gastroparesis (GCSI-R) score in evaluating the severity and prognosis of acute pancreatitis (AP).【Methods】A total of 100 patients with AP were divided into mild (n=59), moderate (n=29) and severe (n=12) groups according to the severity of the disease. They were divided into survival (n=92) and death (n=8) groups according to whether they died within 28 days after admission. The serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score of AP patients with different severity and prognosis were compared;Spearman correlation coefficient was used to analyze the relationship between serum DAO, D-LA, APACHE Ⅱ score, GCSI-R score and severity of AP patients;The prognostic value of AP patients was evaluated by ROC analysis of serum DAO, D-LA,APACHE Ⅱ score and GCSI-R score.【Results】 Compared with serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score, the difference was statistically significant between mild group and moderate group and severe group(P<0.05);By correlation analysis, the severity of AP patients was positively correlated with serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score (P<0.05); The serum DAO, D-LA, APACHE Ⅱ score and GCSI-R score in the survival group were significantly lower than those in the death group (P<0.05); ROC analysis showed that DAO ≥ 42.315 mg/L, D-LA ≥ 40.690 U/L, APACHE Ⅱ score ≥ 26.000, GCSI-R score ≥ 12.585 were the best cut-off values for evaluating the prognosis of AP patients, all of which were P<0.05. 【Conclusion】DAO, D-LA, APACHE Ⅱ and GCSI-R scores can be used to reflect the severity and prognosis of AP patients, and are positively correlated with the severity of AP. 2022 Vol. 39 (10): 1452-1455 [Abstract] ( 73 ) HTML (1 KB)  PDF (1205 KB)  ( 60 ) 1456 Correlation between Thromboelastography and Short-term Prognosis of Cerebral Hemorrhage LI Ming-hui, TUO Hua-bin, LUO Chang-wen, et al DOI: 10.3969/j.issn.1671-7171.2022.10.005 【Objective】To analyze the correlation between thromboelastography (TEG) and short-term prognosis of cerebral hemorrhage.【Methods】A total of 89 patients with cerebral hemorrhage who were admitted in our hospital were collected in our study. After enrollment, patients received both TEG and skull CT to calculate amount of cerebral hemorrhage. Rankin prognostic rating scale (mRs) was performed on the patients 30 days after discharge. According to the mRs score, patients were divided into good prognosis group (n=71) and poor prognosis group (n=18). The relationship of cerebral hemorrhage with prognosis and TEG was analyzed. The receiver operating characteristic (ROC) curve was used to evaluate value of TEG in predicting poor prognosis of cerebral hemorrhage in patients, and the relationship between TEG and poor prognosis was analyzed by using multivariate Logistic regression. 【Results】Compared to small and moderate cerebral hemorrhage, the R time of a large cerebral hemorrhage was higher, while MA, angle and CI were lower, and Pearson correlation showed that the amount of cerebral hemorrhage had positive correlation with coagulation reaction time (R) was significantly prolonged in the massive intracerebral hemorrhage group, but the maximum amplitude (MA), α angle and coagulation comprehensive index (CI) were significantly shortened. Pearson correlation analysis showed that the amount of intracerebral hemorrhage was positively correlated with R (r=0.428, P<0.05), while it was negative correlation with MA (r=-0.561, P<0.05) and angle (r=-0.384, P<0.05). Compared with the poor prognosis group, patients with the good prognosis had shorter R time and longer MA and CI.The ROC curve showed that the area under the value curve (AUC) (95%CI) of R for predicting negative prognosis was 0.87 (0.77-0.96).Multivariate Logistic regression analysis showed that R time and MA were closely related to the poor prognosis with odds ratios (OR) of 2.25 (1.16-4.38) and 0.93 (0.87-0.98),respectively. 【Conclusion】TEG was related to amount of cerebral hemorrhage and short-term prognosis. R time was an independent risk factor, while CI was a protective factor for the poor prognosis. 2022 Vol. 39 (10): 1456-1458 [Abstract] ( 62 ) HTML (1 KB)  PDF (1252 KB)  ( 24 ) 1459 Effect of Huatuo Zaizao Pill Combined with Dual Antiplatelet Therapy on Severe Cerebral Infarction FENG Yan-ning, CHEN Wei-qiang DOI: 10.3969/j.issn.1671-7171.2022.10.006 【Objective】To explore the clinical effect of Huatuo Zaizao pill combined with dual antiplatelet therapy on severe cerebral infarction. 【Methods】A total of 70 patients with severe cerebral infarction were randomly divided into the control group and the observation group, with 35 cases in each group. The control group was treated with dual antiplatelet therapy, while the observation group was treated with Huatuo Zaizao pill combined with dual antiplatelet therapy. After 4 weeks of continuous treatment, the short-term efficacy and the serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α), Nitric oxide (NO), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were compared before and after treatment between the two groups.【Results】The total effective rate of the observation group was 85.71% (30/35), which was significantly higher than that of the control group [62.86%(22/35)](P<0.05). After treatment, levels of IL-6, IL-8 and TNF-α in both groups were significantly lower than those before treatment (P<0.05), and their levels in the observation group was significantly lower than in the control group (P<0.05). While the NO level in the two groups after treatment was significantly higher than that before treatment (P<0.05), and its level in the observation group was significantly higher than that in the control group (P<0.05). Levels of VEGF and ET-1 in the two groups were significantly lower than were significantly lower than those before treatment (P<0.05); and both levels in the observation group were lower than those in the control group (P<0.05). After treatment, SOD and GSH-Px in the two groups were significantly higher than those before treatment (P<0.05), however, levels of SOD and GAH-Px in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the MDA of the two groups was significantly lower than that before treatment (P<0.05), and its level of the observation group was significantly lower than that of the control group (P<0.05). 【Conclusion】Huatuo Zaizao pill combined with dual antiplatelet therapy has nice effects on severe cerebral infarction. It can alleviate inflammatory reaction, improve vascular endothelial function and reduce oxidative stress injury. 2022 Vol. 39 (10): 1459-1462 [Abstract] ( 63 ) HTML (1 KB)  PDF (1127 KB)  ( 37 ) 1463 Analysis of Monitoring Results of Tacrolimus Blood Trough Concentration in Children with Nephrotic Syndrome CHEN Jun-xiao, LI Na DOI: 10.3969/j.issn.1671-7171.2022.10.007 【Objective】 To analyze the monitoring results of tacrolimus blood trough concentration in children with nephrotic syndrome (NS) and its guiding significance. 【Methods】 A total of 97 children with nephrotic syndrome were selected as the study object. All the children were treated with tacrolimus, and their drug use was recorded. Their gender, age, dosage and distribution of different blood trough concentrations were analyzed. Their treatment effects were statistically analyzed. The changes of blood trough concentrations of tacrolimus and adverse reactions in children with different therapeutic effects were observed, Spearman correlation analysis was used to explore the correlation between the blood trough concentration of tacrolimus and the therapeutic effect in children.【Results】 There was no significant difference in gender and age distribution of children with different blood drug concentration (P>0.05); The difference in clinical dosage was statistically significant (P<0.05). After treatment in 97 children with NS, there were 32 patients with CR (32.99%), 41 patients with PR (42.27%), and 24 patients with NR (24.74%). There was a statistically significant difference in the blood concentration of tacrolimus in the first, second and third weeks of children with different therapeutic effects (P<0.05); The trough concentration of tacrolimus in children with CR at week 1, 2 and 3 was higher than that in children with PR and NR, and that in children with PR was higher than that in children with NR (P<0.05). The incidence of adverse reactions in children with CR was 53.12%, that in children with PR was 51.22%, and that in children with NR was 33.33%. There was no significant difference in the incidence of adverse reactions in children with different therapeutic effects (P>0.05). Spearman correlation analysis showed that there was a positive correlation between the therapeutic effect of NS children and the blood trough concentration of tacrolimus (rs=0.842). 【Conclusion】 The sex and age of children with nephrotic syndrome have little influence on the blood trough concentration of tacrolimus, and the dosage of tacrolimus can affect the blood trough concentration to a certain extent. To reasonably reduce the adverse reactions caused by drugs in clinical practice, it is necessary to formulate appropriate dosage of tacrolimus blood to improve the safety of treatment. 