风湿性心脏病合并房颤患者心房组织中TGF-β1、eNOS、IL-1β水平变化及其临床意义

doi:10.3969/j.issn.1671-7171.2022.10.028

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Abstract 【Objective】To investigate the change and its clinical significanc of the levels transforming growth factor-β1(TGF-β1) , endothelial nitric oxide synthase (eNOS) and interleukin-1β(IL-1β)in patients with rheumatic heart disease (RHD) complicated with atrial fibrillation (AF) . 【Methods】 A total of 105 patients with RHD admitted to the two hospitals from January 2020 to January 2022 were selected and divided into observation group (with AF, n=65) and control group (without AF, n=40) according to the presence of AF. Distribution of atrial collagen and atrial TGF- β1, eNOS, IL-1β, mRNA and their protein expression levels in two the groups were compared.【Results】The volume fraction of myocardial collagen in the observation group was significantly higher than that in the control group (P<0.05).The expression level TGF-β1 and IL-1β mRNA of atrial tissue in observation group was significantly higher than that of the control group (P<0.05), and the expression level of eNOS mRNA in atrial tissue was significantly lower than that in control group (P<0.05). The protein expression level of TGF-β1 and IL-1β of atrial tissue in the observation group was significantly higher than that of the control group (P<0.05). The expression level of eNOS protein in atrial tissue was significantly lower than that in the control group (P<0.05). 【Conclusion 】 TGF-β1, eNOS and IL-1β may participate in the pathogenesis of RHD patients complicated with AF, and play an important role in the process of myocardial cell remodeling.

Key words： Rheumatic Heart Disease/CO Atrial Fibrillation/CO Transforming Growth Factor beta1 Nitric Oxide Synthase Interleukin-1beta

Received: 10 March 2022

PACS:

R541.2

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	WEN Guan-liang
	MAO Dian-bo

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WEN Guan-liang,MAO Dian-bo. Clinical Significanc of the Levels Transforming growth factor-β1, Endothelial Nitric oxide Synthase and Interleukin-1β in Patients with Rheumatic Heart Disease Complicated with Atrial Fibrillation[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1542-1545.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.10.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I10/1542

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