Abstract：【Objective】To investigate wingless integrin(Wnt10B) and β Catenin( β- Expression of catenin) in cervical squamous cell carcinoma and its clinical significance.【Methods】Immunohistochemistry was used to detect the expression of Wnt10B and β-catenin protein in 19 cases of normal cervix, 27 cases of cervical precancerous lesions and 50 cases of cervical squamous cell carcinoma,the positive expression of the three terms were compared and the correlation of Wnt10B and β-catenin with clinicopathological features were analyzed. 【Results】The positive expression rate of Wnt10B was 36.84%(7/19) in normal cervical tissue, 66.67%(18/27) in CIN tissues, and 94.00%(47/50) in cervical squamous cell carcinoma, the difference was statistically significant(χ2=25.381, P<0.05). The positive expression rate of β-catenin was 52.63%(10/19) in normal cervical tissues, 74.07%(20/27) in CIN tissues, and 90.00%(45/50) in cervical squamous cell carcinoma tissues, and the difference was statistically significant(χ2=11.611, P<0.05). The positive expression of Wnt10B and β-catenin were significantly correlated with the depth of invasion, stage and differentiation of cervical squamous cell carcinoma. 【Conclusion】The expression of Wnt10B and β-catenin in cervical lesions increased gradually with the progression of lesions, and the expression of both was positively correlated, suggesting that both are involved in the occurrence and progression of tumors.
[1] 魏长慧,朱继存,牛媛娜,等.2004-2016年中国女性生殖系统恶性肿瘤死亡趋势分析[J].中华疾病控制杂志,2019,23(5):506-511. [2] 刘萍. 中国大陆13年宫颈癌临床流行病学大数据评价[J].中国实用妇科与产科杂志, 2018,34(1):41-45. [3] 王宇,宋淑芳,刘凤.我国宫颈癌流行病学特征和发病高危因素的研究进展[J].中国妇幼保健,2019,34(5):1207-1209. [4] YOSHIKAWA H, MATSUBARA K, ZHOU X.WNT10B functional dualism:beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer[J].Mol Biol Cell,2007,18(11):4292-4303. [5] WU X D, BIE Q L, ZHANG B, et al. Wnt10B is critical for the progression of gastric cancer[J] .Oncol Lett,2017,13(6):4231-4237. [6] SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics, 2018[J].CA Cancer J Clin,2018,68(4):284-296. [7] CLEVERS H,NUSE R.Wnt/beta-catenin signaling and disease[J].Cell,2012,149(6):1192-1205. [8] 董碧莹,陈毅斌,林陈胜.分泌型卷曲相关蛋白家族在Wnt信号通路中的双向调节作用[J].中国生物化学与分子生物学报,2020,36(3):281-288. [9] TYAGI A M, YU M, DARBY T M,et al. The Microbial metabolite butyrate stimulates bone formation via the regulatory cell-mediated regulation of WNT10B expression[J].Immunity,2018 ,49(6):1116-1131. [10] EL AYACHI I, FATIMA I, WEND P.The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer[J].Cancer Res,2019,79(5):982-993. [11] MADUEKE I, HU W Y, HU D,et al. The role of WNT10B in normal prostate gland development and prostate cancer[J].Prostate,2019 ,79(14):1692-1704. [12] WEND P, RUNKE S, WEND K,et al.WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer[J].EMBO Mol Med,2013 ,5(2):264-279. [13] 白红松,刘晓琪,寿建,等. β-catenin在恶性间叶源性肿瘤中的研究进展[J].癌症进展, 2019,17(6):636-638.
2021, Vol. 38 
