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Quick Search     Adv Search 2020 Vol. 37, No. 4 Published: 2020-04-30   495 Bone Metabolism Changes and Influencing Factors in Patients with Primary Sjogren Syndrome LOU Fang-ming, SUO Xing-xing, QIU Ying-ying, et al DOI: 10.3969/j.issn.1671-7171.2020.04.005 【Objective】 To investigate the bone status, influencing factors associated with bone mass, and bone metabolism markers during bone mass changes in patients with primary Sjogren syndrome (pSS). 【Methods】 A total of 55 patients with pSS were selected as the observation group and 50 healthy volunteers were recruited as the control group. The bone mineral density (BMD) of lumbar vertebrae and femoral neck and the bone metabolic markers such as type Ⅰ collagen C-terminal peptide cross-linking (CTX),type Ⅰ procollagen N-terminal propeptide (PINP) and osteocalcin (OC) of the two groups were compared. The correlations of bone metabolic markers with age, duration of disease, body mass index, erythrocyte sedimentation rate(ESR), C-reactive protein(CRP), complement (C3,C4 and C1q) and hormone usage were analyzed. The relationship between BMD and bone metabolism markers in patients with pSS was evaluated as well. 【Results】 The levels of BMD, PINP and OC of lumbar vertebrae and femoral neck in pSS group were lower than those in the control group, while the level of CTX in pSS group was higher than that in control group (P<0.05). The BMD of lumbar vertebrae and femoral neck in pSS group were negatively correlated with age and C1q; and the BMD of lumbar vertebrae was also negatively correlated with hormone usage (P<0.05).The level of CTX in pSS group was negatively correlated with C4 ( P<0.05) and positively correlated with hormone usage (P<0.05).The levels of PINP and OC in patients with pSS were negatively correlated with the levels of CRP and hormone usage, while the level of OC was positively correlated with C4 level (P<0.05). The level of CTX in pSS patients with osteopenia group and osteoporosis subgroup was higher than that in pSS subgroup with normal bone mass; and the levels of PINP and OC in osteoporosis subgroup were lower than those in normal bone mass subgroup. Compared to the control group, the levels of PINP and OC in normal bone mass subgroup of pSS were lower; and the difference was statistically significant (P<0.05).【Conclusion】 Patients with pSS have abnormal BMD and bone metabolism which are correlated with disease activity and hormone usage. The bone metabolic markers can evaluate the status of bone mass in pSS patients. 2020 Vol. 37 (4): 495-498 [Abstract] ( 97 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 499 Effect of Parthenolide on Polarization of Macrophage Cell Line RAW264.7 LIN Shan, DAI Li-bing, WENG Chun-hui, et al DOI: 10.3969/j.issn.1671-7171.2020.04.006 【Objective】 To investigate the effect of parthenolide (PAR) on the polarization typing of macrophage cell line RAW264.7. 【Methods】 The macrophage cell line RAW264.7 was divided into control group, model group and experimental group. The control group was given routine culture, the model group was added with 100μg/L lipopolysaccharide, the experimental group were added with low, medium and high concentrations of par (2.5μmol/L, 5μmol/L, 10μmol/L); after 7 days of continuous culture, the levels of TNF-α, MCP-1, TGF-β1 and IL-4 in RAW264.7 were detected by ELISA; flow cytometry was used to detect the expression of CD16/32 and CD206 on the surface of two kinds of cells; Western blot was used to detect the level of ApoE protein in three groups of par cells with different concentrations; real-time fluorescent PCR (RT-qPCR) was used to detect the levels of IL-10, Arg-1 and iNOS mRNA in three groups of cells.【Results】 The levels of TNF- α and MCP-1 in the experimental group were significantly lower than those in the control group and the model group (P<0.05), and the levels of TGF- β 1, IL-4 and apoE protein in the experimental group were significantly higher than those in the control group and the model group (P<0.05). The levels of TNF- α and MCP-1 in the experimental group decreased in turn, while the levels of TGF-β 1, IL-4 and apoE protein in the experimental group increased in turn, and the differences between the two groups were statistically significant (P<0.05). The M2/M1 of the model group was 0.47, significantly lower than 0.85 of the control group, while the M2/M1 of the experimental group was 0.61, 0.69 and 0.73, respectively, significantly higher than that of the model group (P<0.05); the M2/M1 of the low, medium and high concentrations increased in turn, with a statistically significant difference (P<0.05). Compared with the control group, the level of Arg-1 mRNA decreased significantly; the level of IL-10 and iNOS mRNA increased significantly (P<0.05); the level of IL-10 and iNOS mRNA in the high concentration of the experimental group was significantly lower than that in the low concentration and the middle concentration; the level of Arg-1 mRNA was significantly higher than that in the low concentration and the middle concentration, and the difference was statistically significant (P<0.05). 【Conclusion】 PAR may further induce RAW264.7 polarization from M1 pro-inflammatory phenotype to M2 anti-inflammatory phenotype. 2020 Vol. 37 (4): 499-501 [Abstract] ( 122 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 502 Arthroscopic Repair of Lafosse Type Ⅰ and Type Ⅱ Injury of Subscapular Tendon with Modified Mason Allen Technique XIAO Yu-hui, QUE Meng, LIU Zhong-fan, et al DOI: 10.3969/j.issn.1671-7171.2020.04.007 【Objective】 To explore the technique and clinical effect of arthroscopic single channel modified Mason Allen suture in the repair of lafosei Ⅰ and Ⅱ injury of subscapular tendon. 【Methods】 From January 2018 to December 2018, the clinical data of 24 patients with subscapular tendon tears repaired by single channel modified Mason Allen technique were analyzed retrospectively. According to the visual analogue scale (VAS), the preoperative and postoperative pain scores of patients during rest (night time) and passive movement were evaluated. The angle of passive flexion, lateral rotation and lateral rotation were recorded before and after operation. At least 6 months after operation, MRI of shoulder joint was reexamined.【Results】 According to the Lafosse classification of subscapular muscle injury under arthroscopy, there were 7 cases of type Ⅰ and 17 cases of type Ⅱ, 5 cases of isolated subscapular tendon injury and 19 cases of supraspinatus tendon injury. All the patients were followed up for 6 to 12 months. No complications such as blood vessel, nerve and infection occurred. No re tear of subscapular tendon was found. Among them, at 6 months after operation, VAS score at rest (at night) and VAS score at passive activity were significantly lower than that before operation (P<0.05). There was no significant difference in active flexion, abduction and lateral rotation before and after operation (P>0.05). Six months after operation, UCLA and ASES were significantly higher than those before operation (P<0.01). 【Conclusion】 The modified Mason-Allen suture technique with single operation channel under the arthroscope has the advantages of convenient operation and small injury to repair the Lafosse type Ⅰ and Ⅱ injury of the subscapular tendon. 