Abstract：【Objective】To analyze the drug resistance of Smear-positive tuberculosis patients aged 15~24 years in this area. 【Methods】The clinical data of 250 smear-positive pulmonary tuberculosis patients registered in Foshan tuberculosis control project from January 2017 to June 2018 were selected. 246 strains of Mycobacterium tuberculosis (MTB) were isolated by using the proportions recommended by WHO and the International Federation of Tuberculosis and Pulmonary Diseases to determine drug susceptibility tests of first and second-line anti-tuberculosis such as streptomycin (SM), isoniazid (INH), rifampicin (RFP), ethambutol (EMB) and ofloxacin (OFX). amikacin (AM), capreomycin (CM), isonicotinamide propionate (PTO) and aminosalicylic acid (PAS).【Results】Among 246 strains of Mtb,there were 51 strains (20.73%) with total drug resistance, 34 strains (13.82%) with single drug resistance, 12 strains (4.88%) with multi-drug resistance, 4 strains (1.63%) with multi-drug resistance and 1 strain (0.41%) with extensive drug resistance. The total drug resistance rate of male was 19.61%(30/154), which was lower than that of female 22.58% (21/93), but there was no significant difference between male and female (χ2<0.31,P>0.05). The total drug resistance rates were 19.44% (7/36) in Sanshui District, 18.18% (14/77) in Nanhai District, 24.53% (26/106) in Chancheng District and 14.81% (4/27) in Gaoming District, respectively. There was no significant difference among regions (χ2 ≤ 0.63,P>0.05).【Conclusion】The epidemic trend of drug resistance among Smear positive pulmonary tuberculosis patients aged 15~24 in Foshan City is not optimistic. It is necessary to strengthen the control of key links and reduce drug resistance.
2019, Vol. 36 
