强化阿托伐他汀对不稳定型心绞痛患者PCI围术期不同亚群单核细胞及单核细胞-血小板聚集体及预后的影响

doi:10.3969/j.issn.1671-7171.2018.02.022

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Abstract 【Objective】To investigate the effect of intensive dose atorvastatin on different subsets of monocytes, monocytes, platelet aggregates (MPA) and prognosis in unstable angina pectoris (UAP) patients with PCI (percutaneous coronary intervention) during the perioperative period.【Methods】A total of 94 patients with UAP undergoing elective PCI surgery in our hospital from June 2015 to June 2017 were selected. According to the random number method, patients were divided into the study group (47 cases) and the control group (47 cases). The patients in both groups were treated with standard PCI. The control group was given conventional antiplatelet and β-blocker drugs before and after PCI. The observation group was given intensive doses of atorvastatin on the basis of the control group. The levels of monocytes and MPA in the two groups before and after surgery were analyzed quantitatively. The levels of cardiac troponin (cTnI), creatine phosphokinase (CK-MB) and C-reactive protein (CRP) were observed before and after PCI as well. The postoperative TIMI grading and postoperative no-reflow, slow blood flow of coronary were recorded. The incidence of adverse cardiovascular events was recorded at 3 months after operation in both groups.【Results】The levels of type 2 mononuclear cells (MON 2), total MPA, type 1 monocyte platelet aggregates and type 2 monocyte platelet aggregates in patients of the study group were significantly lower than those in the control group; the differences were statistically significant (P<0.05). After treatment, serum levels of cTnI, CK-MB and CRP in both groups significantly increased, while the levels of cTnI, CK-MB and CRP in patients of study group after treatment were significantly lower than those in the control group (P<0.05). The postoperative TIMI grade in the study group was significantly better than that in the control group, while the incidence of postoperative no-reflow and slow blood flow was significantly lower than that in the control group; the differences were statistically significant (P<0.05). The total incidence of adverse cardiovascular events in the study group was significantly lower than that in the control group with statistical significance (P<0.05); the study group patients with postoperative TIMI flow grade was significantly better than the control group, and after no reflow and slow flow rate were significantly lower than the control group, the difference was statistically significant (P<0.05); the total incidence of patients in the study group after treatment of adverse cardiovascular events was significantly lower than the control group, with the difference being statistically significant (P<0.05).【Conclusion】Intensive doses of atorvastatin may reduce myocardial damage by reducing monocyte and MAP levels in patients with UAP, and may effectively improve myocardial blood flow status and inflammatory response to decrease the risk of cardiovascular events.

Key words： Angina, Unstable/TH Angioplasty, Transluminal, Percutaneous Coronary Antilipemic Agents/PD Intraoperative Period Monocytes Platelet Aggregation Prognosis

Received: 25 September 2017

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R541.42

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	Articles by authors
	XIAN Hai-ying
	CHUAI Yu-juan
	SHEN Bin
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Cite this article:

XIAN Hai-ying,CHUAI Yu-juan,SHEN Bin, et al. Effect of Intensive Dose Atorvastatin on Different Subsets of Monocytes and Monocytes Platelet Aggregates and Prognosis in Patients with Unstable Angina Pectoris during PCI[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 274-277.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.02.022 OR http://www.jcr.net.cn/EN/Y2018/V35/I2/274

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