Home  |  About Journal  |  Editorial Board  |  Instruction  |  Subscribe  |  Advertisement  |  Messages Board  |  Contact Us  |  中文

Forthcoming Articles    Current Issue    Archive    Advanced Search    Read Articles    Download Articles    Email Alert

Quick Search     Adv Search 2021 Vol. 38, No. 7 Published: 2021-07-26   966 Clinical Significance of Heat Shock Protein 90 Expression in Patients with Lung Squamous Cell Carcinoma TANG Yao-xiang, LUO Jia-di, FENG Juan,et al DOI: 10.3969/j.issn.1671-7171.2021.07.002 【Objective】To investigate the expression of heat shock protein 90(HSP90) in lung squamous cell carcinoma and analyze the relationship between its expression and clinicopathological characteristics and prognosis. 【Methods】 The cancer tissues of 159 lung squamous cell carcinoma(SCC) patients with complete follow-up data and 53 non-cancer control lung tissues(Non-CLT), who were selected from the thoracic surgery of the Second Xiangya Hospital of Central South University between 2003 and 2013, were retrospectively evaluated. High-throughput tissue microarray(TMA) were constructed and the expression of HSP90 were detected by immunohistochemistry(IHC). Kaplan-Meier univariate and Cox multivariate hazard regression analysis were performed to assess the prognosis of patients with lung SCC. 【Results】 Compared with Non-CLT, the positive expression rate of HSP90 in lung SCC tissue was significantly higher(P<0.05); and the expression level of HSP90 in clinical stage Ⅲ patients was higher than that in clinical stage Ⅰ-Ⅱ patients(P=0.010). The expression level of HSP90 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P=0.016). The overall survival rate of patients with lung squamous cell carcinoma with high expression of HSP90 was significantly lower than that of patients with low expression of HSP90(P=0.002). Cox multivariate risk regression analysis found that patients with lung SCC with high expression of HSP90 had a worse prognosis than low expression of HSP90(P=0.042). 【Conclusion】 In addition to the clinical stage and pathological grade of the tumor, the high expression of HSP90 can be used as an independent molecular marker for evaluating the poor prognosis of patients with surgically removed lung SCC. 2021 Vol. 38 (7): 966-970 [Abstract] ( 61 ) HTML (1 KB)  PDF (1900 KB)  ( 68 ) 971 Expression and Clinical Significance of Wnt10B and β-catenin in Cervical Squamous Cell Carcinoma WANG Jing-yun, WU Ya-hong, LI Zhao,et al DOI: 10.3969/j.issn.1671-7171.2021.07.003 【Objective】To investigate wingless integrin(Wnt10B) and β Catenin( β- Expression of catenin) in cervical squamous cell carcinoma and its clinical significance.【Methods】Immunohistochemistry was used to detect the expression of Wnt10B and β-catenin protein in 19 cases of normal cervix, 27 cases of cervical precancerous lesions and 50 cases of cervical squamous cell carcinoma,the positive expression of the three terms were compared and the correlation of Wnt10B and β-catenin with clinicopathological features were analyzed. 【Results】The positive expression rate of Wnt10B was 36.84%(7/19) in normal cervical tissue, 66.67%(18/27) in CIN tissues, and 94.00%(47/50) in cervical squamous cell carcinoma, the difference was statistically significant(χ2=25.381, P<0.05). The positive expression rate of β-catenin was 52.63%(10/19) in normal cervical tissues, 74.07%(20/27) in CIN tissues, and 90.00%(45/50) in cervical squamous cell carcinoma tissues, and the difference was statistically significant(χ2=11.611, P<0.05). The positive expression of Wnt10B and β-catenin were significantly correlated with the depth of invasion, stage and differentiation of cervical squamous cell carcinoma. 【Conclusion】The expression of Wnt10B and β-catenin in cervical lesions increased gradually with the progression of lesions, and the expression of both was positively correlated, suggesting that both are involved in the occurrence and progression of tumors. 2021 Vol. 38 (7): 971-974 [Abstract] ( 57 ) HTML (1 KB)  PDF (1744 KB)  ( 41 ) 975 Application Value of Budesonide Combined with Endotracheal Intubation, Active Substances on the Lung Surface, Extubation and Continuous Positive Airway Pressure Ventilation in Premature Infants with Respiratory Distress Syndrome ZHU Xi-yi, LI Liu-qing, LI Fu-bing,et al DOI: 10.3969/j.issn.1671-7171.2021.07.004 【Objective】To explore the use of Application value of budesonide combined with endotracheal intubation, active substances on the lung surface, extubation and continuous positive airway pressure ventilation in premature infants with respiratory distress syndrome. 【Methods】The clinical data of 30 premature infants with NRDS treated in our hospital from January 2018 to December 2019 were retrospectively analyzed. According to different treatment methods, they were divided into observation group and control group, with 15 cases in each group. Both groups were treated with insert technology, and the observation group was treated with budesonide. The blood gas analysis indexes, PS reuse rate, average weaning time, average total oxygen inhalation time, incidence and severity of BPD were compared between the two groups, and the complications during treatment were recorded and compared between the two groups. 【Results】 At 12 h and 24 h after administration, the levels of ph and PaCO2 in the two groups were higher than those at 4 h after administration, and those in the observation group were higher than those in the control group; The level of PaCO2 in the two groups was lower than 4 hours after administration, and the level of PaCO2 in the observation group was lower than that in the control group(mean P<0.05). The reuse rate of PS, the incidence of BPD and the proportion of moderate to severe BPD in the observation group were lower than those in the control group(P<0.05). After CPAP treatment, the average withdrawal time and average total oxygen inhalation time in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of retinopathy, late-onset sepsis, necrotizing enterocolitis and periventricular intraventricular hemorrhage between the two groups(P>0.05).【Conclusion】Budesonide combined with insert technology in the treatment of respiratory distress syndrome of preterm infants can effectively improve the blood gas index of children, improve the treatment effect, reduce the occurrence of BPD in preterm infants, and do not increase the risk of complications during treatment. It is worthy of popularization and application. 2021 Vol. 38 (7): 975-977 [Abstract] ( 50 ) HTML (1 KB)  PDF (1151 KB)  ( 65 ) 978 Effects of ω-3PUFAs on Peripheral Blood Mononuclear Cells in Patients with Inflammatory Bowel Disease FENG Xiao-ling, GAO Hong-liang DOI: 10.3969/j.issn.1671-7171.2021.07.005 【Objective】To explore effects of ω-3 polyunsaturated fatty acids(ω-3PUFAs) on inflammatory bowel disease(IBD) and its mechanism. 【Methods】Peripheral blood samples were collected from 60 patients with active IBD, and peripheral mononuclear cells were isolated. They were randomly divided into three groups, 20 in each group.Respectively they were treated withω- 3PUFAs eicosapentaenoic acid(EPA), docosahexaenoic acid(DHA) and saturated fatty acid stearic acid(SA) for 48 hours;In addition, 20 blood samples of healthy volunteers who underwent physical examination in our hospital in the same period were collected to obtain mononuclear cells. Cell culture was resuspended as the blank group. The morphological changes of cells in the four groups were observed after 48 hours; The number of CD4+CD25+FoxP3+ and CD4+CD25+CD127-T cells was detected by flow cytometry; The mRNA levels of CD80 and CD86 were detected by semi quantitative reverse transcription polymerase chain reaction(RT-PCR); Interleukin-12(IL-12), IL-10 and tumor necrosis factor-α(TNF-α)level in cell supernatant were measured by enzyme-linked immunosorbent assay(ELISA).【Results】The numbers of CD4+CD25+FoxP3+ and CD4+CD25+CD127-T cells in the blank group and the SA group were higher than those in the EPA group and the DHA group(P<0.05). The numbers of CD4+CD25+FoxP3+ and CD4+CD25+CD127-T cells in the SA group was lower than that in the blank group(P<0.05). The CD80 and CD86 mRNAs in supernatants in the blank group and the SA group were higher than those in the EPA group and the DHA group(P<0.05). The CD80 and CD86 mRNAs in supernatants in the SA group were lower than those in the blank group(P<0.05). The concentration of IL-12 and TNF-α in cell supernatant in the blank group and SA group was higher than that in the EPA group and the DHA group(P<0.05), while IL-10 concentration was lower than that in the EPA group and the DHA group(P<0.05). The concentration of IL-12 and TNF-α in cell supernatant in the SA group was lower than that in the blank group, while IL-10 concentration was higher than that in the blank group(P<0.05). There was no significant difference in the above indexes between the EPA group and the DHA group(P>0.05). 