Abstract:【Objective】To investigate the clinical effect of minimally invasive FasT-Fix suture repair in the treatment of knee meniscus injury. 【Methods】 A total of 72 patients with knee meniscus injury in our hospital from February 2015 to December 2016 were treated with minimally invasive FasT-Fix suture repair was performed. The IKDC and Lysholm scoring systems were used to evaluate the function of knee joint. γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), interleukin -4 (IL-4), IL-8, tumor necrosis factor (TNF-α)and C reactive protein (CRP) before and after treatment were detected. 【Results】The surgery time frame was 17~45min with average surgery time (27.80 ± 6.81) min. The amount of intraoperative blood loss was 5~30 mL with average amount 15.40 ± 6.11 mL. The follow-up time ranged from 9 to 31 months, the average follow-up time was (20.42 ± 6.88) months.The clinical healing rate was 90.28%.The IKDC and Lysholm scores at 1, 3, and 6 months after surgery were significantly improved compared to before surgery (P<0.05).The levels of TNF-α, IL-4, IL-8 and CRP at 3 d and 7 d post-operation did not show significant differences compared to pre-operation (P>0.05). 【Conclusion】Minimally invasive FasT-Fix suture repair for the treatment of knee meniscus injury is effective for better postoperative knee function recovery and less inflammatory response. It is worthy of clinical application.