2022 Vol. 39 (10): 1463-1465 [Abstract] ( 71 ) HTML (1 KB)  PDF (1099 KB)  ( 13 ) 1466 Comparison of Two Kinds of PEEK Suture Anchors in Arthroscopic Rotator Cuff Repair YUAN Ming-hao, YANG Yi-bo, WANG Hong-tao, et al DOI: 10.3969/j.issn.1671-7171.2022.10.008 【Objective】To compare the efficacy of two kinds of PEEK suture anchor in arthroscopic rotator cuff repair. 【Methods】A total of 34 patients with rotator cuff tears who received arthroscopic rotator cuff repair in Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University) from September 2017 to March 2019 were randomly divided into the observation group and the control group, with 17 patients in each group. In the observation group, PEEK suture anchor nail from the Delta Medical's PEEK suture anchor was used during the operation; The control group was treated with PEEK suture anchor of the Smith & Nephew. The clinical effective rate, intact rate of rotator cuff, VAS score, range of motion of shoulder joint and incidence of complications were compared between the two groups. 【Results】 Six months after operation, the clinical effective rate in the observation group was 76.5% (13/17), which had no significant difference compared with 62.5% (10/16) in the control group (P>0.05). Three months after operation, MRI showed that 15 cases (88.2%) in the observation group had intact rotator cuff, 2 cases (11.3%) had Sugaya Grade Ⅳ incomplete rotator cuff, and 16 cases (100%) in the control group had intact rotator cuff; Six months after operation, the rotator cuff was intact in 15 cases (88.2%) in the observation group, while only 13 cases (81.3%) in the control group; Sugaya Ⅴ type complete re tear did not occur 3 months and 6 months after operation in both groups. There was no significant difference in VAS scores between the two groups before operation under rest and active activity (P>0.05); In the passive activity state, the preoperative VAS score of the observation group was lower than that of the control group (P<0.05). There was no significant difference in VAS scores between the two groups at 3 and 6 months after operation under resting and active activities (P>0.05); In the passive activity state, the VAS scores of the observation group at 3 and 6 months after operation were significantly lower than those of the control group (P<0.05). The shoulder joint range of motion of active flexion and abduction in both groups was significantly improved 6 months after operation (P<0.05); The range of motion of active and passive abduction and external rotation shoulder joints in the observation group before operation was significantly higher than that in the control group (P<0.05), and the range of motion of passive abduction and external rotation shoulder joints 6 months after operation was significantly higher than that in the control group (P<0.05). There was no loosening, displacement or breakage of the anchor in both groups 2 weeks and 3 months after operation; There were no complications such as infection, vascular or nerve injury. 【Conclusions】 Two kinds of PEEK suture anchors have good efficacy in arthroscopic rotator cuff repair, improving shoulder joint function and relieving pain. However, the PEEK suture anchor of Demei Company has lower cost and is suitable for patients with rotator cuff tear, especially low-income people. 2022 Vol. 39 (10): 1466-1470 [Abstract] ( 127 ) HTML (1 KB)  PDF (1149 KB)  ( 93 ) 1471 Effects of Different Treatments of Liliequist Membrane on the Risk of Complications in Patients with Aneurysmal Subarachnoid Hemorrhage CHEN Bin, ZHANG Dong-zi DOI: 10.3969/j.issn.1671-7171.2022.10.009 【Objective】 To study the effect of different treatments of Liliequist membrane on the risk of complications in patients with aneurysmal subarachnoid hemorrhage.【Methods】A total of 70 patients with aneurysmal subarachnoid hemorrhage admitted to our hospital from January 2020 to January 2022 were selected as the study subjects. They were randomly divided into the observation group (35 cases) and the control group (35 cases). Both groups underwent intracranial aneurysm clipping. In the observation group, the Liliequist membrane was opened during the operation, while in the control group, the Liliequist membrane was not opened during the operation. The clinical effects of the two groups were compared; The scores of Glasgow Coma Scale (GCS), Modified Rankin Scale (mRS) and Montreal Cognitive Assessment Scale (MoCA) were compared between the two groups before operation and one month after operation; Serum levels of matrix metalloproteinase-9 (MMP-9), high mobility group protein 1 (HMGB1), vascular endothelial growth factor (VEGF) and postoperative complications were compared before and one month after surgery.【Results】Compared with the control group (60.00%), the total effective rate of the observation group (82.86%) was higher (P<0.05); After operation, GCS and MoCA scores were improved, while mRS scores were decreased in both groups (P<0.05); After operation, compared with the control group, the GCS and MoCA scores of the observation group were higher, while the mRS scores were lower (P<0.05); After operation, the level of MMP-9 increased, while the levels of HMGB1 and VEGF decreased in both groups (P<0.05); After operation, the levels of MMP-9, HMGB1 and VEGF in the observation group were lower than those in the control group (P<0.05); Compared with the control group (37.14%), the incidence of postoperative complications in the observation group (14.29%) was lower (P<0.05). 【Conclusion】In the treatment of aneurysmal subarachnoid hemorrhage with aneurysm clipping, opening the Liliequist membrane during the operation can improve the therapeutic efficiency, improve the cognitive function and prognosis of patients, and reduce the incidence of hydrocephalus and other complications. 2022 Vol. 39 (10): 1471-1473 [Abstract] ( 37 ) HTML (1 KB)  PDF (1101 KB)  ( 20 ) 1474 Prevalence and Influencing Factors of Nonalcoholic Fatty Liver Disease in Children and Adolescents with Type 1 Diabetes LIU Ting, LI Bin-long, LI Yan DOI: 10.3969/j.issn.1671-7171.2022.10.010 【Objective】 To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) in children and adolescents with type 1 diabetes (T1DM) by proton density fat fraction (MRI-PDFF) with MRI and analyze the influencing factors. 【Methods】 A total of 164 children and adolescents with T1DM admitted to Xi'an Tangcheng Hospital from January 2012 to January 2021 were selected and divided into observation group (NAFLD, n=26) and control group (NAFLD, n=138) according to whether NAFLD was combined or not. Univariate and multivariate logistic regression were used to analyze the related influencing factors of adolescent T1DM patients with NAFLD, and to compare the different liver histologic characteristics of children and adolescents with T1DM patients with NAFLD MRI-PDFF.【Results】 Among 164 children and adolescents with T1DM, there were 26 patients with NAFLD. The prevalence of NAFLD was 15.8% (26/164). The proportion of BMI-SDS, HDL, TG, ALT, acanthosis nigricans and MRI-PDFF in the two groups were statistically significant (P<0.05). Multivariate logistic regression analysis showed that BMI SDS and MRI-PDFF were independent predictors of NAFLD in children and adolescents with T1DM (P<0.05). In children and adolescents of F3 hanepatic steatosis with T1DM combined with NAFLD, MRI-PDFF was significantly higher than that of F2, F1, F0 (P<0.05); MRI-PDFF in patients with liver fibrosis at F3 and F4 stages was significantly higher than that in patients with liver fibrosis at F2, F1 and F0 stages, and that in patients with liver fibrosis at F4 stage was significantly higher than that in patients with liver fibrosis at F3 stage (P<0.05). 【Conclusion】 BMI-SDS and MRI-PDFF are independent predictors of NAFLD in children and adolescents with T1DM. MRI-PDFF is helpful to quantitatively evaluate the degree of liver steatosis and the stage of liver fibrosis in NAFLD patients, and has important clinical significance. 2022 Vol. 39 (10): 1474-1477 [Abstract] ( 49 ) HTML (1 KB)  PDF (1133 KB)  ( 43 ) 1478 Characteristics of Lipid Metabolism in Patients with Gestational Hypertension and Its Relationship with Pregnancy Outcomes XIA Ting-e, SUN Bei DOI: 10.3969/j.issn.1671-7171.2022.10.011 【Objective】To investigate the characteristics of lipid metabolism in patients with gestational hypertension and its relationship with pregnancy outcomes. 【Methods】From December 2019 to December 2021,80 patients with gestational hypertension who were admitted to the Obstetrics and Gynecology Department of Zhashui County People's Hospital,Shangluo City,Shaanxi Province were selected as the observation group,and 80 pregnant women who underwent physical examination during the same period were selected as the control group. The levels of glucose metabolism [fasting blood glucose (FPG),glycosylated hemoglobin (HbA1c)],lipid metabolism indexes [triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),High-density lipoprotein cholesterol (HDL-C)] levels and pregnancy outcomes in the observation group and the control group were compared. According to the severity of gestational hypertension,the observation group was divided into the mild group (n=53) and the severe group (n=27). The glucose,lipid metabolism and adverse pregnancy outcomes were compared between the mild and severe groups. Thus,the correlation of the metabolism of glucose and lipid to adverse pregnancy outcomes in patients with blood pressure was analyzed. 