2020 Vol. 37 (4): 502-505 [Abstract] ( 95 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 506 Evaluation Value of Pulmonary Ultrasound Score in Prognosis and Severity of Acute Respiratory Distress Syndrome WANG Chun-mei, CHENG Rui-hong, ZHAO Yin-hua, et al DOI: 10.3969/j.issn.1671-7171.2020.04.008 【Objective】 To evaluate the value of pulmonary ultrasound (LUS) score in the prognosis and severity of acute respiratory distress syndrome (ARDS).【Methods】 From January 2018 to January 2019, 103 patients with ARDS who were diagnosed and treated in the respiratory department of our hospital were divided into mild group (11 cases), moderate group (43 cases) and severe group (49 cases) according to the Berlin standard of ARDS in 2012, and then divided into survival group (72 cases) and death group (31 cases) according to the prognosis. All patients underwent LUS and arterial blood gas analysis on the day of admission, and the prognosis was evaluated by acute physiology and APACHEⅡ. The correlation between LUS score, prognosis and severity of the disease was analyzed by stepwise linear regression.【Results】 The scores of LUS and Apache Ⅱ in the survival group were (15.71 ± 2.31) and (13.69 ± 2.06) respectively, which were significantly lower than those in the death group (23.77±4.82) and (24.73±3.94). The differences were statistically significant (t=11.726,P<0.001;t=10.861,P<0.001). The scores of LUS, peep and PaO2/FiO2 in mild, moderate and severe groups increased in turn, and the differences between the two groups were statistic8ally significant (P<0.05). Stepwise linear regression analysis showed that LUS score was positively correlated with prognosis and severity of the disease.【Conclusion】 LUS score has a positive correlation with the prognosis and severity of the patients with ARDS, which can be used as an important auxiliary index to evaluate the condition and prognosis of the patients with ARDS. 2020 Vol. 37 (4): 506-508 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 509 Effect of Preoperative Adriamycin Combined with Cisplatin on the Expression of Puma and Survivin in Lung Cancer WANG Hui DOI: 10.3969/j.issn.1671-7171.2020.04.009 【Objective】 To investigate the effect of preoperative doxorubicin combined with cisplatin interventional chemotherapy on puma and survivin protein expression in lung cancer tissues. 【Methods】 A total of 88 patients with lung cancer in our hospital were enrolled in the study, who were divided into two groups randomly.The two groups received radical resection of lung cancer, while the observation group received preoperative interventional therapy with adriamycin and cisplatin.The expression levels of puma and survivin in tumor tissues were compared between the two groups before and after interventional therapy. The surgical related indexes were recorded and the 3-year survival rates were compared between the two groups. 【Results】 The surgical pathology confirmed that the diameter of tumors in the observation group was significantly shorter than that in the control group, the stage of tumors in the observation group was significantly lower than that in the control group (P<0.05).There were no significant difference in operation time and the degree of differentiation between the two groups (P>0.05).The results of operation and pathology showed that the positive rate and expression level of puma protein in the observation group were higher than those in the control group, while the positive rate and expression level of survivin protein in the observation group were significantly lower than those in the control group (P<0.05).The average 3-year survival time of the observation group was significantly longer than that of the control group (P<0.05).There was no significant difference in 3-year survival rate between the two groups (P>0.05). 【Conclusion】 The preoperative interventional therapy with adriamycin and cisplatin is helpful to reduce the clinical stage and prolong the survival time of patients with lung cancer, which may be related to the regulation of puma and survivin protein levels. 2020 Vol. 37 (4): 509-512 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 513 Effect of Dexmedetomidine on Immune Function and Stress Response in Laparoscopic Resection of Rectal Cancer LIU Zhi, HE Hui-xin, TENG Yong-jie DOI: 10.3969/j.issn.1671-7171.2020.04.010 【Objective】 To investigate the effect of dexmedetomidine on immune function and stress response in patients with rectal cancer undergoing laparoscopic resection.【Methods】 From May 2017 to may 2018, 88 patients with rectal cancer undergoing laparoscopic surgery were selected and divided into observation group and control group according to the random number table method, 44 cases in each group. In the observation group, dexmedetomidine was pumped 0.5 hours before anesthesia induction, the loading dose was 0.5 μg/kg, and then maintained 0.3 μ g/(kg?h) until the end of the operation. In the control group, the same loading dose and the same maintenance dose of normal saline were given. The two groups were compared before anesthesia induction (T0), immediately after operation (T1), 24 hours after operation (T2), and T lymphocyte subsets 72 hours after operation(T3) , noradrenaline (NE) and adrenaline (E) levels . The changes of heart rate (HR) and mean arterial pressure (MAP) in T0, Ta, T1 and Tb were recorded.【Results】 There was no significant difference in CD8+ level between the two groups (P>0.05). There was significant difference in CD3+, CD4+, CD4+/CD8+ between T1-T3 and T0 in the two groups, and the levels of CD3+, CD4+, CD4+/CD8+ in the observation group were higher than those in the control group (P<0.05) .There was significant difference between the NE and E levels of T1-T3 and T0, and the levels of NE and E in T1-T3 stage in the observation group were significantly lower than those in the control group (P<0.05). The HR and MAP of Ta, T1 and Tb in the control group were significantly different from those in T0, and the HR and MAP of Ta, T1 and Tb in the observation group were significantly different from those in the control group (P<0.05).【Conclusion】 The pump of dexmedetomidine in patients with rectal cancer during laparoscopic surgery can improve the immune function and alleviate the perioperative stress response, which is worthy of clinical reference. 2020 Vol. 37 (4): 513-515 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 516 Screening and Treatment of congenital hypothyroidism in Huangshan City from 2012 to 2016 BAO Kuan-ye, CHEN Yue-ling, WANG De-zhi, et al DOI: 10.3969/j.issn.1671-7171.2020.04.011 【Objective】 To investigate the screening and treatment of congenital hypothyroidism (CH) in Huangshan City from 2012 to 2016. 【Methods】 The live births who received neonatal thyroid stimulating hormone (TSH) screening from the medical institutions in Huangshan City between January 2012 to December 2016 were selected for the study. Venous blood was re-collected for those with high level of TSH to test thyroid function and confirm the diagnosis of congenital hypothyroidism. The CH confirmed children were given low dose levothyroxine sodium tablets. After 2-3 years of follow-up, the incidence of transient CH and persistent CH was observed. 