【Conclusion】 ω-3 PUFAs can regulate IBD immune disorder, maintain immune balance, reduce inflammatory response, promote the repair of damaged cell membrane, or may become a new direction of IBD treatment research. 2021 Vol. 38 (7): 978-982 [Abstract] ( 50 ) HTML (1 KB)  PDF (1352 KB)  ( 68 ) 983 Exploration of Phase Angel Combined with Fat Free Mass Index or Relative Appendicular Skeletal Muscle Index to Define Malnutrition of peri- Hematopoietic Stem Cell Transplantation Patients FENG Guo, LIU Hong, WANG Meng,et al DOI: 10.3969/j.issn.1671-7171.2021.07.006 【Objective】 This research is aimed to explore the significance of phase angle(PA) combined with fat-free body mass index(FFMI) or relative limb skeletal muscle index(RAMS) in the evaluation of malnutrition in peri-hematopoietic stem cell transplantation(HSCT) patients. 【Methods】A total of 98 patients treated with HSCT were recruited for the study. The nutritional risk was assessed by Nutritional Risk Screening 2002(NRS2002) and malnutrition status was diagnosed according to standard of GLIM. PA, FFMI and RAMS were tested by Bio Impedance Analysis(BIA). Correlations among PA, FFMI and RAMS were analyzed by Pearson analysis. The combined data of PA and FFMI and combined data of PA and RAMS of 98 patients were calculated by Logistic analysis. The ROC analysis was used to detect the area under the curve(AUC) of PA, FFMI, RAMS, PA combined with FFMI, and PA combined with RAMS. 【Results】The positive rate of NRS2002 in peri-hematopoietic stem cell transplantation patients was 100%. It showed the strong positive relationship of PA with FFMI and PA with RAMS(P<0.01). Using GLIM criteria as the standard for the diagnosis of malnutrition, the area under the ROC curve of PA, FFMI, and RAMS were 0.308, 0.204 and 0.270, respectively(P<0.01). The area under the ROC curve of the combined data of PA and FFMI and the combined data of PA and RAMS were 0.791 and 0.737(P<0.01). 【Conclusion】PA, FFMI and RAMS alone have poor accuracy in diagnosing malnutrition, but the combined data of PA and FFMI and the combined data of PA and RAMS are more accurate in diagnosing malnutrition. It is suggested that combining PA with FFMI and PA with RAMS may provide evidence for malnourished diagnosis. 2021 Vol. 38 (7): 983-986 [Abstract] ( 45 ) HTML (1 KB)  PDF (1474 KB)  ( 116 ) 987 Efficacy of TCD and BCD in Initial Treatment of Multiple Myeloma WANG Ming-di, CUI Hai-jia, WU Dao-xiang,et al DOI: 10.3969/j.issn.1671-7171.2021.07.007 【Objective】To explore the survival rate and safety of TCD and BCD in the treatment of multiple myeloma(MM).【Method】Seventy-two patients with MM were enrolled in our hospital. The patients were divided into A group and B group by treatment methods, with 36 cases in each group. The A group was treated with the TCD regimen and the B group was treated with the BCD regimen. The clinical efficacy and serum levels of β2-microglobulin(β2-MG), C-reactive protein(CRP), and serum creatinine(Cr) were compared between the two groups. The tumor markers such as antigen(CEA), carbohydrate antigen 125(CA125), neuron-specific enolase(NSE) and cytokeratin fragment antigen 21-1(CYFRA21-1) were compared as well between the two groups before and after treatment. The survival rate and incidence of adverse reactions between the two groups were analyzed.【Results】The total effective rate of 63.89%(23/36) in the A group was significantly lower than that in the B group(88.89%, 32/36)(P<0.05). The difference of Cr in the A group was significantly lower than that in the B group(P<0.05). After treatment, the β2-MG and CRP levels in the two groups were significantly lower (P< 0.05). However, there was no significant difference between the two groups in either before or after treatment(P>0.05). Compared to before treatment, levels of CEA, CA125 and NSE were significantly lower in both groups after the treatment(P<0.05). While there was no significant difference between the two groups in either before or after treatment with CEA, CA125 and NSE(P>0.05). The survival rate was similar; And the difference was not statistically significant(P>0.05). The total incidence of adverse reactions in the A group was 25.00% compared with 19.44% in the B group, and the difference was not statistically significant(P>0.05).【Conclusion】The BCD regimen is used in the treatment of newly diagnosed MM. The safety and survival rate are comparable to those of the TCD regimen. It is better than the TCD regimen and worthy of clinical attention. 2021 Vol. 38 (7): 987-989 [Abstract] ( 67 ) HTML (1 KB)  PDF (1222 KB)  ( 41 ) 990 Effects of rTMS Combined with Hyperbaric Oxygen on Inflammatory Factors, Cognitive Function and Cerebral Blood Flow in Comatose Patients with Severe Craniocerebral Injury ZHAO Dong-sheng, XU Feng, BIE Xiao-hua,et al DOI: 10.3969/j.issn.1671-7171.2021.07.008 【Objective】To explore the effect of repeated transcranial magnetic stimulation(rTMS) combined with hyperbaric oxygen treatment on inflammatory factors, cognitive function and cerebral blood flow in patients with severe head injury caused by coma. 【Methods】 A total of 120 comatose patients with severe craniocerebral injury treated in our hospital from October 2017 to February 2020 were randomly divided into observation group and control group, with 60 cases in each group. RTMS and rTMS combined with hyperbaric oxygen were used respectively. The changes of electroencephalogram(EEG), inflammatory factors, cerebral hemodynamics, Glasgow Coma Scale score(GCS), revised coma recovery scale score(CRS-R) and mini mental state examination scale score(MMSE) were compared between the two groups. 【Results】At 2 and 4 weeks after treatment, the GCS scores of the observation group were(10.49±3.26) and(13.87±1.41) respectively; The crs-r scores were(16.49±3.62) and(21.32±1.39) respectively. There was significant difference between the two groups(P<0.05). The total MMSE score of the observation group 4 weeks after treatment was(27.46±2.46), which was significantly higher than that of the control group(23.39±2.33)(P<0.05). At 2 and 4 weeks after treatment, the mean cerebral blood flow velocity(Vm), end diastolic blood flow velocity(Vd), middle cerebral artery peak systolic velocity(Vs), pulsatility index(PI), interleukin-6(IL-6) and tumor necrosis factor(TNF-α) and C-reactive protein(CRP) were better than those in the control group(P<0.05).【Conclusion】rTMS combined with hyperbaric oxygen is effective in the treatment of comatose patients with severe craniocerebral injury. It can reduce the level of inflammatory factors, improve cerebral blood flow and promote the recovery of cognitive function. 2021 Vol. 38 (7): 990-994 [Abstract] ( 50 ) HTML (1 KB)  PDF (1200 KB)  ( 143 ) 995 Serum Level and Clinical Significance of ACLY in Patients with Acute Myeloid Leukemia ZHAO Li-dan, LI Rong-fang DOI: 10.3969/j.issn.1671-7171.2021.07.009 【Objective】 To investigate the expression and significance of serum ATP citrate lyase(ACLY) in patients with acute myeloid leukemia(AML). 【Methods】From March 2013 to January 2016, 85 patients with AML admitted to Hematology Department of our hospital were selected as the study subjects. Relative expressions of ACLY in serum of AML patients were detected by RT-q PCR, and the relationship between ACLY in serum and prognosis of AML patients was analyzed. 【Results】The 3-year survival rate in 85 patients with AML was 28.24%(24/85). The relative expression of ACLY in serum of AML patients of death group was significantly higher than that of survival group AML patients [(1.72 ±0.37) vs(1.21 ±0.32), P<0.05]. The AUC of the prognosis of AML assessed by ACLY was 0.860. The median survival time of AML patients with ACLY ≥ 1.57 was significantly lower than that of AML patients with ACLY<1.57[10(95%CI:8~16) months vs 20(95% CI:10~31) months, P<0.05]. Univariate and multivariate Cox regression analysis showed that WBC(white blood cell), NCCN stratification, bone marrow primordial granulocyte count, complete remission, ACLY were closely related to the prognosis of AML patients(P<0.05). 【Conclusion】ACLY is closely related to the prognosis of AML. Detection of serum ACLY is helpful to evaluate the prognosis of AML patients. 2021 Vol. 38 (7): 995-997 [Abstract] ( 56 ) HTML (1 KB)  PDF (1210 KB)  ( 48 ) 998 Efficacy and Tumor-associated Markers Analysis of Chinese Medicine Combined with Paclitaxel and Carboplatin in the Treatment of Advanced Ovarian Cancer CHEN Zhi-mei DOI: 10.3969/j.issn.1671-7171.2021.07.010 【Objective】To explore the efficacy of Chinese medicine combined with paclitaxel and carboplatin in the treatment of advanced ovarian cancer and its effect on tumor-associated markers. 