|
|
|
| Expression and Significance of Serum VEGF and ET-1 in Patients with Refractory Diabetic Foot |
| WANG Peng, CHEN Yong-feng, ZHANG Da-wei, et al |
| The First Affiliated Hospital of Air Force Medical University,Xi'an Shaanxi 710032 |
|
|
|
|
Abstract 【Objective】To investigate the expression and significance of serum vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) in patients with refractory diabetic foot. 【Methods】A total of 101 patients with diabetic foot admitted to our hospital from July 2019 to November 2021 were selected as the study group,while 68 patients with simple diabetes (without diabetic foot) admitted to our hospital during the same period were selected as the control group. The basic data of patients in the two groups were collected to analyze the factors affecting the occurrence of diabetic foot and the predictive value of serum VEGF and ET-1 in diabetic foot. The levels of serum VEGF and ET-1 in patients with different grades of diabetic foot in the study group were statistically analyzed. 【Results】The levels of fasting blood glucose (FPG),glycosylated hemoglobin,vascular cell adhesion molecule-1 (VCAM-1),fibroblast growth factor 2 (FGF2),C-reactive protein (CRP) and ET-1 in the study group were significantly higher than those in the control group (P<0.05). The level of VEGF was significantly lower than that in the control group (P<0.05). Logistic multifactor regression analysis showed fasting blood glucose (FPG),vascular cell adhesion molecule-1 (VCAM-1),VEGF and ET-1 were risk factors affecting the occurrence of diabetic foot (P<0.05). ROC curve results showed that the sensitivity of serum VEGF,ET-1 and their combination in predicting diabetic foot occurrence was 70.30%,78.22% and 70.30%,respectively; their specificities were 70.59%,79.41% and 94.12%,respectively and their AUC values were 0.757,0.766,and 0.910,respectively. There were statistically significant differences of VEGF and ET-1 in grade Ⅰ to Ⅴdiabetic foot groups (P<0.05). The levels of ET-1 in grade Ⅰ to Ⅴ diabetic foot groups were significantly increased with the increase of grading (P<0.05);While VEGF levels in grade Ⅰ to Ⅴ diabetic foot groups were significantly decreased with the increase of grading (P<0.05). 【Conclusion】Serum VEGF and ET-1 are not only related to the occurrence of diabetic foot,but also related to its progression to refractory diabetic foot. VEGF combined with ET-1 has a better early prediction of diabetic foot occurrence.
|
|
Received: 26 August 2022
|
|
|
|
|
|
[1] DIXON D,EDMONDS M. Managing diabetic foot ulcers:pharmacotherapy for wound healing[J].Drugs,2021,81(1):29-56.
[2] CHANG M,NGUYEN T T. Strategy for treatment of infected diabetic foot ulcers[J].Acc Chem Res,2021,54(5):1080-1093.
[3] AHLUWALIA R,MAFFULLI N,LAZARO-MARTINEZ J L,et al. Diabetic foot off loading and ulcer remission:exploring surgical off-loading[J].Surgeon,2021,19(6):526-535.
[4] 郑海龙,曹晓琳,吴海丽,等. 糖尿病足患者感染特征与下肢血管病变及免疫功能和C反应蛋白的效果研究[J].中华保健医学杂志,2021,23(5):508-509.
[5] 王美君,许洪梅,葛甜甜,等. 糖尿病足患者溃疡愈合后5年复发和死亡的随访结果及其危险因素分析[J].中华糖尿病杂志,2021,13(3):227-232.
[6] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志,2021,13(4):315-409.
[7] 中华医学会糖尿病学分会,中华医学会感染病学分会,中华医学会组织修复与再生分会. 中国糖尿病足防治指南(2019版)(Ⅲ)[J].中华糖尿病杂志,2019,11(4):238-247.
[8] ERDOGAN A,DUZG N A P,ERDOGAN K,et al. Efficacy of hyperbaric oxygen therapy in diabetic foot ulcers based on wagner classification[J].J Foot Ankle Surg,2018,57(6):1115-1119.
[9] MORBACH S,LOBMANN R,ECKHARD M,et al. Diabetic foot syndrome[J].Exp Clin Endocrinol Diabetes,2021,129(1):82-90.
[10] KRISTIANTO H,WALUYO A,GAYATRI D,et al. Neuromuscular taping treatment of diabetic foot:a concept analysis[J].Clin Ter,2021,172(3):231-235.
[11] 胡静,赵艳君,姜丽,等. 前列地尔辅助硫辛酸治疗糖尿病足溃疡合并感染的临床效果[J].中华医院感染学杂志,2021,13(3):227-232. |
|
|
|
2022, Vol. 39 
