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Quick Search     Adv Search 2022 Vol. 39, No. 4 Published: 2022-04-26 Original Articles          Original Articles 481 Analysis of Related Risk Factors of Intracranial Infection after Class Ⅰ Incision Craniotomy ZHANG Shi-yuan, SHI Hai-ping, ZENG Chun, et al DOI: 10.3969/j.issn.1671-7171.2022.04.001 【Objective】To explore the risk factors of intracranial infection after neurosurgical class Ⅰ incision craniotomy. 【Methods】 The clinical data of 725 patients who underwent class Ⅰ incision craniotomy in our hospital from January 2018 to December 2019 were analyzed retrospectively. The possible risk factors were analyzed by univariate analysis and multivariate logistic regression analysis. 【Results】Intracranial infection occurred in 63 of 725 patients (8.69%). Univariate analysis showed that age >50 years, BMI >27 kg/m2, operation time >4 h, diabetes history, emergency operation, open lateral ventricle, preoperative prophylactic use of antibiotics, drainage tube, postoperative cerebrospinal fluid leakage, and intraoperative microscopy were associated risk factors for intracranial infection after operation (P<0.05). Multivariate Logistic regression analysis showed that age, history of diabetes, preoperative antibiotic use, cerebrospinal fluid leakage, and drainage tube were independent risk factors for intracranial infection after operation (P<0.05). 【Conclusion】Age, history of diabetes, preventive use of antibiotics, indwelling drainage tube and cerebrospinal fluid leakage are risk factors for intracranial infection after craniotomy. Clinical preventive measures should be taken to intervene early in these risk factors, so as to reduce the incidence of intracranial infection after operation. 2022 Vol. 39 (4): 481-483 [Abstract] ( 69 ) HTML (1 KB)  PDF (1154 KB)  ( 54 ) 484 Expression and Significance of MMP-3、CD10 and Ki-67 in Triple-negative Breast Carcinoma YU Jing, LIANG Li-ping, XU Bao-qun, et al DOI: 10.3969/j.issn.1671-7171.2022.04.002 【Objective】To detect the expression and clinical significance of matrix metalloproteinase(MMP-3)、commonacute lymphoblastic leukemia antigen(CD10) and cell proliferation antigen Ki-67 in Triple-negative breast cancer(TNBC).【Methods】The manifestations of MMP-3、CD10 and Ki-67 were detected in 55 cases of TNBC,136 cases of Non-triple-negative breast cancer(N-TNBC) and 42 cases benign epithelial lesions of the breast by immunohistochemistry method.【Results】The overexpression rates of MMP-3、CD10 and Ki-67 protein in TNBC were 50.9％、45.5％and 56.4％,respectively, which were significantly higher than in N-TNBC(19.9%、21.3%、27.9%) and non-tumor tissues(9.5%、7.1%、0).The differences were statistically significant(P<0.05).The expression of MMP-3 was positively correlated with that of CD10 and Ki-67in TNBC(rs=0.312,P=0.020;rs=0.310,P=0.021,P<0.05). The positive rates of MMP-3、CD10 and Ki-67 overexpression were strongly associated with histological type of breast carcinoma, lymph node involvement and pN grades in TNBC (P<0.05).【Conclusion】High levels of MMP-3、CD10 and Ki-67 expression are significant in TNBC,which maybe play an importan trole in invasive event.Detection of the three markers together may contribute to the judgment of the grade of malignancy, the ability of tumor infiltration and the potency of metastasis.MMP-3、CD10 and Ki-67 proteins are closely associated with TNBC progression and subtypes,which may be a new potential prognostic biomarkers and therapeutic targets for TNBC. 2022 Vol. 39 (4): 484-487 [Abstract] ( 62 ) HTML (1 KB)  PDF (1582 KB)  ( 45 ) 488 Comparative Analysis of Allergen Detection Results of Allergic Rhinitis (AR) and AR Patients with AIDS in Changsha Area SHEN Li-li, ZHANG Jun-jie, LI Yin DOI: 10.3969/j.issn.1671-7171.2022.04.003 【Objective】To investigate the expression level and significance of serum CD4+T lymphocytes and specific IgE (sIgE) in patients with allergic rhinitis (AR) and acquiredimmunodeficiency syndrome (AIDS).【Methods】 A total of 132 cases were divided into the simple AR group (group A) and AR with AIDS group (group B) according to the diagnosis.The sIgE positive level, distribution difference, degree of sensitization, type of sensitization and the CD4+T lymphocyte count of 18 common allergens in the two groups were compared.【Results】Common inhaled allergens in group A and B were mixed grass, tree pollen, house dust mite, dust mite and mold combination. The common ingestion allergens in the two groups were shrimp, crab , beef and mutton.The positive detection rate and dust mite sensitization intensity of mixed grass in group A were higher than those in group B, and the difference between the two groups was statistically significant (P<0.05).The positive detection rate of nut combination in group B was higher than that in group A, and the difference between the two groups was statistically significant (P<0.05).There was no significant difference in the positive rate of serum sIgE between the two groups (P>0.05).There was statistically significant difference in the number of allergen positive species between the two groups (P<0.05), and the number of allergen positive species in both groups was ≥4. There was statistical significance in the positive rate of sIgE in group B with different CD4+T lymphocyte count levels in the AR and AIDS group (P<0.05).【Conclusion】 The positive level, distribution differences and sensitization degrees of serum allergen sIgE were similar between the two groups.The positive rate of serum allergen sIgE was higher in patients with lower CD4+T lymphocyte count. 2022 Vol. 39 (4): 488-491 [Abstract] ( 68 ) HTML (1 KB)  PDF (1175 KB)  ( 45 ) 492 Relationship of GSES and SSRS Scores with Anxiety in Patients with Hypertension during Pregnancy LI Cai-juan, YAO Yi-fang DOI: 10.3969/j.issn.1671-7171.2022.04.004 【Objective】To investigate the relationship of self-efficacy (GSES) and social support (SSRS) scores with anxiety in patients with hypertension during pregnancy.【Methods】A retrospective analysis of the clinical data of 182 patients with hypertension during pregnancy in our hospital from January 2018 to January 2019. The occurrence of anxiety, patients' monthly income, education level, pregnancy times, serum follicle stimulating hormone (FSH), serum progesterone (P), estradiol (E2), self-rating anxiety scale (SAS) score, GSES and SSRS scores were analyzed by multivariate logistic regression analysis to reveal the independent risk factors affecting anxiety in patients with hypertension during pregnancy. 