【Methods】A total of 80 patients with advanced ovarian cancer in our hospital were randomly divided into control group and observation group. The control group was treated with paclitaxel and carboplatin while the observation group was treated with traditional Chinese medicine on the basis of the same chemotherapy as the control group. The clinical efficacy, serum CA125, CA199, human epididymis protein 4(HE4) and the effect on immune function of the two groups were compared. The complications of the two groups were recorded. 【Results】The clinical efficacy of the observation group was significantly higher than that of the control group(92.50% vs 75.00%)(P<0.05);There was no significant difference in the levels of CA125, CA199 and HE4 between the two groups before treatment(P>0.05).After treatment, the levels of CA125, CA199 and HE4 in the observation group were significantly better than those in the control group(P<0.05).After chemotherapy, the levels of CD3+, CD4+, CD8+, CD4+/CD8+ in both groups were worse than before chemotherapy(P<0.05), but after chemotherapy, the levels of CD3+, CD4+, CD8+, CD4+/CD8+ in the observation group were better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(30.00% vs 57.50%)(P<0.05). 【Conclusion】The combination of traditional Chinese and Western medicine in the treatment of patients with advanced ovarian cancer can effectively improve the clinical efficacy, improve the immune function of patients, and ultimately improve the prognosis of patients. 2021 Vol. 38 (7): 998-1001 [Abstract] ( 54 ) HTML (1 KB)  PDF (1171 KB)  ( 399 ) 1002 Estrogen Levels and Receptors in the High Incidence of Biliary Calculi in Obese Patients in Xinjiang Azatijiang Ainiwaer, Abuduwail Erken, YU Su-fu,et al DOI: 10.3969/j.issn.1671-7171.2021.07.011 【Objective】To investigate the relationship between estrogen level and the high incidence of biliary calculi in obese patients in Xinjiang. 【Methods】The clinical data of 118 obese patients with biliary tract stones(the observation group) were retrospectively collected, and the clinical data of 118 inpatients in the weight loss center of our hospital during the same period were selected(the control group). The levels of estradiol(E2), luteinizing hormone(LH), follicle-stimulating hormone(FSH), testosterone(T), progesterone(P) and prolactin(PRL) in 118 obese patients with biliary calculi and 118 obese patients without biliary calculi were compared and analyzed between the two groups.【Results】Compared with the control group, the hormone levels of FSH, T, P and PRL in obese men with cholelithiasis were not statistically significant. Serum LH and E2 levels were significantly higher than those of the control group, and the difference was statistically significant(P<0.05) .There was no statistically significant difference in the levels of LH, FSH, T, P and PRL between the obese premenopausal female stone patients and the control group. The serum E2 level was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). Compared with the control group, the E2 level was significantly different before menopause(P< 0.04) and after menopause(P< 0.001). LH, FSH, T, P and PRL levels were not significantly different in patients with multiple calculi and single calculi, while the E2 level in patients with multiple calculi was significantly higher than those with single calculi(P<0.02). 【Conclusion】The increase of serum E2 levels in female patients with biliary tract stones before and after menopause may be related to the onset of biliary stones, and the increase of serum LH and E2 levels in male patients may be related to the onset of biliary stones. 2021 Vol. 38 (7): 1002-1004 [Abstract] ( 57 ) HTML (1 KB)  PDF (1156 KB)  ( 43 ) 1005 Analysis on the Distribution Characteristics of New Pneumoconiosis in Nanjing from 2009 to 2019 TAO Xiao-chao, ZHAO Tong-tong, JIANG Yu DOI: 10.3969/j.issn.1671-7171.2021.07.012 【Objective】To summarize the new pneumoconiosis cases in Nanjing from 2009 to 2019 and analyze their distribution characteristics. 【Methods】The data was collected in January 2020. The relevant file information of patients admitted to hospital for treatment was retrieved through the "Health Hazard Factors Information Monitoring System" platform to analyze new cases of pneumoconiosis occurred in Nanjing from 2009 to 2019. According to statistics and summary of the case data, a total of 141 cases were included in this investigation. The distribution characteristics of new pneumoconiosis was analyzed. 【Results】The distribution characteristics of new pneumoconiosis in Nanjing from 2009 to 2019 were:males were predominant, the onset of working years was concentrated between 5-35 years, the predominant type of silicosis was mainly concentrated in the first stage, and the age of onset of most cases was between the ages of 70 and 80. The type of work was mainly pure excavator, followed by electric welders, and the type of enterprise is mainly state-owned, Enterprises as a whole have contributed insufficient efforts toward pneumoconiosis health education. 【Conclusion】The distribution characteristics of new pneumoconiosis(such as type of work, type of disease, etc.) in the period from 2009 to 2019 in Nanjing are obvious. Efforts to take targeted prevention and intervention measures should be intensified. 2021 Vol. 38 (7): 1005-1007 [Abstract] ( 61 ) HTML (1 KB)  PDF (1260 KB)  ( 50 ) 1008 Clinical Application of Pitavastatin in Treatment of Elderly Diabetes with Hyperlipidemia ZHAO Xiang-fang, CHANG Lian-qing, LYU Chun-lei, et al DOI: 10.3969/j.issn.1671-7171.2021.07.013 【Objective】To investigate the efficacy and safety of pitavastatin in the treatment of hyperlipidemia with type 2 diabetes mellitus(T2DM) in elderly patients. 【Methods】A total of 83 elderly patients with hyperlipidemia and type 2 diabetes mellitus who admitted to 464 PLA Hospital from May 2016 to April 2019 were enrolled in the study. Lab examinations such as liver, renal and thyroid function were carried out , then the original statins were replaced by pitavastatin. The FPG(fasting glucose),2hPG(2 h postprandial blood glucose), HbAlC(glycosylated hemoglobin), TC and TG(triacylglycerol) levels were compared before and after treatment. 【Results】After treatment with Pravastatin, the levels of FPG, 2hPG, HbA1C, TG and mAlb(urine microalbumin) were further decreased(P<0.05), while CK(creatine kinase) , CKMB(creatine kinase isoenzyme), LDH(lactate dehydrogenase), BUN(urea nitrogen) , SCr(creatinine), ALT(alanine aminotransferase) and T3(triiodothyronine) did not change significantly, and no adverse reactions occurred during the treatment. 【Conclusion】Efficacy and safety of pitavastatin in elderly men with hyperlipidemia disease and type 2 diabetes mellitus were better. It is worthy of clinical popularization and application. 2021 Vol. 38 (7): 1008-1010 [Abstract] ( 53 ) HTML (1 KB)  PDF (1157 KB)  ( 43 ) 1011 Clinical Efficacy of Zopiclone in the Treatment of Schizophrenia Complicated with Sleep Disorder and its Effect on the Level of Related Nerve Factors LI Ying, AN Guo-song DOI: 10.3969/j.issn.1671-7171.2021.07.014 【Objective】To explore the clinical effect and mechanism of zopiclone in the treatment of schizophrenia with sleep disorders. 【Methods】The clinical data of 90 patients with schizophrenia complicated with sleep disorder treated in our hospital from February 2019 to February 2020 were retrospectively analyzed. According to different treatment methods, they were divided into control group and observation group, with 45 cases in each group. The control group was given oral aripiprazole + alprazolam, and the observation group was given oral aripiprazole + zopiclone. The clinical efficacy, sleep quality(PSQI), serum serotonin(5-HT) and nuclear transcription factor were compared between the two groups before and after treatment-κB(NF-κB). The adverse reactions of the two groups were observed and recorded. 【Results】After one week of treatment, the PSQI score of the observation group was lower than that of the control group(P<0.05); There was no significant difference in PSQI scores between the two groups before treatment, 2 weeks and 3 weeks of treatment(P>0.05). The effective rate of the observation group was 75.56%(34/45), which was significantly higher than 55.56%(25/45) of the control group(χ2 =3.986,P=0.046＜0.05). After treatment, serum NF-κB , the level of was lower than that before treatment, and the level of 5-HT was higher than that before treatment, and there was significant difference between the observation group and the control group(P<0.05). The incidence of adverse reactions in the observation group was 24.44%(11/45), which was lower than 44.44%(20/45) in the control group(P<0.05).