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Quick Search     Adv Search 2018 Vol. 35, No. 2 Published: 2018-02-28 Article          Article 209 Effect of Early Rehabilitation Training Combined with Closed Reduction and Percutaneous Hollow Nail Fixation on Salter-Harris Ⅲ Epiphyseal Fracture of Medial Malleolus in Children ZHANG Li, ZHAO Ming-jia, HUANG Nan-xiang, et al DOI: 10.3969/j.issn.1671-7171.2018.02.001 【Objective】To investigate the effect of early rehabilitation training combined with closed reduction and percutaneous hollow nail fixation on Salter-Harris Ⅲ epiphyseal fracture of medial malleolus in children.【Methods】From January 2014 to January 2016, 36 children with Salter-Harris type Ⅲ epiphyseal fracture of medial malleolus were randomly divided into two groups: study group (n=18) and control group (n=18). The control group was treated with closed reduction and internal fixation with percutaneous hollow nail and functional exercise began after the fracture line was blurred. The study group received early rehabilitation training after operation and the ASOFAS rehabilitation scores, the rate of satisfaction and the occurrence of complications of the two groups were compared.【Results】The excellent and good rates of the observation group were 66.67% and 83.33% at 4 months, 8 months and 12 months, respectively, which were significantly higher than that of the control group (55.56%). The difference was statistically significant (P<0.05). The satisfaction rate of the observation group was 88.89%, which was significantly higher than that of the control group (66.67%). The difference was statistically significant (P<0.05). In the control group, there were 2 cases of incision infection, 1 case of malleolus varus malformation and 1 case of delayed fracture healing. In the study group, the fracture of internal fixation occurred in 1 case (P<0.05).【Conclusion】Early rehabilitation training combined with closed reduction and internal fixation with percutaneous hollow nail for the treatment of Salter-Harris Ⅲ epiphyseal fractures of the medial malleolus in children is helpful to improve the rehabilitation effect of children and accelerate the recovery of joint function in children. Effective reduction of complications, children are more satisfied with the treatment. 2018 Vol. 35 (2): 209-211,215 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 212 Applied Anatomy of Lumbar Intervertebral Nucleus Pulposus Resection in the Treatment of Lumbar Disc Herniation XIAO Sheng, WEN Jie DOI: 10.3969/j.issn.1671-7171.2018.02.002 【Objective】To study the applied anatomy of lumbar intervertebral disc nucleus pulposus in the treatment of lumbar disc herniation.【Methods】Ten adult cadaver specimens of lumbar spine were selected to measure the length, width and height of the lumbar intervertebral foramen. In addition, 46 patients with transplanted nucleus pulposus resections under their lumbar discs who were in our hospital were selected to evaluate the curative effect.【Results】From L1to L5, the intervertebral foramen width gradually decreased (P<0.05), the height gradually increased (P<0.05), and the distance from the lower edge of nerve root to the lower edge of intervertebral foramen gradually increased (P<0.05). The same intervertebral foramen width, height, length, and the distance from the inferior edge of nerve root to the lower edge of intervertebral foramina had no statistical significance (P>0.05). There was no significant difference between the medial and lateral sagittal plane of the pedicle, upper and lower articular process to the sagittal plane, and distance from the isthmus of the vertebral arch to the sagittal plane on the left and right sides (P>0.05). The postoperative clinical efficacy rate was 93.5% (43/46) in the 46 patients. The JOA score and the height of the intervertebral space were significantly higher than those before operation (P<0.05).【Conclusion】The intervertebral foramen has its unique anatomical structure. Cervical intervertebral foramen endoscopic discectomy has good clinical curative effect, simple operation procedure, and less surgical trauma. It is a better surgical method for the treatment of lumbar disc herniation. 2018 Vol. 35 (2): 212-215 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 216 Study on the Difference of Serum Concentration and Cognitive Function Abnormalities before and after Treatment of Schizophrenia DONG Wei, GU Wei-xia, TANG Xiao-wei, et al DOI: 10.3969/j.issn.1671-7171.2018.02.003 【Objective】To analyze the changes of serum BDNF concentration and cognitive function before and after treatment of schizophrenia and its correlation.【Methods】From December 2014 to December 2016, 60 patients with schizophrenia treated in our hospital were selected as the research object, and their basic information such as their names, ages, sex, age of onset and frequency of seizures were recorded and collected The plasma of patients before and after treatment was studied. The expression of BDNF was detected by enzyme-linked immunosorbent assay (ELISA) after centrifugation. At the same time, the cognitive function of patients before and after treatment was evaluated and analyzed.【Results】Serum BDNF levels of schizophrenia patients were significantly higher than those before treatment (t=4.298, P<0.05). The WCST index of schizophrenic patients was improved after treatment (P<0.05). The evaluation of personal and social life function scale (PSP) showed that the damage was alleviated (P<0.05) compared with that before treatment. There was a positive correlation between WCST index and BDNF concentration, but no correlation was found among other indexes.【Conclusion】The serum BDNF levels of patients with schizophrenia are significantly increased after treatment, which is positively correlated with cognitive function. The treatment can improve BDNF serum concentration and improve the cognitive dysfunction of schizophrenia. 2018 Vol. 35 (2): 216-218 [Abstract] ( 58 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 219 Biofeedback in the Treatment of Postpartum Stress Urinary Incontinence LI Pei-ying, YIN Wan-ping, CHEN Yan-fang, et al DOI: 10.3969/j.issn.1671-7171.2018.02.004 【Objective】To investigate the clinical efficacy of biofeedback treatment on patients with postpartum stress urinary incontinence, and to analyze the significance of the changes of electrical signals on the surface of pelvic floor muscles.