Abstract：【Objective】 To analyze the correlation between neutrophil count/lymphocyte count (NLR), platelet count/lymphocyte count (PLR) and clinicopathological parameters in patients with breast cancer.【Methods】 Four hundred and thirty-three cases of breast cancer patients (breast cancer group), 631 cases of breast BIRADS class 1 (normal group) and 309 cases of breast BIRADS 2-3 (benign breast disease group) in our hospital from June to December 2018 were selected as the research objects. The age, neutrophil count, lymphocyte count, platelet count of each group were collected, and the clinicopathological data of breast cancer group were collected, including clinical stage, molecular typing, pathological grade, Ki67, lymph node metastasis and other indicators. NLR, platelet count and lymphocyte count were calculated to calculate PLR value. The NLR and PLR of normal group, benign breast disease group and breast cancer group were compared, and the relationship between NLR, PLR and clinicopathological parameters of breast cancer was analyzed.【Results】 There were significant differences in NLR among breast cancer group, benign breast disease group and normal group (P<0.05). There was significant difference in PLR among the three groups (P<0.05), but there was no significant difference between breast cancer and benign breast disease group, between breast cancer and normal group (P>0.05). The area under ROC curve (AUC) was 0.573, 95% CI was 0.54-0.606. NLR and PLR had no significant correlation with pathological grade, Ki67 and molecular typing of breast cancer (P>0.05). However, NLR was correlated with lymph node metastasis of breast cancer (P<0.05), and was positively correlated with NLR (rs=0.103, P=0.033). PLR was positively correlated with PLR (rs=0.188, P=0.00) and clinical stage (rs=0.135, P=0.005).【Conclusion】 The level of NLR and PLR can predict lymph node metastasis to a certain extent. PLR is positively correlated with clinical stage, suggesting that NLR and PLR have certain correlation with prognosis of breast cancer patients.
刘丛芳, 王保祥, 邬玉辉, 肖志, 周薇, 王素芳. NLR及PLR与乳腺癌的相关性研究[J]. 医学临床研究, 2020, 37(8): 1184-1187.
LIU Cong-fang, WANG Bao-xiang, WU Yu-hui, et al. Relationship between NLR, PLR and Breast Cancer. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1184-1187.
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2020, Vol. 37 