【Conclusion】Zopiclone can better improve the sleep quality of schizophrenic patients with sleep disorders, and the incidence of adverse reactions is less. It may be related to the regulation of serum 5-HT and NF-κB by zopiclonelevel. 2021 Vol. 38 (7): 1011-1013 [Abstract] ( 43 ) HTML (1 KB)  PDF (1150 KB)  ( 53 ) 1014 Application of Lieberman Theory Combined with Trait Mindfulness and Control Point in Acute Schizophrenia and its Effect on Patients' Bad Mood WANG Xiao-li, WANG Yan-yan, YU YAN-hong DOI: 10.3969/j.issn.1671-7171.2021.07.015 【Objective】To explore the application of Lieberman theory combined with trait mindfulness and control point in acute schizophrenia and its effect on patients' bad mood. 【Methods】114 patients with acute schizophrenia treated in our hospital from March 2018 to March 2020 were divided into observation group(July 2019 to March 2020) and control group(March 2018 to June 2019), with 57 cases in each group. The control group was given routine intervention, and the observation group was given Lieberman theory combined with trait mindfulness and control point for 8 weeks. The bad mood(Panas), mindfulness level(MAAS) and control level(LOCS) were compared between the two groups before intervention, 4 weeks and 8 weeks after intervention. 【Results】After 4 and 8 weeks of intervention, the positive emotion score of the two groups was higher than that before the intervention, and the negative emotion score was lower than that before the intervention, and there was significant difference between the observation group and the control group(P<0.05); The perceived action, non reactivity to internal experience and non critical scores of internal experience in the two groups were higher than those before intervention, and the observation group was higher than that in the control group(P<0.05); The LOCS scores of internal control and external control in the two groups were higher than those before intervention, and the observation group was higher than that in the control group(P<0.05). The nursing satisfaction in the observation group was 94.74%(54/57), which was higher than 73.68%(42/57) in the control group(χ2 =9.50,P=0.002＜0.05).【Conclusion】 Lieberman's theory combined with trait mindfulness and control point can alleviate the bad mood of patients with acute schizophrenia, improve the level of mindfulness and enhance the ability of self-control through life skills, social independence skills and mindfulness intervention. 2021 Vol. 38 (7): 1014-1016 [Abstract] ( 44 ) HTML (1 KB)  PDF (1150 KB)  ( 80 ) 1017 Efficacy of Transcortical Temporary Fixation in Treatment of Femoral Intertrochanteric Fracture with PFNA YUN Shao-jun, DING Jun-jie DOI: 10.3969/j.issn.1671-7171.2021.07.016 【Objective】To investigate the clinical effect of maintaining reduction by transcortical temporary fixation in the treatment of femoral intertrochanteric fracture with PFNA(proximal femoral nail antirotation). 【Methods】From January 2017 to January 2019, 80 cases of intertrochanteric fracture of femur treated with closed reduction and proximal femoral anti rotation intramedullary nailing(PNFA) were selected as the study objects. According to the order of admission, the patients were divided into the control group and the observation group. The control group received routine treatment during the PFNA surgery and the observation group received transcortical temporary fixation during PFNA surgery. The operation time, intraoperative hemorrhage, blood transfusion, intraoperative fluoroscopy times, intraoperative reduction quality and postoperative weight-bearing time of the two groups were observed. The complications and fracture healing time were compared during the follow-up. Harris score was used to evaluate the recovery of hip joint function of the two groups one year after operation. 【Results】Both groups of patients were successfully completed the operation. There was no significant difference in operation time, blood loss, blood transfusion and weight-bearing time between the two groups(P>0.05).The times of fluoroscopy in the observation group was less than that in the control group, and the quality of reduction during operation was better than that in the control group(P< 0.05).After operation, the patients in both groups were followed up for 1-16 months, with no lost patients. The average follow-up time was(13.67±1.68) months. During the follow-up period, there were no related complications in the two groups, and there was no difference in fracture healing time between the two groups(P>0.05).The Harris score of the observation group was significantly higher than that of the control group at 1 year after operation(P< 0.05). 【Conclusion】The use of transcortical temporary fixation technique in closed reduction of PNFA can significantly maintain the reduction effect of intertrochanteric fracture of femur, improve the reduction quality, and do not increase the operation time and the amount of intraoperative bleeding, which is conducive to the recovery of hip joint function. 2021 Vol. 38 (7): 1017-1020 [Abstract] ( 46 ) HTML (1 KB)  PDF (1171 KB)  ( 84 ) 1021 Effect of Tooth Extraction Site Preservation Technique Based on Bio-Oss Geistlich on the Short-term Aesthetic Effect and Prognosis of Anterior Dental Implant Patients CHEN Ping, LIU Xu DOI: 10.3969/j.issn.1671-7171.2021.07.017 【Objective】To explore the effect of tooth extraction site preservation technique based on bio-oss Geistlich on the short-term aesthetic effect and prognosis of patients with anterior dental implantation so as to provide certain theoretical reference for clinical practice. 【Methods】A total of 90 patients with anterior dental implantation admitted to our hospital from July 2018 to June 2019 were selected as study subjects. According to the patient's wishes, they were divided into the control group and the observation group with 45 cases each. The control group was treated with conventional tooth extraction and oral implant therapy, while the observation group was treated with bio-oss Geistlich based tooth extraction site preservation technique and oral implant therapy. Alveolar bone height, width, bone density, short-term aesthetic effect, and prognosis were compared between the two groups. 【Results】Before treatment, there was no significant difference in alveolar bone height, width or bone density between the two groups(P>0.05). After treatment, alveolar bone height, width and bone density in both groups decreased compared to before treatment, but the difference between the observation group and the control group was statistically significant(P<0.05). The soft tissue color, soft tissue attachment height, and aesthetic effect score of front row dentition in the observation group were higher than those in the control group with statistical significance(P<0.05). The rates of gingival redness and swelling, alveolar bone resorption and implant loosening in the observation group were 8.89%, 6.67% and 2.22%, respectively, which were significantly lower than those in the control group(24.44%, 22.22% and 13.33%, respectively) with statistically significant differences(P<0.05). 【Conclusion】The application of tooth extraction site preservation technique based on bio-oss Geistlich can improve the short-term aesthetic effect and prognosis of patients with anterior dental implantation, which is worthy of promotion. 2021 Vol. 38 (7): 1021-1023 [Abstract] ( 51 ) HTML (1 KB)  PDF (1147 KB)  ( 44 ) 1024 Analysis of Serum SCCA and MiR-501 in Clinical Diagnosis and Prognostic Value of Cervical Cancer ZHANG Tao, LIU Ning-ning, TIAN Rui-hong DOI: 10.3969/j.issn.1671-7171.2021.07.018 【Objective】To study the value of serum SCCA and miR-501 in the clinical diagnosis and prognosis of patients with cervical cancer. 【Methods】Sixty patients with cervical cancer admitted to the Oncology Department in our hospital from January 2018 to June 2020 were selected as the research objects and served as the observation group. A total of 60 healthy physical examination volunteers in the same period were selected as the control group. The serum SCCA and miR-501 levels of the two groups were compared. At the same time, the observation group's disease stage, lymph node metastasis, pathological differentiation and histopathological classification were counted, and the relationship of serum SCCA and miR-501 levels with the patient's disease characteristics was analyzed. 