Abstract：【Objective】 To investigate the changes and significance of serum cystatin C, high-sensitivity C-reactive protein (hs-CRP) and endothelin-1 (ET-1) in patients with coronary artery slow flow phenomenon (CSFP). 【Methods】 From January 2016 to December 2019, 88 CSFP patients with coronary heart disease confirmed by coronary angiography (observation group) were selected, and 90 patients with normal coronary blood flow and no obvious coronary stenosis were selected as control group. The coronary flow frame number, coronary microcirculation resistance index, serum Cys-C, hs CRP and ET-1 levels were compared between the two groups, and the correlation between serum Cys-C, hs CRP, ET-1 and coronary microcirculation resistance index was analyzed. 【Results】 The left anterior descending artery, right coronary artery, left circumflex artery and overall mean coronary blood flow frame number in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05).The left anterior descending artery, right coronary artery, left circumflex artery and the total microcirculation resistance index of the observation group were higher than those of the control group, the difference was statistically significant (P<0.05).The levels of Cys-C, hs CRP and ET-1 in the observation group were higher than those in the control group (P<0.05). The levels of serum Cys-C, hs CRP and ET-1 in the observation group were significantly positively correlated with coronary microcirculation resistance index (P<0.05).【Conclusion】 The levels of serum Cys-C, hs CRP and ET-1 in CSFP patients are significantly increased, and they are significantly correlated with the increase of coronary microcirculation resistance index.
2020, Vol. 37 
