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医学临床研究  2020, Vol. 37 Issue (8): 1210-1212    DOI: 10.3969/j.issn.1671-7171.2020.08.028
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中性粒细胞水平对不同类型间质性肺病的鉴别价值
黄任远1, 宋远园2, 殷寒秋2
1.徐州医科大学,江苏 徐州 221000;
2.徐州医科大学附属医院,江苏 徐州 221000
Value of Neutrophil Level in Differentiating Diagnosis for Different Types of Interstitial Lung Disease
HUANG Ren-yuan, SONG Yuan-yuan, YING Han-qiu
Xuzhou Medical University,Xuzhou,Jiangsu 221000
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摘要 目的】 探讨中性粒细胞水平对不同类型间质性肺病(ILD)的鉴别价值。【方法】 本院收治的ILD患者98例,其中包括特发性间质性肺纤维化(IPF)48例(A组),结缔组织病相关ILD(CTD-ILD)50例(B组),同期于本院体检的50例健康体检者作为对照组。比较三组中性粒细胞水平,绘制受试者工作特征曲线(ROC)分析中性粒细胞水平对ILD类型的鉴别价值。比较不同类型ILD患者的血清人γ干扰素诱导的蛋白-10(IP-10)、人上皮细胞衍生中性粒细胞激活肽-78(ENA-78)、I型前胶原(PCI)水平。分析ILD患者中性粒细胞水平与血清IP-10、ENA-78、PCI的相关性。【结果】 A组、B组的中性粒细胞水平显著高于对照组(P<0.05);A组的中性粒细胞水平显著高于B组(P<0.05)。中性粒细胞水平鉴别IPF、CTD-ILD的曲线下面积为0.657(P<0.05)。A组血清IP-10水平显著高于B组(P<0.05),两组血清ENA-78、PCI比较差异无显著性(P>0.05)。相关分析提示中性粒细胞水平与血清IP-10呈正相关(P<0.05),与ENA-78、PCI无明显相关性(均P>0.05)。【结论】 中性粒细胞水平对IPF、CTD-ILD具有一定的鉴别价值,且其与ILD患者的血清IP-10水平呈正相关。
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黄任远
宋远园
殷寒秋
关键词 肺疾病, 间质性中性白细胞    
Abstract:【Objective】 To explore the value of neutrophil level in differential diagnosis for different types of interstitial lung disease (ILD).【Methods】 A total of 98 ILD patients were admitted to our hospital, including 48 cases of idiopathic interstitial pulmonary fibrosis (IPF-ILD,A group )and 50 cases of connective tissue disease-related ILD (CTD-ILD,B group ). In the same time period, 50 healthy volunteers who underwent physical examination were selected as the control group. The levels of neutrophils in three groups were compared. The ROC curve was drawn to analyze the differential value of neutrophils in different types of ILD.Serum levels of human interferon-gamma induced protein-10 (IP-10), human epithelial cell-derived neutrophil activating peptide-78 (ENA-78) and type I procollagen (PCI) were measured in patients with different types of ILD. The correlation of neutrophil level with serum IP-10, ENA-78 and PCI in patients with ILD was analyzed.【Results】 The levels of neutrophils in ILD patients of both A group and B group were significantly higher than that in the control group (P<0.05).The level of neutrophils in A group was significantly higher than that in B group (P<0.05).The area under the curve of differentiating IPF-ILD and CTD-ILD at neutrophil level was 0.657 (P<0.05).The level of serum IP-10 in A group was significantly higher than that in B group (P<0.05). There was no significant difference in serum ENA-78 and PCI between the two groups (P>0.05). Pearson analysis showed that neutrophil level was positively correlated with serum IP-10 ( P<0.05), but not with ENA-78 and PCI ( P>0.05).【Conclusion】 The level of neutrophils has certain value in differentiating IPF-ILD and CTD-ILD, and it is positively correlated with serum IP-10 in patients with ILD.
Key wordsLung Diseases, Interstitial    Neutrophils
收稿日期: 2019-09-16     
PACS:  R563  
通讯作者: E-mail:kuanzaisky@163.com   
引用本文:   
黄任远, 宋远园, 殷寒秋. 中性粒细胞水平对不同类型间质性肺病的鉴别价值[J]. 医学临床研究, 2020, 37(8): 1210-1212.
HUANG Ren-yuan, SONG Yuan-yuan, YING Han-qiu. Value of Neutrophil Level in Differentiating Diagnosis for Different Types of Interstitial Lung Disease. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1210-1212.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.08.028     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I8/1210
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