【Results】The serum SCCA and miR-501 levels of the observation group were significantly higher than those of the control group(P<0.05). Serum SCCA and miR-501 were the best for diagnosis of cervical cancer The cut-off points are 15.2 ng/ml and 0.73, respectively. Serum SCCA and miR-501 levels increased with the increase of cervical cancer stage. The difference between stage Ⅰ, stage Ⅱ and stage Ⅲ was statistically significant(P<0.05), and the difference between stage Ⅲ and stage Ⅳ was not statistically significant(P>0.05). Serum SCCA and miR-501 levels increased with the decrease of cervical cancer pathological differentiation, and those with lymph node metastasis were significantly higher than those without lymph node metastasis, with statistically significant difference(P<0.05). The serum SCCA of patients with squamous cell carcinoma was significantly higher than that of patients with adenocarcinoma, and the difference was statistically significant(P<0.05). The level of serum miR-501 in patients with squamous cell carcinoma was significantly higher than that of adenocarcinoma. The difference between patients was not statistically significant(P>0.05). The area under the ROC curve for the diagnosis of cervical cancer by serum SCCA and miR-501 levels were 0.869(95% CI:0.809~0.929) and 0.911(95% CI:0.861~0.961), respectively. The best cut-off points of serum SCCA and miR-501 for diagnosis of cervical cancer were 15.2 ng/mL and 0.73, respectively. The OS of SCCA≤15.2 ng/ml was significantly longer than that of SCCA>15.2 ng/ml(P<0.05), and the OS of miR-501≤0.73 was significantly longer than that of miR-501>0.73(P<0.05). 【Conclusion】Serum SCCA and miR-501 levels can be used to assist clinical diagnosis of cervical cancer, predict the malignant degree of cervical cancer, histopathological classification and patient prognosis. 2021 Vol. 38 (7): 1024-1027 [Abstract] ( 48 ) HTML (1 KB)  PDF (1325 KB)  ( 32 ) 1028 Serum Expression Level and Clinical Significance of MiR-221 in Patients with Ovarian Cancer YUE Hua, WANG Zhen DOI: 10.3969/j.issn.1671-7171.2021.07.019 【Objective】To study the correlation between circulating miR-221 level and the prognosis of ovarian cancer patients. 【Methods】A total of 84 ovarian cancer patients admitted to the Department of Obstetrics and Gynecology of Xi'an XD Group Hospital from January 2015 to January 2020 were selected as the research objects. At the same time, 84 healthy volunteers in the same period in our hospital were selected as the control group. The relative expression of miR-221 in the patient's serum was determined, and the relationship of the circulating miR-221 level with the patient's disease stage, lymph node metastasis, pathological differentiation, histopathological type and prognosis were analyzed. 【Results】The relative expression of miR-221 in the serum of the ovarian cancer group was(7.152±2.61), which was higher than that of the control group(2.102±0.49); and the difference was statistically significant(t=17.429, P<0.05). The level of circulating miR-221 was significantly related to the stage of ovarian cancer(P=0.043), lymph node metastasis(P=0.014), and pathological differentiation type(P<0.001). By the end of the follow-up, a total of 32(38.1%) of 84 patients died, 9(10.7%) were lost to follow-up, 43(51.2%) were alive, and the median follow-up time was 30(4～51) months. The circulating miR-221 level was significantly correlated with overall survival(OS)(P<0.001), and the correlation coefficient was -0.775. The median survival time of patients in the low-level group was 42 months(40.2±4.6), and the median survival time of patients in the high-level group was 29 months(29.3±3.6). The OS of the low-level group was significantly better than that of the high-level group(P<0.001). 【Conclusion】The late disease stage, lymph node metastasis, and poor pathological differentiation of ovarian cancer patients are associated with higher circulating Mir-221 levels. The level of circulating miR-221 is significantly related to OS, and patients with lower levels of circulating miR-221 have a better prognosis. 2021 Vol. 38 (7): 1028-1030 [Abstract] ( 47 ) HTML (1 KB)  PDF (1171 KB)  ( 25 ) 1031 Application Value of Portable Ultrasound-guided Central Venous Catheterization in Neurological Intensive Patients(a Case Report of its Rare Complication Attached) ZHOU Li, PENG Yi DOI: 10.3969/j.issn.1671-7171.2021.07.020 【Objective】To explore the effect and safety of portable ultrasound-guided central venous catheterization. 【Methods】A total of 125 cases of central venous catheterization in our department were collected, 56 of which were used as the observation group, which was catheterized under portable ultrasound guidance, and the other 69 cases were used as the control group using traditional body surface markers to locate. Puncture success rate, complication rate, and puncture time were compared between the two groups. 【Results】The success rate of one puncture in the observation group was significantly higher than that in the control group [92.9%(52/56)vs 72.5%(50/69),P<0.05], the complication rate in the observation group was lower than that in the control group[0%(0/56) vs 11.6%(8/69),P<0.05], and the puncture time in the observation group was shorter than that in the control group [(8.31±1.41)min vs.(11.72±1.52)min,P<0.05]. A patient in the control group caused the guide wire to be incarcerated and could not be pulled out because the guide wire was mistakenly inserted into the transverse hole. After that, the guide wire was removed by surgery. 【Conclusion】Portable ultrasound can significantly improve the success rate of one-time puncture, shorten the puncture time, reduce the incidence of complications, and provide convenience for clinical treatment, which is worthy of wide promotion. 2021 Vol. 38 (7): 1031-1034 [Abstract] ( 43 ) HTML (1 KB)  PDF (2017 KB)  ( 71 ) 1035 Effect of Rehabilitation Assisted Basic Therapy on Nerve Function and Mental Health of Patients with Facial Nerve Palsy SUN Hui, ZHANG Yuan DOI: 10.3969/j.issn.1671-7171.2021.07.021 【Objective】To explore the effect of rehabilitation combined basic therapy on the facial nerve function and mental health status of patients with facial nerve palsy. 【Methods】A total of 200 patients with facial paralysis treated in Yulin Second Hospital were randomly divided into the study group(n=100) and the control group(n=100). Patients in both groups were given basic Western medicine treatment. Patients in the study group also received rehabilitation comprehensive therapy(Chinese medicine acupuncture, physiotherapy, functional rehabilitation training). Clinical efficacy, facial nerve function score, and symptom self-rating scale(SCL-90) scores of the two groups before and after intervention were compared. 【Results】After one month of treatment, the clinical efficacy of the study group(96%, 96/100) was better than that of the control group(87%, 87/100); and the difference was statistically significant(P<0.05). Before treatment, the difference in facial nerve function scores and SCL-90 scores between the two groups was not statistically significant(P>0.05). After treatment, the facial nerve function score of the study group was higher than that of the control group(P<0.05). Also, after treatment, the somatization, interpersonal sensitivity, depression, anxiety, psychosis symptom factors score of the study group were lower than the control group; the difference was statistically significant(P<0.05). 【Conclusion】 Rehabilitation comprehensive therapy assisted basic Western medicine treatment of facial nerve paralysis is beneficial to the recovery of facial nerve function and improve the mental health of patients. 2021 Vol. 38 (7): 1035-1037 [Abstract] ( 43 ) HTML (1 KB)  PDF (1146 KB)  ( 69 ) 1038 Serum BDNF, MIF, EGF Levels and their Correlation with Cognitive Function in Patients with Schizophrenia GUO Jun, LI Ying DOI: 10.3969/j.issn.1671-7171.2021.07.022 【Objective】To explore the serum brain-derived neurotrophic factor (BDNF), serum macrophage migration in-hibitory factor (MIF), epidermal growth factor (EGF) and their relationship with cognitive function in peripheral blood of schizophrenia. 【Methods】 The clinical data of 54 schizophrenic patients treated in our hospital from January 2017 to January 2019 (observation group) and 58 healthy volunteers in the same period (control group) were selected. The levels of serum BDNF, MIF and EGF in the two groups were detected by enzyme-linked immunosorbent assay. The clinical symptoms were evaluated by positive and negative symptom scale (PANSS), and the cognitive function was evaluated by cognitive function package consensus Version (MCCB). At the same time, the relationship between the levels of BDNF, MIF and EGF in peripheral blood of schizophrenia and cognitive function was analyzed by Pearson linear correlation. 