Abstract：【Objective】 To investigate the expressions of UHRF-1 (ubiquitin-like PHD with ring finger domain-1) and DNMT-1 (DNA methyltransferase-1) in gastric cancer and its relationship with clinicopathological features. 【Methods】A total of 75 gastric cancer patients treated in our hospital were selected as the research subjects. The lesion tissues and para-cancerous tissues were collected. The mRNA expressions of UHRF-1, DNMT-1 were detected by RT-PCR and immunohistochemistry, and the relationship between expression and the clinicopathological characteristics were analyzed. 【Results】The protein positive rates of UHRF-1, DNMT-1 in gastric cancer tissues were 84% (63/75) and 70.7% (53/75), respectively, which were significantly higher than those in the para-cancerous tissues 45% (34/75) and 20% (18/75), respectively (P<0.05). The mRNA expression levels of UHRF-1, DNMT-1 in gastric cancer tissues were significantly higher than those of para-cancerous tissues (P<0.05). The protein positive rates of UHRF-1 and DNMT-1 in gastric cancer tissues with tumor size (≥3 cm), moderately or poorly differentiated carcinomas, serosal invasion, stage Ⅲ+Ⅳ and lymphatic metastasis were higher than that of tumors <3 cm, well-differentiated carcinomas, none serosal infiltration, stage Ⅰ+Ⅱ, and no lymphatic metastasis. The difference was significant (P<0.05).【Conclusion】The expressions of UHRF-1and DNMT-1 in the lesion tissues of gastric cancer patients are significantly increased, and they are closely related to the clinicopathological features of patients with gastric cancer.
肖琴容, 朱卫芳, 笪荣峰, 余新堂. 泛素样含PHD和环指域-1和DNA甲基转移酶-1在胃癌组织中的表达及其临床意义[J]. 医学临床研究, 2021, 38(11): 1687-1689.
XIAO Qin-rong, ZHU Wei-fang, DA Rong-feng, et al. Expressions and Significance of UHRF-1 and DNMT-1 in Tissues of Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1687-1689.
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2021, Vol. 38 
