卵巢子宫内膜异位症恶变与卵巢癌患者临床病理特征对比分析

doi:10.3969/j.issn.1671-7171.2018.02.023

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Abstract 【Objective】To investigate the clinicopathological features and long-term prognosis of endometriosis malignant transformations (EMS) to reveal its differences from ovarian cancer.【Methods】Eighty patients with EMS malignant ovarian cancer (observation group) and 80 patients with non-EMS malignant ovarian cancer (control group) who were in our hospital from January 2009 to January 2012 were selected. The clinicopathological characteristics and prognosis of the two groups were compared.【Results】The proportion of patients less than 50 years old in the observation group was higher than that in the control group (P<0.05). The proportion of patients with stage Ⅲ~Ⅳ and serum CA-125>1000 U / mL was lower than that of the control group (P<0.05). The other indicators in the two groups were also statistically significant differences (P<0.05). The 5-year survival rate was 68.75% (55/80) in the observation group, which was significantly higher than that in the control group (50.00%, 40/80); the difference was statistically significant (χ²=5.830, P=0.016). The 5-year survival rate was taken as the dependent variable, with age, irregular vaginal bleeding, tumor diameter, FIGO stage, pathological type, CA125, whether EMS malignant as independent variables. Logistic regression analysis showed that FIGO hyperplasia, serous adenocarcinoma and CA125>1000 IU/mL were independent risk factors for poor prognosis in patients with ovarian cancer (P<0.05). The prognosis of patients with EMS malignant lesions was relatively better than that of non-EMS malignant ovarian cancer patients (OR=0.682, P<0.05).【Conclusion】The clinical features of patients with malignant change of EMS are quite different from the clinical pathological characteristics of patients with non EMS malignant transformed ovarian cancer. Patients with EMS malignancy have a better prognosis than patients with non-EMS malignant ovarian cancer.

Key words： Endometriosis/PA Ovary Ovarian Neoplasms/PA Prognosis

Received: 15 November 2017

PACS:

R711.71

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	LUO Li-ping
	ZHAO Fu-qing
	LIU Qing-xiu
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Cite this article:

LUO Li-ping,ZHAO Fu-qing,LIU Qing-xiu, et al. Comparative Study on the Clinicopathological Features of Malignant Transformations of Endometriosis and Ovarian Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2018, 35(2): 278-280.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2018.02.023 OR http://www.jcr.net.cn/EN/Y2018/V35/I2/278