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医学临床研究  2019, Vol. 36 Issue (3): 495-497    DOI: 10.3969/j.issn.1671-7171.2019.03.027
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高血压合并T2DM患者动态脉压指数与血流介导的内皮依赖性血管舒张功能的相关性分析
徐东1, 吴琦楠2
1.重庆市沙坪坝区陈家桥医院内分泌科,重庆 401331;
2.重庆市肿瘤医院内分泌肾内科,重庆 400030
Correlation between Ambulatory Pulse Pressure Index and Flow-mediated Dilation in Patients with Type 2 Diabetes Mellitus and Hypertension
XU Dong, WU Qi-nan
Department of Endocrinology, Chenjiaqiao Hospital of Shapingba District, Chongqing Sichuan 401331
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摘要 【目的】探讨2型糖尿病(T2DM)合并高血压患者动态脉压指数(APPI)与血流介导的内皮依赖性血管舒张功能(FMD)的相关性。【方法】选取2018年1~10月在本院诊治的单纯原发性高血压患者30例(高血压组)、原发性高血压合并T2DM患者30例(糖尿病合并组),另外选取本院健康体检者的30例(对照组)。比较各组患者的血压、APPI和FMD,采用Pearson软件分析FMD与血压、APPI的相关性。【结果】糖尿病合并组、高血压组SBP、DBP显著高于对照组;糖尿病合并组24hSBP、APPI、24h DBP显著高于高血压组和对照组,且高血压组24hSBP、APPI显著高于对照组。糖尿病合并组基础状态下的血管内径、反应性充血后或含服硝酸甘油后的血管最大内径显著高于高血压组和对照组;糖尿病合并组FMD显著低于高血压组和对照组,且高血压组显著低于对照组。FMD与24h SBP、APPI均呈显著负相关(P<0.05)。【结论】T2DM合并高血压患者的APPI显著升高,FMD显著降低,且两者呈显著负相关。
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徐东
吴琦楠
关键词 高血压/并发症糖尿病2型/病理生理学    
Abstract:【Objective】To investigate the correlation between ambulatory pulse pressure index (APPI) and flow-mediated endothelium-dependent vasodilation(FMD)in patients with type 2 diabetes mellitus (T2DM) complicated with hypertension. 【Methods】Thirty patients with primary hypertension and 30 patients with primary hypertension and type 2 diabetes from January 2018 to October 2018 were enrolled for the study as hypertension group and hypertension combined with diabetes mellitus group, respectively. Further, 30 healthy adult volunteer who received physical examination in our hospital were selected as the control group. The results of blood pressure and FMD were compared among three groups, and Pearson correlation coefficient was performed to analyze the correlation of APPI and FMD. 【Results】 There were significant differences in SBP, DBP, 24h SBP, 24h DBP and APPI among three groups (P<0.05). The SBP and DBP in the hypertension combined with diabetes mellitus group and the hypertension group were significantly higher than those in the control group. The 24h SBP, 24h DBP and APPI in the hypertension combined with diabetes mellitus group were significantly higher than those in the hypertension group and the control group. The 24h DBP: and APPI in the hypertension group were significantly higher than those in the control group. There were significant differences in basic vascular diameter, maximum diameter after reactive congestion or nitroglycerin administration, and FMD among the three groups (P<0.05). The diameter of the vessel under the basal state and the maximum diameter of the blood vessel after reactive hyperemia or nitroglycerin in the hypertension combined with diabetes mellitus group were significantly higher than those in the hypertension group and the control group. The FMD in the hypertension combined with diabetes mellitus group was significantly lower than that of the hypertension group and the control group, and FMD in the hypertension group was significantly lower than that in the control group. FMD was negatively correlated with 24h SBP and APPI in all subjects (P<0.05). 【Conclusion】The APPI of T2DM patients with hypertension was significantly increased and FMD significantly decreased. There was a significant negative correlation between APPI and FMD.
Key wordsHypertension/CO    Diabetes Mellitus    Type 2/PP
收稿日期: 2019-01-15     
PACS:  R544.1  
基金资助:重庆沙坪坝区科卫联合医学科研项目(2018SQKWLH005);重庆医药高等专科学校科研项目(ygz2018116)
引用本文:   
徐东, 吴琦楠. 高血压合并T2DM患者动态脉压指数与血流介导的内皮依赖性血管舒张功能的相关性分析[J]. 医学临床研究, 2019, 36(3): 495-497.
XU Dong, WU Qi-nan. Correlation between Ambulatory Pulse Pressure Index and Flow-mediated Dilation in Patients with Type 2 Diabetes Mellitus and Hypertension. JOURNAL OF CLINICAL RESEARCH, 2019, 36(3): 495-497.
链接本文:  
http://journal07.magtech.org.cn/yxlcyj/CN/10.3969/j.issn.1671-7171.2019.03.027     或     http://journal07.magtech.org.cn/yxlcyj/CN/Y2019/V36/I3/495
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