【Methods】A retrospective analysis of 200 patients with postpartum stress urinary incontinence in our hospital from January 2016 to January 2017 was performed. According to the different treatment methods, patients were divided into an observation group and control group, with 100 cases in each. Patients in the observation group were treated with pelvic floor rehabilitation biofeedback therapy while patients in the control group received conventional pelvic floor muscle training. Pelvic floor surface electrical signal changes were measured and analyzed in the two groups.【Results】The efficacy rate in the observation group was 93.0%, which was significantly higher than that in the control group 82%; the difference was significant (P<0.05). The average values of type Ⅰ fiber and type Ⅱ myofiber potential in the observation group after treatment were higher than those in the control group (P<0.05). After treatment, the total urinary volume in the observation group was 4698.2 ± 297.5 mL, the total number of urination was 31.8 ± 6.7 times, and the total number of urinary leakage was 11.8 ± 2.7 times, which were all better than those in the control group. The differences were statistically significant (P<0.05). The Cullen index before treatment in the observation group had no significant difference compared with the control group (P>0.05). After treatment, the Cullen index degree 0 in the observation group was significantly higher than that in the control group, and the Cullen index degree Ⅳ was significantly lower than that in the control group. The difference between the two groups was statistically significant (P<0.05).【Conclusion】Patients with postpartum stress urinary incontinence can improve significantly after using biofeedback treatment; the curative effect is superior to the conventional pelvic floor muscle training. This treatment can effectively restore pelvic floor tissue injury caused by childbirth. 2018 Vol. 35 (2): 219-221,225 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 222 Effects of Metformin Combined with Liraglutide on Islet α and β Cells, Cytokines and Cellular Immune Function in Patients with T2DM LIU Ling-lin, ZHANG Chen-chen, XIONG Wei DOI: 10.3969/j.issn.1671-7171.2018.02.005 【Objective】To investigate the effects of metformin combined with liraglutide on islet α and β cells, cytokines and cellular immune function in patients with type 2 diabetes mellitus (T2DM).【Methods】From April 2016 to April 2017, 102 patients with T2DM were selected. According to the random table method, the patients were divided into observation group and control group with 51 cases in each group. The observation group was treated with metformin and liraglutide, the control group was treated only by metformin. The course of treatment was 12 weeks in both groups. Before and after treatment, the changes of FPG, 2hPG, HbA1c, HOMA-IR, HOMA-β, fasting glucagon (FGlg), IL-6, IGF-1, TNF-α, CD3+and CD4+CD4+/CD8+were compared between the two groups.【Results】After treatment, FPG, 2h PG and HbA1c in both groups were significantly lower than those before treatment (P<0.05). After treatment, HOMA-IR and FGlg decreased and HOMA-β increased in both groups (P<0.05). After treatment, HOMA-IR and FGlg in the observation group were lower than those in the control group, but HOMA-β was higher than that in the control group (P<0.05). After treatment, the level of IL-6, IGF-1, TNF-αdecreased in both groups (P<0.05). The level of IL-6, IGF-1 and TNF-αin the observation group was lower than that of the control group (P<0.05). CD4 and CD4/CD8 of CD8 were increased in both groups after treatment (P<0.05). The levels of CD3+, CD4+and CD4+/CD8+in the observation group were higher than those in the control group (t=10.8227、5.9040、7.1660, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】The curative effect of metformin combined with Lilaru peptide on T2DM patients is significant. It can improve the islets alpha and beta cells, cytokines and cellular immune functions of the patients, and is worthy of clinical application. 2018 Vol. 35 (2): 222-225 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 226 Value of Collateral Circulation in Evaluating the Clinical Curative Effect and Prognosis of Patients with Ischemic Stroke LU Guo DOI: 10.3969/j.issn.1671-7171.2018.02.006 【Objective】To explore the value of collateral circulation in evaluating clinical curative effect and prognosis of patients with ischemic stroke.【Methods】Seventy-five patients with ischemic stroke admitted to our hospital between January 2014 and October 2015 were analyzed retrospectively. According to CT angiography (CTA), collateral compensation was evaluated, and according to this, the subjects were divided into collateral circulation group and non collateral circulation group. The imaging findings, neurological deficit scores (NIHSS) before and after treatment and prognosis in 1-year follow-up were compared between the two groups.【Results】The incidence rates of single lesion and occlusion in collateral circulation group (68.89%, 48.89%) were significantly higher than those in non collateral circulation group (40%, 16.67%) (P<0.05); The NIHSS scores in the collateral circulation group before treatment, 3 months and 1 year after treatment [ (8.17±1.02), (3.20±1.75), (0.88±0.76)] were significantly lower than those in the non collateral circulation group [ (10.35±1.28), (5.07±1.89), (2.76±1.28)] (P<0.05); 1 year after treatment, the excellent and good rate of prognosis in the collateral circulation group (68.89%) was significantly higher than that in the non collateral circulation group (43.33%) (P<0.05).【Conclusion】The establishment of collateral circulation is closely related to the degree of vascular stenosis, which is of certain value in evaluating the clinical curative effect and prognosis. 2018 Vol. 35 (2): 226-228 [Abstract] ( 45 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 229 Relationship among Plasma Hydrogen Sulfide (H2S) Level, Blood Lipid and Body Lipid Distribution in Healthy Young Men with Normal Glucose Tolerance YIN Fu-zai, FAN Dong-mei, WANG Di, et al DOI: 10.3969/j.issn.1671-7171.2018.02.007 【Objective】The purpose of the study was to investigate the relationship among plasma hydrogen sulfide (H2S) level, blood lipid and body lipid distribution in healthy young men with normal glucose tolerance.【Methods】A total of 47 healthy volunteers with normal glucose tolerance were recruited. The following data were all collected from the subjects: height, body mass, weight, waist circumference (WC), blood pressure, visceral fat area (VFA), total body fat (TBF), total body fat content (TFM), muscles content, triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG) and H2S level. According to the median VFA (82.4 cm2), subjects were divided into two groups: the observation group (VFA≥82.4 cm2) and the control group (VFA<82.4 cm2). The above indexes were compared and analyzed between the two groups.