【Results】The levels of serum BDNF in the control group were significantly higher than those in the observation group, and the levels of serum MIF and EGF were lower than those in the observation group (P<0.05). There was a positive correlation between PAS and NSF (r=286.05,P<0.05). The score of connection test in the control group was lower than that in the observation group, and the symbol coding, visual memory, verbal memory and semantic fluency were higher than those in the observation group (P<0.05). In the observation group, serum MIF level was positively correlated with visual spatial memory (r=0.485,P<0.05), and EGF level was positively correlated with visual spatial memory (r=0.331,P<0.05).【Conclusion】The levels of serum MIF and EGF are closely related to the clinical manifestations and some cognitive impairment of schizophrenic patients, and they are also related to the level of BDNF. 2021 Vol. 38 (7): 1038-1041 [Abstract] ( 54 ) HTML (1 KB)  PDF (1171 KB)  ( 40 ) 1042 Effect of ANG-2 on Prognosis of Elderly Patients with Acute Ischemic Stroke SU Hang, MA Da DOI: 10.3969/j.issn.1671-7171.2021.07.023 【Objective】 To explore the correlation between angiopoietin-2(Ang-2) and the prognosis of elderly patients with acute ischemic stroke(AIS). 【Methods】A total of 160 elderly patients with acute ischemic stroke who were treated in our hospital from December 30, 2016 to June 30, 2018, aged ≥65 years, were enrolled. The level of ANG-2 in peripheral blood was measured at admission. Patients were followed up. The follow-up deadline was April 30, 2019, and the end of follow-up was death. The correlation between ANG-2 and death in elderly patients with acute ischemic stroke was observed, and the prognostic factors were analyzed. The ROC curve was used to evaluate the predictive value of ANG-2 for death. 【Results】 At the time of admission, the ANG-2 level in patients with NIHSS score > 14 points was higher than that in patients with NIHSS score ≤14 points, the difference was statistically significant(P<0.05). The area under the ROC curve was 0.73. When the ANG-2 threshold was 25.2 ng/L, the specificity and sensitivity of ANG-2 diagnosis of death were 63.4% and 81.2%, respectively. The median follow-up time was 16.9 months and a total of 35 patients died. The age, proportion of stroke history and atrial fibrillation, the incidence of cerebral palsy, total cholesterol, pre-treatment NIHSS score, and ANG-2 level in the death group were higher than those in the survival group(P<0.05). Multivariate analysis showed that age, cerebral palsy, total cholesterol, pre-treatment NIHSS score, ANG-2(P=0.040, OR:1.244, 95% CI:1.055-2.197) were independent influence factors of deaths in elderly patients with acute ischemic stroke(P<0.05). 【Conclusion】The ANG-2 level at admission can predict the prognosis of elderly patients with acute ischemic stroke, and the patients with elevated ANG-2 have a poor prognosis. 2021 Vol. 38 (7): 1042-1044 [Abstract] ( 57 ) HTML (1 KB)  PDF (1154 KB)  ( 37 ) 1045 Level and Value of circRNA MICRA in Patients with Acute Myocardial Infarction ZHENG Jun-chen, ZHOU Xiao-lin DOI: 10.3969/j.issn.1671-7171.2021.07.024 【Objective】To analyze the level of circRNA MICRA in patients with acute myocardial infarction(AMI) and its clinical significance. 【Methods】A total of 73 patients with AMI who were diagnosed in the department of cardiology from January 2017 to May 2018 were enrolled as the AMI group and 73 healthy volunteers examined in the same time period in our hospital were included as healthy controls(HC) group. Venous blood was drawn from subjects immediately at admission to detect level of circRNA MICRA, and AMI patients were followed up 6 months after discharge and the major adverse cardiovascular events(MACE) in the group were recorded. MICRA levels were compared between the AMI and HC groups to explore the difference in level and the correlation between level of MICRA and AMI condition and prognosis. 【Results】Compared to the HC group, the level of MICRA in AMI group was significantly reduced [(1.63±0.28) vs(2.97±0.74), t=14.470, P<0.01];Receiver Operation Characterist Curve(ROC) evaluation of the effectiveness of MICRA as a diagnostic marker for AMI showed that the area under the curve(AUC)(95% CI) was 0.81(0.73-0.90) and the cutoff value was 1.47.Compared to patients with good prognosis, patients with poor prognosis had lower MICRA levels [(0.87±0.22) vs(2.19±0.85), t=12.845, P<0.01]. 【Conclusion】Level of MICRA was down-regulated in AMI patients and was closely related to AMI patient prognosis. It is a potential biomarker for the diagnosis and evaluation of AMI patients. 2021 Vol. 38 (7): 1045-1047 [Abstract] ( 42 ) HTML (1 KB)  PDF (1209 KB)  ( 20 ) 1048 Improvement of Placental Perfusion in Preeclampsia Model Rat by Transplantation of Angiogenic T Cells CAO Wu-zhan, GUO Ye-qing, HE Xin,et al DOI: 10.3969/j.issn.1671-7171.2021.07.025 【Objective】The purpose was to investigate whether the placental perfusion in preeclampsia model rats can be improved by transplantation of angiogenic T cells(Tang). 【Methods】Thirty adult healthy female rats were selected and kept in the same cage as the male rats at a ratio of 2:1 during the estrus period. The vaginal plug shedding was observed daily; and it was marked as pregnancy d1 when the day of the vaginal plug was seen. Then, 30 pregnant rats were randomly divided into experimental group, control group and normal group, with 10 rats in each group. The rats' model of preeclampsia was induced by intraperitoneal infected with L-NAME. The pregnant rats of the experimental group and the control group were intraperitoneally injected with L-arginine methyl ester(L-NAME) 250 mg/(kg·d) from d7 of pregnancy for 5 consecutive days, and the tail arteries of rats were measured on d7, d10, d13, d16, and d19 of pregnancy, respectively. The systolic blood pressure is found to be significantly elevated, which is regarded as the successful modeling of the preeclampsia pregnant mouse model. Umbilical venous blood was taken from healthy pregnant rats, then isolation of cord blood mononuclear cells was performed by density gradient centrifugation, followed by magnetic activated cell sorting(MACS) and flow cytometry for the isolation Tang cells. The Tang cells were transplanted by means of tail vein injection to the rats with preeclampsia. Meanwhile, the control group was injected with the same amount of normal saline in the tail vein for 6 consecutive days. No treatment was done in the normal group. The blood pressure, urine protein concentration, placental blood vessel density, placental weight, fetal weight and other indicators were compared among the three groups. The micro vascular density of placenta was detected by positive expression of CD31 as shown by inmunofluorescence histochemistry. The gestational result was observed by measurement of the weight of placenta rat fetus and placenta. 【Results】On d13, d16, and d19 of pregnancy, the blood pressure and urine protein concentration of pregnant rats in the experimental group and the control group were higher than those of the normal group; on d16, d19 of pregnancy, the blood pressure and urine protein concentration of the experimental group were significantly lower than those of the control group, and the differences were statistically significant(P<0.05). There was no significant difference in the number of fetal rats and placenta weight among the three groups(P>0.05). The birth weight and the fluorescence density of placental neovascularization of the experimental group and the control group were significantly lower than those of the normal group, but the experimental group's birth weight and the fluorescence density of placental neovascularization were significantly higher than those of the control group; and the difference was statistically significant(P<0.05). The placenta HE staining showed that the placental tissue cells of the control group were disordered, the amount of cells was small, the cell edema and vacuole-like changes were more, the placental intervascular membrane was thickened, and fibrinoid necrosis was seen. On the other hand, the placental tissue of the experimental group was more obvious than the control group Improved, there is no obvious cell edema and vacuoles, there is still a small amount of fibrinoid necrosis, and the new blood vessels are significantly increased compared with the control group.【Conclusion】Tang transplantation can increase the density of placental neovascularization in preeclampsia rats and improve pregnancy outcome, indicating that it has a certain effect on placental perfusion. 2021 Vol. 38 (7): 1048-1051 [Abstract] ( 48 ) HTML (1 KB)  PDF (1791 KB)  ( 53 ) 1052 Clinical Effect of Traditional Chinese Medicine Decoction Combined with Bloodletting on Acute Gouty Arthritis CHEN Xiao-peng, BAI Yan-li, YUAN Qing DOI: 10.3969/j.issn.1671-7171.2021.07.026 【Objective】To explore the clinical value of traditional Chinese medicine decoction combined with bloodletting in the treatment of acute gouty arthritis. 