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| Effect of Long Term Home-used Non-invasive Positive Pressure Ventilation in Patients with Stable Severe Chronic Obstructive Pulmonary Disease |
| ZHAO Fei, LIU Zhi-guang, ZHANG Wei-dong |
| Department of Respiratory, The First Affiliated Hospital of Hunan Normal University, Changsha 410005 China |
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Abstract 【Objective】To evaluate the efficacy of long-term non-invasive positive pressure mechanical ventilation in the treatment of stable severe chronic obstructive pulmonary disease (COPD).【Methods】Thirty-one patients with severe stable COPD were randomly divided into control group (n=16) and observation group (n=15). The patients were followed up for 1 year after treatment. The blood gas analysis, the lung function, 6 minutes walking distance (6MW DX), the modified British Medical Research Society dyspnea scale (mMRC), St. George's score and sleep time of the two groups were compared.【Results】There were no cases of death or withdrawal from other causes during one year of treatment in both groups.Of the two groups of patients before treatment, there was no significant difference in PaO2, FEV1, FEV1/FVC, PaCO2, 6MWD, mMRC score, St George's score and sleep time (P>0.05). The scores of PaCO2and St. George in the observation group were decreased after treatment, and the difference was statistically significant compared with the control group (P<0.05). However, there was no significant difference in PaO2、FEV1 (L)、FEV1/FVC (%)、6MWD、MRC score and sleep duration between the two groups (P>0.05).【Conclusion】Home-used noninvasive ventilation therapy can improve respiratory failure and quality of life in patients with severe COPD. It is an effective treatment for stable severe COPD patients and is worthy of clinical application.
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Received: 01 April 2017
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2018, Vol. 35 