【Results】Among the 182 patients with hypertension during pregnancy, 46 cases (25.27%) developed anxiety which were classified as the anxiety group; the remaining 136 cases (74.73%) did not develop anxiety that were classified as the non-anxiety group. There were no statistically significant differences in age, gestational weeks, ethnicity, FSH, P, E2, and blood pressure levels between the two groups (P>0.05). The proportion of monthly income ≥ 3000 yuan, with bachelor degree or above, pregnancy times ≥ 2 times, GSES score and SSRS score in the anxiety group were lower than those in the non-anxiety group (P<0.05), while the SAS score was significantly higher than that in the non-anxiety group (P<0.05). Multivariate logistic regression analysis showed that monthly income, education level, pregnancy times, SAS score, GSES score, SSRS score were independent risk factors affecting anxiety in patients with hypertension during pregnancy (P<0.05). 【Conclusion】The anxiety of hypertensive patients during pregnancy is not only closely related to monthly income, education level and number of pregnancy, but also closely related to SAS, GSES and SSRS scores. 2022 Vol. 39 (4): 492-494 [Abstract] ( 56 ) HTML (1 KB)  PDF (1159 KB)  ( 29 ) 495 Application of Pain Quantification and Grading Management Model in Multiple Injuries Complicated with Pelvic Fractures GUO Xiao-yu, ZUO Ting-ting DOI: 10.3969/j.issn.1671-7171.2022.04.005 【Objective】 To explore the effect of graded pain management model based on quantitative evaluation of pain in multiple injuries complicated with pelvic fractures. 【Methods】A total of 104 patients with multiple injuries complicated with pelvic fractures hospitalized in the Department of orthopedics of our hospital from February 2020 to May 2021 were collected as the research object. They were divided into control group and observation group according to the random number table method, with 52 cases in each group. The patients in the observation group were given pain management based on the grading of routine nursing, and the patients in the control group were given pain management based on the grading of routine nursing. The cognitive level of pain related knowledge, visual analog scales (VAS), general comfort questionnaire (GCQ) and Pittsburgh sleep quality index (PSQI) before and after intervention were compared between the two groups. 【Results】 The cognitive rate of pain knowledge in the observation group was significantly higher than that in the control group (P<0.05); Before intervention, the pain score and GCQ scores of the two groups had no statistical significance (P>0.05); One week after the intervention, the pain score in the study group was at a low level, and the GCQ scores of physiology, psychology, social environment and culture in the study group were higher than those in the control group (P<0.05); The PSQI scores of sleep time, sleep quality, sleep efficiency, sleep time and daytime function in the observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】 The application of graded pain management mode based on pain quantitative evaluation in multiple injuries complicated with pelvic fractures can reduce the pain feeling of patients during treatment, alleviate adverse physical symptoms, improve sleep quality and promote rapid recovery of patients. 2022 Vol. 39 (4): 495-499 [Abstract] ( 58 ) HTML (1 KB)  PDF (1197 KB)  ( 171 ) 500 Cardiac Magnetic Resonance T1 Mapping Quantitative Analysis of Severe Aortic Regurgitation Myocardial Fibrosis LI Ya, GAO Li, HU Guo-ying, et al DOI: 10.3969/j.issn.1671-7171.2022.04.006 【Objective】To explore the application value of T1 mapping quantified with cardiac MR (CMR) in the evaluation of left ventricular systolic function and myocardial fibrosis in severe aortic regurgitation (AR) patients. 【Methods】28 patients with severe AR in our hospital from January 2018 to November 2020 and 30 subjects at the same period for physical examination were selected as study group and control group respectively, and they were given cardiac magnetic resonance (CMR) and T1 mapping. The left ventricular myocardial mass (LVMM), left ventricular end diastolic volume index (LVEDVi), left ventricular end systolic volume index (LVESVi), left ventricular stroke volume index (LVSVi) , left ventricular ejection fraction (LVEF) , initial T1 value, enhanced T1 value and ECV value were compared between the two groups,and Pearson coefficient for correlation analysis. 【Results】 The LVMM, LVEDVi, LVESVi and LVSVi in study group were higher than those in control group (P<0.05); the LVEF in study group was lower than those in control group (P<0.05); the initial T1 value and ECV in study group were higher than those in control group (P<0.05); Pearson Correlation analysis showed that the initial T1 value and ECV value were negatively correlated with LVEF (P<0.05). 【Conclusion】T1 mapping can reflect the diffuse fibrosis of the myocardium in patients with severe AR, which is related to early cardiac remodeling and left ventricular systolic dysfunction to identify subclinical myocardial changes caused by volume overload before clinical symptoms appear. 2022 Vol. 39 (4): 500-502 [Abstract] ( 65 ) HTML (1 KB)  PDF (1158 KB)  ( 50 ) 503 Effect of Gabapentin Combined with Sodium Hyaluronate on Pain , Serum β-Endorphin and Prostaglandin E2 in Patients with Knee Osteoarthritis ZHANG Qiang, ZHOU Fei, CHANG Rui, et al DOI: 10.3969/j.issn.1671-7171.2022.04.007 【Objective】To investigate the effect of gabapentin combined with sodium hyaluronate on pain, β-endorphin and prostaglandin E2 levels in patients with knee osteoarthritis (KOA). 【Methods】A total of 86 patients with KOA treated in Yan'an people's Hospital from July 2019 to June 2021 were randomly divided into control group (given sodium hyaluronate) and observation group (given gabapentin + sodium hyaluronate), with 43 cases in each group. VAS score, knee function score and serumβ- Endorphin, prostaglandin E2 and their safety were compared between the two groups .【Results】Before treatment, there was no significant difference in VAS score, serum β-endorphin, prostaglandin E2 level and knee Lysholm score between the two groups (P>0.05). Compared with before treatment, the VAS scores of the two groups decreased after 1, 2 and 4 weeks of treatment, and the VAS scores of the observation group after 2 weeks of treatment and 4 weeks of treatment were lower than those of the control group (P<0.001). After treatment, the levels of the serum β- endorphins of the two groups of patients increased and the levels of prostaglandin E2 decreased in the observation group; The level of β- endorphin was higher than that in the control group (P<0.001), and the level of prostaglandin E2 was lower than that in the control group (P<0.001). After treatment, the knee Lysholm score of the two groups increased, and the knee Lysholm score of the observation group was higher than that of the control group (P<0.001). The total incidence of adverse reactions was similar between the two groups (χ2=0.453,P=0.501). 