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| Analysis of Monitoring Results of Tacrolimus Blood Trough Concentration in Children with Nephrotic Syndrome |
| CHEN Jun-xiao, LI Na |
| Xianyang Hospital of Yan'an University,Xianyang Shaanxi 712000 |
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Abstract 【Objective】 To analyze the monitoring results of tacrolimus blood trough concentration in children with nephrotic syndrome (NS) and its guiding significance. 【Methods】 A total of 97 children with nephrotic syndrome were selected as the study object. All the children were treated with tacrolimus, and their drug use was recorded. Their gender, age, dosage and distribution of different blood trough concentrations were analyzed. Their treatment effects were statistically analyzed. The changes of blood trough concentrations of tacrolimus and adverse reactions in children with different therapeutic effects were observed, Spearman correlation analysis was used to explore the correlation between the blood trough concentration of tacrolimus and the therapeutic effect in children.【Results】 There was no significant difference in gender and age distribution of children with different blood drug concentration (P>0.05); The difference in clinical dosage was statistically significant (P<0.05). After treatment in 97 children with NS, there were 32 patients with CR (32.99%), 41 patients with PR (42.27%), and 24 patients with NR (24.74%). There was a statistically significant difference in the blood concentration of tacrolimus in the first, second and third weeks of children with different therapeutic effects (P<0.05); The trough concentration of tacrolimus in children with CR at week 1, 2 and 3 was higher than that in children with PR and NR, and that in children with PR was higher than that in children with NR (P<0.05). The incidence of adverse reactions in children with CR was 53.12%, that in children with PR was 51.22%, and that in children with NR was 33.33%. There was no significant difference in the incidence of adverse reactions in children with different therapeutic effects (P>0.05). Spearman correlation analysis showed that there was a positive correlation between the therapeutic effect of NS children and the blood trough concentration of tacrolimus (rs=0.842). 【Conclusion】 The sex and age of children with nephrotic syndrome have little influence on the blood trough concentration of tacrolimus, and the dosage of tacrolimus can affect the blood trough concentration to a certain extent. To reasonably reduce the adverse reactions caused by drugs in clinical practice, it is necessary to formulate appropriate dosage of tacrolimus blood to improve the safety of treatment.
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Received: 20 January 2022
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2022, Vol. 39 