【Methods】 A total of 114 patients with acute gouty arthritis admitted to our hospital from February 2018 to October 2019 were selected and randomly divided into observation group(n=57) and control group(n=57) according to admission sequence parity method. The control group was treated with etoscoxib, while the observation group was treated with self-made traditional Chinese medicine decoction combined with bloodletting on the basis of the control group. After 7 days of treatment, erythrocyte sedimentation rate(ESR), serum uric acid(UA) and inflammatory factor levels, joint swelling pain score and clinical efficacy were compared between the two groups before and after treatment. 【Results】 The total effective rate of the observation group was 94.74%(54/57), which was higher than 75.44%(43/57) of the control group(P<0.05); After treatment, the joint swelling and pain scores, ESR and UA levels, interleukin-6(IL-6) and interleukin-1(IL-1) of the two groups were compared β( IL-1 β) And C-reactive protein(CRP) levels decreased compared with before treatment(P<0.05), and the observation group decreased more significantly than the control group(P<0.05). 【Conclusion】Self made traditional Chinese medicine decoction combined with bloodletting in the treatment of patients with acute gouty arthritis can reduce the level of serum inflammatory factors, relieve the clinical symptoms of patients, with good clinical efficacy. 2021 Vol. 38 (7): 1052-1054 [Abstract] ( 37 ) HTML (1 KB)  PDF (1147 KB)  ( 142 ) 1055 Value of Ankle-Brachial Index Combined with Vascular Endothelial Function Indexes in Predicting Coronary Artery Stenosis in Diabetic Patients with Coronary Disease XING Meng, LIU Jin-jin DOI: 10.3969/j.issn.1671-7171.2021.07.027 【Objective】To observe the value of ankle brachial index(ABI) and vascular endothelial function(FMD) on type 2 diabetes with coronary stenosis. 【Methods】From January 2018 to January 2019, 150 patients with type 2 diabetes mellitus(T2DM) and coronary heart disease who underwent coronary CTA in Department of Endocrinology, Xi'an High-Tech Hospital were selected as the observation group, and 30 patients with type 2 diabetes mellitus without coronary heart disease were selected as the control group. The 150 patients in the observation group were divided into the single-vessel disease group(65 cases), the double-vessel disease group(50 cases), and the severe disease group(triple-vessel, 35 cases). The FMD and ABI for each group were checked and compared. 【Results】The FMD and ABI in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). The FMD and ABI in the severe lesion group were lower than those in the double-vessel disease group and single-vessel disease group; the difference was statistically significant(P<0.05). The FMD and ABI of the double-vessel disease group were lower than those in the single-vessel disease group; the difference was statistically significant(P<0.05). FMD was positively correlated with ABI(r=0.35, P=0.02), while FMD and ABI were negatively correlated with Gensini scores(r=-0.45, -0.49, P=0.01, 0.00). The area under the ROC curve(AUC)(95%CI) of FMD and ABI for the diagnosis of severe coronary heart disease was 0.71(0.64-0.82) and 0.75(0.68-0.87), respectively, the specificity of them in diagnosis of coronary heart severe disease was 67.2% and 66.1%, respectively, and the sensitivity was 76.9% and 79.1%, respectively. The specificity of FMD combined with ABI in the diagnosis of coronary heart severe disease was 60.2%, and the sensitivity was 85.3%.【Conclusion】 FMD and ABI are reduced in patients with diabetic coronary stenosis. FMD and ABI have negative correlation with the degree of stenosis. The combination of FMD and ABI is of high value in predicting coronary heart severe disease in patients with type 2 diabetes. 2021 Vol. 38 (7): 1055-1058 [Abstract] ( 48 ) HTML (1 KB)  PDF (1259 KB)  ( 54 ) 1059 Clinical Analysis of Robot-Assisted Partial Nephrectomy for Isolated Renal Tumors YANG Xin-xuan, WANG Yan-zhu, LI Wei DOI: 10.3969/j.issn.1671-7171.2021.07.028 【Objective】To investigate the clinical efficacy of robot assisted partial nephrectomy in the treatment of solitary renal tumors. 【Methods】 The clinical data of 12 patients with solitary renal tumors treated by robot assisted partial nephrectomy in our hospital from June 2016 to January 2018 were retrospectively analyzed, including 1 case of contralateral renal atrophy, 2 cases of congenital solitary kidney, 1 case of contralateral benign renal disease and 8 cases of contralateral malignant renal tumor. All patients underwent robot assisted partial nephrectomy. The operation conditions were recorded and followed up for 12 months. The incidence of postoperative complications and prognosis were recorded. 【Results】The operation of 12 patients was successfully completed, and there was no conversion to open operation. The operation time was 108~210 min, with an average of(163.5 ± 15.4) min; The intraoperative bleeding volume was 120~460 mL, with an average of(240.6 ± 25.7) mL; The hospital stay was 6~15 days, with an average of(9.8 ± 2.1) days. Postoperative pathological diagnosis:9 cases of renal clear cell carcinoma and 3 case of angioleiomyoma, the cutting edge was negative, and the tumor capsule was relatively complete. One patient developed hematuria and one patient developed infection. All patients returned to normal after relevant effective intervention. Following up for 3 months, 12 patients had normal renal function indexes such as serum creatinine, urea nitrogen, glomerular filtration rate and urinary albumin; Followed up for 6 months, 1 patient had a slight increase in serum creatinine and urea nitrogen; After 9 months of follow-up, 2 patients had significantly increased serum creatinine and urea nitrogen, and the qualitative examination of proteinuria was positive; After 12 months of follow-up, the glomerular filtration rate of 1 patient was less than 100 ml/min, but no patient underwent renal dialysis, and there was no tumor recurrence and metastasis. 【Conclusion】Robot assisted partial nephrectomy can effectively preserve the renal function of patients with solitary renal tumor, has high safety, and is worthy of popularization and application. 2021 Vol. 38 (7): 1059-1061 [Abstract] ( 44 ) HTML (1 KB)  PDF (1147 KB)  ( 86 ) 1062 Efficacy and Renal Function Effect of Laparoscopic Nephron-sparing Surgery for Early Stage Renal Cell Carcinoma ZHANG Ying, MA Bing, WANG Lin-lin DOI: 10.3969/j.issn.1671-7171.2021.07.029 【Objective】To investigate the efficacy of laparoscopic nephron-sparing surgery(NSS) for early stage renal cell carcinoma and its effect on renal function. 【Methods】 The clinical data of 65 patients with early(T1a) renal cell carcinoma treated in our hospital were retrospectively analyzed. According to the different treatment methods, they were divided into a control group(n=29) and an observation group(n=36). The control group underwent radical nephrectomy(RN), and the observation group underwent NSS. The evaluation of operation procedure was compared between the two groups. Hemoglobin(Hb), urinary creatinine(Cr), urea nitrogen(BUN), and urinary cystatin C(urine Cys C) were detected in the two groups. Stress response indicators, including C-reactive protein(CRP), tumor necrosis factor-α(TNF-α), cortisol(Cor) and angiopoietin-Ⅱ(Ang Ⅱ) differences across the two groups, were analyzed. Quality of life(SF-36 scale), recurrence and survival after 1 year of follow-up were compared between the two groups. 【Results】(1)Compared to the control group, the operation time of the observation group was significantly shortened, and the intraoperative blood loss was significantly reduced(P<0.05). There was no significant difference between the two groups in drainage, bedtime and hospital stay(P>0.05).(2) Compared to the control group, the Hb of the observation group was significantly higher, and the Cr, BUN and urinary Cys C were significantly lower(P<0.05).(3) One day after operation, CRP, TNF-α and Cor were higher than those before operation, and the control group was higher than the observation group(P<0.05). The AngII levels of the two groups were lower after the operation than those before operation, and that of the observation group was lower than that of the control group(P<0.05).(4) One year after operation, the SF-36 scores of the two groups were significantly higher than those before the operation, and those of the observation group was significantly higher than those of the control group(P<0.05).(5) After 1 year of follow-up, the imaging examination of the two groups showed no recurrence and distant metastasis; the survival rate of the control group was 93.10%(27/29) and the survival rate of the observation group was 94.44%(34/36). There was no significant difference in the 1-year survival rate between the two groups(P>0.05). 