Abstract：【Objective】To investigate the changes and significance of serum neutrophil gelatinase-associated lipid carrier protein (NGAL) in patients with diabetic nephropathy (DN). 【Methods】 Fourty healthy volunteers were selected as group A, 40 patients with type 2 diabetes mellitus (group B), 40 patients with diabetes mellitus and microalbuminuria (group C, urinary albumin/creatinine 30-300 mg/g), 40 patients with diabetic albuminuria (group D, urinary albumin/creatinine greater than 300 mg/g). NGAL, serum creatinine (SCr), urea nitrogen (BUN) and urinary microalbumin (UmALB) levels were measured and compared among the four groups.【Results】The levels of NGAL and UmALB in the group C and D were significantly higher than those in the group A and the group B (P<0.05), and the levels of NGAL, SCr, BUN and UmALB in the group D were significantly higher than those in the group A, group B and group C (P<0.05). NGAL was positively correlated with SCr, BUN and UmALB in DN patients (P<0.05). The critical value of NGAL in diagnosing DN was 80.04 ng/mL, the sensitivity was 85.29%, the specificity was 76.04%, the missed diagnosis rate was 14.71%, the misdiagnosis rate was 23.96%, and the AUC value under ROC curve was 0.807.【Conclusion】The level of NGAL increased in the early stage of DN patients, and it has a certain correlation with the degree of renal function damage. Early detection of NGAL has a certain value in the differential diagnosis of DN.
张建林, 林见敏. 糖尿病肾病患者尿NGAL水平变化及其临床意义[J]. 医学临床研究, 2019, 36(3): 507-509.
ZHANG Jian-lin, LIN Jian-min. Changes of Urinary NGAL Levels in Patients with Diabetic Nephropathy and its Clinical Significance. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 507-509.
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2019, Vol. 36 
