超声引导下经皮冷冻消融配合全雄激素阻断治疗前列腺癌的临床效果及对患者免疫功能的影响

doi:10.3969/j.issn.1671-7171.2022.10.031

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Abstract 【Objective】 To investigate the clinical effect of ultrasound guided percutaneous cryoablation combined with total androgen blockade in the treatment of prostate cancer and its influence on patients' immune function. 【Methods】 The clinical data of 78 patients with prostate cancer admitted to our hospital from February 2013 to February 2016 were analyzed retrospectively, and they were divided into the observation group (n=40) and the control group (n=38) according to different treatment schemes. The control group was treated with total androgen blockade, and the observation group was treated with ultrasound guided percutaneous cryoablation on the basis of the control group. The serum prostate specific antigen (PSA), free prostate antigen (fPSA), human pregradient protein 2 (AGR2), immune function indicators (CD3⁺, CD4⁺, CD4⁺/CD8⁺), and expanded prostate cancer composite index (EPIC) scores were compared between the two groups before treatment and 6 months after treatment, and the survival conditions of 2, 3, and 5 years after operation were calculated. 【Results】 The levels of serum PSA, fPSA, AGR2 in the observation group were lower than those in the control group 6 months after treatment, and the levels of serum CD3⁺, CD4⁺, CD4⁺/CD8⁺ were higher than those in the control group (P<0.05); EPIC scores in the observation group were higher than those in the control group 6 months after treatment (P<0.05). There was no significant difference in the 2-year and 3-year survival rates between the two groups (P>0.05). The 5-year survival rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). 【Conclusion】 Ultrasound guided percutaneous cryoablation combined with total androgen blockade can reduce the serum PSA, fPSA, AGR2 levels, improve the immune function and quality of life of patients with prostate cancer, and improve the survival rate, which is worthy of clinical reference.

Key words： Prostatic Neoplasms Cryosurgery Ultrasonography Androgen Antagonists

Received: 15 September 2021

PACS:

R737.25

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	Articles by authors
	ZHANG Peng-fei
	LEI Yi
	XUE Jing

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ZHANG Peng-fei,LEI Yi,XUE Jing. Clinical Effect of Ultrasound Guided Percutaneous Cryoablation Combined with Total Androgen Blockade in the Treatment of Prostate Cancer and its Influence on Patients' Immune Function[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(10): 1553-1556.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.10.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I10/1553

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