【Conclusion】 Compared to RN, NSS is reliable and has little effect on renal function, effectively reducing intraoperative stress response and improving postoperative quality of life. 2021 Vol. 38 (7): 1062-1064 [Abstract] ( 44 ) HTML (1 KB)  PDF (1150 KB)  ( 68 ) 1065 Relationship between Peripheral Blood GRA, MLR, TLR-9, B7-H3 and Secondary Infection of Severe Acute Pancreatitis and its Evaluation Value for the Degree of Infection ZHANG Tao, CHANG Liang, ZHANG Li,et al DOI: 10.3969/j.issn.1671-7171.2021.07.030 【Objective】To explore the relationship between peripheral blood neutrophilic granulocyte(GRA), monocyte to lymphocyte ratio(MLR), Toll-like receptor-9(TLR-9), B7-H3 and secondary infections of severe acute pancreatitis and the evaluation value of the degree of infection. 【Methods】From June 2017 to March 2020, patients with severe acute pancreatitis in our hospital were selected as the research objects. According to whether the patients had secondary infections, 51 cases were in the secondary infection group and 72 cases were in the non-secondary infection group. The general data, peripheral blood GRA, MLR, TLR-9, B7-H3 of the two groups were compared, and the factors affecting the secondary infection of severe acute pancreatitis and the correlation between the above peripheral blood indicators were analyzed. The receiver operating(ROC) curve was used to analyze the diagnostic value of peripheral blood indicators for the secondary and severe infections of severe acute pancreatitis. 【Results】 The levels of GRA, MLR, TLR-9 and B7-H3 in peripheral blood were all influencing factors of secondary infection of severe acute pancreatitis(P<0.05). There was a positive correlation between GRA, MLR, TLR-9, and B7-H3 in patients with secondary infection of severe acute pancreatitis(P<0.05). The levels of GRA, MLR, TLR-9 and B7-H3 in peripheral blood of patients with severe infection were higher than those of patients with local infection(P<0.05). The ROC curve showed that the AUC areas for the combined diagnosis of severe acute pancreatitis with secondary infection and severe infection were 0.871 and 0.889, which were higher than any single index. 【Conclusion】Peripheral blood GRA, MLR, TLR-9, B7-H3 are all overexpressed in patients with secondary infection of severe acute pancreatitis, and their expression levels are related to the degree of infection. The levels of these indicators can be monitored to guide the formulation of clinical medication regimens. 2021 Vol. 38 (7): 1065-1068 [Abstract] ( 43 ) HTML (1 KB)  PDF (1359 KB)  ( 43 ) 1069 Effect of Different Lateral Iliac Osteotomy Methods on Knee Function Rehabilitation after C3 Fracture of Distal Femur YANG Hui, CUI Bo DOI: 10.3969/j.issn.1671-7171.2021.07.031 【Objective】To investigate the effect of different methods of iliac osteotomy on the rehabilitation of knee function after C3 fracture of distal femur. 【Methods】A total of 52 patients with C3 fracture of distal femur treated in our hospital from July 2017 to July 2019 were selected as the research objects. They were divided into control group and observation group according to the digital parity method, with 26 cases in each group. During intraoperative bone grafting, ipsilateral iliac osteotomy was used in the control group and contralateral iliac osteotomy was used in the observation group. The operation time, knee activity time, excellent and good rate of knee function score 6 months after operation and the incidence of postoperative complications were compared between the two groups.【Results】The operation time in the observation group was significantly shorter than that in the control group(P<0.05). The time of active straightening to 10 ° and active flexion to 120 ° in the observation group was shorter than that in the control group(P<0.05); The excellent and good rate of knee function score in the observation group was significantly better than that in the control group(80.77% vs 53.85%,χ2=4.282,P=0.039); There was no significant difference in the incidence of complications between the two groups(P>0.05).【Conclusion】Compared with ipsilateral bone extraction, contralateral bone extraction is conducive to the rehabilitation of knee function after operation of C3 fracture of distal femur. 2021 Vol. 38 (7): 1069-1071 [Abstract] ( 37 ) HTML (1 KB)  PDF (1146 KB)  ( 64 ) 1072 Effect of Timing of Rehabilitation Treatment on Recovery of Cognitive and Motor Functions in Patients with Cerebral Unfarction LI Shuo-hua DOI: 10.3969/j.issn.1671-7171.2021.07.032 【Objective】To investigate the effects of different start times of rehabilitation therapy on cognitive and motor functions in patients with cerebral infarction. 【Methods】We collected 160 patients with cerebral infarction admitted to our hospital from January 2016 to January 2021 who met the inclusion criteria, and retrospectively analyzed the clinical rehabilitation effects of the treatment of patients with cerebral infarction after different rehabilitation treatment intervention times, and divided them into two groups according to the time point at which the patients received the rehabilitation intervention. Eighty of the patients started rehabilitation treatment on day 2 after onset(experimental group) and the other 80 patients started rehabilitation treatment on day 7 after onset(control group), and the same interventions were used in both groups(see Methods section for details). The patients' cognitive and motor functions were evaluated using the Mini-mental State Examination(MMSE) scale score, the Fugl-Meyer-FMA scale score and the Activities Of Daily Living(ADL) scale score. The prognosis of the patients was evaluated before, one month and three months after treatment, and the clinical rehabilitation effects of the two groups were compared at different times of rehabilitation treatment intervention. 【Results】The differences in MMSE score, FMA score and ADL score before treatment were not statistically significant in both groups(P>0.05). The MMSE scores, FMA scores and ADL scores were significantly higher in both groups at 1 month after treatment and 3 months after treatment than before treatment, and were significantly higher in the experimental group than in the control group at 3 months after treatment, and the differences were statistically significant(P<0.05). 【Conclusion】 Early rehabilitation interventions for patients with cerebral infarction are more effective in improving cognitive function and limb movement function. 2021 Vol. 38 (7): 1072-1074 [Abstract] ( 37 ) HTML (1 KB)  PDF (1146 KB)  ( 46 ) 1075 Application Value of Anti-angiogenesis Drugs Combined with Paclitaxel and Cisplatin in Non-small Cell Lung Cancer XIE Lin, HUAI Bao-hua DOI: 10.3969/j.issn.1671-7171.2021.07.033 【Objective】 To investigate the application value of anti angiogenesis drugs combined with paclitaxel and cisplatin in non-small cell lung cancer(NSCLC).【Methods】A total of 80 patients with NSCLC in our hospital were selected and divided into control group(n=40, paclitaxel and cisplatin chemotherapy) and observation group(n=40, bevacizumab combined with paclitaxel and cisplatin chemotherapy) according to different treatment schemes. The clinical effective rate, changes of tumor markers and immune indexes, quality of life and adverse reactions of the two groups were compared. 【Results】The total effective rate of the observation group was 57.5%(23/40), which was higher than 25.00%(10/40) of the control group, and there was significant difference between the two groups(P<0.05); Carcinoembryonic antigen, vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(bFGF) of the two groups were improved after treatment(P<0.05), and the observation group was better than the control group(P<0.05); After treatment, the levels of CD3+ CD4+ CD8+ CD4+/CD8+ in the observation group were higher than those before treatment(P<0.05); The levels of CD3+ CD4+ CD8+ in the control group were lower than those before treatment(P<0.05), and the indexes in the observation group were higher than those in the control group(P<0.05); The quality of life score of the observation group was(46. 81±7. 58) was higher than(38. 17 ±7. 29)(P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】 Anti angiogenic drugs combined with paclitaxel and cisplatin in the treatment of NSCLC has higher clinical efficacy and fewer adverse reactions, which can effectively improve the immune system damage, promote the recovery of tumor markers and improve the quality of life of patients. 2021 Vol. 38 (7): 1075-1078 [Abstract] ( 36 ) HTML (1 KB)  PDF (1177 KB)  ( 61 )

Copyright © Editorial Board of JOURNAL OF CLINICAL RESEARCH Supported by:Beijing Magtech