【Results】 From 2012 to 2016, there were 62276 live births in Huangshan City. Among those, 60945 cases received the CH screening. The screening rate was 97.86%.There were 59 positive CH cases showing the positive rate 0.968‰. In 2014, the positive rate of CH screening was the highest (1.15‰) and the lowest rate was 0.725‰ in 2016. A total of 57 CH screening positive cases were followed up and showed 36 CH patients, whose incidence rate was 0.591‰ including 17 males and 18 females (the ratio of male to female was 1∶1.06). There were 21 cases of hyper-TSHemia with an incidence rate of 0.345‰. After 2-3 years of treatment, 19 out of the 36 CH patients were persistent (52.78%) and 17 patients were temporary (47.22%) CH. 【Conclusion】 Huangshan City shows a high-incidence area of neonatal CH from 2012 to 2016. CH can be diagnosed early by neonatal CH screening. The incidence of temporary CH in Huangshan City is also high. It is necessary to strengthen the education during pregnancy and adjust the diet structure to reduce the incidence of CH in newborns in this area. 2020 Vol. 37 (4): 516-518 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 519 Investigation and Analysis on the Level of Disease Uncertainty and Coping Style of Colorectal Cancer and Rectal Cancer Patients in Bao'an District of Shenzhen City WU Wen, ZHANG Heng-bin, LIAO Xiao-hong DOI: 10.3969/j.issn.1671-7171.2020.04.012 【Objective】 To investigate and analyze the level of disease uncertainty and coping style of colorectal cancer patients in Bao'an District of Shenzhen.【Methods】 From January 2015 to January 2018,500 patients with colorectal cancer in Baoan District of Shenzhen City were selected as the subjects. All patients were diagnosed by pathological examination and participated in the questionnaire survey. the chinese version of the Mishel disease uncertainty scale (MUIS) was calculated for each item average, uncertainty score, complexity score, overall uncertainty total score using the medical coping modes questionnaire (MCMQ) survey to count the patient face, avoidance, yield score. correlation analysis of coping style and uncertainty in colorectal cancer patients.【Results】 Among the 493 valid questionnaires, the uncertainty score was (54.33±9.06), the complexity score was (33.76±5.13), and the total score was (89.29±13.75). Among them, 116 (23.53%) had low degree uncertainty, 211 (42.80%) had medium degree uncertainty and 166 (33.67%) had high degree uncertainty. There was no significant difference in the unclear score between rectal cancer patients and colorectal cancer patients (P>0.05); the complexity score and total score of rectal cancer patients were significantly higher than those of colorectal cancer patients, and the difference was statistically significant (P<0.05). The MCMQ volume surface score of rectal cancer patients was lower than that of colorectal cancer, and the avoidance, yield score was higher than that of colorectal cancer patients, and the difference was statistically significant (P<0.05). Pearson correlation analysis showed that there was no significant correlation between coping style, avoidance, yield and uncertainty score, complexity score and total score (P>0.05).【Conclusion】 The disease uncertainty of colorectal cancer patients is more serious, among which rectal cancer patients are more obvious, the coping style appears the tendency of yielding and avoiding, so the patients should be targeted to guide, so that patients can face the disease more actively. 2020 Vol. 37 (4): 519-521 [Abstract] ( 73 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 522 Clinical Study on the Treatment of Type Ⅲ B Prostatitis (damp heat stasis syndrome) with Chinese Medicine Sitz Bath combined with Tamoxin and Prostate Massage GAO Sen, XI Jin-bo, LIU Shao-ming, et al DOI: 10.3969/j.issn.1671-7171.2020.04.013 【Objective】 To explore the clinical effect of Chinese medicine sitz bath combined with tamoxin and prostate massage on type Ⅲ B prostatitis (CP).【Methods】 From October 2018 to may 2019, 70 patients with type Ⅲ B CP admitted to the urology clinic of our hospital were divided into two groups according to the random number table method: the observation group (Chinese medicine sitz bath combined with oral tamoxin, and given transrectal prostate massage treatment) and the control group (warm water sitz bath combined with oral tamoxin, and given transrectal prostate massage treatment), 35 cases in each group.After treatment, NIH-CPSI and TCM syndrome differentiation score were statistically improved, and the ratio of the number of the lecithin corpuscles (SPL) to normal and the efficiency of clinical treatment after treatment were compared.【Results】 The clinical effective rate of the observation group was 88.6% (31/35), higher than that of the control group (68.6% (24/35), the difference was statistically significant (P<0.05). The quality NIH-CPSI life score and its total score of the two groups after treatment were improved compared with that before treatment, and the observation group was better than the control group, and the difference was statistically significant (P<0.05).After treatment, the scores of TCM syndrome differentiation in the two groups decreased, and the difference between the observation group and the control group was statistically significant (P<0.05). After treatment, 25 cases (71.4%) in the observation group and 16 cases (45.7%) in the control group recovered to normal in the count of SPL in the prostatic fluid (ESP), the difference was statistically significant (P<0.05). Followed up after 3 months of treatment, the recurrence rate in the observation group was 9.4%(3/32), which was lower than 20.8%(5/24) in the control group, and the difference was statistically significant (P<0.05).【Conclusion】 The comprehensive therapy of traditional Chinese medicine sitz bath combined with tamoxin and prostate massage can improve the quality of life of patients with type Ⅲ B CP (damp heat stasis syndrome), which has the advantages of significant clinical effect, slight side effects and high safety, and is worthy of clinical reference. 2020 Vol. 37 (4): 522-524 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 525 Expression and Clinical Significance of LIMK1 and Cofilin Expression in Prostate Cancer SHI Tao, HANG Zhen-yu, SHEN Lu-ming DOI: 10.3969/j.issn.1671-7171.2020.04.014 【Objective】 To investigate the correlation of the expression of LIM-kinase1 (LIMK1) and Cofilin with clinicopathological features and prognosis of prostate cancer.【Methods】 In this study, protein expression levels of LIMK1 and Cofilin in tissues measured by immunohistochemistry were collected from 93 cases of prostate cancer and 51 cases of benign prostatic hyperplasia treated in our hospital from September 2015 to June 2018. The correlations of LIMK1 nad Cofilin with their clinicopathological features and prognosis were analyzed. 【Results】 The positive rates of LIMK1 and Cofilin protein in prostate cancer tissues were significantly higher than those in benign prostatic hyperplasia (P<0.05). The expression levels of LIMK1 and Cofilin protein in prostate cancer patients with different prostate volume, seminal invasion, lymph node metastasis, capsule invasion, positive margin, PSA level, PSAD, Gleason score and clinical T stage were significantly different (P<0.05). The expressions of LIMK1 and Cofilin were significantly associated with the survival rate of prostate cancer patients (P<0.05). The expression of LIMK1 protein was positively correlated with Cofilin expression in prostate cancer tissues (P<0.05). 