中药组方联合紫杉醇与卡铂治疗晚期卵巢癌的疗效及对肿瘤标记物的影响

doi:10.3969/j.issn.1671-7171.2021.07.010

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Abstract 【Objective】To explore the efficacy of Chinese medicine combined with paclitaxel and carboplatin in the treatment of advanced ovarian cancer and its effect on tumor-associated markers. 【Methods】A total of 80 patients with advanced ovarian cancer in our hospital were randomly divided into control group and observation group. The control group was treated with paclitaxel and carboplatin while the observation group was treated with traditional Chinese medicine on the basis of the same chemotherapy as the control group. The clinical efficacy, serum CA125, CA199, human epididymis protein 4(HE4) and the effect on immune function of the two groups were compared. The complications of the two groups were recorded. 【Results】The clinical efficacy of the observation group was significantly higher than that of the control group(92.50% vs 75.00%)(P<0.05);There was no significant difference in the levels of CA125, CA199 and HE4 between the two groups before treatment(P>0.05).After treatment, the levels of CA125, CA199 and HE4 in the observation group were significantly better than those in the control group(P<0.05).After chemotherapy, the levels of CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ in both groups were worse than before chemotherapy(P<0.05), but after chemotherapy, the levels of CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ in the observation group were better than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(30.00% vs 57.50%)(P<0.05). 【Conclusion】The combination of traditional Chinese and Western medicine in the treatment of patients with advanced ovarian cancer can effectively improve the clinical efficacy, improve the immune function of patients, and ultimately improve the prognosis of patients.

Key words： Ovarian Neoplasms/DT Antineoplastic Agents/TU Taxoids/TU Carboplatin/TU Treatment Outcome

Received: 12 October 2020

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R737.31

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	CHEN Zhi-mei

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CHEN Zhi-mei. Efficacy and Tumor-associated Markers Analysis of Chinese Medicine Combined with Paclitaxel and Carboplatin in the Treatment of Advanced Ovarian Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(7): 998-1001.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.07.010 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I7/998

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