【Conclusion】 Gabapentin combined with sodium hyaluronate in the treatment of KOA patients can effectively relieve pain and regulate the levels ofβ- endorphin and prostaglandin E2, and improve knee functions, which is safe and reliable, and is worthy of clinical application. 2022 Vol. 39 (4): 503-506 [Abstract] ( 65 ) HTML (1 KB)  PDF (1188 KB)  ( 73 ) 507 Effect of Cranioplasty Timing on Cerebral Hemodynamics and Cognitive Function in Patients with Skull Defects after Decompressive Craniectomy KANG Zhi-qiang, DU Bao-shun, CHENG Zhen-guo DOI: 10.3969/j.issn.1671-7171.2022.04.008 【Objective】To explore the effect of cranioplasty timing on cerebral hemodynamics and cognitive dysfunction in patients with skull defects after decompressive craniectomy. 【Methods】The clinical data of 82 patients with skull defect after decompressive craniectomy in our hospital were prospectively selected, and they were divided into observation group (n=40) and control group (n=42) according to different skull repair timings. The two groups were further divided into mild group, moderate group and severe group according to the degree of cognitive impairment. The scores of the Mini-Mental State Scale (MMSE) before and after surgery were compared between the two groups of patients with different cognitive functions, and the cerebral blood flow before and after surgery in each group was compared as well.【Results】3 months after operation, the local blood flow of ACA, MCA and PCA in patients with mild, moderate and severe cognitive impairment in the two groups were all higher than those 2 days before operation, and the observation group was higher than the control group, and the difference was statistically significant (P<0.05); the MMSE scores of the patients with mild and moderate cognitive impairment in the two groups were higher than 2 days before surgery, and the difference was statistically significant (P<0.05); the MMSE scores of the patients with mild and moderate cognitive impairment in the observation group were higher than In the control group, the difference was statistically significant (P<0.05); the MMSE scores of the patients with severe cognitive impairment in the two groups were not significantly improved compared with those before operation, and the difference was not statistically significant (P>0.05).【Conclusion】Early cranioplasty can significantly improve local cerebral blood flow in the patients with skull defect, thus significantly promote the recovery of cognitive function in patients with mild to moderate cognitive impairment. However, for the patients with severe cognitive impairment, early cranioplasty and late cranioplasty have no obvious effect on the improvement of cognitive function. 2022 Vol. 39 (4): 507-509 [Abstract] ( 51 ) HTML (1 KB)  PDF (1159 KB)  ( 57 ) 510 Efficacy of Huazhirougan Granules on Regofinil Targeted Therapy of Middle and Advanced Liver Cancer Patients with Damp Heat Accumulation Type MA Jun-rong, ZHANG Kui DOI: 10.3969/j.issn.1671-7171.2022.04.009 【Objective】To investigate the therapeutic effect of Huazhirougan granules on regofinil targeted therapy of middle and advanced liver cancer patients with damp heat accumulation type.【Methods】A total of 110 patients with damp-heat accumulation type mid-advanced liver cancer admitted to the hospital were randomly divided into two groups. The control group was given symptomatic supportive treatment such as liver protection, antiemetic and leukocytes elevation on the basis of targeted therapy of regorafenil, while the observation group was given Huazhirougan granules treatment on the basis of administration in the control group. The Chinese medicine syndrome scores of damp-heat accumulation type (refer to the evaluation guidelines for clinical research of traditional Chinese medicines), ALT and AST levels,serum carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP)before treatment and 3 months after the treatment were recorded and compared between the two groups. The adverse drug reactionsin both groups were compared as well.【Results】Before treatment, there were no statistically significant differences in terms of all parameters between the two groups (P>0.05).After 3 months of treatment, the scores of the Chinese medicine syndrome (TCM) scores of damp-heat accumulation type were decreased in both groups (P<0.05), and those indicators in the observation group was lower than those in the control group (P<0.05).The ALT and AST levels in the control group were increased (P<0.05), while ALT and AST levels in the observation group did not obvious changes,which were lower than the control group (P<0.05). The total remission rate of the observation group was higher than that of the control group (P<0.05). There were no significant difference in CEA levels between the two groups after 3 months of treatment (P>0.05).The levels of AFP were decreased in both groups (P<0.05), however,AFP level in the observation group was lower than that in the control group (P<0.05).There were no statistically significant difference in the incidence of adverse drug reactions between the two groups (P>0.05). 【Conclusion】Huazhirougan granules used for regorafenil targeted treatment of mid-advanced liver cancer patients with damp-heat accumulation type can improve their clinical symptoms, have a protective effect on liver function, regulate tumor marker levels and reduce regorafenil-induced fatigue. 2022 Vol. 39 (4): 510-513 [Abstract] ( 76 ) HTML (1 KB)  PDF (1181 KB)  ( 81 ) 514 Effect of Methotrexate Combined with Uterine Artery Embolization on Uterine Curettage in Patients with Scar Pregnancy ZHANG Fu-e, LI Juan DOI: 10.3969/j.issn.1671-7171.2022.04.010 【Objective】 To investigate the effect of methotrexate combined with uterine artery embolization on uterine curettage in patients with scar pregnancy.【Methods】 A total of 60 patients with scar pregnancy who were diagnosed and treated in Baoji people's Hospital of Shaanxi Province from March 2018 to may 2021 and planned to undergo uterine curettage were randomly divided into control group and observation group. The control group was pretreated with mifepristone combined with methotrexate before uterine curettage, and the observation group was pretreated with methotrexate combined with uterine artery embolization before uterine curettage. The amount of intraoperative bleeding, menstrual recovery time, serum human chorionic gonadotropin(β- HCG), sex hormone level and occurrence of adverse reactions of the two groups were compared. 