【Results】The levels of HbA1c,FPG,TC,TG and LDL-C in the observation group were significantly higher than those in the control group (P<0.05),while the level of HDL-C was lower than those in the control group (P<0.05). The incidence rates of premature birth,macrosomia,fetal distress,postpartum hemorrhage,oligohydramnios,premature rupture of membranes,polyhydramnios,cesarean section,and low-quality infants in the observation group higher than the control group (P<0.05). The levels of HbA1c,FPG,TC,TG and LDL-C in the severe group were higher than those in the mild group (P<0.05),while the level of HDL-C was lower than those in the mild group (P<0.05). In the severe group,the incidence rates of premature birth,macrosomia,fetal distress,postpartum hemorrhage,oligohydramnios,premature rupture of membranes,polyhydramnios,cesarean section,and low-quality infants were higher than those of the mild group (P<0.05). The Spearman test showed that the levels of FPG,HbA1c,TG,TC,and LDL-C in patients with gestational hypertension were positively correlated with adverse pregnancy outcomes (P<0.05),and the level of HDL-C was negatively correlated with adverse pregnancy outcomes (P<0.05). 【Conclusion】The glucose and lipid metabolism in patients with gestational hypertension is significantly abnormal,which is closely related to adverse pregnancy outcomes. 2022 Vol. 39 (10): 1478-1481 [Abstract] ( 44 ) HTML (1 KB)  PDF (1118 KB)  ( 56 ) 1482 Application of Negative Enrichment of Circulating Tumor Cells in Peripheral Blood Combined with FISH in Diagnosis of Breast Cancer HUANG Lu, DONG Fei-tian DOI: 10.3969/j.issn.1671-7171.2022.10.012 【Objective】To explore the application of negative enrichment of circulating tumor cells (CTC) in peripheral blood combined with fluorescence in situ hybridization (FISH) in diagnosis of breast cancer.【Methods】A total of 94 suspected breast cancer patients were underwent CTC negative enrichment test combined with FISH. The diagnostic value of negative enrichment of peripheral blood circulation tumor cells combined with FISH technique was analyzed. According to the gold standard of pathological results from puncture biopsy,94 patients were divided into the observation group (with breast cancer group) and the control group (non-breast cancer group).The clinical characteristics of patients with different CTC expression were recorded and the 2-year survival rates of patients with different CTC expression were compared.【Results】Of the 94 patients,there were 78 patients with breast cancer and 16 with benign breast lesions. The number of CTC cells in the observation group was (4.85±1.93) and the control group was (1.57±0.62);There was significant difference between the two groups (P<0.05).The ROC analysis showed that the AUC of CTC number for breast cancer was 0.706,whose sensitivity was 0.615 and specificity was 0.875. Among the 78 cases of breast cancer,58 cases were CTC positive and 20 cases were CTC negative. There were no significant differences in CTC positive detection rates among patients of different ages,body mass index,T stage and N stage (P>0.05).However,there were significant differences in the positive rates of CTC in patients with different M stage and differentiation degree (P<0.05).The 2-year progression-free survival rate of CTC negative patients was 80.00%,which was significantly higher than that of CTC positive patients of 55.17%,the difference was statistically significant. (P<0.05). The 2-year overall survival rates of CTC positive and negative patients were 70.69% and 80.00%,respectively,there was no significant difference between the two groups(P>0.05).【Conclusion】The CTC enrichment combined with FISH is helpful to improve the diagnostic specificity of breast cancer. The CTC is related to the stage of breast cancer. So it is helpful to evaluate the prognosis of patients by detecting the expression of CTC. 2022 Vol. 39 (10): 1482-1485 [Abstract] ( 39 ) HTML (1 KB)  PDF (1187 KB)  ( 21 ) 1486 Application of Morinda Officinalis Oligosaccharide Capsules in Treatment of Elderly Patients with Mild Depression after Stroke AI Wen-jun, GAO Ying DOI: 10.3969/j.issn.1671-7171.2022.10.013 【Objective】To investigate the value of morinda officinalis oligosaccharide capsules in the treatment of elderly patients with mild depression after stroke. 【Methods】A total of 90 elderly patients with mild depression after stroke who were admitted to two hospitals were randomly divided into two groups, with 45 cases in each group. The control group was treated with escitalopram, and the observation group was additionally treated with morinda officinalis oligosaccharide capsules on the basis of the control group. The clinical efficacy of the two groups was compared, and the scores of the Self-rating Depression Scale (SDS), Hamilton Depression Scale (HAMD), Simple Social Coping Scale (SCSQ) and Montreal Cognitive Assessment Scale (MoCA) score changes, and the incidence of adverse reactions in the two groups was observed. 【Results】The total effective rate in the observation group was 95.56%, which was higher than 82.22% in the control group (P<0.05). There was no significant difference in the scores of SDS, HAMD, MoCA and SCSQ between the two groups before treatment (P>0.05). After treatment, the scores of SDS, HAMD and negative coping style in the two groups were lower than those before treatment (P<0.05), while the scores of MoCA and positive coping style were higher than those before treatment. The scores of SDS, HAMD and negative coping style of post-treatment in the observation group were lower than those in the control group (P<0.05); And the scores of MoCA and positive coping style in the observation group were higher than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 11.11% (5/45), which was not significantly different from 8.89% (4/45) in the control group (P>0.05). 【Conclusion】Morinda oligosaccharide capsules have significant curative effect in the treatment of elderly patients with mild depression after stroke, which can improve the antidepressant effect, improve the coping style of patients, and will not increase the risk of adverse reactions. 2022 Vol. 39 (10): 1486-1488 [Abstract] ( 49 ) HTML (1 KB)  PDF (1099 KB)  ( 82 ) 1489 Effect of Brain Biofeedback Device Combined with Tandospirone Therapy on Emotional Recovery and Neuroelectrophysiology of Mixed Anxiety and Depression Disorders BAI Ru-yu, LI Chen-xi DOI: 10.3969/j.issn.1671-7171.2022.10.014 【Objective】To investigate the effect of brain biofeedback device combined with tandospirone on the emotional recovery of mixed anxiety and depression disorder and neuroelectrophysiology. 【Methods】A total of 106 patients with mixed anxiety and depression in our hospital from February 2019 to January 2021 were selected and divided into observation group and control group by random single-blind method, with 53 cases in each group. The control group was given tandospirone, and the observation group was treated with a brain biofeedback device on the basis of the control group, and both were treated for 12 weeks. To compare the efficacy, the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), RCSQ score, neuroelectrophysiological indicators (P3b, P3a, N2 latency and amplitude) levels before treatment, 12 weeks after treatment between the two groups, and count the occurrence of adverse reactions.【Results】The total effective rate of the observation group after 12 weeks of treatment was 92.45% higher than that of the control group 73.58%, the difference was statistically significant (P<0.05); The HAMA and HAMD scores of the observation group were lower than those of the control group after 12 weeks of treatment, and the difference was statistically significant (P<0.05); The RCSQ scores of the observation group were higher than those of the control group after 12 weeks of treatment, and the difference was statistically significant (P<0.05); After 12 weeks of treatment in the observation group, the latency of P3b, P3a, and N2 were all shorter than those of the control group, and the amplitudes were all higher than those of the control group,the difference was statistically significant (P<0.05); There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period (P>0.05). 【Conclusion】The brain biofeedback device assisted by tandospirone can effectively alleviate the mood disorders of patients with mixed anxiety and depression, and improve the quality of sleep, may be related to the regulation of neuro-electrophysiological functions. 2022 Vol. 39 (10): 1489-1492 [Abstract] ( 75 ) HTML (1 KB)  PDF (1124 KB)  ( 165 ) 1493 Clinical Characteristics,Drug Resistance and Prognosis of VAP Caused by Candida Albicans Combined with Acinetobacter Baumannii LIU Cui-ying, ZHANG Chun-feng, XU Xian-biao DOI: 10.3969/j.issn.1671-7171.2022.10.015 【Objective】To investigate the clinical characteristics,drug resistance and prognosis of ventilator-associated pneumonia (VAP) caused by Candida albicans combined with Acinetobacter baumannii. 