【Results】The body mass index (BMI), WC, TBF, TFM, FPG and LDL-C in the observation group were significantly higher than those in the control group (P<0.05), while the level of H2S in the observation group was significantly lower than that in the control group (P<0.05). The other indexes between the two groups did not show significant difference. Pearson correlation analysis showed that H2S level were negatively correlated with BMI、WC、VFA、TBF、TFM and LDL-C (P<0.05). Multivariate linear regression analysis showed that LDL-C and WC were the influencing factors of H2S level (P<0.05).【Conclusion】With the increase of visceral fat, H2S level drops and FPG and LDL-C increase in healthy young men with normal glucose tolerance. It indicates that the dropping of H2S level is closely correlated to the increase of LDL-C and visceral adipose. 2018 Vol. 35 (2): 229-231 [Abstract] ( 38 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 232 Comparison of the Effect of Two Different Surgical Procedures on the Quality of Life of Patients with Mild and Moderate OSAHS LIAO Shi-chuan, ZHU Li, FAN Nai-cong DOI: 10.3969/j.issn.1671-7171.2018.02.008 【Objective】To compare the effect of nasal cavity expansion and nasal cavity structural correction in the treatment of mild to moderate obstructive sleep apnea hypopnea syndrome (OSAHS) and its influence on the quality of life of patients.【Methods】From January 2013 to March 2016, 68 patients with mild to moderate OSAHS in otolaryngology department of our hospital were studied. According to the different operation methods, they were divided into two groups: the nasal cavity dilatation group (n=38) and the nasal cavity orthodontics group (n=30).The apnea Hypopnea index (AHI), the lowest oxygen saturation (LSaO2), the mean oxygen saturation (MSaO2), the awakening Index, the Epworth sleepiness scale (ESS), the snoring (SOS), nasal congestion visual analogue scale (VAS), quality of life (QOL), postoperative complications and satisfaction were compared between the two groups before and after operation.【Results】At 3 months after operation, the AHI and awakening index of the two groups decreased significantly. The scores of LSaO2and MSaO2increased significantly. The scores of ESS, SOS and VAS decreased significantly (P<0.05), and the scores of quality of life (QOL) increased significantly. In the nasal cavity enlargement group, the VAS score and the quality of life score decreased or increased 3 months after operation, and the difference was statistically significant (P<0.05). The incidence of complications in the nasal cavity orthopedic group was 10%, the satisfaction rate was 94.74%, while in the nasal cavity dilatation group it was 0% and 76.67, respectively. The difference between the two groups was statistically significant (P<0.05).【Conclusion】Both nasal cavity enlargement and nasal structure orthodontics were effective in the treatment of mild to moderate OSAHS, but nasal augmentation was more effective in improving symptoms and quality of life, with fewer complications and higher satisfaction, which was worthy of clinical recommendation. 2018 Vol. 35 (2): 232-235 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 236 Effect of Hierarchical Training Based on Energy Level Advanced Mode on the Core Competence of General Nurses LUO Wan-hong, WANG Xiao-juan, JING Xue-ming, et al DOI: 10.3969/j.issn.1671-7171.2018.02.009 【Objective】To explore the effect of hierarchical training based on energy level advanced mode on the core competence of general nurses.【Methods】From January 2014 to December 2015, 53 general nurses in our hospital were selected as the study subjects. All of them were given stratified training based on the energy level advanced mode. The nurses' advanced status, core competence and professional identity were compared before and after training.【Results】One year after the training, 40 nurses (75.47%) were promoted to the next level. The proportion of middle and senior nursing staff was significantly higher than that before training (χ2=5.399, P<0.05).After 6 months of training, the nurses' critical thinking / scientific research ability, clinical nursing, leadership ability, interpersonal relationship were significantly higher than those before training. The total scores of ethics and legal practice, professional development, education and counseling, core competence were significantly higher than those before training (P<0.05), and the total scores of professional identity, career goal, professional attitude, professional values, professional self-concept and total score were significantly higher than those before training (P<0.05).【Conclusion】The hierarchical training based on the energy level advanced mode is helpful to optimize the echelon structure of general nurses, enhance the core competence of nurses and enhance the professional identity. 2018 Vol. 35 (2): 236-238 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 239 Risk Factors of DVT in Deep Vein Thrombosis of Lower Extremity after Spinal Surgery JIN Qiang, YANG Tie-yi, SONG Wei-zhong DOI: 10.3969/j.issn.1671-7171.2018.02.010 【Objective】To investigate the risk factors of DVT in deep vein thrombosis of lower extremity after spinal surgery.【Methods】From August 2014 to August 2016, 246 patients were collected in our hospital for spinal surgery. According to the occurrence of DVT in the lower extremities after operation, the patients were divided into DVT group (n=45) and non-DVT group (n=201). The clinical data, surgical and postoperative factors were compared between the two groups. The influencing factors of DVT after spinal surgery were analyzed by logistics regression analysis.【Results】The incidence of DVT after spinal surgery in this group was 18.29% (45/246). In the comparison of age, body mass index (BMI), diabetes mellitus, preoperative ultrasound results, four items of preoperative coagulation, intraoperative blood loss, intraoperative blood transfusion, operation time, early bed-rest time after operation and physical anticoagulation in the DVT and non-DVT groups, the difference of was statistically significant (P<0.05). Multivariate Logistic regression analysis showed that age, preoperative ultrasound, preoperative coagulation function, intraoperative blood transfusion, early postoperative bed rest and physical anticoagulation were independent risk factors for DVT after spinal surgery.