【Conclusion】 Both LIMK1 and Cofilin are positively expressed in prostate cancer tissues, which are correlated to the prostate volume, seminal invasion, lymph node metastasis, capsule invasion, positive margin, PSA level, PSAD, Gleason score and clinical T stage; meanwhile, the lymph node metastasis, capsule invasion, positive margin, Gleason score, T stage and protein expression levels of LIMK1 and Cofilin are associated with the survival rate of prostate cancer patients. Thus, LIMK1 and Cofilin protein expression levels can be serves as indicators for diagnosis and prognosis of prostate cancer. 2020 Vol. 37 (4): 525-527 [Abstract] ( 72 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 528 Effect of Prenatal Delivery Rehearsal on Success Rate of Primipara Natural Delivery and Postpartum Complications PENG Yu-xia, HU Xiao-fei, ZHANG Qiu-ling, et al DOI: 10.3969/j.issn.1671-7171.2020.04.015 【Objective】 To investigate the effect of routine prenatal health education training combined with prenatal delivery rehearsal practice on the success rate of primipara natural delivery and postpartum complications. 【Methods】 A total of 86 primiparas who were delivered in the Department of Obstetrics and Gynecology of Beijing Huairou Hospital from September 2016 to September 2018 were enrolled in the study. They were divided into two groups according to the prenatal delivery education methods. Patients in the control group (n=44) received routine prenatal health education training before delivery, while patients in the observation group (n=42) practiced delivery rehearsal based on the training of the control group. The self-efficacy scale (GSES), depression self-assessment scale (SDS) and anxiety self-assessment scale (SAS) scores were compared between the two groups. The success rate of natural delivery and the incidence of postpartum complications in the two groups were compared as well. 【Results】 Compared to the control group, the total delivery process including the first, second and third phases, neonatal asphyxia rate, postpartum SDS and SAS scores of the observation group were decreased (P<0.05); While the natural delivery success rate and GSES were increased in the observation group (P<0.05). The incidence of postpartum hemorrhage, infection, urinary retention, milk deposition/stasis and total complication rate in the observation group were lower than those in the control group (P<0.05). 【Conclusion】 The prenatal management method of routine prenatal health education training combined with prenatal delivery rehearsal practice can effectively increase the success rate of primipara natural delivery, shorten the labor process and reduce the incidence of postpartum complications. 2020 Vol. 37 (4): 528-531 [Abstract] ( 77 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 532 Effect of Structural Bone Grafting on Acetabular Bone Defect in Total Hip Replacement GUO Yu-li, HU Yi-san, DIAO Xi-cai, et al DOI: 10.3969/j.issn.1671-7171.2020.04.016 【Objective】 To explore the effect of structural bone grafting in the treatment of acetabular bone defect in total hip replacement.【Methods】 From January 2008 to December 2014, the clinical data of 31 cases of structural bone graft during hip replacement were analyzed. The follow-up period was 5.8 (4-10) years. The causes of operation were as follows: 9 cases of developmental dysplasia of Crowe Ⅱ type with 9 hips, 16 cases of Crowe Ⅲ type with 16 hips, 6 cases of acetabulum fracture with infection, necrosis of femoral head and acetabulum defect with 6 hips. 25 cases underwent structural bone grafting with autologous femoral head and 6 cases with structural bone grafting with allograft to observe the clinical effect.【Results】 The incision of all patients healed in one stage, without infection, thrombosis, vascular and nerve injury. The VAS score decreased from (6.2±1.3) before operation to (1.6±0.3) during follow-up (P<0.05). The Harris score increased from (56±6.2) before operation to (87±4.5) during follow-up (P<0.05). There were no cases of moderate or severe pain, and no cases of thigh pain. 23 cases had normal gait and 8 cases had mild claudication. All the 31 patients were satisfied with the results of the operation. In all cases, the bone graft healed with the ilium bone bed, but the bone graft was partially absorbed in 2 hips, and there were some discontinuous transparent bands between the bone graft and the bone bed in 2 hips. There were no cases of screw fracture and bone graft displacement, no cases of prosthesis loosening and need to be repaired again. There was no difference in abduction angle and anteversion angle between early postoperative and last follow-up (P>0.05).【Conclusion】 The indication of the operation was well grasped and the operation standard was followed. The structural bone graft was satisfactory in the treatment of acetabular bone defect in total hip arthroplasty in the mid-term, which is worthy of clinical application. 2020 Vol. 37 (4): 532-535 [Abstract] ( 89 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 536 Effects of Nabocone Injection on Sedation, Analgesia and Negative Emotions after Cesarean Section LI Shi-hong, DENG Hong-yan, MOU Jun-jie DOI: 10.3969/j.issn.1671-7171.2020.04.017 【Objective】 To explore the effects of nabocone hydrochloride on sedation, analgesia and negative emotions after cesarean section in women. 【Methods】 A total of 128 patients of full-term pregnant women who received cesarean section in our hospital were selected and randomly divided into two groups. There were 64 cases in the observation group who received intravenous injection of nabocone hydrochloride, while 64 cases in the control group received intravenous sufentanil analgesia. The sedative and analgesic effects of the two groups were observed and compared. The degree of postpartum depression of the two groups were measured and compared as well, while the total incidence of adverse reactions was calculated. 【Results】 The analgesic scores of 6h, 12h and 24h in the observation group were significantly lower than those in the control group; and the sedation score in the observation group was also lower than that in the control group. The difference between the two groups was significant (P<0.05). There was no significant difference in the antenatal depression score between the two groups (P>0.05). The postpartum depression score of the observation group 3 days after delivery in the observation group was significantly lower than that in the control group (P<0.05). The total postpartum depression rate in the observation group was7.81% which was significantly lower than that of the control group (23.44%, P<0.05). The incidence of adverse reactions in the observation group was 11.76% (8/64), which was significantly lower than that in the control group (59.38%, 38/64). The difference between the two groups was statistically significant (P<0.05). 【Conclusion】 Nabocone hydrochloride injection has a good effect on postoperative analgesia and sedation in cesarean parturients, the possibility of postpartum depression and the incidence of adverse reactions are low. It is suitable for clinical popularization. 