血清同型半胱氨酸水平与H型高血压合并2型糖尿病患者颈动脉内膜中层厚度的相关性分析

doi:10.3969/j.issn.1671-7171.2019.06.027

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摘要 【目的】探讨同型半胱氨酸(Hcy)水平与H型高血压合并2型糖尿病(T2DM)患者颈动脉内膜中层厚度(IMT)的相关性。【方法】选取本院收治的82例H型高血压合并T2DM患者为研究对象。根据IMT数值的大小,将患者分为IMT正常组(n=28,IMT＜0.9 mm)、IMT增厚组(n=30,0.9 mm≤IMT＜1.3 mm)、颈动脉斑块组(n=24,IMT≥1.3 mm)。比较三组患者体质量指数(BMI)、血压、血糖、血脂、血清 Hcy、血尿酸( UA) 、糖化血红蛋白(HbA1C)、血肌酐(SCr)、IMT水平,分析血清 Hcy、HbA1C、血压与颈动脉IMT的关系。【结果】三组患者血清Hcy、HbA1C水平及IMT、收缩压(SBP)、舒张压(DBP)水平组间比较,差异有统计学意义(P<0.05)。颈动脉斑块组患者血清Hcy、HbA1C水平及IMT、SBP、DBP水平明显高于IMT增厚组,IMT增厚组明显高于IMT正常组,差异有统计学意义(均P＜0.05)。Pearson相关性分析显示,IMT与Hcy、HbA1C、SBP、DBP均呈正相关(均P<0.05)。Logistic回归分析显示,IMT增厚的独立危险因素是Hcy、HbA1C、SBP。【结论】H型高血压合并T2DM患者血清Hcy、HbA1C水平及SBP与IMT具有明显相关性,是IMT增厚的独立危险因素。

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	朱凌峰

关键词 ：高血压/并发症, 糖尿病, 2型/并发症, 半胱氨酸, 颈动脉/超声检查

Abstract：【Objective】To investigate the Correlation between homocysteine level and carotid intima-media thickness in patients with type 2 diabetes mellitus complicated with H-type hypertension. 【Methods】There were 82 patients with type 2 diabetes mellitus complicated with H-type hypertension treated in our hospital from January to February 2019 were enrolled. According to the value of carotid intima-media thickness (IMT), patients were divided into IMT normal group (28 cases), IMT thickening group (30 cases) and carotid plaque group (24 cases). Detecting and comparing the body mass index (BMI), blood pressure, blood glucose, blood lipids, serum Hcy, blood uric acid (UA), glycosylated hemoglobin (HbA1C), serum creatinine (Scr), IMT levels among the three groups. The relationship between serum Hcy, HbA1C, blood pressure and carotid IMT was analyzed. 【Results】There were significant differences in serum Hcy, HbA1, IMT, systolic blood pressure and diastolic blood pressure between the three groups (P<0.05). The levels of serum Hcy, HbA1, IMT, systolic blood pressure and diastolic blood pressure in the carotid plaque group were significantly higher than those in the IMT thickening group. The serum levels of Hcy, HbA1, IMT, systolic blood pressure and diastolic blood pressure were significantly higher in the IMT thickening group than that in the normal IMT Group (P<0.05). Pearson correlation analysis showed that IMT was positively correlated with Hcy, HbA1C, systolic blood pressure and diastolic blood pressure (P<0.05). Using IMT as the test variable, Hcy, HbA1C, systolic blood pressure and diastolic blood pressure were used as independent variables to carry out two-class logistic regression analysis. The results showed that independent risk factors for IMT thickening were Hcy and systolic blood pressure. 【Conclusion】 The levels of serum Hcy, HbA1C and systolic blood pressure in patients with type 2 diabetes mellitus complicated with H-type hypertension are significantly correlated with IMT, which is an independent risk factor for IMT thickening.

Key words： Hypertension/CO Diabetes Mellitus, Type 2/CO Homocysteine Carotid Arteries

收稿日期: 2019-03-11

PACS:

R544.1

引用本文:

朱凌峰. 血清同型半胱氨酸水平与H型高血压合并2型糖尿病患者颈动脉内膜中层厚度的相关性分析[J]. 医学临床研究, 2019, 36(6): 1120-1122.
ZHU Ling-feng. Correlation Between Homocysteine Level and Carotid Intima-media Thickness in Patients with Type 2 Diabetes Mellitus Complicated with H-type Hypertension. JOURNAL OF CLINICAL RESEARCH, 2019, 36(6): 1120-1122.

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http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.06.027 或 http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I6/1120