【Conclusion】The elderly, abnormal ultrasound before operation, four items of abnormal preoperative coagulation (more than 2), intraoperative blood transfusion, early postoperative bed time (over 5 d) were independent risk factors of DVT patients after spinal surgery, while early bed activity, physical anticoagulation are protective factors for DVT following spinal surgery. 2018 Vol. 35 (2): 239-241,245 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 242 Evaluation of Short and Long Term Efficacy of Laparoscopic Cylindrical Abdominoperineal Resection for Low Rectal Cancer ZHANG Bin, LI Teng-teng, LIU Hao, et al DOI: 10.3969/j.issn.1671-7171.2018.02.011 【Objective】To investigate the short and long term efficacy of laparoscopic cylindrical abdominoperineal resection for treatment of the low rectal cancer.【Methods】The clinical data of 80 patients with lower rectal cancer treated in the Department of Gastrointestinal Surgery of Affiliated Hospital of Xuzhou Medical University from February 2009 to February 2014 were analyzed retrospectively. Among them, 43 patients treated with laparoscopic cylindrical abdominoperineal resection were recorded as group A, and 37 patients treated with abdominal perineal resection were recorded as group B. The operation times, intraoperative blood loss, and postoperative intestinal exhaust, drainage tube removal and ambulation times were compared and analyzed between the two groups. The complications and the recurrence rate of the tumors after 3 months, 6 months and 1 years of operation and the mortality rates after 6 months, 1 year and 3 years of operation of the two groups were observed.【Results】The operation times of group A and group B had no significantly different (P>0.05), but the postoperative intestinal exhaust, drainage tube removal and ambulation times in the A group were significantly shorter than those in the B group (P<0.05). The intraoperative blood loss of the A group was significantly less than that of the B group (P<0.05). The total complication incidence rate of the A group was 6.98% (3/43), which was significantly lower than that of 32.43% (12/37) of the B group (P<0.05). There were no significant differences in the rates of local tumor recurrence at 3 and 6 months after operation between the two groups (P>0.05), or between the mortality rate after 6 months and 1 year after operation (P>0.05). However, he local tumor recurrence rate after 1 year of operation and mortality rate after 3 years of operation in the A group were significantly lower than those in the B group (P<0.05).【Conclusion】Laparoscopic cylindrical abdominoperineal resection for the treatment of patients with low rectal cancer can obviously reduce surgical injury, reduce complications, reduce tumor recurrence rate and mortality rate. 2018 Vol. 35 (2): 242-245 [Abstract] ( 54 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 246 Effect of Sleep Intervention on Sleep Quality and Fatigue Symptoms of Hospitalized Patients with Stable Chronic Obstructive Pulmonary Disease (COPD) JIANG Juan DOI: 10.3969/j.issn.1671-7171.2018.02.012 【Objective】To investigate the effect of sleep intervention on sleep quality and fatigue symptoms of hospitalized patients with stable chronic obstructive pulmonary disease (COPD).【Methods】A total of 112 cases of patients with stable COPD and hospitalized from April 2015 to March 2016 were selected as the research objects and divided into observation group and control group using random number table method, with 56 cases in each group. Patients in the control group were given symptomatic treatment and routine nursing, on this basis, patients in the observation group were also performed sleep intervention. After the intervention, the sleep quality and fatigue symptoms of these patients were assessed using Pittsburgh sleep quality index (PSQI) and fatigue self-rating scale (FS-14).【Results】The aggregate score of subjective sleep quality, fall-sleep time, sleep time, sleep disorders, use of hypnotic drugs, daytime dysfunction and PSQI in the observation group was significantly lower than those in the control group (P<0.05); the aggregate score of physical fatigue, mental fatigue and FS-14 was significantly lower than in the control group (P<0.05).【Conclusion】Sleep intervention can help to improve sleep quality and relieve fatigue symptoms of patients with stable COPD. 2018 Vol. 35 (2): 246-248 [Abstract] ( 51 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 249 Effect of Ulinastatin on Inflammatory Response and Renal Function in Patients Undergoing Abdominal Surgery SHU Yuan-fu DOI: 10.3969/j.issn.1671-7171.2018.02.013 【Objective】To observe the effect of ulinastatin injection on inflammatory reaction of abdominal surgery in the perioperative period and its effect on renal functions.【Methods】One hundred and eight patients undergoing abdominal surgery were randomly divided into control group (n=90) and observation group (n=90). The control group received intravenous drip of Glucose Injection in the perioperative period, and the observation group was given intravenous drip of Ulinastatin Injection. The changes of inflammatory factors, renal function indexes and postoperative complications were compared between the two groups.【Results】Before operation, there was no significant difference in the two groups in the levels of inflammatory factors such as interferon-β (IFN-β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as renal function, blood urea nitrogen, uric acid and creatinine levels (P>0.05);The levels of inflammatory factors, blood urea nitrogen, uric acid and creatinine in the observation group were significantly lower than those in the control group, and the difference was significant (P<0.05);The postoperative complication rate of the observation group was 4.44% (4/90), which was lower than that of the control group 11.11% (10/90), and the difference between the two groups was significant (P<0.05).【Conclusion】Ulinastatin injection is ideal for patients undergoing abdominal surgery. It can reduce the inflammatory response and improve the renal function of patients. 2018 Vol. 35 (2): 249-251 [Abstract] ( 55 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 251 Relationship between Recurrence and Metastasis and Expression of Thioredoxin -1 after Radical Resection of Distal Gastric Cancer PAN Tao DOI: 10.3969/j.issn.1671-7171.2018.02.014 【Objective】To investigate the relationship between recurrence and metastasis and the expression of thioredoxin-1 (Trx-1) after radical resection of distal gastric cancer.