高血压患者发生急性脑梗死的相关因素

doi:10.3969/j.issn.1671-7171.2022.10.021

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Abstract 【Objective】To investigate the related factors of hypertension patients with acute cerebral infarction (ACI). 【Methods】The clinical data of 240 patients with hypertension in our hospital were retrospectively analyzed. They were divided into ACI group (126 cases) and non ACI group (114 cases) according to whether ACI occurred. Clinical data information of two groups of patients [Sex, age, body mass index (BMI), diabetes, smoking, drinking, intracranial vascular stenosis, extracranial vascular stenosis] and laboratory indicators [Differences in hs-CRP, LDH, Lp-PLA2, Hcy, NO, eNOS] were counted and compared. The ROC curve was used to analyze the value of related indicators in predicting the occurrence of ACI in hypertensive patients; Non conditional logistic stepwise regression analysis was used to identify the risk factors of ACI.【Results】There was no significant difference between the two groups in terms of gender, age, BMI, diabetes, smoking history, drinking history, LDH, hs-CRP, and Lp-PLA2 levels (P>0.05). The proportion of intracranial and extracranial vascular stenosis in ACI group was significantly higher than that in the non ACI group, and the level of Hcy was significantly higher than that in the non ACI group, while the levels of NO and eNOS were significantly lower than that in the non ACI group, and the difference was statistically significant (P<0.05). According to ROC analysis, Hcy ≥ 22.41 μmol/L, NO≤53.28 μmol/L and eNOS ≤ 51.39 U/mL were the best cut-off values for predicting the occurrence of ACI in hypertensive patients (all P<0.05); Logistic stepwise regression analysis showed intracranial vascular stenosis, extracranial vascular stenosis, Hcy≥22.41 μmol/L, NO≤53.28 μmol/L and eNOS≤51.39 U/mL were the risk factors of ACI in hypertensive patients (P<0.05). 【Conclusion】 Intracranial vascular stenosis, extracranial vascular stenosis and Hcy, NO, eNOS levels are closely related to the occurrence of ACI in patients with hypertension. More attention should be paid to these indicators in clinical practice.

Key words： Hypertension Brain Infarction Root Cause Analysis

Received: 07 April 2022

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R544.1

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	YANG Tao
	MI Wan-jun

Cite this article:

YANG Tao,MI Wan-jun. Related Factors of Hypertension Patients with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1517-1519.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.10.021 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I10/1517

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