【Results】 The amount of bleeding in the observation group was (75.62 ± 28.39) ml, which was significantly less than (106.57±34.86) mL in the control group (P<0.05). The operation time ,the negative time of β-HCG and the recovery time of menstruation were (25.18±5.34) min, (22.39±6.17) d and (38.35±5.76) d, respectively, which were shorter than those of the control group (33.75±7.29) min, (29.84±7.63) d and (49.56±6.84) d (P<0.05); At 1 and 3 months after operation, the levels of sex hormones in the two groups were lower than those before operation (P<0.05); Three months after operation, the levels of sex hormones in both groups were higher than that in one month after operation, and the change range of sex hormone levels in the observation group was smaller (P<0.05); The total incidence of adverse reactions in the observation group was 6.67%, which was lower than 30.00% in the control group (P<0.05).【Conclusion】Methotrexate combined with uterine artery embolization can reduce the bleeding volume of complete curettage of uterine cavity, shorten the time of β-HCG turning negative, promote the recovery of menstruation after operation, and have little effect on sex hormone level and low incidence of adverse reactions. 2022 Vol. 39 (4): 514-516 [Abstract] ( 67 ) HTML (1 KB)  PDF (1156 KB)  ( 32 ) 517 Value of Imagine Examination in Differential Diagnosis of Uterine Sarcoma and Degenerative Uterine Leiomyoma HAN Ji-rong, TIAN Yan-ni, LI Si-man, et al DOI: 10.3969/j.issn.1671-7171.2022.04.011 【Objective】To investigate the value of diffusion-weighted imaging (DWI), dynamic contrast-enhanced magnetic resonance imaging (MRI) and color Doppler ultrasound in the differential diagnosis of uterine sarcoma and degenerative uterine leiomyoma. 【Methods】From November 2018 to May 2020, 82 patients with degenerative uterine leiomyoma (the degenerative uterine leiomyoma group) and 79 patients with uterine sarcoma (the uterine sarcoma group), who were treated in our hospital and confirmed by operation and pathology, were selected as the research objects. All clinical data were analyzed to evaluate that color Doppler ultrasound parameters, arterial resistance index (RI), pulsatility index (PI), DWI parameters, apparent diffusion coefficient (ADC), dynamic contrast-enhanced MRI parameters, time to peak (TTP) and maximum contrast enhancement (MCER) in differential diagnostic value of uterine sarcoma and degenerative uterine leiomyoma.【Results】The levels of RI, PI, ADC and TTP in uterine sarcoma group were significantly lower than those in degenerative uterine leiomyoma group, and MCER was significantly higher than that in degenerative uterine leiomyoma group. The differences were statistically significant (P<0.05). The area under the curve (AUC) of RI, PI, ADC, TTP and MCER in the differential diagnosis of uterine sarcomas and degenerative uterine leiomyoma was 0.797, 0.825, 0.913, 0.847 and 0.824, respectively, the cut-off value was 0.547, 0.640, 1.199×10-3 mm2/s, 51.534 s, 196.078%, respectively, the specificity was 92.4%, 97.5%, 92.4%, 70.9% and 72.2%, respectively, and the sensitivity was 54.9%, 67.1%, 79.3%, 84.1% and 81.7%, respectively. The AUC of combination of the five methods was 0.981. The specificity was 93.7% and the sensitivity was 98.8%.【Conclusion】Color Doppler ultrasound, DWI and dynamic contrast-enhanced MRI have certain characteristics in uterine sarcoma and degenerative uterine leiomyoma. With the combination of relevant parameters, it is more helpful to differentiate the diagnosis of two diseases. 2022 Vol. 39 (4): 517-520 [Abstract] ( 72 ) HTML (1 KB)  PDF (1273 KB)  ( 87 ) 521 Relationship between PROX1 and Recurrence after Minimally Invasive Resection of Early Non-small Cell Lung Cancer HOU Su-juan, KE Zhen-yu, LU Chun-hui, et al DOI: 10.3969/j.issn.1671-7171.2022.04.012 【Objective】To analyze the relationship between Prospero related homeobox protein 1 (PROX1) and recurrence after minimally invasive resection of early non-small cell lung cancer(NSCLC).【Methods】A total of 106 patients with early NSCLC who underwent minimally invasive resection were recruited in the study. The expression of PROX1 in cancer tissues and adjacent tissues was detected and compared. The factors of postoperative recurrence were analyzed. In addition, all patients were followed up for 1 year, the recurrence rate was counted, and the survival of patients within 1 year was analyzed by Kaplan Meier method.【Results】The positive expression rate of PROX1 in cancer tissues was higher than that in adjacent tissues (P<0.05). The postoperative recurrence rate was19.81%(21/106). The recurrence group had higher proportion of TNM stage Ⅱ, maximum tumor diameter >3 cm, lymph node metastasis, low or undifferentiation and PROX1 positive expression than those in the non-recurrence group (P<0.05). Multivariate logistic regression analysis showed that TNM stage Ⅱ, maximum tumor diameter >3 cm, lymph node metastasis, low/undifferentiation and PROX1 positive expression were the postoperative recurrenceinfluencing factors of patients with early NSCLC(P<0.05). By the end of one-year follow-up, 1 out of 80 PROX1 positive patients was lost to follow-up,and 12 died.The cumulative survival rate was 84.81%(67/79).Of the 16 PROX1 negative patients,one was lost to follow-up and one died. The cumulative survival rate was 93.33%(14/15).There was no significant difference in the total survival rate curve between the two groups (P>0.05).【Conclusion】The positive expression rate of PROX1 in early NSCLCis high. TNM stage Ⅱ, maximum tumor diameter >3 cm, lymph node metastasis, low or undifferentiated tumorand PROX1 positive expression are all risk factors for recurrence within 1 year. PROX1 is closely related to recurrence after minimally invasive resection of early NSCLC. 2022 Vol. 39 (4): 521-523 [Abstract] ( 74 ) HTML (1 KB)  PDF (1156 KB)  ( 31 ) 524 Clinical Efficacy and Safety of Caffeine Citrate Combined with Noninvasive Respiratory Support in the Treatment of Neonatal Severe Aspiration Pneumonia ZHANG Fen-xia, FENG Cheng-hu, WU Xiao-yu, et al DOI: 10.3969/j.issn.1671-7171.2022.04.013 【Objective】 To investigate the clinical efficacy and safety of caffeine citrate combined with noninvasive respiratory support in the treatment of neonatal severe aspiration pneumonia. 【Methods】 A total of 70 newborns with severe aspiration pneumonia treated in our hospital from June 2018 to April 2020 were prospectively selected and randomly divided into observation group (caffeine citrate combined with nasal continuous positive airway pressure ventilation,n= 34) and control group (caffeine citrate combined with nasal synchronous intermittent positive pressure ventilation,n= 36). The indexes of pulmonary function, respiratory mechanics and serum insulin-like growth factor binding protein-3 (IGFBP-3) and β- Endorphins(β- EP) were compared between the two groups,and the incidence of complications were also compared. 