Abstract：【Objective】To evaluate the effect of long-term electroacupuncture stimulation (EA) on sensory and motor function recovery after PNI anastomosis by the establishment of a rat model of peripheral nerve injury (PNI).【Methods】Ninety male rats were selected and divided into control group, PNI group and PNI+EA group according to the method of computer random number table. 30 rats in each group were divided into PNI group and PNI+EA group. The PNI model was established by transection of sciatic nerve in PNI group and PNI+EA group. The PNI + EA group was treated with discontinuous wave EA, while the PNI group and the control group were not treated. The experiment lasted for 8 weeks. The effects of EA on PNI nerve regeneration were assessed by leg function index (LFI), stimulus reflex threshold (ST), temperature stimulation threshold (TST) and nerve conduction function (NCF).【Results】The LFI values of the PNI + EA group and the PNI group decreased rapidly in the first week of the experiment, and began to rise in the second to the eighth week, while the LFI values of the PNI + EA group were higher than those of the PNI group in the fifth to seventh week, but there was no significant difference between the two groups (P>0.05). The ST value of the PNI + EA group and the PNI group decreased gradually from 2 to 8 weeks after the experiment. At the 8th week, the ST value of the PNI + EA group was significantly lower than that of the PNI group (P<0.05). The TST value of PNI + EA group decreased gradually at the 2nd to 6th week, and the TST value of the PNI + EA group was significantly lower than that of the PNI group at the 4th to 8th week (P<0.05). The NCF values of the PNI group and the PNI + EA group were lower than those of the control group at 8 weeks of experiment, while those of the PNI + EA group were higher than those of the PNI group (P<0.05).【Conclusion】Short-term EA may have no significant effect on the regeneration of injured peripheral nerves in rats. Long-term sustained stimulation can promote nerve regeneration and functional recovery.
胡春鹤, 金驰, 徐屹, 张晓, 张栋栋, 杨庆健. 长期电针刺激对大鼠周围神经吻合术后感觉及运动功能恢复的影响[J]. 医学临床研究, 2019, 36(5): 846-848.
HU Chun-he, JIN Chi, XU Yi, et al. Effect of Long-term Electroacupuncture Stimulation on the Recovery of Sensory and Motor Function after Peripheral Nerve Anastomosis in Rats. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 846-848.
[1] Chu H, Seo J, Kim C,et al. Electroacupuncture for migraine protocol for a systematic review of controlled trials[J].Medicine,2018, 97(17): e9999. [2] Jung YS, Lee SW, Park JH, et al. Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke[J].J Biomed Sci,2016, 23(1): 1-11. [3] Kim HN, Pak ME, Shin MJ, et al. Comparative analysis of the beneficial effects of treadmill training and electroacupuncture in a rat model of neonatal hypoxia-ischemia[J].Int J Mol Med,2017, 39(6): 1393-1402. [4] Nakahara H, Kawada T, Ueda SY, et al. Electroacupuncture most effectively elicits depressor and bradycardic responses at 1 Hz in humans[J].Clin Auton Res,2016, 26(1): 59-66. [5] Pak ME, Da HJ, Hong JL, et al. Combined therapy involving electroacupuncture and treadmill exercise attenuates demyelination in the corpus callosum by stimulating oligodendrogenesis in a rat model of neonatal hypoxia-ischemia[J].Exp Neurol,2017, 300: 222-231. [6] Penson DF. Re: Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical trial[J].J Urol,2017, 199(1): 35-36. [7] Salazar TE, Richardson MR, Beli E, et al. Electroacupuncture promotes cns-dependent release of mesenchymal stem cells[J].Stem Cells,2017, 35(5): 1303-1315. [8] 李振鹏, 孔抗美, 邹延澄,等. 生长相关蛋白在电针治疗大鼠脊髓损伤中的表达及意义[J].医学临床研究, 2011, 28(12): 2237-2239.
2019, Vol. 36 
