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| Effect of Oxycodone Preemptive Analgesia on Nervous System Sensitivity and Inflammatory Response Level in Emergency Surgery Patients with Closed Abdominal Injury |
| DING Lian-ren |
| Pain Department, People's Hospital of Huimin County, Shandong Binzhou 251700 |
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Abstract 【Objective】 To evaluate the effect of preemptive analgesia with oxycodone on neurological sensitivity and inflammatory response in patients with closed abdominal injury. 【Methods】 A total of 136 patients with abdominal closed injury underwent emergency anesthesia for open surgery. The patients were randomly divided into the observation group (n=69) and the control group (n=67). The observation group received intravenous injection of oxycodone 0.1 mg/kg at 10 min before anesthesia induction, while the control group received an equal volume of 0.9% sodium chloride solution. Visual analogue scales (VAS scores) and levels of serum tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), serotonin (5-HT) and substance P were compared at the time of awakening (T1) and 2h (T2), 6h (T3), 12h (T4), 24h (T5) after surgery between the two. 【Results】 The VAS scores of the observation group at time points within 12 hours after operation were significantly lower than those of the control group (all P<0.01). The levels of TNF-α, IL-1β and IL-6 increased from T1, then TNF-α and IL-1β reached the maximum at T5, and IL-6 reached the maximum at T3, thereafter they gradually decreased. At the time period of T2-T5, the levels of TNF-α, IL-1β and IL-6 in the two groups were significantly different from levels of T0 in the same group (P<0.05). Compared to the control group, levels of serum inflammatory factors at each time point in the observation group were reduced (P<0.05). Serum substance P and 5-HT levels of the two groups increased gradually from 24 hours after surgery. Compared to the control group, levels of serum P and 5-HT at the time of T1-T5 in the observation group were significantly lower (all P<0.05). 【Conclusion】 Preemptive analgesia with oxycodone inhibits the release of inflammatory factors and reduces the sensitivity of central and peripheral nervous system in patients with emergency surgery of closed abdominal injury. Thus it effectively reduces postoperative pain.
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Received: 19 August 2018
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2020, Vol. 37 