【Results】 After treatment, tidal volume (TV), peak time ratio (TPTEF/TE), peak volume ratio (VPEF/VE) and peak expiratory flow rate (PEF) in the two groups were higher than those before treatment (P<0.05), respiratory rate (RR), functional residual capacity (FRC) and effective airway resistance were lower than those before treatment (P<0.05), and there were significant differences between the observation group and the control group (P<0.05); The oxygenation index and lung compliance of the two groups were higher than those before treatment (P<0.05), and the inspiratory resistance was lower than that before treatment (P<0.05). There was significant difference between the observation group and the control group (P<0.05); The level of serum IGFBP-3 in the two groups was higher than that before treatment, and the level of β- EP was lower than that before treatment (P<0.05), and there was significant difference between the observation group and the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05).【Conclusion】 Caffeine citrate combined with noninvasive respiratory support model in the treatment of neonatal severe aspiration pneumonia can improve the indexes of pulmonary function and respiratory mechanics, and regulate serum IGFBP-3 and β- EP level, but transnasal synchronous intermittent positive pressure ventilation is better than transnasal continuous positive airway pressure ventilation. 2022 Vol. 39 (4): 524-527 [Abstract] ( 70 ) HTML (1 KB)  PDF (1184 KB)  ( 68 ) 528 Effects of Combined Spinal-Epidural Anesthesia with Low Dose Ropivacaine and Sufentanil on Painless Labor Analgesia, Duration of Labor and Neonatal Outcomes ZHAO Rui, YANG Yong-peng DOI: 10.3969/j.issn.1671-7171.2022.04.014 【Objective】To explore the effects of combined spinal-epidural anesthesia with low dose ropivacaine and sufentanil on painless labor analgesia, duration of labor and neonatal outcomes. 【Methods】From October 2019 to June 2020, 88 cases of puerperas with painless delivery in Baoji Central Hospital were selected, and they were divided into observation group (44 cases) and control group (44 cases), the grouping method was random number table. The control group was given epidural anesthesia with low-dose ropivacaine and sufentanil, while the study group was given combined spinal-epidural anesthesia with low dose ropivacaine and sufentanil, the painless labor analgesia, labor process time and neonatal outcomes were compared between the two groups. 【Results】 Compared with that before analgesia, the VAS scores of the two groups decreased at 5 min, 10 min and 30 min after analgesia, and there were significant differences in VAS scores at different time points (P<0.05); At 5-30 min after analgesia, VAS score, local anesthetic dosage, onset time of sensory block and motor block and maximum sensory block plane in the observation group were lower than those in the control group; The duration of anesthesia was longer than that of the control group, and the difference was statistically significant (P<0.05). The first stage of labor, the second stage of labor and the total stage of labor in the observation group were shorter than those in the control group (P<0.05), but there was no significant difference in the rate of conversion to cesarean section and Apgar scores at 1 min and 5 min after birth between the observation group and the control group (P>0.05). The total incidence of adverse events in the observation group was lower than that in the control group (4.55% vs 18.18%), and the difference was statistically significant (χ2=4.062, P<0.05).【Conclusion】 Combined spinal-epidural anesthesia with low dose ropivacaine and sufentanil can improve the analgesic effect of painless labor, reduce the use of narcotic drugs, shorten the labor process and reduce the incidence of adverse events. 2022 Vol. 39 (4): 528-531 [Abstract] ( 50 ) HTML (1 KB)  PDF (1176 KB)  ( 61 ) 532 Diagnostic Value of CT in Pelvic Lymph Node Metastasis of Cervical Carcinoma ZHONG She-lan, ZHAO Lin DOI: 10.3969/j.issn.1671-7171.2022.04.015 【Objective】To investigate the diagnostic value of computed tomography (CT) in pelvic lymph node metastasis of cervical cancer. 【Methods】The clinical data of 94 patients with cervical cancer diagnosed and treated in our hospital from January 2018 to January 2020 were retrospectively analyzed. According to whether the patients had pelvic lymph node metastasis, they were divided into metastasis group and non metastasis group. The CT characteristic indexes, such as the diameter of single lymph node, round lymph node, visible central necrosis, visible envelope invasion and the diagnostic value of combination in pelvic lymph node metastasis of cervical cancer were analyzed. 【Results】The diameter of single lymph node in the non metastasis group was smaller than that in the metastasis group (P<0.05), and the proportion of round lymph node, central necrosis and envelope invasion in the non metastasis group was lower than that in the metastasis group (P<0.05). The sensitivity and accuracy of single lymph node diameter ≥ 1.0 cm in the diagnosis of pelvic lymph node metastasis of cervical cancer were the highest, 90.48% and 89.36% respectively; The specificity of central necrosis and envelope invasion in the diagnosis of pelvic lymph node metastasis of cervical cancer was the highest, both of which were 96.77%. The sensitivity, specificity and accuracy of combined indexes in the diagnosis of pelvic lymph node metastasis of cervical cancer were 98.41%, 96.77% and 97.87%, respectively. The consistency between CT diagnosis results and pathological diagnosis gold standard was excellent (P<0.05); Among the CT indexes, the diameter of a single lymph node ≥ 1.0 cm has the highest diagnostic value for pelvic lymph node metastasis of cervical cancer, and the combined CT indexes have high diagnostic value for pelvic lymph node metastasis of cervical cancer.【Conclusion】CT has high diagnostic value for pelvic lymph node metastasis of cervical cancer, and can provide reference basis for clinical diagnosis and curative effect evaluation. 2022 Vol. 39 (4): 532-534 [Abstract] ( 75 ) HTML (1 KB)  PDF (1257 KB)  ( 63 ) 535 Effect of Thymosin α1 on Immune Imbalance in Rats with Pseudomonas Aeruginosa-induced Bronchiectasis LYU Jian-ning, LI Qiong DOI: 10.3969/j.issn.1671-7171.2022.04.016 【Objective】To explore interventional effect of thymosin α1 and participation of high mobility group box B1 (HMGB1)/receptor advanced glycation end products (RAGE)/Toll-like receptor 9 (TLR9) signaling pathway on immune imbalance in rats with pseudomonas aeruginosa-induced bronchiectasis. 