Abstract：【Objective】To observe the plasma levels of neuropeptide Y (NPY) and substance P (SP) in parturients and analyze the risk factors associated with postpartum anxiety. 【Methods】A total of 136 cases of puerpera delivered in our hospital from August 2018 to August 2020 were selected as the research objects. General data of puerpera were collected, including age, body mass index, whether primipara, education level, history of adverse pregnancy, stage of labor, gender of newborn, monthly family income, mode of delivery, Pittsburgh sleep quality index (PSQI), self-efficacy and NPY, SP. State Anxiety Scale (S-AI) was used to evaluate the anxiety of puerpera. According to the existence of anxiety, parturients were divided into the anxiety group and non-anxiety group. The independent influencing factors of postpartum anxiety were analyzed. 【Results】 Of the 136 parturients, 30 cases (22.06%) had anxiety after childbirth and 106 cases (77.94%) had no anxiety after childbirth. The proportion of patients with adverse pregnancy history, family monthly income < 3000 yuan, mode of delivery, PSQI score ≤ 7 and plasma SP level in the anxiety group were significantly higher than those in the non-anxiety group (P<0.05); and the plasma NPY level in the anxiety group was significantly lower than that in that in the non-anxiety group (P<0.05). ROC curve showed that plasma NPY and SP had certain predictive value for postpartum anxiety whose area under the curve was 0.810 and 0.758, respectively. The best cutoff value of plasma NPY level in predicting postpartum anxiety was 6.41 μ g/ml, with sensitivity of 0.821 and specificity of 0.798; The best cutoff value of plasma SP level in predicting postpartum anxiety was 6.72 μ g/ml, with sensitivity of 0.786 and specificity of 0.757. Multivariate logistic regression analysis showed that history of adverse pregnancy, monthly family income, mode of delivery, PSQI score, NPY and SP were the risk factors for postpartum distress (P<0.05). 【Conclusion】Plasma NPY and SP levels are related to the occurrence of postpartum anxiety, which can be used as auxiliary indicators to predict postpartum anxiety.
买苗, 姬超, 段元丽. NPY、SP在产后焦虑患者血浆中的表达及其临床意义[J]. 医学临床研究, 2021, 38(11): 1683-1686.
MAI Miao, JI Chao, DUAN Yuan-li. Expression and Clinical Significance of Plasma NPY and SP Levels in Patients with Postpartum Anxiety. JOURNAL OF CLINICAL RESEARCH, 2021, 38(11): 1683-1686.
2021, Vol. 38 