【Methods】A total of 139 patients who underwent radical resection of distal gastric cancer in our hospital were collected in the study. It included 62 cases of recurrence and metastasis (recurrence group) and 77 cases of non recurrence and metastasis (non-recurrence group).. The expression of Trx-1 was detected by immunohistochemical staining, and its relationship with recurrence and metastasis after radical resection of distal gastric cancer was analyzed.【Results】The positive expression rate of Trx-1 in the tissues of recurrence patients (87.10±8.72)% was significantly higher than those in the tissues of non-recurrence patients and normal tissues [ (25.58±10.25)% and (10.25±3.14)%] (P<0.05). There was no significant difference in the positive rate of Trx-1 between normal and non-recurrent patients (P>0.05). Among 62 recurrent cases, the median disease-free survival time of patients with high expression was (13.5±2.84) months, which was shorted than that of patients with low expression with (18.6±3.58) months. Multivariate Cox model showed that high expression of Trx-1, TNM stages, tumor size and lymph node metastasis were the independent factors for the disease-free survival of patients with gastric cancer.【Conclusion】The increased expression of Trx-1 is associated with the shortening of disease-free survival time after radical resection of distal gastric cancer. Trx-1 can be used as a marker for predicting recurrence and metastasis of distal gastric cancer after radical resection. 2018 Vol. 35 (2): 251-253 [Abstract] ( 49 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 254 Effect of Emotional Support Based on Nursing Ethics on Negative Emotion and Quality of Life of Patients Undergoing Unilateral Salpingotomy for Ectopic Tubal Pregnancy WANG Ying DOI: 10.3969/j.issn.1671-7171.2018.02.015 【Objective】To explore the effect of emotional support based on nursing ethics on negative emotion and quality of life of patients undergoing unilateral salpingotomy for ectopic tubal pregnancy.【Methods】From June 2015 to May 2016, 112 cases of unilateral oviductal resection of unmarried ectopic pregnancy were selected. The control group was given routine nursing care such as health education, psychological intervention and discharge guidance. The observation group combined with emotional support based on nursing ethics on the basis of the control group. The recovery, anxiety / depression and quality of life were compared between the two groups.【Results】The time of disappearance of abdominal pain, the time of anal exhaust, the time of getting out of bed and the time of hospitalization in the observation group were significantly shorter than those in the control group (P<0.05). The scores of SAS and SDS were significantly lower than those of the control group (P<0.05). The scores of physiological function, role function, emotion function and social function in the observation group were significantly higher than those in the control group (P<0.05).【Conclusion】Emotional support based on nursing ethics helps relieve the degree of anxiety and depression, promote postoperative recovery and improve the quality of life in unmarried ectopic pregnancy patients undergoing unilateral tubal resection. 2018 Vol. 35 (2): 254-256 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 257 Effect of Metformin Combined with Diane-35 on Pregnancy Outcomes of Patients with Polycystic Ovarian Syndrome YAN Hong-li, DENG Xiao-hong, BAI Chang-min, et al DOI: 10.3969/j.issn.1671-7171.2018.02.016 【Objective】To analyze the effect of metformin (MET) combined with Diane-35 on pregnancy outcomes of patients with polycystic ovary syndrome (PCOS).【Methods】Ninety-four patients with insulin resistant (IR) PCOS were randomly divided into the MET group and control group, 47 cases in each group. The control group were treated with Diane-35 while the observation group were treated with Diane-35 and MET. After 3 menstrual cycles, the levels of glucose and lipid metabolism, hormone levels, endometrial thickness, ovulation rate, pregnancy rate and abortion rate were compared between the two groups before and after treatment.【Results】After treatment, the body mass index, fasting blood glucose, fasting insulin and IR levels in the two groups decreased significantly, and the decreasing range in MET group was greater than that in the control group (P<0.05). After treatment, the total cholesterol and triglyceride in MET group were significantly lower than those before treatment and those in the control group after treatment, the difference was statistically significant (P<0.05). After treatment, the follicle stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH and testosterone decreased significantly, the estradiol increased significantly, and the endometrial thickness was significantly thinner. The changes in MET group after treatment were more obvious than those in the control group (P<0.05). After treatment, the ovulation rate, pregnancy rate and abortion rate in the MET group were 89.36%, 55.32% and 4.26% while those in the control group were 68.09%, 34.04% and 17.02%, the difference was statistically significan (P<0.05).【Conclusion】Metformin combined with Dain-35 can regulate the disorder of glucose and lipid metabolism, decrease IR, improve endocrine disorders and endometrial dysplasia, increase pregnancy rate and reduce abortion rate It is worth popularizing clinical application. 2018 Vol. 35 (2): 257-259,262 [Abstract] ( 61 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 260 Effect of Long Term Home-used Non-invasive Positive Pressure Ventilation in Patients with Stable Severe Chronic Obstructive Pulmonary Disease ZHAO Fei, LIU Zhi-guang, ZHANG Wei-dong DOI: 10.3969/j.issn.1671-7171.2018.02.017 【Objective】To evaluate the efficacy of long-term non-invasive positive pressure mechanical ventilation in the treatment of stable severe chronic obstructive pulmonary disease (COPD).【Methods】Thirty-one patients with severe stable COPD were randomly divided into control group (n=16) and observation group (n=15). The patients were followed up for 1 year after treatment. The blood gas analysis, the lung function, 6 minutes walking distance (6MW DX), the modified British Medical Research Society dyspnea scale (mMRC), St. George's score and sleep time of the two groups were compared.【Results】There were no cases of death or withdrawal from other causes during one year of treatment in both groups.Of the two groups of patients before treatment, there was no significant difference in PaO2, FEV1, FEV1/FVC, PaCO2, 6MWD, mMRC score, St George's score and sleep time (P>0.05). The scores of PaCO2and St. George in the observation group were decreased after treatment, and the difference was statistically significant compared with the control group (P<0.05). However, there was no significant difference in PaO2、FEV1 (L)、FEV1/FVC (%)、6MWD、MRC score and sleep duration between the two groups (P>0.05).