【Methods】A total of 60 healthy male rats were divided into the blank control group, model group, low-dose and high-dose thymosin groups, with 15 cases in each group. Except blank control group, all rats in the other groups were given tracheal perfusion of Pseudomonas aeruginosa to induce bronchiectasis models. The low-dose and high-dose thymosin groups were intraperitoneally injected with 1.25 and 2.50 mg/kg thymosin α1, while blank control group and the model group were injected with the same volume of normal saline for 20d. At 24h after the last administration, changes of respiratory function monitoring indexes were detected. The levels of serum HMGB1, RAG and interferon-γ (IFN-γ) were detected by ELASA. The distribution of T cell subsets was detected by flow cytometry. The expressions of HMGB1 and RAGE in bronchial tissues were detected by Western blot. 【Results】Compared with the blank control group, the tidal volume, minute ventilation volume, IFN-γ, CD3+, CD4+ and CD4+/CD8+ levels decreased in model group (P<0.05), while respiratory rate, levels of HMGB1 and RAGE, expressions of HMGB1 and TLR9 increased (P<0.05).However, there was no significant change in CD8+ percentage (P>0.05). Compared with the model group, tidal volume, minute ventilation volume, IFN-γ, CD3+, CD4+ and CD4+/CD8+ levels increased in low-dose and high-dose thymosin group (P<0.05), while respiratory rate, levels of HMGB1 and RAGE and CD8+, expressions of HMGB1 and TLR9 decreased (P<0.05). 【Conclusion】Intraperitoneal injection of thymosin α1 can prevent the cascade effect of cytokines and inflammatory mediators in bronchiectasis rats induced by Pseudomonas aeruginosa through inhibiting HMGB1/RAGE/TLR9 signaling pathway, which can improve immune function in rats. 2022 Vol. 39 (4): 535-538 [Abstract] ( 44 ) HTML (1 KB)  PDF (1185 KB)  ( 60 ) 539 Comparison of Clinical Characteristics between Patients with Hypertension Complicated with Chronic Kidney Disease and Patients with Simple Hypertension WANG Rui-juan, ZHANG Nan DOI: 10.3969/j.issn.1671-7171.2022.04.017 【Objective】To observe the clinical characteristics of hypertension with chronic kidney disease and simple hypertension.【Methods】A total of 40 patients with hypertension complicated with chronic kidney disease in our hospital were selected as the observation group, and 40 patients with simple hypertension were selected as the control group.The blood pressure parameters, blood pressure variability and blood pressure load value of all patients [daytime systolic blood pressure (SBP), nighttime SBP, 24h average value of SBP, daytime diastolic blood pressure (DBP), nighttime DBP and 24h average value of DBP], the blood pressure types and heart rate variability indexes of the two groups were measured and compared between the two groups[standard deviation of all sinus beats in R-R interval (SDNN), standard deviation of the average value of N-N interval every 5 minutes (SDANN), square root of the difference between two adjacent N-N intervals (RMSSD), and the proportion of heart beats with the difference between two adjacent R-R intervals >50 ms in the total number (pNN50)].【Results】The SBP and DBP at night in the observation group were higher than those in the control group(P<0.05).The variability of SBP and DBP in the observation group was higher than that in the control group(P<0.05).The night SBP load value and night DBP load value of the observation group were higher than those of the control group (P<0.05).The number of non-dipper blood pressure cases in the observation group was significantly higher than that in the control group, and the number of reverse dipper blood pressure cases in the observation group was significantly lower than that in the control group(P<0.05).The SDNN, SDANN, RMSSD and PNN50 of the observation group were lower than those of the control group(P<0.05).【Conclusion】Blood pressure parameters, load values at night, blood pressure rhythm, blood pressure variability, heart rate variability of hypertension patients with chronic kidney disease are all different from essential hypertension, which can be used as a reference for the corresponding treatment of patients with hypertension and chronic kidney disease. 2022 Vol. 39 (4): 539-541 [Abstract] ( 68 ) HTML (1 KB)  PDF (1157 KB)  ( 56 ) 542 Relationship between the Phosphatidylinositol-3 Kinase p110 Catalytic Subunit Gene Mutation of Circulating Tumor Cells and Clinicopathological Characteristics in Breast Cancer Patients WANG Qiao-ge, YAN Feng-na DOI: 10.3969/j.issn.1671-7171.2022.04.018 【Objective】To explore the relationship of phosphatidylinositol-3 kinase p110 catalytic subunit (PIK3CA) gene mutations in circulating tumor cells with clinicopathological characteristics in breast cancer patients.【Methods】Seventy-eight breast cancer patients admitted to the hospital were selected as the observation group, and 72 healthy women who came to the hospital for physical examination during the same period were selected as the control group. The microdrop digital technology was used to examine the PIK3CA mutations in the peripheral blood circulating tumor cells in the two groups, and the clinical characteristics of breast cancer patients were counted. Kaplan-Meier was used for survival analysis.【Results】The positive expression rate of peripheral blood PIK3CA in peripheral blood circulating tumor cells of breast cancer patients were higher than that in the control group (P<0.05). The PIK3CA gene mutation rate of circulating tumor cells in the peripheral blood of 78 breast cancer patients was 29.49% (23/78). The clinical stage, degree of differentiation, and Ki-67 index composition of patients with PIK3CA gene mutations in peripheral blood circulating tumor cells of breast cancer were significantly different from those withou tmutation patients, the difference was statistically significant (P<0.05). The 3-year survival of breast cancer patients showed that the survival rate of patients with PIK3CA gene mutations in peripheral blood circulating tumor cells was 43.48% (13/23), which was lower than that of non-mutated patients 83.02% (44/53).The difference between the two were statistically significant (P<0.05).【Conclusion】The clinical stages Ⅲ-Ⅳ, poor differentiation, and Ki-67 index ≥20% are all related to the PIK3CA gene mutation in circulating tumor cells of breast cancer patients.It suggests that PIK3CA gene mutation has important value in the prognosis of breast cancer. 2022 Vol. 39 (4): 542-545 [Abstract] ( 48 ) HTML (1 KB)  PDF (1230 KB)  ( 61 ) 546 Clinical Effect of Doxorubicin Liposomes in Neoadjuvant Chemotherapy for Stage Ⅱ and Ⅲ Breast Cancer HAN Qian-qian, HONG Yue-yan, WU Xuan DOI: 10.3969/j.issn.1671-7171.2022.04.019 【Objective】 To investigate the clinical effect of doxorubicin liposomes in neoadjuvant chemotherapy for stage Ⅱ and Ⅲ breast cancer. 