踝肱指数联合血管内皮功能对2型糖尿病合并冠心病患者冠状动脉狭窄程度的预测价值

doi:10.3969/j.issn.1671-7171.2021.07.027

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Abstract 【Objective】To observe the value of ankle brachial index(ABI) and vascular endothelial function(FMD) on type 2 diabetes with coronary stenosis. 【Methods】From January 2018 to January 2019, 150 patients with type 2 diabetes mellitus(T2DM) and coronary heart disease who underwent coronary CTA in Department of Endocrinology, Xi'an High-Tech Hospital were selected as the observation group, and 30 patients with type 2 diabetes mellitus without coronary heart disease were selected as the control group. The 150 patients in the observation group were divided into the single-vessel disease group(65 cases), the double-vessel disease group(50 cases), and the severe disease group(triple-vessel, 35 cases). The FMD and ABI for each group were checked and compared. 【Results】The FMD and ABI in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). The FMD and ABI in the severe lesion group were lower than those in the double-vessel disease group and single-vessel disease group; the difference was statistically significant(P<0.05). The FMD and ABI of the double-vessel disease group were lower than those in the single-vessel disease group; the difference was statistically significant(P<0.05). FMD was positively correlated with ABI(r=0.35, P=0.02), while FMD and ABI were negatively correlated with Gensini scores(r=-0.45, -0.49, P=0.01, 0.00). The area under the ROC curve(AUC)(95%CI) of FMD and ABI for the diagnosis of severe coronary heart disease was 0.71(0.64-0.82) and 0.75(0.68-0.87), respectively, the specificity of them in diagnosis of coronary heart severe disease was 67.2% and 66.1%, respectively, and the sensitivity was 76.9% and 79.1%, respectively. The specificity of FMD combined with ABI in the diagnosis of coronary heart severe disease was 60.2%, and the sensitivity was 85.3%.【Conclusion】 FMD and ABI are reduced in patients with diabetic coronary stenosis. FMD and ABI have negative correlation with the degree of stenosis. The combination of FMD and ABI is of high value in predicting coronary heart severe disease in patients with type 2 diabetes.

Key words： Coronary Disease/CO Diabetes Mellitus, Type 2/CO Coronary Artery Disease Ankle Humerus

Received: 14 January 2021

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R542.22

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	XING Meng
	LIU Jin-jin

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XING Meng,LIU Jin-jin. Value of Ankle-Brachial Index Combined with Vascular Endothelial Function Indexes in Predicting Coronary Artery Stenosis in Diabetic Patients with Coronary Disease[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(7): 1055-1058.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.07.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I7/1055

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