【Conclusion】Home-used noninvasive ventilation therapy can improve respiratory failure and quality of life in patients with severe COPD. It is an effective treatment for stable severe COPD patients and is worthy of clinical application. 2018 Vol. 35 (2): 260-262 [Abstract] ( 44 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 263 Efficacy of Microendoscopy Discectomy in the Treatment of Patients with Complicated Lumbar Spinal Stenosis ZHOU Yong-tai, HAN Peng, LIAO Cong-hui DOI: 10.3969/j.issn.1671-7171.2018.02.018 【Objective】To investigate the efficacy of microendoscopy disectomy in the treatment of patients with complicated lumbar spinal stenosis.【Methods】Forty-eight patients with complicated lumbar spinal stenosis were selected as subjects, including 26 patients complicated with spondylolisthesis, 10 patients complicated with lumbar fractures and 12 patients complicated with scoliosis. All patients were treated with posterior microendoscopy disectomy, and they were treated by orthopaedic treatment, reduction, fixation and intervertebral or intertransverse fusion with transpedicular instrument according to different conditions. Changes in scores of Visual Analog Scale (VAS score), Oswestry disability index (ODI), quality of life [World Health Organization on Quality of Life Brief Scale (WHOQOL-BREF)] and related symptoms before and after surgery were evaluated comprehensively.【Results】Scores of postoperative VAS, ODI and symptoms of 48 cases were significantly lower than those before surgery (P<0.05), while WHOQOL-BREF scores were significantly higher than those before surgery (P<0.05).【Conclusion】Microendoscopy disectomy can effectively relieve pain symptoms in patients with complicated lumbar spinal stenosis, and it has positive effect on relieving functional disability and improving the quality of life. 2018 Vol. 35 (2): 263-265 [Abstract] ( 76 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 266 Influence of Microwave Ablation Therapy on Serum Levels of VEGF and MMP-9 in Patients with Advanced Non-small Cell Lung Cancer QI Jiu-de, REN Gang, WANG Ji-song, et al DOI: 10.3969/j.issn.1671-7171.2018.02.019 【Objective】To investigate the effect of microwave ablation on serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in patients with advanced non-small cell lung cancer (NSCLC).【Methods】A total of 57 patients with advanced non-small cell lung cancer were randomly divided into two groups:30 cases in the observation group who received microwave ablation therapy, and 27 cases in the control group who did not receive microwave ablation treatment. Blood was drawn on the day of treatment and two weeks after treatment. Serum levels of VEGF and MMP-9 were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, complications associated with the treatment were evaluated.【Results】Serum levels of MMP-9 and VEGF were not significantly different between the two groups before treatment (P＞0.05). After treatment, serum VEGF levels in both groups showed a decreasing trend, but the difference was not statistically significant (P＞0.05). However, after treatment, the serum MMP-9 levels of two groups were significantly lower than those before treatment (P<0.05), and the decrease in the observation group was greater than that in the control group (P<0.05). No serious adverse reactions occurred in the observation group.【Conclusion】Microwave ablation therapy can significantly reduce the serum level of MMP-9 levels in patients with advanced non-small cell lung cancer. It provides the therapeutic evidence for the application of local hyperthermia in advanced peripheral lung cancer. 2018 Vol. 35 (2): 266-267,270 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 3 ) 268 Relationship between Gensini Score and MACE in Patients with Acute Coronary Syndrome CHENG Min-ju, WEI Qing-min, CHENG Min-jing, et al DOI: 10.3969/j.issn.1671-7171.2018.02.020 【Objective】To explore the relationship between Gensini score and major adverse cardiac events (MACE) in patients with coronary artery disease (ACS).【Methods】A total of 78 patients with coronary artery disease (ACS) from December 2015 to July 2016 were collected for the study. Based on the incidence of MACE during the follow-up period, patients were divided into the MACE group and No-MACE group. The differences of Homocysteine (Hcy), Myeloperoxidase ( MPO) and Gensini scores between the two groups were recorded and analyzed.【Results】The MACE group had a Gensini score of (65.77±4.03), which was higher than that of non-MACE group (46.16±5.02); the difference was statistically significant (P＜0.01). Levels of Hcy and MPO in the MACE group were (18.63±4.37)μmol/L, (4149.52±955.41)pmol/L, respectively, which were higher than those in No-MACE group (15.21±2.70)μmol/L and (2302.74±1107.83)pmol/L, respectively. The differences were statistically significant (P＜0.05). Multivariate Logistic regression analysis was used to analyze the factors influencing the MACE prognosis of patients with ACS and the Hcy, MPO and Gensini scores during follow-up. The results showed that the Gensini score could be used as an independent predictor of MACE risk in ACS patients from 1 to 6 months of ACS.【Conclusion】The Gensini score has certain advantage in predicting the risk of MACE with high accuracy. It has positive correlation between the occurrence of MACE risk and Gensini score. 2018 Vol. 35 (2): 268-270 [Abstract] ( 70 ) HTML (1 KB)  PDF  (0 KB)  ( 4 ) 271 Effect of Butorphenol Combined with Midazolam and Pethidine Combined with Promethazine on Relieving Gastric Stretch in Patients with Gastric Perforation Repair ZHANG Guo-yan, CHEN Xiao-fang DOI: 10.3969/j.issn.1671-7171.2018.02.021 【Objective】To investigate the effect of butorphenol combined with midazolam and pethidine combined with promethazine on relieving gastric stretch in patients with gastric perforation repair.【Methods】Among 100 patients undergoing gastric perforation repair, 50 patients were treated with butorphen and midazolam intravenously in 5 minutes before incision after satisfactory epidural anesthesia. The other 50 cases were given pethidine plus promethazine intravenously as group B. The changes of heart rate, mean arterial pressure (MAP), pulse oxygen saturation (SpO2), Ramsay sedative score and the degree of gastric retraction were compared between the two groups.