【Methods】A total of 128 patients with VAP caused by Candida albicans combined with Acinetobacter baumannii who were admitted to our hospitals from March 2018 to July 2021 were selected as the research objects. The clinical characteristics and drug resistance of the patients were analyzed. After 4 weeks of follow-up,the factors for patient prognosis were analyzed as well. 【Results】The clinical features of 128 patients with VAP caused by Candida albicans combined with Acinetobacter baumannii were mostly cough,expectoration,dyspnea,fever,and blisters in the lungs. Candida albicans strains are more sensitive to mycotoxins and clotrimazole,whose resistance rates were 0 and 6.25%,respectively. However,the resistance rates to other antibiotics were all >10%. Acinetobacter baumannii strains were sensitive to tigecycline and minocycline,with resistance rates of 0 and 23.44%,respectively. And its resistance rates to other antibiotics were all >30%. Logistic multivariate regression analysis showed that albumin,acute physiology and chronic health evaluation score Ⅱ(APACHE Ⅱ),clinical pulmonary infection score (CPIS),secondary tracheal intubation,antibiotic use time were factors that affected the prognosis of VAP patients caused by candida combined with acinetobacter baumannii (P<0.05). 【Conclusion】The clinical characteristics of patients with VAP caused by candida albicans combined with acinetobacter baumannii are diverse,and they are highly resistant to a variety of commonly used antibiotics. The first choices for clinical treatment of VAP caused by candida albicans combined with acinetobacter baumannii were mycotoxins,clotrimazole,tigecycline and minocycline. Albumin,APACHE Ⅱ score,CPIS score,secondary tracheal intubation,antibiotic use time are the factors that affect the prognosis of patients with VAP caused by Candida and Acinetobacter baumannii. 2022 Vol. 39 (10): 1493-1496 [Abstract] ( 52 ) HTML (1 KB)  PDF (1123 KB)  ( 43 ) 1497 Effect of L-arginine Combined with Whole Protein Compound Preparation on Immune Function and Tumor Marker Level in Patients after Radical Resection of Esophageal Cancer ZHANG Yong, LIU Hong-gang, JING Xin, et al DOI: 10.3969/j.issn.1671-7171.2022.10.016 【Objective】To investigate the effect of L-arginine combined with whole protein compound preparation on immune function and tumor marker level in patients after radical resection of esophageal cancer. 【Methods】 A total of 98 patients undergoing radical resection of esophageal cancer in our hospital were randomly divided into observation group and control group, with 49 patients in each group. Patients in the observation group received L-arginine combined with whole protein compound preparation after operation, and patients in the control group received glucose saline enteral nutrition after operation. The levels of T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), cytokeratin 19 serum segment 21-1 (CYFRA21-1), albumin (ALB), prealbumin (PA), transferrin (TRF), urea nitrogen (BUN), serum creatinine (Scr), alanyl aminotransferase (ALT) Aspartate transferase (AST) in the two groups before treatment and after treatment were compared. 【Results】 After treatment, CD4+, CD4+/CD8+ in the two groups were significantly higher than those before treatment, and CD8+ was significantly lower than those before treatment (P<0.05). After treatment, CD4+, CD4+/CD8+ in the observation group were significantly higher than those in the control group, and CD8+ was significantly lower than those in the control group (P<0.05); After treatment, CEA, CA19-9, CA125, CYFRA21-1 in both groups were significantly lower than those before treatment, and those in the observation group were significantly lower than those in the control group (P<0.05); After treatment, ALB, PA and TRF in the two groups were significantly higher than those before treatment, and those in the observation group were significantly higher than those in the control group (P<0.05); There was no significant difference in BUN, Scr, ALT and AST between the two groups before and after treatment (P>0.05). 【Conclusion】 L-arginine combined with whole protein compound preparation can improve the nutritional status and immune function of patients after radical resection of esophageal cancer, and reduce the level of tumor markers. 2022 Vol. 39 (10): 1497-1500 [Abstract] ( 55 ) HTML (1 KB)  PDF (1121 KB)  ( 56 ) 1501 Expression of TLR-4 and HMGB1 in Peripheral Blood of Patients with Preeclampsia and its Diagnostic Value for Rena Injury ZHAO Jing, MAO Xiao-mei DOI: 10.3969/j.issn.1671-7171.2022.10.017 【Objective】 To investigate the expression levels of Toll-like receptor-4(TLR-4) and high mobility group protein 1 (HMGB1) in peripheral blood of patients with preeclampsia and their diagnostic value for renal injury. 【Methods】A total of 98 patients with preeclampsia diagnosed and treated in Xi'an International Medical Center Hospital from June 2020 to December 2021 (observation group) were selected, and 92 healthy pregnant women (control group) who came to the hospital for pregnancy examination at the same time were selected. The expression levels of TLR-4 and HMGB1 in the peripheral blood of the two groups of pregnant women were compared. According to the occurrence of renal injury in patients with preeclampsia, they were divided into the concurrent group and the non concurrent group. The expression level and clinical characteristics of TLR-4 and HMGB1 in peripheral blood of pregnant women in the concurrent group and the non concurrent group were compared. Logistic regression was used to analyze the influencing factors of renal injury in preeclampsia patients, and the diagnostic value of TLR-4 and HMGB1 expression in peripheral blood in preeclampsia patients with renal injury was analyzed using the ROC curve. 【Results】 The expression levels of TLR-4 and HMGB1 in peripheral blood of pregnant women in the observation group were higher than those in the control group (P<0.05); The incidence of renal injury in the observation group was 23.47%, and the expression levels of TLR-4 and HMGB1 in the peripheral blood of the pregnant women with complications were higher than those of the pregnant women without complications (P<0.05); The 24 hour urine protein content and serum creatinine level of the pregnant women in the concurrent group were significantly higher than those in the non concurrent group (P<0.05). Logistic regression analysis showed that TLR-4, HMGB1 levels in peripheral blood and 24h urine protein content were independent risk factors for renal injury in patients with preeclampsia (P<0.05); ROC curve analysis showed that the optimal cut-off points for TLR-4 and HMGB1 expression levels in peripheral blood to diagnose renal injury in patients with preeclampsia were 3.54 ng/mL and 18.40 ng/mL, respectively, with sensitivity of 78.26%, 82.61%, specificity of 74.67%, 70.67%, and area under the curve (AUC) of 0.748, 0.782. The combined specificity and AUC of the two were 93.33% and 0.872, respectively. 【Conclusion】 The expression levels of TLR-4 and HMGB1 in peripheral blood of pre eclampsia pregnant women are abnormally elevated, and both of them are independent risk factors for renal injury in pre eclampsia pregnant women. The clinical detection of TLR-4 and HMGB1 expression levels in peripheral blood of pre eclampsia pregnant women can be used as sensitive indicators for diagnosing renal injury in pre eclampsia pregnant women. 2022 Vol. 39 (10): 1501-1504 [Abstract] ( 45 ) HTML (1 KB)  PDF (1164 KB)  ( 45 ) 1505 Application Value of Color Ultrasound Combined with Serum gal-3 and sST2 in the Diagnosis of Hypertensive Left Ventricular Hypertrophy with Left Heart Failure JIA Bei, XIAO Wang-li DOI: 10.3969/j.issn.1671-7171.2022.10.018 【Objective】To study the application value of color ultrasound combined with serum galactose agglutinin-3(gal-3) and soluble growth stimulating expression gene 2 protein(sST2) in the diagnosis of hypertensive left ventricular hypertrophy with left heart failure. 【Methods】96 hypertensive left ventricular hypertrophy with left heart failure patients diagnosed in our hospital from January 2018 to December 2021 were included in the study group, and 96 patients without cardiovascular disease who underwent physical examination in our hospital during the same period were included in the control group.Color ultrasound combined with serum gal-3 and sST2 were performed in both groups. Color ultrasound indexes and serum gal-3 and sST2 levels of patients with different cardiac function grades were compared between the two groups and the study group. The color ultrasound indexes and serum gal-3 and sST2 levels of patients with different cardiac function grades in the study group were compared, and the correlation between color ultrasound indexes, serum gal-3 and sST2 levels and cardiac function grades was analyzed by Pearson correlation.