【Methods】Eighty two patients with stage Ⅱ-Ⅲ breast cancer who were admitted to our hospital were recruited in the study. Patients were divided into the observation group and the control group by random method, with 41 cases in each group. The control group received doxorubicin 40 mg/m2 combined with cyclophosphamide 600 mg/m2, sequentially followed by docetaxel 85 mg/m2 neoadjuvant chemotherapy, while the observation group received doxorubicin liposome 40 mg/m2 combined with cyclophosphamide 600 mg/m2 followed by docetaxel 85 mg/m2 chemotherapy for 8 cycles of treatment. The clinical efficacy, surgical treatment and postoperative pathology of the two groups were compared between the two groups. and the incidence of adverse reactions during neoadjuvant chemotherapy were counted. Follow up the survival of the two groups were followed up and performed Kaplan-Meier survival analysis. 【Results】There were no statistically significant differences between the two groups in treatment efficiency, clinical control rate, disease control rate, pathological complete remission rate, and axillary lymph node conversion rate (P>0.05). During the neoadjuvant chemotherapy between the two groups, the incidence of grade Ⅰ~Ⅱ myocardial damage and grade Ⅰ~Ⅱ hand-foot syndrome in the observation group was lower than those in the control group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of other side effects between the two groups (P>0.05). Kaplan-Meier survival analysis showed that the 3-year progression-free survival curve of the observation group was better than that of the control group (P<0.05), however, there was no statistically significant difference in the overall survival curve between the two groups (P>0.05). 【Conclusion】The short-term effect of doxorubicin liposome combined with cyclophosphamide sequentially followed by docetaxel neoadjuvant chemotherapy for patients with stage Ⅱ and Ⅲ breast cancer is definitely effective, which can reduce the incidence of myocardial damage and hand-foot syndrome, and prolong progression-free survival, but has no significant effect on overall survival. 2022 Vol. 39 (4): 546-549 [Abstract] ( 178 ) HTML (1 KB)  PDF (1308 KB)  ( 199 ) 550 Effect of Simvastatin Combined with Conventional Therapy on Renal Function and Renal Fibrosis in Patients with Early Diabetic Nephropathy YIN Jun, QIU Jun-si, SHAO Fang DOI: 10.3969/j.issn.1671-7171.2022.04.020 【Objective】To explore the effect of simvastatin combined with conventional treatment on renal function and renal tissue fibrosis in patients with early diabetic nephropathy. 【Methods】A total of 88 patients with early diabetic nephropathy who were admitted to our hospital were selected and randomly divided into the observation group (simvastatin combined with conventional treatment) and the control group (conventional blood glucose control), with 44 cases in each group. The control group received conventional blood glucose control, while the observation group received simvastatin in addition to the conventional blood glucose control group. The clinical effective rate, renal function indexes [serum creatinine (SCr), urea nitrogen (BUN), β2 - microglobulin (β2 - MG), urinary albumin-to-creatinine ratio (UACR), and 24 - hour urinary protein quantitation], renal fibrosis indexes [type IV collagen (Ⅳ-C), transforming growth factor (TGF-β1), and tissue matrix metalloproteinase inhibitor-1 (TIMP-1)] were compared between the two groups after treatment, and the adverse drug reactions during treatment were observed as well. 【Results】After treatment, the total effective rate in the observation group was 86.36% (38/44), which was higher than 65.91% (29/44) in the control group, and the difference was statistically significant (P<0.05).After treatment, the levels of SCr, BUN, β2-MG, UACR and 24h urinary protein in both groups decreased (P<0.05), and the observation group showed even lower level (P<0.05). After treatment, the levels of Ⅳ-C, TGF-β1 and TIMP-1 in the two groups decreased (P<0.05), and the comparison between the two groups showed that the level in the observation group were lower than the control group (P<0.05). The adverse reactions of the observation group was 18.18% (8/44) and of the control group was 25.00% (11/44), which showed no difference (P>0.05).【Conclusion】Simvastatin combined with conventional treatment can improve the clinical efficiency and renal function, while slow down the process of renal fibrosis in patients with early diabetic nephropathy, with high safety. 2022 Vol. 39 (4): 550-552 [Abstract] ( 61 ) HTML (1 KB)  PDF (1160 KB)  ( 29 ) 553 Study on Correlation of Serum lncRNA MALAT1 Level with Markers of Myocardial Injury and Coagulation Function in Patients with Acute Myocardial Infarction WANG Xing, HU Ya-hong DOI: 10.3969/j.issn.1671-7171.2022.04.021 【Objective】To detect the expression level of long non-coding RNA-lung adenocarcinoma metastasis-associated transcription factor 1 (IncRNA MALAT1) in serum of patients with acute myocardial infarction and analyze its relationships with marks of myocardial injury and coagulation function in actual myocardial infarction (AMI). 【Methods】A total of 103 patients with acute myocardial infarction admitted to our hospital from January 2017 to January 2019 were selected as the observation group, and 103 healthy volunteers who were examined in our hospital during the same period were selected as the control group. The level of lncRNA MALAT1 in serum was detected by qRT-PCR and the levels of myocardial injury markers and coagulation factors were detected by ELISA. The correlations of the level of lncRNA MALAT1 with myocardial injury and coagulation function were analyzed. 【Results】The levels of NT-proBNP, CK-MB, CK, cTnI, MYO, coagulation indexes such as PT, APTT, INR, FIB, vWF, PAI-1 and serum lncRNA MALAT1 in acute myocardial infarction group were significantly higher than those in healthy control group (all P<0.05), while the values of PT, APTT and INR were lower than those in the control group, and the differences were statistically significant. (P<0.05). Serum lncRNA MALAT1 was positively correlated with NT-proBNP, CK-MB, cTnI, vWF and PAI-1 in patients with acute myocardial infarction (P<0.05), and IncRNA MALAT1 level was negatively correlated with PT and APTT (P<0.05). High NT-proBNP level, high CK-MB level, low APTT level, high vWF level and high lncRNA MALAT1 level were risk factors for acute myocardial infarction (all P<0.05). 【Conclusion】The expression level of serum lncRNA MALAT1 of patients with acute myocardial infarction was significantly increased, which may promote the occurrence of acute myocardial infarction by influencing the changes of myocardial markers and coagulation indexes. 