不稳定心绞痛患者血清PAC-1、CD40L、CD62p水平的变化及其意义

doi:10.3969/j.issn.1671-7171.2020.04.028

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Abstract 【Objective】 To investigate the changes and significance of platelet activating complex 1 (PAC-1), leukocyte differentiation antigen 40 Ligand (CD40L) and platelet membrane glycoprotein CD62P in patients with unstable angina pectoris (UAP).【Methods】 The clinical data (observation group) of 90 UAP patients admitted to our hospital from January 2017 to January 2018 were selected, and 100 healthy volunteers were selected as the control group to detect the levels of PAC-1, CD40L and CD62p in the peripheral blood of the two groups, and to analyze the correlation between the levels of PAC-1, CD40L and CD62p in the serum of UAP patients and the severity grading of UAP (Braunwald grading).【Results】 The levels of PAC-1, CD40L and CD62p in the observation group were significantly higher than those in the control group (P<0.05). The levels of PAC-1, CD40L and CD62p in patients with Braunwald grade Ⅲ were significantly higher than those in patients with grade Ⅰ and grade Ⅱ (P<0.05);The serum levels of PAC-1, CD40L and CD62p in Braunwald grade Ⅱ patients were significantly higher than those in grade Ⅰ patients (P<0.05). The serum levels of PAC-1, CD40L and CD62p were positively correlated with Braunwald grade (mean P<0.05).【Conclusion】 The expression of PAC-1, CD40L and CD62p in serum of UAP patients is increased, which is positively correlated with the severity of the disease.

Key words： Angina,Unstable Antigens,CD

Received: 18 September 2018

PACS:

R541.42

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2020.04.028 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2020/V37/I4/570

[1] 黎艺毅,王正东,陈坚,等.尼可地尔对不稳定型心绞痛患者PCI术后心肌损伤的影响[J].医学临床研究,2015,32(11):2179-2180.
[2] Gurses KM,ZKocyigit D, Yalcin MU, et al. Enhanced platelet toll-like receptor 2 and 4 expression in acute coronary syndrome and stable angina pectoris[J].Am J Cardiol,2015,116(11):1666-1671.
[3] 柳晓娜,朱宁,魏国峰,等. 糖尿病合并急性冠状动脉综合征患者血小板表面PAC-1和CD62P表达水平[J].中国动脉硬化杂志,2015,23(2):161-164.
[4] 李向欣,王艳飞,解俊敏,等. 急性ST段抬高型心肌梗死PCI术后血小板CD40L及血小板指标临床相关性分析[J].中国心血管病研究,2015,13(2):152-155.
[5] 张波涛,张学虎,马列,等. 不同剂量氯吡格雷对冠状动脉粥样硬化性心脏病患者血清CD62p水平的影响[J].中国综合临床,2015,30(4):363-366.
[6] 缐海英,啜玉娟,沈彬,等.强化阿托伐他汀对不稳定型心绞痛患者PCI围术期不同亚群单核细胞及单核细胞‐血小板聚集体及预后的影响[J].医学临床研究,2018,35(2):274-276.
[7] Ornek E, Kurtul A. Relationship of mean platelet volume to lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris[J].Coronary Artery Dis,2017,28(6):492-497.
[8] 马丽,李杰,穆叶塞,等. 急诊介入治疗前后AMI患者P选择素和血小板膜糖蛋白GPⅡb/Ⅲa复合物表达研究[J].新疆医科大学学报,2015,38(9):1110-1112.
[9] 倪林,夏向阳,韩卡,等. 急性ST段抬高型心肌梗死PCI术后血小板CD40L与血小板指标临床相关性分析[J].中国心血管病研究杂志,2016,14(7):588-591.
[10] 侯敏,于靖,张连祥,等. 冠心病支架植入术前后CD62P和血小板活化糖蛋白GPⅡb/Ⅲa纤维蛋白原受体的变化及意义[J].中华医学杂志,2014,94(10):766-768.
[11] 韩世华. 急性冠状动脉综合征患者CD40L、TNF-α、IL-6及hs-CRP水平与室性心律失常相关性研究[J].中国现代医药杂志,2016,18(5):57-59.
[12] 耿俊梅,万昌武,乐翠云,等. 人冠状动脉粥样硬化病灶内CD40L水平与病灶结构变化的关系[J].中国动脉硬化杂志,2017,25(4):355-359.
[13] 高翔,郑晓静,伦佳,等. 血浆sCD(40)L与急性冠状动脉综合征相关性的研究[J].中国医药指南,2016,14(34):15-16.