Clinical Significanc of the Levels Transforming growth factor-β1, Endothelial Nitric oxide Synthase and Interleukin-1β in Patients with Rheumatic Heart Disease Complicated with Atrial Fibrillation
WEN Guan-liang, MAO Dian-bo
Qianxian Traditional Chinese Medicine Hospital,Qian Xian Shaanxi 713300
Abstract 【Objective】To investigate the change and its clinical significanc of the levels transforming growth factor-β1(TGF-β1) , endothelial nitric oxide synthase (eNOS) and interleukin-1β(IL-1β)in patients with rheumatic heart disease (RHD) complicated with atrial fibrillation (AF) . 【Methods】 A total of 105 patients with RHD admitted to the two hospitals from January 2020 to January 2022 were selected and divided into observation group (with AF, n=65) and control group (without AF, n=40) according to the presence of AF. Distribution of atrial collagen and atrial TGF- β1, eNOS, IL-1β, mRNA and their protein expression levels in two the groups were compared.【Results】The volume fraction of myocardial collagen in the observation group was significantly higher than that in the control group (P<0.05).The expression level TGF-β1 and IL-1β mRNA of atrial tissue in observation group was significantly higher than that of the control group (P<0.05), and the expression level of eNOS mRNA in atrial tissue was significantly lower than that in control group (P<0.05). The protein expression level of TGF-β1 and IL-1β of atrial tissue in the observation group was significantly higher than that of the control group (P<0.05). The expression level of eNOS protein in atrial tissue was significantly lower than that in the control group (P<0.05). 【Conclusion 】 TGF-β1, eNOS and IL-1β may participate in the pathogenesis of RHD patients complicated with AF, and play an important role in the process of myocardial cell remodeling.
WEN Guan-liang,MAO Dian-bo. Clinical Significanc of the Levels Transforming growth factor-β1, Endothelial Nitric oxide Synthase and Interleukin-1β in Patients with Rheumatic Heart Disease Complicated with Atrial Fibrillation[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1542-1545.
[1] JAME S,BARNES G.Stroke and thromboembolism prevention in atrial fibrillation[J].Heart,2020,106(1):10-17.
[2] XUE X,LING X,XI W,et al.Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway[J].Mol Med Rep,2020,22(3):1759-1766.
[3] MATSUSHITA N,ISHIDA N,IBI M,et al.IL-1β plays an important role in pressure overload-induced atrial fibrillation in mice[J].Biol Pharm Bull,2019,42(4):543-546.
[4] 中华医学会风湿病学分会.风湿热诊断和治疗指南[J].中华风湿病学杂志,2011,15(7):483-486.
[5] JANUARY C T,WANN L S,CALKINS H,et al.2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation:a report of the American college of cardiology/American heart association task force on clinical practice guidelines and the heart rhythm society in collaboration with the society of thoracic surgeons[J].Circulation,2019,140(2):125-151.
[6] CHUNG M K,REFAAT M,SHEN W K,et al.Atrial fibrillation:JACC council perspectives[J].J Am Coll Cardiol,2020,75(14):1689-1713.
[7] KORNEJ J,BÖRSCHEL C S,BENJAMIN E J,et al.Epidemiology of atrial fibrillation in the 21st century:novel methods and new insights[J].Circ Res,2020,127(1):4-20.
[8] 李磊,董亚辉,杨探,等.转化生长因子-β1受体依赖的心肌纤维化伴随大电导钙激活钾通道的表达和功能下调[J].中国循环杂志,2021,36(6):612-618.
[9] 聂慧娟,黄织春.转化生长因子β1诱导心肌成纤维细胞转分化过程中Hedgehog信号通路的作用机制[J].中国组织工程研究,2021,25(5):754-760.
[10] ZHANG M,WANG H,WANG X,et al.MG53/CAV1 regulates transforming growth factor-beta1 signaling-induced atrial fibrosis in atrial fibrillation[J].Cell Cycle,2020,19(20):2734-2744.
[11] 蒋庆娟,应燕萍.内皮型一氧化氮合酶与血栓性疾病的研究进展[J].中国比较医学杂志,2020,30(6):140-144.
[12] LU Y Y,WU W S,LIN Y K,et al.Angiotensin 1-7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway[J].Eur J Clin Invest,2018,48(1):1-5.
[13] LIU Q,ZHANG F,YANG M,et al.Increasing level of interleukin-1beta in epicardial adipose tissue is associated with persistent atrial fibrillation[J].J Interferon Cytokine Res,2020,40(1):64-69.
[14] CHENG C,LIU H,TAN C,et al.Mutation in NPPA causes atrial fibrillation by activating inflammation and cardiac fibrosis in a knock-in rat model[J].FASEB J,2019,33(8):8878-8891.
2022, Vol. 39 