2020 Vol. 37 (4): 536-538 [Abstract] ( 87 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 539 Effect of Bone Mineral Density on Bone Pain in Elderly Patients with Spinal Fracture and Analysis of Risk Factors LI Hao, LI Xiao-miao, SHEN Yi, et al DOI: 10.3969/j.issn.1671-7171.2020.04.018 【Objective】 To investigate the effect of bone mineral density (BMD) on the bone pain and operative prognosis in elderly patients with spinal fracture. 【Methods】 From July to December 2017, 118 elderly patients (> 60 years old) with spine fracture who were operated in our orthopedic department were collected. The BMD was measured by dual energy X-ray. According to the BMD level, they were divided into low level BMD group (t value < 1.0) and high level BMD group (t value ≥ 1.0). The degree of pain was assessed by VAS in both groups, and the prognosis of the patients was evaluated by postoperative related indexes.【Results】 The VAS score of the low-level BMD group was significantly higher than that of the high-level BMD group (P<0.05) at 12 h and 24 h after operation, but there was no significant difference between the two groups at 48 h after operation (P>0.05); there were significant differences between the two groups in the days from operation to discharge, the total days in hospital, the complicated infection and the proportion of hypokalemia (P<0.05); 12 h after operation There was a significant negative correlation between vas and BMD (P<0.05). There was no significant correlation between vas and BMD at 24 and 48 hours after operation (P>0.05). The decrease of BMD was the risk factor for the increase of the degree of bone pain (P<0.05); in addition, the postoperative infection, the number of fracture segments and the degree of vertebral compression were also the risk factors for the increase of the degree of bone pain (P<0.05).【Conclusion】 Low BMD level may be a risk factor for the level of bone pain in the elderly patients with spinal fracture. At the same time, low BMD level may also affect the prognosis of the patients. 2020 Vol. 37 (4): 539-541 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 542 Correlation between the Changes of Serum ,Urine conglomeration protein, Serum Inflammatory Factors and the Pathogenesis of Renal Calculi WU Yong-qiang, LIU Xiao-tong, LUO Fei DOI: 10.3969/j.issn.1671-7171.2020.04.019 【Objective】 To explore the correlation between the levels of serum and urine conglomeration protein and serum inflammatory factors and the pathogenesis of renal calculi.【Methods】 From January 2017 to may 2018, 105 patients (observation group) with renal calculi were selected, including 57 patients with initial onset and 48 patients with recurrence. Meanwhile, 100 healthy volunteers were selected as the control group. The levels of conglomeration protein, serum interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-2 (IL-2) in serum and urine were compared between the two groups, and the correlation between the levels and the pathogenesis of kidney stones was analyzed.【Results】 The serum and urine cluster protein in the observation group was lower than that in the control group, and the serum IL-1b、IL-6 was higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in serum IL-2 levels between the two groups (P>0.05). The urine tufted protein in recurrent patients was significantly lower than that in primary patients, the difference was statistically significant (P<0.05), and the serum tufted protein and IL-1b、IL-6、IL-2 levels in recurrent patients and primary patients were not statistically significant (P>0.05). Pearson correlation analysis showed that serum cluster proteins were negatively correlated with serum IL-1b、IL-6(r=-0.422,-0.412,P<0.05), and urine cluster proteins were negatively correlated with serum IL-1b、IL-6(r=-0.302,-0.311,P<0.05, respectively).【Conclusion】 The serum and urine conglomeration protein in patients with renal calculi decreased significantly, which was related to the serum inflammatory factors IL-1 and IL-6. Meanwhile, the urine conglomeration protein may be related to the recurrence of calculi. 2020 Vol. 37 (4): 542-544 [Abstract] ( 86 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 545 Changes of Omentin-1 and MPO Levels in Patients with Coronary Heart Disease LV Xiao-yan, MA Hong-en, WANG Xin, et al DOI: 10.3969/j.issn.1671-7171.2020.04.020 【Objective】 To investigate the changes of plasma retinin-1(Omentin-1), serum myeloperoxidase (MPO) levels and their relationship with the severity of patients with coronary heart disease (CHD). 【Methods】 A total of 120 CHD patients (observation group) and 60 healthy volunteers were selected as control group. The levels of plasma omentin-1 and serum MPO were measured and compared between the two groups. The CHD group was stratified according to different disease types and the number of coronary lesions. 【Results】 The serum MPO level of the observation group was significantly higher than that of the control group, and the plasma omentin-1 level was significantly lower than that of the control group (P<0.05). The levels of MPO and omentin-1 in patients with acute myocardial infarction (AMI), stable angina pectoris (SAP) and unstable angina pectoris (UAP) were significantly lower than those in the control group (P<0.05). The level of serum MPO in patients with single, double and three vessel lesions increased gradually, and the difference between the groups was statistically significant (P<0.05); the level of plasma omentin-1 in patients with single, double and three vessel lesions decreased gradually, and the difference between the groups was statistically significant (P<0.05).【Conclusion】 The plasma Omentin-1 level of patients with coronary heart disease is significantly lower than that of healthy people, and the serum MPO level is significantly higher than that of healthy people. It is related to the number of coronary lesions and the severity of the disease. 2020 Vol. 37 (4): 545-547 [Abstract] ( 81 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 548 TPCE Ccombined with CT Guided Percutaneous Microwave Ablation for Advanced Non-small Cell Lung Cancer RAN Li, ZHANG Rong-hua, QIN HE-ping DOI: 10.3969/j.issn.1671-7171.2020.04.021 【Objective】 To investigate the clinical effect and survival rate of TPCE combined with CT guided percutaneous microwave ablation in the treatment of advanced non-small cell lung cancer (NSCLC).【Methods】 The clinical data of 116 patients with advanced lung cancer in our hospital were analyzed retrospectively. According to different treatment methods, they were divided into observation group and control group, 58 cases in each group. TPCE was given to the patients in the control group, and tpce combined with percutaneous microwave ablation (PMAT) was used in the observation group. Three months after treatment, contrast-enhanced CT was performed to compare the therapeutic effect of the two groups. Serum CEA, CA125 and VEGF levels were compared before and after treatment. The survival rates of 1,2,3 years were recorded.