【Results】Compared with T0 before treatment, HR, MAP, SpO2at T1~T4after treatmentin the group A were stable (P>0.05), and HR and MAP in the group B were fluctuating significantly (P<0.05), while SpO2was stable (P>0.05).There were no significant difference between the two groups compared Ramsay scores at T1and T2 (P<0.05), while at T3and T4in the group A were significantly higher than those in the group B (P<0.05).The excellent and good rate of in the group A (86%) was significantly higher than that in the group B (70%) (P<0.05).【Conclusion】Midazolam combined with Bhutto enphol can significantly reduce the effect of gastric traction in the operation, and its effect is better than piperidine + promethazine. 2018 Vol. 35 (2): 271-273 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 274 Effect of Intensive Dose Atorvastatin on Different Subsets of Monocytes and Monocytes Platelet Aggregates and Prognosis in Patients with Unstable Angina Pectoris during PCI XIAN Hai-ying, CHUAI Yu-juan, SHEN Bin, et al DOI: 10.3969/j.issn.1671-7171.2018.02.022 【Objective】To investigate the effect of intensive dose atorvastatin on different subsets of monocytes, monocytes, platelet aggregates (MPA) and prognosis in unstable angina pectoris (UAP) patients with PCI (percutaneous coronary intervention) during the perioperative period.【Methods】A total of 94 patients with UAP undergoing elective PCI surgery in our hospital from June 2015 to June 2017 were selected. According to the random number method, patients were divided into the study group (47 cases) and the control group (47 cases). The patients in both groups were treated with standard PCI. The control group was given conventional antiplatelet and β-blocker drugs before and after PCI. The observation group was given intensive doses of atorvastatin on the basis of the control group. The levels of monocytes and MPA in the two groups before and after surgery were analyzed quantitatively. The levels of cardiac troponin (cTnI), creatine phosphokinase (CK-MB) and C-reactive protein (CRP) were observed before and after PCI as well. The postoperative TIMI grading and postoperative no-reflow, slow blood flow of coronary were recorded. The incidence of adverse cardiovascular events was recorded at 3 months after operation in both groups.【Results】The levels of type 2 mononuclear cells (MON 2), total MPA, type 1 monocyte platelet aggregates and type 2 monocyte platelet aggregates in patients of the study group were significantly lower than those in the control group; the differences were statistically significant (P<0.05). After treatment, serum levels of cTnI, CK-MB and CRP in both groups significantly increased, while the levels of cTnI, CK-MB and CRP in patients of study group after treatment were significantly lower than those in the control group (P<0.05). The postoperative TIMI grade in the study group was significantly better than that in the control group, while the incidence of postoperative no-reflow and slow blood flow was significantly lower than that in the control group; the differences were statistically significant (P<0.05). The total incidence of adverse cardiovascular events in the study group was significantly lower than that in the control group with statistical significance (P<0.05); the study group patients with postoperative TIMI flow grade was significantly better than the control group, and after no reflow and slow flow rate were significantly lower than the control group, the difference was statistically significant (P<0.05); the total incidence of patients in the study group after treatment of adverse cardiovascular events was significantly lower than the control group, with the difference being statistically significant (P<0.05).【Conclusion】Intensive doses of atorvastatin may reduce myocardial damage by reducing monocyte and MAP levels in patients with UAP, and may effectively improve myocardial blood flow status and inflammatory response to decrease the risk of cardiovascular events. 2018 Vol. 35 (2): 274-277 [Abstract] ( 46 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 278 Comparative Study on the Clinicopathological Features of Malignant Transformations of Endometriosis and Ovarian Cancer LUO Li-ping, ZHAO Fu-qing, LIU Qing-xiu, et al DOI: 10.3969/j.issn.1671-7171.2018.02.023 【Objective】To investigate the clinicopathological features and long-term prognosis of endometriosis malignant transformations (EMS) to reveal its differences from ovarian cancer.【Methods】Eighty patients with EMS malignant ovarian cancer (observation group) and 80 patients with non-EMS malignant ovarian cancer (control group) who were in our hospital from January 2009 to January 2012 were selected. The clinicopathological characteristics and prognosis of the two groups were compared.【Results】The proportion of patients less than 50 years old in the observation group was higher than that in the control group (P<0.05). The proportion of patients with stage Ⅲ~Ⅳ and serum CA-125>1000 U / mL was lower than that of the control group (P<0.05). The other indicators in the two groups were also statistically significant differences (P<0.05). The 5-year survival rate was 68.75% (55/80) in the observation group, which was significantly higher than that in the control group (50.00%, 40/80); the difference was statistically significant (χ2=5.830, P=0.016). The 5-year survival rate was taken as the dependent variable, with age, irregular vaginal bleeding, tumor diameter, FIGO stage, pathological type, CA125, whether EMS malignant as independent variables. Logistic regression analysis showed that FIGO hyperplasia, serous adenocarcinoma and CA125>1000 IU/mL were independent risk factors for poor prognosis in patients with ovarian cancer (P<0.05). The prognosis of patients with EMS malignant lesions was relatively better than that of non-EMS malignant ovarian cancer patients (OR=0.682, P<0.05).【Conclusion】The clinical features of patients with malignant change of EMS are quite different from the clinical pathological characteristics of patients with non EMS malignant transformed ovarian cancer. Patients with EMS malignancy have a better prognosis than patients with non-EMS malignant ovarian cancer. 2018 Vol. 35 (2): 278-280 [Abstract] ( 59 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 281 Effect of Motivation Interview Based on Motivation Theory on The Cognitive Level and Self-management Ability of Patients with Rectal Cancer after Operation HAN Zheng-feng, PEI Qi, SHAO Lin-jing DOI: 10.3969/j.issn.1671-7171.2018.02.024 【Objective】To explore the effect of motivation interview based on motivation theory on the cognitive level and self-management ability of patients with rectal cancer after operation.