二甲双胍联合达英-35治疗多囊卵巢综合征对妊娠结局的影响

doi:10.3969/j.issn.1671-7171.2018.02.016

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To analyze the effect of metformin (MET) combined with Diane-35 on pregnancy outcomes of patients with polycystic ovary syndrome (PCOS).【Methods】Ninety-four patients with insulin resistant (IR) PCOS were randomly divided into the MET group and control group, 47 cases in each group. The control group were treated with Diane-35 while the observation group were treated with Diane-35 and MET. After 3 menstrual cycles, the levels of glucose and lipid metabolism, hormone levels, endometrial thickness, ovulation rate, pregnancy rate and abortion rate were compared between the two groups before and after treatment.【Results】After treatment, the body mass index, fasting blood glucose, fasting insulin and IR levels in the two groups decreased significantly, and the decreasing range in MET group was greater than that in the control group (P<0.05). After treatment, the total cholesterol and triglyceride in MET group were significantly lower than those before treatment and those in the control group after treatment, the difference was statistically significant (P<0.05). After treatment, the follicle stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH and testosterone decreased significantly, the estradiol increased significantly, and the endometrial thickness was significantly thinner. The changes in MET group after treatment were more obvious than those in the control group (P<0.05). After treatment, the ovulation rate, pregnancy rate and abortion rate in the MET group were 89.36%, 55.32% and 4.26% while those in the control group were 68.09%, 34.04% and 17.02%, the difference was statistically significan (P<0.05).【Conclusion】Metformin combined with Dain-35 can regulate the disorder of glucose and lipid metabolism, decrease IR, improve endocrine disorders and endometrial dysplasia, increase pregnancy rate and reduce abortion rate It is worth popularizing clinical application.

Key words： Metformin/PD Dynein ATPase/PD Polycystic Ovary Syndrome Pregnancy Outcome

Received: 01 March 2017

PACS:

R711.75

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YAN Hong-li
	DENG Xiao-hong
	BAI Chang-min
	et al

Cite this article:

YAN Hong-li,DENG Xiao-hong,BAI Chang-min, et al. Effect of Metformin Combined with Diane-35 on Pregnancy Outcomes of Patients with Polycystic Ovarian Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 257-259,262.

URL:

http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.02.016 OR http://www.jcr.net.cn/EN/Y2018/V35/I2/257

[1] 钟雪辉,许婉红.多囊卵巢综合征患者25-羟维生素D表达及与代谢参数和胰岛素抵抗的相关性研究[J].医学临床研究,2014,31(3):609-611.
[2] 杨见青,张英.月经不调青年女性的超声表现及相关影响因素分析[J].湖南师范大学学报(医学版),2013,10(3):25-27.
[3] 郝明,周楠,胡兴茂,等.妊娠相关蛋白在多囊卵巢综合征早期自然流产患者的表达及临床意义[J].解放军医药杂志,2013,25(9):63-66.
[4] 戴云先,黄颖.多囊卵巢综合征与胰岛素抵抗的研究[J].国际医药卫生导报,2012,18(22):3319-3321.
[5] 江丽琴,周静,黄伟政,等.达英35与二甲双胍治疗多囊卵巢综合征患者妊娠分娩的结局研究[J].西部医学,2014,26(5):564-566.
[6] 崔琳琳,陈子江.多囊卵巢综合征诊断标准和诊疗指南介绍[J].国际生殖健康/计划生育杂志,2011,30(5):405-408.
[7] 陈慧,詹维伟,杨志芳,等.伴或不伴胰岛素抵抗的多囊卵巢综合征的超声特征及其与内分泌指标的相关性[J].中国医学影像技术,2014,30(4):595-599.
[8] 苏宏,孙萌萌,赵跃萍,等.二甲双胍对2型糖尿病患者血浆C反应蛋白和血脂水平影响[J].临床误诊误治,2014,27(6):95-98.
[9] 韩鲜梅.胰岛素抵抗和高胰岛素血症与多囊卵巢综合征的关系[J].现代中西医结合杂志,2015,24(11):1179-1181.
[10] Pasquali R,Gambineri A.Insulin-sensitizing agents in polycystic ovary syndrome[J].Eur J Endocrinol,2006,154(6):763-775.
[11] 黄晓,吉柳,谢红梅,等.二甲双胍治疗多囊卵巢综合征研究进展[J].中国药房,2014,25(12):1143-1145.
[12] 张婧,李荔,陈文芬,等.多囊卵巢综合征发病机制研究进展[J].实用医学杂志,2014,30(2):323-325.
[13] 裴慧琳.达英-35和二甲双胍对多囊卵巢综合征患者性激素水平及胰岛素抵抗的影响[J].中国医药导报,2013,10(1):73-75.
[14] Saxena P,Prakash A,Nigam A.Effect of metformin therapy on 2-h post-glucose insulin levels in patients of polycystic ovarian syndrome[J].J Hum Reprod Sci,2010,3(3):139.