【Results】 The disease control rate of the observation group was 84.5% (49 / 58), higher than that of the control group (67.2%) (39 / 58), the difference was statistically significant (χ2=4.708,P<0.05). Three months after treatment, the serum CEA, CA125 and VEGF levels of the two groups decreased, and the difference was statistically significant (P<0.05). The 1,2,3-year survival rate in the observation group was significantly higher than that in the control group (P<0.05).【Conclusion】 TPCET combined with PMAT sequential treatment can significantly improve the therapeutic effect of NSCLC and improve the survival rate of patients. 2020 Vol. 37 (4): 548-550 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 551 Effect of TACE Combined with Apatinib or Solafinib on Alpha-fetoprotein in Patients with Hepatocellular Carcinoma CHEN Xiu-feng DOI: 10.3969/j.issn.1671-7171.2020.04.022 【Objective】 To investigate the effect of transcatheter arterial chemoembolization (TACE) combined with apatinib or Solafinib on alpha-fetoprotein (AFP) in patients with Hepatocellular Carcinoma (HCC). 【Methods】 A total of 60 patients with HCC admitted to our hospital from July 2015 to April 2019 were randomly divided into two groups. The solafinib group (n=30) was treated with TACE combined with solafinib, while the apatinib group was treated with TACE combined with apatinib. The clinical efficacy of the two groups was analyzed. 【Results】 There was no significant difference in objective remission rate between the apatinib group (56.67%) and the solafinil group (53.33%) (P>0.05).The levels of AFP, heat shock protein 90 α (Hsp90 α) and vascular endothelial growth factor (VEGF) between the two groups before treatment were not significantly different (P>0.05). After treatment, the levels of AFP,Hsp90 α and VEGF in the two groups were lower than those before treatment (P<0.05). However, there was no significant difference in the levels of AFP, Hsp90 α and VEGF between the apatinib group and the solafinil group after treatment (P>0.05). No patients had grade Ⅳ adverse reactions in both groups. The incidence of skin and mucous membrane reaction (73.33%) and hypertension (56.67%) in the apatinib group were higher than those in the solafinil group. The incidence of bone marrow suppression (46.67%) and gastrointestinal reaction (53.33%) of the apatinib group were not significantly different from those of the solafinil group (P>0.05). 【Conclusion】 After TACE, the efficacy of apatinib or solafinib in the treatment of HCC is similar showing that the expression of AFP,Hsp90α and VEGF was decreased, however, the safety of solafinib was relatively higher than that of apatinib. 2020 Vol. 37 (4): 551-553 [Abstract] ( 71 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 554 Serum Levels and Significance of NSE, IL-26 and T lymphocyte Subsets in Patients with Acute Herpes Zoster ZHAO Yan-xia, WANG Shang-shang, WANG Lin, et al DOI: 10.3969/j.issn.1671-7171.2020.04.023 【Objective】 To investigate the levels and significance of serum neuron specific enolase (NSE), interleukin-26 (IL-26) and T lymphocyte subsets in patients with acute herpes zoster. 【Methods】 Seventy-five patients with acute herpes zoster treated in our hospital from February 2016 to February 2019 were selected as the observation group, and 80 healthy volunteers were selected as the control group. Serum NSE, IL-26 and T lymphocyte subsets were measured in the two groups. 【Results】 The levels of serum NSE and IL-26 in the observation group were (13.10±2.71) g/L and (14.40±2.11) pg/mL, respectively, which were significantly higher than those in the control group (P<0.05), while the levels of CD3+, CD4+, and CD8+ were (56.69±10.01)%, (29.82±7.13)% and (25.52±6.82)%, respectively, which were significantly lower than those in the control group (P<0.05). Serum NSE and IL-26 in patients with moderate and severe pain were (14.91±2.00) g/L and (16.72 ±2.43) pg/mL, which were significantly higher than those in patients with mild pain (P<0.05). There were no significant differences in serum levels of CD3+, CD4+ and CD8+ among patients with mild, moderate and severe pain (P>0.05). Serum NSE and IL-26 were positively correlated with VAS score (r=0.401 and 0.332, respectively, P<0.05), while serum levels of CD3+, CD4+ and CD8+ were not correlated with VAS score (P>0.05). 【Conclusion】 The levels of serum NSE and IL-26 are increased and T lymphocyte subsets are disordered in patients with herpes zoster in acute stage, among which NSE and IL-26 are related to the degree of pain. 2020 Vol. 37 (4): 554-556 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 557 Effect of Follow-up Self-management Guidance on Self-care Ability and Life Quality in Postoperative Meningioma Patients HUANG Wen-fang DOI: 10.3969/j.issn.1671-7171.2020.04.024 【Objective】 To explore the effect of follow-up self-management guidance on self-care ability and life quality in postoperative meningioma patients.【Methods】 One hundred and two patients with meningioma surgery from August 2016 to August 1818 were enrolled. The subjects were divided into treatment group and control group by using random number table method,51 cases in each group. The control group received routine nursing intervention for meningioma including health education, psychological counseling, rehabilitation exercise, and prevention of complications. The treatment group was combined with self-management guidance mode based on follow-up. Three months follow-up was performed to compare the self-protection ability, complications, quality of life and other indicators of the two groups.【Results】 In the treatment group, the self-protection ability index, active and passive physical function training, daily activity self-care and complete self-care were significantly higher than those of the control group (94.12% vs 70.59%, 98.04% vs 78.43%, 100.00% vs 70.59%, 92.17% vs 72.55%) (χ2=8.163, 7.650, 15.320, 5.464,P<0.05, P<0.01); physical function, role function, emotional function and social function score were significantly higher than those of the control group (t=5.932, 4.125, 5.770, 4.972, P<0.05); the incidence of complications such as pulmonary infection was 3.92%,which was significantly lower than that of the control group 45.10% (χ2=40.267,P<0.01).【Conclusion】 The self-management guidance model based on follow-up can help to promote the self-care ability of postoperative meningioma patients, reduce the incidence of postoperative complications and improve the quality of life of patients. 2020 Vol. 37 (4): 557-559 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 560 Effect and Clinical Significance of Procalcitonin Level on Delirium of ICU Patients TANG Hong-mei, LU Wei DOI: 10.3969/j.issn.1671-7171.2020.04.025 【Objective】 To evaluate the value and clinical significance of procalcitonin level on delirium in ICU patients. 【Methods】 A total of 90 inpatients admitted to ICU of our hospital from January 30, 2016 to December 30, 2018 were enrolled. According to the ICU Consciousness Assessment Measurement Scale (CAM-ICU), patients were divided into the CAM-ICU positive group (patients with delirium) and the CAM-ICU negative group (patients without delirium) . Procalcitonin levels in peripheral blood were tested. The serum markers and clinical data were evaluated to the correlation with delirium; and multivariate analysis was used to assess the influencing factors of delirium. The receiver operating characteristic curve (ROC) was applied to analyze the predictive effect of procalcitonin levels on the occurrence of delirium in ICU patients. 