Abstract：【Objective】 To investigate the clinical efficacy and safety of metoprolol combined with eplidone in the treatment of hypertensive heart failure. 【Methods】 A total of 104 patients with hypertensive heart failure who were treated in our hospital were enrolled in the study. The patients were divided into two groups,control group (n=52) and observation group (n=52). View Blood pressure, amino terminal brain natriuretic peptide precursor (NT-proBNP), 6min walking test distance (6MWT), cardiac function index, clinical efficacy and adverse reaction rate were observed before and after treatment in two groups. 【Results】 The total effective rate of the observation group was 92.31% (48/52), significantly higher than that of the control group 67.31% (35/52), the difference was statistically significant (P<0.05). After treatment, SBP, DBP and NT-proBNP in plasma of the two groups were lower than before treatment, and 6MWT was higher than before treatment. SBP, DBP and NT-proBNP, 6MWT in plasma of the observation group were significantly improved compared with the control group (P<0.05). After treatment, LVEDd and LVESD of the two groups were lower than before treatment, LVEF was higher than before treatment, NYHA classification was better than before treatment, and the heart function index and NYHA classification of the observation group were better than that of the control group, the difference was statistically significant (P>0.05). During the treatment of the two groups, the incidence of adverse reactions such as nausea and vomiting, slow heart rate, dizziness, rash, hyperkalemia, joint pain were compared, and the difference was not statistically significant (11.54% vs 9.62%,P>0.05).【Conclusion】 Metoprolol combined with eplidone has a good clinical effect in the treatment of hypertension combined with heart failure. It can significantly reduce the blood pressure of patients, improve the heart function of patients, and has a high safety. It is worth clinical application.
周琳. 美托洛尔联合依普利酮治疗高血压合并心衰52例疗效观察[J]. 医学临床研究, 2020, 37(5): 718-720.
ZHOU Lin. Metoprolol Combined with Eplidone in the Treatment of 52 Cases of Hypertension with Heart Failure. JOURNAL OF CLINICAL RESEARCH, 2020, 37(5): 718-720.
2020, Vol. 37 