【Methods】From June 2015 to June 2016, 84 patients with postoperative rectal cancer were divided into two groups: observation group (n=42) and control group (n=42). Routine nursing intervention was performed in the control group. The patients in the observation group were followed up for 3 months with motivation interview based on motivation theory to compare the disease cognitive level, self-management ability and complications between the two groups.【Results】After 3 months follow-up, the scores of cleaning and replacement of fecal bags, skin nursing, regular defecation training, proper diet and observation of complications in the observation group were significantly higher than those in the control group. The total scores of stoma nursing skills, daily life ability, social ability, functional exercise and self management were significantly higher than those of the control group (P<0.05). The total scores of stoma nursing skills, daily life ability, social ability, functional exercise and self management were significantly higher than those of the control group (P<0.05). The complications such as infection in the stoma were 4.76%, which was significantly lower than that of the control group (19.05%) (χ2=4.086, mean P<0.05).【Conclusion】Motivational interview based on incentive theory can significantly improve the cognitive level and self-management ability of the patients with intestinal stoma after rectal cancer surgery, and reduce the incidence of complications. 2018 Vol. 35 (2): 281-283,287 [Abstract] ( 34 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 284 Effects of Enalapril Maleate Folic Acid Tablets Combined with Mild Hypothermia on Vascular Endothelial Function, Nerve Function Defect and Prognosis in Patients with H Type Hypertension Ischemic Stroke HUANG Yu DOI: 10.3969/j.issn.1671-7171.2018.02.025 【Objective】To investigate the effect of folic acid tablets of enalapril maleate combined with mild hypothermia on clinical indexes in patients with H type hypertensive ischemic stroke.【Methods】From January 2015 to January 2016, 88 patients with H type hypertensive ischemic stroke were selected. The patients were divided into control group (mild hypothermia enalapril maleate tablet) and observation group (44 cases each for 3 months) by random number method. After the course of treatment, the changes of ambulatory blood pressure, plasma homocysteine, IL-24, platelet α granule membrane protein-140 (GMP-140), platelet derived growth factor (PDGF), endothelial function [ET-1, nitric oxide], vascular endothelial function were detected before and after treatment. NIHSS and modified Rankin scale were used to evaluate the recent neurological impairment and prognosis.【Results】The levels of 24hSBP, 24hDBP, daytimeSBP, daytimeDBP, nocturnal SBP and nocturnal DBP in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the level of Hcy, PDGF, GMP-140, and IL-24 and NO were higher than those of the control group, and the difference was statistically significant (P<0.05). The NIHSS score in the observation group was significantly lower than that in the control group after treatment. The proportion of mRS ≥ 2 was 70.45%, which was significantly higher than that of the control group (47.73%, P<0.05).【Conclusion】Folic acid tablets of enalapril maleate combined with mild hypothermia on clinical indexes in patients with H type hypertensive ischemic stroke can lower the level of Hcy in patients with blood pressure. It can also inhibit abnormal platelet activation, improve vascular endothelial function, alleviate neurological deficit and improve short-term prognosis. 2018 Vol. 35 (2): 284-287 [Abstract] ( 35 ) HTML (1 KB)  PDF  (0 KB)  ( 6 ) 288 Application of Different Perioperative Antiplatelet Regimens in Patients with Unruptured Intracranial Aneurysms Treated by Interventional Therapy and Comparison of the Risks of Bleeding after Operation ZHOU Jing-bin, WANG Mu-chun, DENG Dong-feng DOI: 10.3969/j.issn.1671-7171.2018.02.026 【Objective】To investigate the application of different perioperative antiplatelet regimens in patients with unruptured intracranial aneurysms treated by interventional therapy and compare the risks of bleeding.【Methods】A total of 160 cases of patients with unruptured intracranial aneurysms treated by interventional therapy in our hospital from February 2012 to October 2016 were enrolled in the study. According to the different treatment methods, the patients were divided into A group [treated with loading dose (8μg/kg) of tirofiban for 3 min, followed by the maintenance dose (0.1μg/kg·min), n=50], B group (treated with loading dose of clopidogrel at 2h~24h before operation, n=60) and C group (treated with 75mg of clopidogrel and 100mg of Bayaspirin at 3~5d before operation, n=50). We observed the incidence of bleeding and thromboembolic events, the occurrence of complications, changes of Glasgow Coma Scale (GOS) scores, and follow-up results.【Results】After operation, the incidence rates of bleeding events, thromboembolic events and complications were significantly lower in A group than B group and C group. The prognosis of A group was significantly better than that of B group and C group (P<0.05). However, there were no statistically significant differences between B group and C group in the incidence rates of bleeding events, thromboembolic events and complications and the prognosis (P>0.05). There were no significant differences in GOS scores among the three groups before treatment (P>0.05). At 1 month, 2 months and 3 months after operation, the GOS scores of the three groups were significantly higher, and the increase was more obvious in A group than B group and C group (P<0.05). However, there was no significant difference between B group and C group (P>0.05). The follow-up rate was 100% (50/50) in group A, 98.33 (59/60) in group B, and 96.00 (48/50) in group C. The follow-up results showed that the prognosis of group A was significantly better than group B and group C ; the difference was statistically significant (P<0.05).【Conclusion】Tirofiban regimen can be used as a safe and effective antiplatelet treatment for patients with unruptured intracranial aneurysms treated by interventional therapy. Compared with dual antiplatelet regimen and loading dose of clopidogrel regimen, it has more advantages, and the risks of bleeding are lower. 2018 Vol. 35 (2): 288-291 [Abstract] ( 50 ) HTML (1 KB)  PDF  (0 KB)  ( 5 )

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