【Results】LVESD, LVEDD, LAD, IVST, LVPWT, left ventricular Tei index and serum gal-3 and sST2 levels in the study group were higher than those in the control group, LVFS, LVEF and E/A were lower than those in the control group (P<0.05). In the study group, LVESD, LVEDD, LAD, IVST, LVPWT, left ventricular Tei index and serum gal-3 and sST2 levels of patients with grade Ⅳ cardiac function were higher than those of patients with grade Ⅱ and Ⅲ cardiac function, LVFS, LVEF and E/A were lower than those of patients with grade Ⅱ and Ⅲ cardiac function (P<0.05). LVESD, LVEDD, LAD, IVST, LVPWT, left ventricular Tei index and serum gal-3 and sST2 levels were higher in grade Ⅲ patients than in grade Ⅱ patients, LVFS, LVEF and E/A were lower than in grade Ⅱ patients (P<0.05). Pearson correlation analysis showed that serum gal-3 and sST2 levels of LEFT ventricular Tei index were positively correlated with cardiac function grading, while E/A, LVEF, LVFS were negatively correlated with cardiac function grading (P<0.05). There was no correlation between LVESD, LVEDD, LAD, IVST, LVPWT and cardiac function grading (P>0.05). 【Conclusion】Color ultrasound combined with serum gal-3 and sST2 has high diagnostic value for hypertensive left ventricular hypertrophy with left heart failure, and can be applied to clinical diagnosis of hypertensive left ventricular hypertrophy with left heart failure. 2022 Vol. 39 (10): 1505-1508 [Abstract] ( 35 ) HTML (1 KB)  PDF (1127 KB)  ( 18 ) 1509 Predictive Value of DRAGON Score Combined with TIBI Grading within 24 hours after Mechanical Thrombectomy for Prognosis of Acute Ischemic Cerebral Infarction LIU Fei, GAO Bei, XUE Jin-e, et al DOI: 10.3969/j.issn.1671-7171.2022.10.019 【Objective】To explore the predictive value of DRAGON score combined with TIBI within 24 hours after mechanical thrombectomy for acute ischemic cerebral infarction. 【Methods】A total of 98 patients with acute ischemic cerebral infarction who underwent mechanical thrombectomy in our hospital were selected for the study. Both 24 hour DRAGON score and TIBI grading at 24 hours after operation were evaluated. Patients were further divided into the poor prognosis group and good prognosis group according to their prognosis within 1 week after operation. Logistic multivariate regression analysis was used to explore the related factors affecting the prognosis of 1 week after mechanical thrombectomy. The receiver operating characteristic curve (ROC) was used to analyze the predictive value of DRAGON score and TIBI grading alone and in combination on recurrence of cerebral infarction within 1 week after operation.【Results】Among the ninety-eight patients, fifty-eight patients had a poor prognosis within 1 week after surgery (the poor prognosis group), accounting for 59.18%. The forty patients had a good prognosis (the good prognosis group), accounting for 40.82%. The poor prognosis group had a poor baseline CTA collateral compensation score, the proportion of TIBI grades 0 to 3, and the DRAGON score level were higher than those in the good prognosis group (P<0.05). The results of Logistic multivariate regression analysis showed that the poor baseline CTA collateral compensation score, the proportion of TIBI grades 0 to 3, and the high DRAGON score were all risk factors for poor prognosis within 1 week after surgery(P<0.05). ROC analysis showed that the area under the curve (AUC) of TIBI classification, DRAGON score and the combination of the two for acute ischemic cerebral infarction undergoing mechanical thrombectomy were 0.769, 0.785, and 0.839, respectively. The TIBI grades or DRAGON score alone had lower predictive value for poor prognosis within 1 week after operation than the combination of the two (P<0.05). 【Conclusion】TIBI grades 0 to 3 and high DRAGON scores are risk factors for poor prognosis in patients with acute ischemic cerebral infarction who underwent mechanical thrombectomy within 1 week after surgery. TIBI grading and DRAGON score alone and in combination have certain clinical predictive value in predicting the prognosis of patients with cerebral infarction undergoing mechanical thrombectomy within 1 week after surgery. 2022 Vol. 39 (10): 1509-1512 [Abstract] ( 60 ) HTML (1 KB)  PDF (1229 KB)  ( 29 ) 1513 Expression and Significance of Serum VEGF and ET-1 in Patients with Refractory Diabetic Foot WANG Peng, CHEN Yong-feng, ZHANG Da-wei, et al DOI: 10.3969/j.issn.1671-7171.2022.10.020 【Objective】To investigate the expression and significance of serum vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in patients with refractory diabetic foot. 【Methods】A total of 101 patients with diabetic foot admitted to our hospital from July 2019 to November 2021 were selected as the study group,while 68 patients with simple diabetes (without diabetic foot) admitted to our hospital during the same period were selected as the control group. The basic data of patients in the two groups were collected to analyze the factors affecting the occurrence of diabetic foot and the predictive value of serum VEGF and ET-1 in diabetic foot. The levels of serum VEGF and ET-1 in patients with different grades of diabetic foot in the study group were statistically analyzed. 【Results】The levels of fasting blood glucose (FPG),glycosylated hemoglobin,vascular cell adhesion molecule-1 (VCAM-1),fibroblast growth factor 2 (FGF2),C-reactive protein (CRP) and ET-1 in the study group were significantly higher than those in the control group (P<0.05). The level of VEGF was significantly lower than that in the control group (P<0.05). Logistic multifactor regression analysis showed fasting blood glucose (FPG),vascular cell adhesion molecule-1 (VCAM-1),VEGF and ET-1 were risk factors affecting the occurrence of diabetic foot (P<0.05). ROC curve results showed that the sensitivity of serum VEGF,ET-1 and their combination in predicting diabetic foot occurrence was 70.30%,78.22% and 70.30%,respectively; their specificities were 70.59%,79.41% and 94.12%,respectively and their AUC values were 0.757,0.766,and 0.910,respectively. There were statistically significant differences of VEGF and ET-1 in grade Ⅰ to Ⅴdiabetic foot groups (P<0.05). The levels of ET-1 in grade Ⅰ to Ⅴ diabetic foot groups were significantly increased with the increase of grading (P<0.05);While VEGF levels in grade Ⅰ to Ⅴ diabetic foot groups were significantly decreased with the increase of grading (P<0.05). 【Conclusion】Serum VEGF and ET-1 are not only related to the occurrence of diabetic foot,but also related to its progression to refractory diabetic foot. VEGF combined with ET-1 has a better early prediction of diabetic foot occurrence. 2022 Vol. 39 (10): 1513-1516 [Abstract] ( 51 ) HTML (1 KB)  PDF (1217 KB)  ( 110 ) 1517 Related Factors of Hypertension Patients with Acute Cerebral Infarction YANG Tao, MI Wan-jun DOI: 10.3969/j.issn.1671-7171.2022.10.021 【Objective】To investigate the related factors of hypertension patients with acute cerebral infarction (ACI). 【Methods】The clinical data of 240 patients with hypertension in our hospital were retrospectively analyzed. They were divided into ACI group (126 cases) and non ACI group (114 cases) according to whether ACI occurred. Clinical data information of two groups of patients [Sex, age, body mass index (BMI), diabetes, smoking, drinking, intracranial vascular stenosis, extracranial vascular stenosis] and laboratory indicators [Differences in hs-CRP, LDH, Lp-PLA2, Hcy, NO, eNOS] were counted and compared. The ROC curve was used to analyze the value of related indicators in predicting the occurrence of ACI in hypertensive patients; Non conditional logistic stepwise regression analysis was used to identify the risk factors of ACI.【Results】There was no significant difference between the two groups in terms of gender, age, BMI, diabetes, smoking history, drinking history, LDH, hs-CRP, and Lp-PLA2 levels (P>0.05). The proportion of intracranial and extracranial vascular stenosis in ACI group was significantly higher than that in the non ACI group, and the level of Hcy was significantly higher than that in the non ACI group, while the levels of NO and eNOS were significantly lower than that in the non ACI group, and the difference was statistically significant (P<0.05). According to ROC analysis, Hcy ≥ 22.41 μmol/L, NO≤53.28 μmol/L and eNOS ≤ 51.39 U/mL were the best cut-off values for predicting the occurrence of ACI in hypertensive patients (all P<0.05); Logistic stepwise regression analysis showed intracranial vascular stenosis, extracranial vascular stenosis, Hcy≥22.41 μmol/L, NO≤53.28 μmol/L and eNOS≤51.39 U/mL were the risk factors of ACI in hypertensive patients (P<0.05). 【Conclusion】 Intracranial vascular stenosis, extracranial vascular stenosis and Hcy, NO, eNOS levels are closely related to the occurrence of ACI in patients with hypertension. More attention should be paid to these indicators in clinical practice. 2022 Vol. 39 (10): 1517-1519 [Abstract] ( 48 ) HTML (1 KB)  PDF (1199 KB)  ( 14 ) 1520 Correlation Analysis of Umbilical Artery Blood Flow Parameters and Serum SP1 with the Degree of Umbilical Cord around the Neck at Late Pregnancy HU Yan-fang DOI: 10.3969/j.issn.1671-7171.2022.10.022 【Objective】 To investigate the relationship between the maximum systolic/diastolic umbilical artery blood flow velocity (S/D), pulsatility index (PI), resistance index (RI) and serum pregnancy specificity β1 glycoprotein (SP1) with the degree of umbilical cord around the neck. 