Abstract：【Objective】 To study the expression and clinical significance of Cys-c (cystatin C), β2-MG (β2-microglobulin) and RBP (retinol binding protein) in patients with type 2 diabetic nephropathy. 【Methods】Eighty-one patients with type 2 diabetic nephropathy were enrolled in this study. According to urinary albumin excretion rate (UAER), patients were divided into group A (30 cases), group B (24 cases) and group C (27 cases). In the same period, 26 healthy volunteers were enrolled as the control group. The levels of Cys-c, β2-microglobulin and RBP in the four groups of patients were recorded. ROC curve was used to analyze the sensitivity and specificity of serum Cys-c, β2-MG and RBP content in the diagnosis of type 2 diabetic nephropathy . 【Results】 The levels of Cys-c, β2-MG and RBP in the control group were not significantly different from those in group A (P>0.05). The levels of Cys-c, β2-MG and RBP in the control group and group A were significantly lower than those in group B and group C (P<0.05). The levels of Cys-c, β2-MG and RBP in group B were significantly lower than those of group C (P<0.05). 【Conclusion】 Cys-c, β2-microglobulin and RBP play an important role in the clinical diagnosis, treatment and disease monitoring of patients with type 2 diabetic nephropathy, all of which have high sensitivity and specificity.
刘蓉芝, 冉恩容. Cys-C、β2-微球蛋白和RBP在2型糖尿病肾病患者中的表达及意义[J]. 医学临床研究, 2019, 36(5): 903-905.
LIU Rong-zhi, RAN En-rong. Expression and Clinical Significance of Cys-c, β2-microglobulin and RBP in Patients with Type 2 Diabetic Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2019, 36(5): 903-905.
2019, Vol. 36 
