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| Serum IL-2 and IL-12 Levels in Children with Mycoplasma Pneumoniae and Epstein Barr Virus Infection and Their Correlation with Prognosis |
| WU Zou-yu, MENG Fa-cai, ZHANG Li, et al |
| Shaanxi Kangfu Hospital,Xi'an Shaanxi 710065 |
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Abstract 【Objective】 To investigate the serum levels of interleukin-2 (IL-2) and interleukin-12 (IL-12) in children with mycoplasma pneumoniae (MP) and EB virus infection and their correlation with the prognosis of the children. 【Methods】 From May 2019 to May 2020, 103 children with MP and EB virus infection (combined group), 103 children with MP infection (MP group), and 103 healthy children (control group) who underwent physical examination at the same time were selected. According to the prognosis of children in the combined group, they were divided into poor prognosis group (n=32) and non poor prognosis group (n=71). The levels of serum IL-2 and IL-12 were detected by enzyme-linked immunosorbent assay (ELISA). Logistic regression analysis was used to analyze the factors affecting the poor prognosis of children with MP combined with EB virus infection. The ROC curve was used to analyze the evaluation value of serum IL-2 and IL-12 on the poor prognosis of children with MP combined with EB virus infection. 【Results】 The levels of serum IL-2 and CRP in the combined group were higher than those in MP group and control group, and those in MP group were higher than those in control group (P<0.05); The serum IL-12 level of children in the combined group was lower than that in MP group and control group, and MP group was lower than that in control group (P<0.05). Serum CRP, IL-2 levels and fever time in the poor prognosis group were higher than those in the non poor prognosis group, and serum IL-12 levels were lower than those in the non poor prognosis group (P<0.05). Logistic regression analysis showed that high expression of IL-2 in serum was an independent risk factor for poor prognosis of MP patients with EB virus infection, and high expression of IL-12 was a protective factor for poor prognosis of MP patients with EB virus infection (P<0.05). ROC curve analysis showed that the area under the curve of serum IL-2, IL-12 and their combination to evaluate the adverse prognosis of MP patients with EB virus infection were 0.746, 0.866 and 0.901, respectively, with sensitivity of 64.5%, 93.5% and 83.9%, and specificity of 88.9%, 79.2% and 81.9%. 【Conclusion】 The serum IL-2 level in MP patients with EB virus infection is increased and the serum IL-12 level is decreased, which is closely related to the prognosis, and has a certain predictive value for the poor prognosis of children, and the combined predictive value of the two is higher.
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Received: 15 December 2021
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2022, Vol. 39 
