高血压合并房颤患者血清AngⅡ、ALD、hs-CRP及RDW的变化及其意义

doi:10.3969/j.issn.1671-7171.2020.10.023

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摘要 【目的】 探讨原发性高血压合并房颤患者血清血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、血清超敏C反应蛋白(hs-CRP)、红细胞分布宽度(RDW)的变化与患者病情的相关性。【方法】 选择本院收治的90例单纯原发性高血压患者(对照组)、原发性高血压合并房颤患者140例作为观察组。检测两组患者血清AngⅡ、ALD、hs-CRP、RDW水平,并比较两组患者左心房内径(LAD)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)。【结果】 观察组患者AngⅡ、ALD、hs-CRP、RDW水平和LAD值均显著高于对照组,差异有统计学意义(P<0.05);两组患者的LVESD、LVEDD比较,差异无统计学意义(P>0.05)。持续性房颤患者AngⅡ、ALD、hs-CRP、RDW水平均显著高于阵发性房颤患者,差异有统计学意义(P<0.05)。房颤患者AngⅡ、ALD与LAD呈正相关(P<0.05);房颤患者hs-CRP、RDW水平与LAD无显著相关性(P>0.05)。【结论】 高血压合并房颤患者血清AngⅡ、ALD、hs-CRP及RDW显著高于较单纯的高血压患者,同时血清AngⅡ、ALD与左心房重塑具有相关性。

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	邹金国
	邴森
	陈小强
	陈霞

关键词 ：高血压/并发症, 心房颤动/并发症, 血管紧张素Ⅱ/血液, C反应蛋白质/血液

Abstract：【Objective】 To investigate the correlation between the changes of serum angiotensin Ⅱ (Ang Ⅱ), aldosterone (ALD), high sensitivity C-reactive protein (hs CRP) and red blood cell distribution width (RDW) in patients with essential hypertension complicated with atrial fibrillation. 【Methods】 Nighty cases of patients with simple primary hypertension (control group) and 140 cases of patients with essential hypertension combined with atrial fibrillation were selected as the observation group. The serum levels of Ang Ⅱ, ALD, hs CRP and RDW were detected, and the left atrial diameter (LAD), left ventricular end systolic diameter (LVESD) and left ventricular end diastolic diameter (LVEDd) were compared between the two groups.【Results】 The levels of AngⅡ, ALD, hs-CRP, RDW and LAD in the observation group were significantly higher than those in the control group (P<0.05); there was no significant difference in LVESD and LVEDd between the two groups (P>0.05). The levels of AngⅡ, ALD, hs-CRP and RDW in patients with persistent atrial fibrillation were significantly higher than those in patients with paroxysmal atrial fibrillation (P<0.05). AngⅡand ALD were positively correlated with LAD (P<0.05), while hs-CRP and RDW levels were not significantly correlated with LAD (P>0.05). 【Conclusion】 The serum levels of AngⅡ, ALD, hs-CRP and RDW in patients with hypertension complicated with atrial fibrillation were significantly higher than those in patients with simple hypertension.

Key words： Hypertension/CO Atrial Fibrillation/CO Angiotensin Ⅱ/BL C-Reactive Protein /BL

收稿日期: 2019-04-04

PACS:

R544.1

引用本文:

邹金国, 邴森, 陈小强, 陈霞. 高血压合并房颤患者血清AngⅡ、ALD、hs-CRP及RDW的变化及其意义[J]. 医学临床研究, 2020, 37(10): 1517-1519.
ZOU Jin-Guo, BING Sen, CHEN Xiao-qiang, et al. Changes and Significance of Serum AngⅡ, ALD, hs-CRP and RDW in Patients with Hypertension Complicated with Atrial Fibrillation. JOURNAL OF CLINICAL RESEARCH, 2020, 37(10): 1517-1519.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2020.10.023 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2020/V37/I10/1517