【Results】 Of the 90 patients, 40 (44.4%) cases had delirium. There were 23 cases of procalcitonin level <0.5 μg/L, 41 cases of procalcitonin level at 0.5~2 μg/L, and 26 cases of procalcitonin level >2 μg/L. Patients with delirium and those without delirium had significant differences in the proportion of diabetes mellitus, serum procalcitonin, C-reactive protein and lactic acid (P<0.05). Multivariate analysis showed that procalcitonin level (95% CI:1.298-5.591), C-reactive protein (95% CI: 1.093-4.789), and lactate levels (95% CI:1.154-5.247) were independent influence factors of delirium (P< 0.05). The optimal threshold for procalcitonin levels to predict delirium in hospitalized ICU patients was 52.1. When the procalcitonin level was 52.1, the sensitivity of the procalcitonin level to predict delirium was 72.2%, the specificity was 82.4%. The area under the AUC curve was 0.82. 【Conclusion】 Inpatients with ICU who have elevated procalcitonin levels are more prone to delirium, and serum procalcitonin levels are effective biological indicators for predicting delirium in hospitalized ICU patients. 2020 Vol. 37 (4): 560-562 [Abstract] ( 75 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 563 Expression and Clinical Significance of EBV-DNA, T-cadherin and PCNA in Serum of Patients with Nasopharyngeal Carcinoma LIN Xiao-mei, NING Chun-yu, PAN Qi-jin, et al DOI: 10.3969/j.issn.1671-7171.2020.04.06 【Objective】 To investigate the expression and clinical significance of EB virus (EBV)-DNA, T-cadherin (T-cadherin) and proliferating nuclear antigen (PCNA) in the serum of patients with NPC. 【Methods】 From January 2013 to December 2015, 150 patients with advanced (Ⅲ-ⅣA) NPC were selected as NPC group, and 50 patients with chronic rhinitis (rhinitis group) and 50 healthy volunteers (control group) were selected as NPC group. The levels of EBV-DNA, T-cadherin mRNA and PCNA mRNA before and after treatment were detected by real-time fluorescent quantitative PCR, and the recurrence and metastasis were recorded after 2 years of follow-up, and the relationship between them and the above detection indexes was analyzed.【Results】 There were statistically significant differences in EBV-DNA positive rate, T-cadherin mRNA and PCNA mRNA between the three groups of the nasopharyngeal carcinoma group, the rhinitis group and the control group (P<0.05); compared with the treatment before treatment, the PCNA mRNA level of the nasopharyngeal carcinoma group was significantly decreased (P<0.05) and the T-cadherin mRNA was significantly increased (P<0.05). 124 cases of treatment sensitivity (TS) and 26 cases of TR were found in 150 patients with nasopharyngeal carcinoma; before treatment, EBV-DNA positive rate and PCNA mRNA in TR patients were higher than those in TS patients, while T-cadherin mRNA was lower than that in TS patients, the difference was statistically significant (P<0.05). Of 150 patients with nasopharyngeal carcinoma after radiotherapy , 35 of them had recurrence and metastasis, and the rate of recurrence and metastasis was 23.33% of which 3 had recurrence and 32 had distant metastasis.The positive rate of EBV-DNA in patients with metastasis was significantly higher than that in patients without recurrence and metastasis (P<0.05), T-cadherin mRNA in patients without recurrence and metastasis was higher than that in patients with recurrence and metastasis (P<0.05), PCNA mRNA in patients without recurrence and metastasis was lower than that in patients with recurrence and metastasis (P<0.05).【Conclusion】 The differential expression of EBV-DNA、T-cadherin and PCNA in the recurrence and metastasis of patients with advanced nasopharyngeal carcinoma before and after radiotherapy is expected to be an effective index for the evaluation of curative effect and prognosis. 2020 Vol. 37 (4): 563-566 [Abstract] ( 68 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 567 Analysis of the Relationship between the Level of Homocysteine in Plasma and the Degree of Dementia LIANG Le, OU Nian-fei, JIANG Hong-bo, et al DOI: 10.3969/j.issn.1671-7171.2020.04.027 【Objective】 To explore the relationship between the level of plasma homocysteine (Hcy) and the degree of senile dementia.【Methods】 From December 2015 to December 2018, 209 elderly patients with cerebrovascular diseases who were treated in the Department of Neurology of our hospital were selected as the observation group, including 94 dementia patients, 115 non dementia patients as the control group, 94 patients in the observation group were divided into vascular dementia (VD) 30 cases, mixed dementia (MD) 32 cases, Alzheimer's disease (AD) 32 cases according to the Hachinski ischemic index scale; the degree of dementia patients was divided according to the MMSE scale, 18 cases were severe, 36 cases were moderate, 40 cases were mild; the clinical data of the comparison group and the control group showed that there were differences in the causes The differences of Hcy in serum between the patients of different dementia types and degrees in the observation group and the control group were compared.【Results】 The age, the proportion of Hcy level increase and the proportion of patients with previous stroke history in the observation group were significantly higher than those in the control group (P<0.05); there was no significant difference between the two groups in terms of gender, the proportion of patients with diabetes mellitus and hypertension (P>0.05); the serum Hcy content was higher than 15 Mol/L, previous stroke history and old age were independent risk factors for dementia in elderly patients with cerebrovascular disease (P<0.05); the serum Hcy content in the control group, MD group, ad group and VD group increased in turn; the serum Hcy content in the control group, mild, moderate and severe groups also increased in turn, with statistical significance (P<0.05).【Conclusion】 Plasma Hcy level is one of the high risk factors of dementia, and is closely related to the severity of dementia. 2020 Vol. 37 (4): 567-569 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 570 Changes and Significance of Serum PAC-1, CD40L and CD62p Levels in Patients with Unstable Angina WANG Li-he, WANG Ji-peng, SHEN Xiao-juan, et al DOI: 10.3969/j.issn.1671-7171.2020.04.028 【Objective】 To investigate the changes and significance of platelet activating complex 1 (PAC-1), leukocyte differentiation antigen 40 Ligand (CD40L) and platelet membrane glycoprotein CD62P in patients with unstable angina pectoris (UAP).【Methods】 The clinical data (observation group) of 90 UAP patients admitted to our hospital from January 2017 to January 2018 were selected, and 100 healthy volunteers were selected as the control group to detect the levels of PAC-1, CD40L and CD62p in the peripheral blood of the two groups, and to analyze the correlation between the levels of PAC-1, CD40L and CD62p in the serum of UAP patients and the severity grading of UAP (Braunwald grading).