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| Influence of Microwave Ablation Therapy on Serum Levels of VEGF and MMP-9 in Patients with Advanced Non-small Cell Lung Cancer |
| QI Jiu-de, REN Gang, WANG Ji-song, et al |
| Laiwu People’s hospital, Shandong 271100, China |
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Abstract 【Objective】To investigate the effect of microwave ablation on serum levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in patients with advanced non-small cell lung cancer (NSCLC).【Methods】A total of 57 patients with advanced non-small cell lung cancer were randomly divided into two groups:30 cases in the observation group who received microwave ablation therapy, and 27 cases in the control group who did not receive microwave ablation treatment. Blood was drawn on the day of treatment and two weeks after treatment. Serum levels of VEGF and MMP-9 were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, complications associated with the treatment were evaluated.【Results】Serum levels of MMP-9 and VEGF were not significantly different between the two groups before treatment (P＞0.05). After treatment, serum VEGF levels in both groups showed a decreasing trend, but the difference was not statistically significant (P＞0.05). However, after treatment, the serum MMP-9 levels of two groups were significantly lower than those before treatment (P<0.05), and the decrease in the observation group was greater than that in the control group (P<0.05). No serious adverse reactions occurred in the observation group.【Conclusion】Microwave ablation therapy can significantly reduce the serum level of MMP-9 levels in patients with advanced non-small cell lung cancer. It provides the therapeutic evidence for the application of local hyperthermia in advanced peripheral lung cancer.
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Received: 12 May 2017
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[1] 冯威健,刘巍,李彩英,等.经皮微波凝固疗法治疗肺肿瘤的临床应用[J].中华肿瘤杂志,2002,24(4):388-390.
[2] Vosl TJ,Naguib NN,Lehnert T,et al.Radioffequency,microwave and laser ablation of pulmonary neoplasms:clinical studies and technical considerations-review article[J].Eur J Radiol,2011,77(2):346-357.
[3] Gillams AR.Image guided tumour ablation[J].Cancer Imaging,2005,5(1):103-109.
[4] Fumkawa K,Miura T,Kato Y,et al.Microwave coagulation therapyin canine peripheral lung tissue[J].J surg Res,2005,123(2):245-250.
[5] 王强,刘瑞宝,张立成.肺癌微波消融治疗进展[J].中国肺癌杂志,2010,13(1):78-81.
[6] Saisho S,Yasuda k,Maeda A,et al.Post-recurrence survival of patients with non-small-cell lung cancer after curative resection with or without induction / adjuvant chemotherapy[J].Interact Cardiovasc Thorac Surg,2013,16(2):166-172.
[7] 苟小丽,邢时云,杨卫兵.联合检测外周血 CEA、CA125、VEGF、MT 及 MMP-9 在晚期非小细胞肺癌表达的相关性[J].遵义医学院学 报,2014,37(2):204-207.
[8] Chakra M,Pujol J,Lamy PJ,et al.Circulating serum vascular endothelial growth factor is not a prognostic factor of non-small cell lung cancer[J].J Thorac Oncol,2008,3(10):1119-1126. |
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2018, Vol. 35 
