|
|
|
| Effect of Ulinastatin on Inflammatory Response and Renal Function in Patients Undergoing Abdominal Surgery |
| SHU Yuan-fu |
| Department of Anesthesiology, Guanghan People's Hospital , Guanghan, Sichuan 618300 China |
|
|
|
|
Abstract 【Objective】To observe the effect of ulinastatin injection on inflammatory reaction of abdominal surgery in the perioperative period and its effect on renal functions.【Methods】One hundred and eight patients undergoing abdominal surgery were randomly divided into control group (n=90) and observation group (n=90). The control group received intravenous drip of Glucose Injection in the perioperative period, and the observation group was given intravenous drip of Ulinastatin Injection. The changes of inflammatory factors, renal function indexes and postoperative complications were compared between the two groups.【Results】Before operation, there was no significant difference in the two groups in the levels of inflammatory factors such as interferon-β (IFN-β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), as well as renal function, blood urea nitrogen, uric acid and creatinine levels (P>0.05);The levels of inflammatory factors, blood urea nitrogen, uric acid and creatinine in the observation group were significantly lower than those in the control group, and the difference was significant (P<0.05);The postoperative complication rate of the observation group was 4.44% (4/90), which was lower than that of the control group 11.11% (10/90), and the difference between the two groups was significant (P<0.05).【Conclusion】Ulinastatin injection is ideal for patients undergoing abdominal surgery. It can reduce the inflammatory response and improve the renal function of patients.
|
|
Received: 14 October 2016
|
|
|
|
|
|
[1] 石佳,李军,张喆,等.乌司他丁对体外循环下心脏手术围术期炎症反应的影响[J].中国循环杂志,2012,27(4):305-310.
[2] 王焰斌,王小雷,李刚,等.乌司他丁预处理对CPB 下心脏瓣膜置换术患者鱼精蛋白诱发肺损伤的影响[J].中华麻醉学杂志,2013,33(5):525-529
[3] CAO Y Z,TU Y Y,CHEN X,et al.Protective effect of ulinastatin against murine models of sepsis:inhibition of TNF-alpha and IL-6 and augmentation of IL-10 and IL-13[J].Exp Toxicol Pathol,2012,64(6):543-547.
[4] 沈丛林,朱东波,龚辉.奥曲肽联合乌司他丁治疗创伤性肠破裂术后早期炎性肠梗阻疗效分析.中国医学前沿杂志(电子版),2014,6(11):83-86.
[5] Zhao L,Lou J,Wu H,et al.Effects of taurine-magnesium coordination compound on ionic channels in rat ventricular myocytes of arrhythmia induced by ouabain[J].Biological Trace Element Res,2012,147(1/3):275-284.[6] 王焰斌,王小雷,李刚,等.乌司他丁预处理对CPB 下心脏瓣膜置换术患者鱼精蛋白诱发肺损伤的影响[J].中华麻醉学杂志,2013,33(5):525-529.
[7] 陈力,徐世元,李传翔,等.乌司他丁对老年人胃肠道大手术围术期心脏功能的影响[J].南方医科大学学报,2014,34(1):117-120.
[8] Ostheimer C,Meyer F,Kornhuber C,et al.What does the general and abdominal surgeon need to know about radiotherapy-aspects of radiotherapy in general and abdominal surgery [J].Zentralbl Chir,2015,140(1):83-93. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(4): 732-734. |
|
|
|
|
2018, Vol. 35 