【Methods】 From February 2019 to May 2020, 90 late pregnant women (observation group) who received prenatal ultrasound examination in the Yichuan County People's Hospital in Shaanxi Province and had fetal umbilical cord around the neck for one week were selected. In addition, 100 healthy pregnant women (control group) who received prenatal ultrasound examination in the Affiliated Hospital of Yan'an University in Shaanxi Province in the same period were selected. The depth of umbilical cord around neck impression, umbilical artery S/D, PI, RI and serum SP1 levels were compared between the two groups; Pearson was used to analyze the correlation between umbilical artery blood flow parameters, serum SP1 level and the depth of fetal umbilical cord around the neck indentation in the observation group. 【Results】 Compared with the control group, the umbilical artery S/D, PI, RI in the observation group were significantly increased (P<0.05), and the serum SP1 level was significantly decreased (P<0.05); When the depth of fetal umbilical cord around the neck indentation is less than 0.60 cm, 0.60～0.79 cm, ≥0.80 cm, the umbilical artery S/D, PI, RI of pregnant women increase in turn (P<0.05), and the serum SP1 level decreases in turn (P<0.05). The S/D, PI, RI of umbilical artery in the observation group were positively correlated with the depth of umbilical cord around the neck (r=0.587, 0.529, 0.657, P<0.05), and the serum SP1 level was negatively correlated with the depth of umbilical cord around the neck (r=-0.538, P<0.05). 【Conclusion】 The increase of S/D, PI, RI of umbilical artery and the decrease of serum SP1 level in late pregnancy women with fetal umbilical cord around the neck are closely related to the degree of fetal umbilical cord around the neck. 2022 Vol. 39 (10): 1520-1523 [Abstract] ( 53 ) HTML (1 KB)  PDF (1163 KB)  ( 100 ) 1524 Relationship between TNF-α and LPL Gene Polymorphisms and Insulin Resistance in GDM Patients and Their Newborns ZHANG Jun, ZHANG Li-wen, LI He-ping DOI: 10.3969/j.issn.1671-7171.2022.10.023 【Objective】To study the relationship between tumor necrosis factor-α (TNF-α) and lipoprotein lipase (LPL) gene polymorphisms and insulin resistance (IR) in gestational diabetes mellitus (GDM) patients and their newbornsnewborns. 【Methods】54 patients with GDM from October 2018 to October 2019 were included as the observation group, another 54 normal pregnant women were included as the control group. The venous blood of pregnant women were collected, the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) were used to detect the distribution of TNF-α gene -857C/T site, -863A/C site and LPL HindⅢ genotype in pregnant women. The distribution of TNF-αgene -857C/T, -863A/C and LPL HindⅢ were compared between the two groups.The levels of homeostasis model assessment of insulin resistance (HOMA-IR) serum TNF-α and LPL were recorded. The relationship between serum TNF-α, LPL and HOMA-IR in pregnant women were analyzed. 【Results】There were significant differences in genotype and allele distribution of -857C/T locus between the observation group and the control group (P<0.05).The patients with CT genotype and T allele in the observation group were significantly higher than those in the control group, the difference were statistically significant (P<0.05).There were significant difference in the distribution of LPL HindⅢ genotype and allele between the two groups (P<0.05),the patients with H+ H+ genotype and H+ allele in the observation group were significantly higher than those in the control group, the difference were statistically significant (P<0.05).The levels of serum TNF-α, HOMA-IR and newborn HOMA-IR in patients with GDM of CT genotype at -857C/T were significantly higher than those in patients with CC and TT, the serum LPL of patients with H+ H+ genotype of LPL HindⅢ was significantly lower than that of patients with H- H- and H+ genotype, the HOMA-IR and newborn HOMA-IR were significantly higher than H- H- and H+ genotypes, the difference were statistically significant (P<0.05).There were significant positive correlation between serum TNF-α and HOMA-IR of pregnant women and newborns (P<0.05),There were significant negative correlation between LPL and HOMA-IR in pregnant women and newborns (P<0.05). 【Conclusion】The TNF-α gene -857C/T site and LPL Hind Ⅲ gene polymorphisms are related to IR in GDM patients and their newborns. The IR is more likely to occur in patients with TNF-α CT genotype and LPL Hind Ⅲ H+ H+ genotype, which leaded to the occurrence and development of GDM. 2022 Vol. 39 (10): 1524-1527 [Abstract] ( 28 ) HTML (1 KB)  PDF (1124 KB)  ( 38 ) 1528 Effect of Different Doses of Ondansetron on Anesthesia and Postoperative Vomiting in Pregnant Women Undergoing Painless Induced Abortion ZHANG Zhu-qing, MENG Ya-jing DOI: 10.3969/j.issn.1671-7171.2022.10.024 【Objective】 To observe the effects of different doses of ondansetron on the anesthesia, recovery and postoperative vomiting of pregnant women undergoing painless induced abortion . 【Methods】A total of 192 pregnant women who received painless induced abortion in both hospitals were divided into control group, low dose group, medium dose group and high dose group according to the medication situation; Each group was anesthetized with diazosine combined with propofol. The control group was not given antiemetic drugs. The low dose group was given 2 mg ondansetron before anesthesia, the medium dose group was given 4 mg ondansetron before anesthesia, and the high dose group was given 8mg ondansetron before anesthesia; The intraoperative indexes, postoperative nausea and vomiting degree and recovery quality of the pregnant women in each group were compared, and the use of additional antiemetic drugs in each group was counted after 24 h follow-up. 【Results】There was no significant difference in operation time, anesthesia time, mean heart rate and mean arterial pressure (MAP) among the four groups (P>0.05). The incidence of nausea and vomiting was 43.75% (21/48) in the control group, 20.83% (10/48) in the low dose group, 6.25% (3/48) in the middle dose group and the high dose group. The low dose group, the middle dose group and the high dose group were lower than the control group (P<0.05), and the middle dose group and the high dose group were lower than the low dose group (P<0.05). There was no significant difference between the middle dose group and the high dose group (P>0.05). There was no significant difference in the recovery time of spontaneous respiration, the time of awakening eyes, the time of clenching fists under command, and the dryness degree score during the awakening period among the pregnant women in each group (P>0.05). The application rate of additional antiemetic drugs in the control group was 27.08% (13/48), 10.42% (5/48) in the low dose group, 2.08% (1/48) in the medium dose group, and no additional antiemetic drugs were used in the high dose group. There was no significant difference in the application rate between low dose group, medium dose group and high dose group (P>0.05). The application rate of control group was higher than that of low dose group, medium dose group and high dose group (P<0.05). 【Conclusion】 Dezocine combined with ondansetron during painless induced abortion can effectively reduce the incidence and degree of postoperative malignant vomiting, and the combination of 4 mg ondansetron is safe. The effect of 4 mg ondansetron is better than that of 2 mg ondansetron, and the effect is not significantly improved when the dosage is increased to 8 mg. 2022 Vol. 39 (10): 1528-1530 [Abstract] ( 45 ) HTML (1 KB)  PDF (1101 KB)  ( 78 ) 1531 Value of Retinol Dehydrogenase 10 in Prognosis of Hepatocellular Carcinoma after TACE Treatment WANG Jie, ZHANG Cui-cui DOI: 10.3969/j.issn.1671-7171.2022.10.025 【Objective】To investigate the value of retinol dehydrogenase 10 (RDH10) in peripheral blood mononuclear cells for the prognosis of hepatocellular carcinoma (HCC) after transhepatic arterial chemoembolization (TACE). 【Methods】A total of 202 HCC patients who were treated in our hospital were divided into the survival group (n=125) and the death group (n=77) according to the 3-year survival prognosis. The fasting venous blood was drawn from patients before TACE (T1), 3 days after TACE (T2) and 7 days after TACE (T3). Ficoll density gradient centrifugation was used to isolate mononuclear cells from peripheral blood. Western blot was used to detect the expression level of RDH10 in mononuclear cells. 【Results】The expression levels of RDH10 in both survival and death groups decreased with time progression. The expression levels of RDH10 at T2 and T3 in the survival group were lower than those in the death group (P<0.05). The efficacy of RDH10 at T3 for predictive prognosis of HCC patients was higher than those of RDH10 at T1 and RDH10 at T2; And the differences were statistically significant (P<0.05). COX regression analysis showed that sorafenib and licartin were independent protective factors for the prognosis of HCC patients (P<0.05). The tumor diameter, tumor stage, and RDH10 (T3) were all independent risk factors for the prognosis of HCC patients (P<0.05). 