【Results】 The levels of PAC-1, CD40L and CD62p in the observation group were significantly higher than those in the control group (P<0.05). The levels of PAC-1, CD40L and CD62p in patients with Braunwald grade Ⅲ were significantly higher than those in patients with grade Ⅰ and grade Ⅱ (P<0.05);The serum levels of PAC-1, CD40L and CD62p in Braunwald grade Ⅱ patients were significantly higher than those in grade Ⅰ patients (P<0.05). The serum levels of PAC-1, CD40L and CD62p were positively correlated with Braunwald grade (mean P<0.05).【Conclusion】 The expression of PAC-1, CD40L and CD62p in serum of UAP patients is increased, which is positively correlated with the severity of the disease. 2020 Vol. 37 (4): 570-572 [Abstract] ( 100 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 573 Effect of Oxycodone Preemptive Analgesia on Nervous System Sensitivity and Inflammatory Response Level in Emergency Surgery Patients with Closed Abdominal Injury DING Lian-ren DOI: 10.3969/j.issn.1671-7171.2020.04.029 【Objective】 To evaluate the effect of preemptive analgesia with oxycodone on neurological sensitivity and inflammatory response in patients with closed abdominal injury. 【Methods】 A total of 136 patients with abdominal closed injury underwent emergency anesthesia for open surgery. The patients were randomly divided into the observation group (n=69) and the control group (n=67). The observation group received intravenous injection of oxycodone 0.1 mg/kg at 10 min before anesthesia induction, while the control group received an equal volume of 0.9% sodium chloride solution. Visual analogue scales (VAS scores) and levels of serum tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), serotonin (5-HT) and substance P were compared at the time of awakening (T1) and 2h (T2), 6h (T3), 12h (T4), 24h (T5) after surgery between the two. 【Results】 The VAS scores of the observation group at time points within 12 hours after operation were significantly lower than those of the control group (all P<0.01). The levels of TNF-α, IL-1β and IL-6 increased from T1, then TNF-α and IL-1β reached the maximum at T5, and IL-6 reached the maximum at T3, thereafter they gradually decreased. At the time period of T2-T5, the levels of TNF-α, IL-1β and IL-6 in the two groups were significantly different from levels of T0 in the same group (P<0.05). Compared to the control group, levels of serum inflammatory factors at each time point in the observation group were reduced (P<0.05). Serum substance P and 5-HT levels of the two groups increased gradually from 24 hours after surgery. Compared to the control group, levels of serum P and 5-HT at the time of T1-T5 in the observation group were significantly lower (all P<0.05). 【Conclusion】 Preemptive analgesia with oxycodone inhibits the release of inflammatory factors and reduces the sensitivity of central and peripheral nervous system in patients with emergency surgery of closed abdominal injury. Thus it effectively reduces postoperative pain. 2020 Vol. 37 (4): 573-575 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 576 Expression of ARHI and BECN1 in Breast Cancer Tissues and Its Relationship with Clinicopathological Parameters of Breast Cancer LI Yan-ju, XIE Ling, ZHANG Chun-li, et al DOI: 10.3969/j.issn.1671-7171.2020.04.030 【Objective】 To investigate expression level of aplasia Ras homologue member I (ARHI) and autophagy related gene Beclin1 (BECN1) in breast cancer tissues and its relationship with clinicopathological parameters of breast cancer. 【Methods】 The cancer tissues and adjacent normal tissues of 82 breast cancer patients were collected in our hospital from May 2013 to May. The immunohistochemical method was used to detect the expression levels of ARHI and BECN1 in two groups. The correlation between ARHI and BECN1 expression in breast cancer and its relationship with clinicopathological parameters were analyzed. 【Results】 The positive expression rates of ARHI and BECN1 in breast cancer tissues were significantly lower than those in normal adjacent tissues (P<0.05). ARHI was positively correlated with the expression of BECN1 in breast cancer tissues (P<0.05). The expression of ARHI was not correlated with age, clinical stage, vascular tumor thrombus, menstrual status, tumor size, family history of tumors, and nerve invasion of breast cancer patients (P>0.05), while it was significantly correlated with lymph node metastasis and tissue differentiation in breast cancer patients (P<0.05). BECN1 expression in patients with breast cancer was not significantly correlated with age, tumor size, family history of tumor, menstrual status, and nerve invasion (P>0.05), while was significantly correlated with degree of tissue differentiation, vascular tumor thrombus, clinical stage and lymph node metastasis (P<0.05). 【Conclusion】 ARHI and BECN1 are lowly expressed in breast cancer tissues, and the two indicators are positively correlated; ARHI expression is correlated with tissue differentiation degree and lymph node metastasis of breast cancer patients. BECN1 expression is correlated with clinical stage, tissue differentiation degree, lymph node metastasis, and vascular thrombus of breast cancer patients. 2020 Vol. 37 (4): 576-579 [Abstract] ( 66 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 580 Effect of ultrasonic knife on incision pain and oxidative stress in patients undergoing thoracoscopic resection of esophageal carcinoma ZHANG Zi-chao, LIU Qing, PAN Mao-jie DOI: 10.3969/j.issn.1671-7171.2020.04.031 【Objective】 To investigate the effect of ultrasonic knife on incision pain and oxidative stress in patients with esophageal carcinoma undergoing thoracoscopic resection. 【Methods】 A total of 127 patients with esophageal cancer admitted to our hospital were selected.65 patients in ultrasonic knife group were treated with ultrasonic knife during thoracoscopic operation, 62 patients in control group were treated with electric knife. The intraoperative conditions and the incidence of complications were compared between the two groups, and the levels of serum pain medium and oxidative stress at different time before and after operation were compared. 【Results】 The operation time, intraoperative bleeding and postoperative thoracic drainage in the ultrasonic knife group were significantly lower than those in the control group, and the number of dissected lymph nodes was significantly higher than that in the control group (P<0.05).The serum levels of 5-HT、K+ and NE in the ultrasonic knife group were significantly lower than those in the control group (P<0. 05).There was no significant difference in the levels of oxidative stress between the two groups at T0 (P>0. 05). The level of SOD,GSH-Px in both groups was lower than that at T0, and it was higher than that at T0.The level of SOD,GSH-Px in ultrasonic knife group was significantly lower than that in control group.The level of MDA was significantly lower than that of control group (P<0. 05).The incidence of complications in the ultrasonic knife group was significantly lower than that in the control group(χ2=9.75,P=0.00). 【Conclusion】 the thoracoscopic resection of esophageal cancer with ultrasonic knife has the advantages of reducing postoperative pain and reducing the level of oxidative stress products. At the same time, it can optimize the operation process and reduce the incidence of postoperative complications. 2020 Vol. 37 (4): 580-582 [Abstract] ( 65 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )

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