Abstract：【Objective】 To investigate the correlation between the changes of granulocyte level and chlorpromazine equivalent in patients with first-episode mental illness and schizophrenia.【Methods】 Prospective selection of patients with first-episode psychosis and schizophrenia admitted to our hospital from May 2017 to February 2020 as the research object, and the same period of adult healthy volunteers as the control group (n=62).The levels of neutrophils at admitment (T0) and 6 weeks after therapy (T6) were recorded, and the positive and negative symptom scale (PANSS) was used to evaluate the mental symptoms. The cumulative chlorpromazine equivalent was calculated according to the dose conversion standard, and the correlation between granulocyte level and clinical symptoms, chlorpromazine equivalent was analyzed.【Results】 At T0 , compared with the control group, the levels of neutrophils and CRP in patients with mental illness (FEP group + SCHIZ group) were increased, while the levels of eosinophils were decreased, and the differences were statistically significant (P<0.05). At T6, BMI, neutrophils, eosinophils, monocytes and CRP levels in patients with mental illness (FEP + SCHIZ group) were higher than those in the control group (P<0.05). Compared with T0, at T6 , the BMI and eosinophil levels of the two groups were increased, and the PANSS score, neutrophil, monocyte and CRP levels were decreased, the differences were statistically significant (P<0.05). Pearson correlation analysis showed that PANSS score of patients with mental illness (FEP + schiz group) was positively correlated with neutrophil and serum CRP level (P<0.05), and negatively correlated with eosinophil level (P<0.05); serum CRP level of patients with FEP was positively correlated with PANSS score (P<0.05). Pearson correlation analysis also showed that chlorpromazine equivalent was negatively correlated with neutrophil level in FEP patients (r=-0.284,P=0.001), positively correlated with eosinophils (r=0.211, 0.011), and no other correlation (P>0.05).【Conclusion】 The occurrence of mental illness and schizophrenia may be related to the changes of innate immune system. A certain amount of chlorpromazine can improve the clinical symptoms of FEP and SCHIZ patients, and monitoring the levels of neutrophils, eosinophils and serum CRP can provide reference for judging the degree of the disease.
于艳红, 王欣, 张军, 魏巍, 齐宏顺. 首发精神疾病和精神分裂症患者粒细胞水平变化及其与氯丙嗪当量的相关性分析[J]. 医学临床研究, 2021, 38(2): 209-212.
YU Yan-hong, WANG Xin, ZHANG Jun, et al. Granulocyte Expression and its Correlation with Chlorpromazine Equivalent in First Episode Mental Illness and Schizophrenia. JOURNAL OF CLINICAL RESEARCH, 2021, 38(2): 209-212.
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2021, Vol. 38 