【Conclusion】The expression level of RDH10 in peripheral blood mononuclear cells on the 7th day after TACE is related to the prognosis of HCC patients, which has certain diagnostic value for the prognosis of TACE treatment. 2022 Vol. 39 (10): 1531-1534 [Abstract] ( 32 ) HTML (1 KB)  PDF (1229 KB)  ( 67 ) 1535 Relationship of Carotid Plaque Stability with Serum ALCAM and PECAM-1 in Patients with Acute Cerebral Infarction and Type 2 Diabetes Mellitus SUN Xiu-juan, LEI Guang-feng DOI: 10.3969/j.issn.1671-7171.2022.10.026 【Objective】To investigate the relationship of carotid plaque stability with serum levels of activated leukocyte cell adhesion molecule (ALCAM) and platelet endothelial cell adhesion molecule-1 (PECAM-1) in patients with acute cerebral infarction complicated with type 2 diabetes mellitus. 【Methods】A total of 80 patients with acute cerebral infarction complicated with type 2 diabetes diagnosed in our hospital were selected as the observation group, while 65 acute cerebral infarction patients without type 2 diabetes in our hospital in the same period were selected as the control group. The levels of ALCAM and PECAM-1 were detected and compared between the two groups, and the relationship of carotid plaque stability and internal vessel formation grade with ALCAM and PECAM-1 in patients with acute cerebral infarction complicated with type 2 diabetes mellitus was analyzed. Pearson correlation analysis was used to analyze the relationship among ALCAM, PECAM-1 and NIHSS score in patients with acute cerebral infarction complicated with type 2 diabetes mellitus.【Results】The levels of ALCAM and PECAM-1 in the observation group were higher than those in the control group (all P<0.05). In the observation group, there were 11 cases without plaque, 24 cases with stable plaque and 45 cases with unstable plaque. The levels of ALCAM and PECAM-1 in patients without plaque were lower than those in patients with stable plaque and unstable plaque (all P<0.05), and the levels of ALCAM and PECAM-1 in patients with stable plaque were lower than those in patients with unstable plaque (all P<0.05). Among the 80 patients, 39 patients had carotid plaque internal vascularization grade of 0～1 and 41 patients had grade 2～3. The levels of ALCAM and PECAM-1 in grade 0～1 patients were lower than those in grade 2～3 patients (all P<0.05). The levels of ALCAM and PECAM-1 were positively correlated with NIHSS score in patients with acute cerebral infarction complicated with type 2 diabetes mellitus (all P<0.05).【Conclusion】 Serum levels of ALCAM and PECAM-1 in patients with acute cerebral infarction complicated with type 2 diabetes mellitus are significantly increased, which are not only closely related to the stability of carotid plaque and internal vascular formation grade, but also significantly positively related to the degree of neurological impairment. Thus, in clinical practice the relationship should be paid attention to. 2022 Vol. 39 (10): 1535-1538 [Abstract] ( 33 ) HTML (1 KB)  PDF (1126 KB)  ( 30 ) 1539 Clinical Analysis of Influencing Factors of Fungal Septicemia in Extremely Low Birth Weight Preterm Infants LI Xiao, WU Yun-qin, LI Gui-nan, et al DOI: 10.3969/j.issn.1671-7171.2022.10.027 【Objective】To investigate the influencing factors of fungal septicemia in extremely low/ultra-low birth weight premature infants. 【Methods】A total of 181 cases of extremely low/ultra-low birth weight preterm infants admitted to the preterm intensive care unit of Hunan Children's Hospital from January 2016 to December 2020 were selected and divided into the observation group (with positive blood fungal culture,n=21) and the control group (with negative blood fungal culture,n=160) according to the occurrence of positive blood fungal culture. The clinical data of the two groups were collected and compared retrospectively. Logistic regression was used to analyze the related influencing factors of fungal sepsis. The results of bacterial strain culture and drug sensitivity were analyzed,while the drug use and outcome of the children were recorded. 【Results】There were no significant differences between the two groups in terms of gender,vaginal delivery,birth asphyxia,premature rupture of membranes,use of pulmonary surfactant (PS) and complication with chronic lung disease (P>0.05). There were significant differences in the combined use of antibiotics for ≥7 days,parenteral nutrition for ≥14 days,PICC indwelling for ≥14 days,and invasive mechanical ventilation for ≥7 days (P<0.05). Logistic regression analysis showed that the combined use of antibiotics ≥7 days,PICC indwelling ≥14 days,and invasive mechanical ventilation ≥7 days were independent risk factors for fungal sepsis in extremely low and ultra-low birth weight preterm infants (P<0.05).Parenteral nutrition ≥14 days was a non-independent risk factor for fungal sepsis in extremely low and ultra-low birth weight preterm infants (P>0.05). 【Conclusion】Fungal sepsis in extremely low and ultra-low birth weight preterm infants is mostly nosocomial infection. Rational use of antibiotics,strengthening the management of PICC and shortening the duration of invasive mechanical ventilation can reduce the infection rate of fungal sepsis. 2022 Vol. 39 (10): 1539-1541 [Abstract] ( 56 ) HTML (1 KB)  PDF (1101 KB)  ( 37 ) 1542 Clinical Significanc of the Levels Transforming growth factor-β1, Endothelial Nitric oxide Synthase and Interleukin-1β in Patients with Rheumatic Heart Disease Complicated with Atrial Fibrillation WEN Guan-liang, MAO Dian-bo DOI: 10.3969/j.issn.1671-7171.2022.10.028 【Objective】To investigate the change and its clinical significanc of the levels transforming growth factor-β1(TGF-β1) , endothelial nitric oxide synthase (eNOS) and interleukin-1β(IL-1β)in patients with rheumatic heart disease (RHD) complicated with atrial fibrillation (AF) . 【Methods】 A total of 105 patients with RHD admitted to the two hospitals from January 2020 to January 2022 were selected and divided into observation group (with AF, n=65) and control group (without AF, n=40) according to the presence of AF. Distribution of atrial collagen and atrial TGF- β1, eNOS, IL-1β, mRNA and their protein expression levels in two the groups were compared.【Results】The volume fraction of myocardial collagen in the observation group was significantly higher than that in the control group (P<0.05).The expression level TGF-β1 and IL-1β mRNA of atrial tissue in observation group was significantly higher than that of the control group (P<0.05), and the expression level of eNOS mRNA in atrial tissue was significantly lower than that in control group (P<0.05). The protein expression level of TGF-β1 and IL-1β of atrial tissue in the observation group was significantly higher than that of the control group (P<0.05). The expression level of eNOS protein in atrial tissue was significantly lower than that in the control group (P<0.05). 【Conclusion 】 TGF-β1, eNOS and IL-1β may participate in the pathogenesis of RHD patients complicated with AF, and play an important role in the process of myocardial cell remodeling. 2022 Vol. 39 (10): 1542-1545 [Abstract] ( 48 ) HTML (1 KB)  PDF (1266 KB)  ( 38 ) 1546 Serum IL-2 and IL-12 Levels in Children with Mycoplasma Pneumoniae and Epstein Barr Virus Infection and Their Correlation with Prognosis WU Zou-yu, MENG Fa-cai, ZHANG Li, et al DOI: 10.3969/j.issn.1671-7171.2022.10.029 【Objective】 To investigate the serum levels of interleukin-2 (IL-2) and interleukin-12 (IL-12) in children with mycoplasma pneumoniae (MP) and EB virus infection and their correlation with the prognosis of the children. 【Methods】 From May 2019 to May 2020, 103 children with MP and EB virus infection (combined group), 103 children with MP infection (MP group), and 103 healthy children (control group) who underwent physical examination at the same time were selected. According to the prognosis of children in the combined group, they were divided into poor prognosis group (n=32) and non poor prognosis group (n=71). The levels of serum IL-2 and IL-12 were detected by enzyme-linked immunosorbent assay (ELISA). Logistic regression analysis was used to analyze the factors affecting the poor prognosis of children with MP combined with EB virus infection. The ROC curve was used to analyze the evaluation value of serum IL-2 and IL-12 on the poor prognosis of children with MP combined with EB virus infection. 【Results】 The levels of serum IL-2 and CRP in the combined group were higher than those in MP group and control group, and those in MP group were higher than those in control group (P<0.05); The serum IL-12 level of children in the combined group was lower than that in MP group and control group, and MP group was lower than that in control group (P<0.05). Serum CRP, IL-2 levels and fever time in the poor prognosis group were higher than those in the non poor prognosis group, and serum IL-12 levels were lower than those in the non poor prognosis group (P<0.05). Logistic regression analysis showed that high expression of IL-2 in serum was an independent risk factor for poor prognosis of MP patients with EB virus infection, and high expression of IL-12 was a protective factor for poor prognosis of MP patients with EB virus infection (P<0.05). ROC curve analysis showed that the area under the curve of serum IL-2, IL-12 and their combination to evaluate the adverse prognosis of MP patients with EB virus infection were 0.746, 0.866 and 0.901, respectively, with sensitivity of 64.5%, 93.5% and 83.9%, and specificity of 88.9%, 79.2% and 81.9%. 【Conclusion】 The serum IL-2 level in MP patients with EB virus infection is increased and the serum IL-12 level is decreased, which is closely related to the prognosis, and has a certain predictive value for the poor prognosis of children, and the combined predictive value of the two is higher. 2022 Vol. 39 (10): 1546-1549 [Abstract] ( 32 ) HTML (1 KB)  PDF (1140 KB)  ( 42 ) 1550 Clinical Efficacy of Recombinant Human Brain Natriuretic Peptide Combined with Bisoprolol in the Treatment of Patients with Ischemic Cardiomyopathy and its Effect on CITED2, miR-182 and HIF-1 ZHOU Fang-zhou, ZHAO Qing-yan, WANG Ai-hong DOI: 10.3969/j.issn.1671-7171.2022.10.030 【Objective】To investigate the clinical efficacy of recombinant human brain natriuretic peptide combined with bisoprolol in the treatment of patients with ischemic cardiomyopathy (ICM) and its effect on the levels of microRNA-182 (miR-182), protein trans acting factor (CITED2) and hypoxia inducible factor-1 (HIF-1). 【Methods】A total of 128 ICM patients treated in the Third Hospital of Shandong Province from October 2018 to October 2020 were prospectively selected and divided into observation group and control group according to the random number table method, with 64 cases in each group. On the basis of routine treatment, the control group was treated with bisoprolol, and the observation group was treated with recombinant human brain natriuretic peptide on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared, and the levels of serum cardiomyocyte apoptosis index [soluble apoptosis related factor (sFas), soluble apoptosis related factor ligand (sFasL)], markers of myocardial ischemia injury[troponin T (cTnT), myoglobin (Mb), creatine kinase isoenzyme (CK-MB)] and CITED2, miR-182 and HIF-1 were compared before and after treatment.【Results】After one month of treatment, the total effective rate in the observation group was higher than that in the control group (P<0.05); The levels of serum sFas, sFasL, cTnT, Mb and CK-MB in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05); The levels of serum CITED2 in the two groups were higher than those before treatment, and the levels of miR-182 and HIF-1 were lower than those before treatment, and the difference between the two groups was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was higher than that in the control group, but the difference was not statistically significant (P>0.05). 【Conclusion】Recombinant human brain natriuretic peptide combined with bisoprolol is effective in the treatment of ICM patients. It can enhance the ability of myocardial anti hypoxia and ischemia, inhibit cardiomyocyte apoptosis, and has good safety. 2022 Vol. 39 (10): 1550-1552 [Abstract] ( 41 ) HTML (1 KB)  PDF (1101 KB)  ( 25 ) 1553 Clinical Effect of Ultrasound Guided Percutaneous Cryoablation Combined with Total Androgen Blockade in the Treatment of Prostate Cancer and its Influence on Patients' Immune Function ZHANG Peng-fei, LEI Yi, XUE Jing DOI: 10.3969/j.issn.1671-7171.2022.10.031 【Objective】 To investigate the clinical effect of ultrasound guided percutaneous cryoablation combined with total androgen blockade in the treatment of prostate cancer and its influence on patients' immune function. 【Methods】 The clinical data of 78 patients with prostate cancer admitted to our hospital from February 2013 to February 2016 were analyzed retrospectively, and they were divided into the observation group (n=40) and the control group (n=38) according to different treatment schemes. The control group was treated with total androgen blockade, and the observation group was treated with ultrasound guided percutaneous cryoablation on the basis of the control group. The serum prostate specific antigen (PSA), free prostate antigen (fPSA), human pregradient protein 2 (AGR2), immune function indicators (CD3+, CD4+, CD4+/CD8+), and expanded prostate cancer composite index (EPIC) scores were compared between the two groups before treatment and 6 months after treatment, and the survival conditions of 2, 3, and 5 years after operation were calculated. 【Results】 The levels of serum PSA, fPSA, AGR2 in the observation group were lower than those in the control group 6 months after treatment, and the levels of serum CD3+, CD4+, CD4+/CD8+ were higher than those in the control group (P<0.05); EPIC scores in the observation group were higher than those in the control group 6 months after treatment (P<0.05). There was no significant difference in the 2-year and 3-year survival rates between the two groups (P>0.05). The 5-year survival rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】 Ultrasound guided percutaneous cryoablation combined with total androgen blockade can reduce the serum PSA, fPSA, AGR2 levels, improve the immune function and quality of life of patients with prostate cancer, and improve the survival rate, which is worthy of clinical reference. 2022 Vol. 39 (10): 1553-1556 [Abstract] ( 50 ) HTML (1 KB)  PDF (1128 KB)  ( 57 ) 1557 Comparison of the Efficacy and Safety of Three-dimensional DSA and CTA Assisted Transpterional Approach in Clipping Ruptured Anterior Communicating Aneurysm GAO Yong-kai, LI Hui-min DOI: 10.3969/j.issn.1671-7171.2022.10.032 【Objective】 To compare the efficacy and safety of three-dimensional DSA and CTA assisted transpterional approach in clipping ruptured anterior communicating aneurysm. 【Methods】 From January 2018 to January 2021, 96 patients with pre ruptured communicating aneurysm who were admitted to Yan'an People's Hospital and planned to undergo pterional approach clipping surgery were selected, and they were divided into observation group and control group according to different preoperative examination methods, with 48 cases in each group. DSA was performed before operation in the observation group, and CTA was performed before operation in the control group. The operation time, intraoperative blood loss, hospital stay, number of cases of complete clipping of anterior communicating artery aneurysm, and complications of the two groups were compared. 【Results】There was no significant difference in gender, age, Hunt Hess grade and tumor diameter between the two groups (P>0.05). There was no significant difference between the two groups in terms of operation time, intraoperative bleeding and hospital stay (P>0.05). There was no significant difference in the number of complete clipping of anterior communicating aneurysm between the two groups (P>0.05). There was no significant difference in GOS scores between the two groups at discharge (P>0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). 【Conclusion】 The effect of three-dimensional DSA and CTA assisted transpterional approach in clipping the ruptured anterior communicating artery aneurysm is similar, the prognosis of the patients is good, and the incidence of complications will not increase significantly, both are safe and reliable. 2022 Vol. 39 (10): 1557-1559 [Abstract] ( 44 ) HTML (1 KB)  PDF (1101 KB)  ( 36 ) 1560 Clinical Efficacy of Ganciclovir in the Treatment of Cytomegalovirus Hepatitis in Children GUO Hui-min, ZHANG Yan-xiang, SONG Jian-gang DOI: 10.3969/j.issn.1671-7171.2022.10.033 【Objective】 To investigate the clinical efficacy of ganciclovir in the treatment of cytomegalovirus (CMV) hepatitis in children. 【Methods】 The clinical data of 88 children with cytomegalovirus hepatitis admitted to our hospital from March 2019 to March 2021 were analyzed retrospectively. They were divided into observation group and control group according to different antiviral drugs, with 44 cases in each group. The children in the control group were treated with reduced glutathione, and the children in the observation group were treated with ganciclovir on the basis of the control group. The jaundice regression time, liver retraction time, spleen retraction time, the level serum total bilirubin (TBIL), alanine aminotransferase (ALT), γ- glutamyltranspeptidase (GGT) before and after the therapy and the clinical efficacy and adverse reactions of the two groups were compared.【Results】 The time of jaundice regression, liver retraction and spleen retraction in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the levels of serum TBIL, ALT and GGT in the two groups were lower than those before treatment, and the levels in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). The total clinical effective rate in the observation group was 93.18% (41/44), higher than that in the control group [77.27% (34/44)], with a statistically significant difference(χ2=4.423,P=0.036). There was no significant difference in the incidence of adverse reactions between the two groups(χ2=1.048,P=0.310).【Conclusion】 Ganciclovir antiviral therapy can shorten the time of clinical symptom disappearance, promote the recovery of liver function, and it is safe and reliable. 2022 Vol. 39 (10): 1560-1562 [Abstract] ( 41 ) HTML (1 KB)  PDF (1102 KB)  ( 24 )

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