2022 Vol. 39 (4): 553-556 [Abstract] ( 45 ) HTML (1 KB)  PDF (1184 KB)  ( 76 ) 557 Curative Effect Analysis of Gamma3 Intramedullary Nail for the Treatment of Unstable Femoral Intertrochanteric Fractures with Lateral Wall Risky LI Cheng, HAN Li-gang, WANG Bing-xin, et al DOI: 10.3969/j.issn.1671-7171.2022.04.022 【Objective】To explore clinical efficacy for the treatment of unstable femoral intertrochanteric fracture with lateral wall risky by Gamma3 intramedullary nail and analyze the clinical effect of comminuted medial cortex. 【Methods】The clinical data of 56 patients with lateral wall risk femoral intertrochanteric fractures treated by Gamma3 intramedullary nail from September 2018 to March 2021were retrospectively analyzed. The quality of fracture reduction, fracture healing, internal fixation position, TAD, CalTAD, the neck shaft angle (NSA) and femoral neck long axis (FNLA) were observed. Baumgaertner criteria were used to evaluate quality of fracture reduction,Harris criteria were used to evaluate hip joint function.【Results】The fracture healing time was 9-15 weeks with average of 11.7 weeks. According to Baumgaertner criteria, 27 cases obtained good results,13 cases were acceptable,and 3 poor healing. The good and acceptable rate was 93%. The neck shaft angle was 122°-147° without hip varus (mean, 132°). The average of TAD was 22.3mm and the average of CalTAD was 23.2mm. The excellent and good rate of Harris score was 88.4％. In the cases with comminuted medial cortex, the NSA(124.4±4.8)°was significantly less than that in the group without comminuted medial cortex(132.8±5.8)°, P<0.05. The FNLA(81.1±4.4)mm in the comminuted medial cortex group was significantly shorter than that in the group without comminuted medial cortex(89.2±5.7)mm, P<0.05. And its Harris hip score(80.8±6.4) was significantly lower than that in the group without comminuted medial cortex(89.8±5.6, P<0.05). 【Conclusion】 In the treatment of femoral intertrochanteric fractures with lateral wall risky, Gamma3 intramedullary nail can achieve an excellent clinical outcome. Along with comminuted medial cortex, the presence of lateral wall result in relatively poor stability of internal fixation and decrease hip function. 2022 Vol. 39 (4): 557-560 [Abstract] ( 60 ) HTML (1 KB)  PDF (1545 KB)  ( 183 ) 561 Effect of Patient-controlled Epidural Analgesia with Free Position on Labor Process and Delivery Outcome in Primipara LI Xiao-li, SHEN Bing-qing DOI: 10.3969/j.issn.1671-7171.2022.04.023 【Objective】To explore the effects of patient-controlled epidural analgesia plus free position on primary maternal labor process and delivery outcomes. 【Methods】A total of 250 primiparous pregnant women who met the requirements in our hospital from January 2020 to December 2020 were selected and divided into the control and the observation groups using the random number table method, with 125 cases in each group. The control group received patient-controlled epidural analgesia + traditional position delivery, wile the observation group received patient-controlled epidural analgesia + free position delivery. The duration of labor, length of hospital stay, 2-hour postpartum hemorrhage, delivery outcome, postpartum pelvic floor function, visual analog scale (VAS) score for delivery pain and condition of lumbar acid were compared between the two groups. 【Results】The duration of labor, VAS score, 2-hour postpartum blood loss, perineal lateral resection rate, cesarean section rate, forceps delivery rate, postpartum bleeding rate in the observation group were lower than those in the control group (P<0.05).There were no differences in the length of hospital stay and incidence of neonatal asphyxia between the two groups (P>0.05). The amount of 2H postpartum haemorrhage in the observation group patients was lower than that in the control group (P<0.05). Patients in the observation group had higher VRP, VSP, fiber strength class Ⅰ, and fiber strength class Ⅱ at 6 weeks postpartum compared to the control group, and the duration of contractions was longer than the control group as well (P<0.05). Patients in the observation group had lower VAS scores at delivery compared to the control group, whereas improvement in lumbar acid was better (P<0.05) . 【Conclusion】Compared with the conventional lying flat position, patient-controlled epidural analgesia with free position delivery can relieve labor pain, shorten labor process, relieve pain, improve delivery outcome,and promote pelvic floor function recovery 2022 Vol. 39 (4): 561-564 [Abstract] ( 46 ) HTML (1 KB)  PDF (1184 KB)  ( 53 ) 565 Efficacy of Omeprazole and Lansoprazole in the Treatment of Chronic Gastritis and Gastric Ulcer and their Effects on Serum PCT and GAS Levels LIU Ying, GAO Di DOI: 10.3969/j.issn.1671-7171.2022.04.024 【Objective】To investigate the efficacy of omeprazole and lansoprazole in the treatment of chronic gastritis and gastric ulcer and their effects on the levels of serum procalcitonin (PCT) and gastrin (gas). 【Methods】 A total of 72 patients with chronic gastritis and gastric ulcer treated in our hospital from February 2019 to February 2021 were randomly divided into observation group and control group, with 36 cases in each group. The control group was treated with omeprazole and the observation group was treated with lansoprazole. The treatment time of both groups was 14 days. The symptom disappearance time, clinical efficacy, serum PCT and gas levels, HP eradication rate and adverse reactions were compared between the two groups.【Results】The disappearance time of acid reflux, belching, epigastric pain and abdominal distension in the observation group was shorter than that in the control group (P<0.05).The total clinical effective rate in the observation group was 94.44% (34/36), which was significantly higher than 75.00% (27/36) in the control group (P<0.05); Before treatment, there was no significant difference in the levels of serum PCT and GAS between the two groups (P>0.05); After treatment, the levels of serum PCT and GAS in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The eradication rate of HP in the observation group was 94.44% (34/36), which was higher than 77.78% (28/36) in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Lansoprazole in the treatment of patients with chronic gastritis and gastric ulcer can shorten the disappearance time of clinical symptoms and has good curative effect. At the same time, it can reduce the levels of serum PCT and gas and improve the eradication rate of HP. It is safe and reliable. 2022 Vol. 39 (4): 565-567 [Abstract] ( 55 ) HTML (1 KB)  PDF (1159 KB)  ( 32 ) 568 Diagnostic Value of Anaplastic Lymphoma Kinase in Uterine Inflammatory Myofibroblastic Tumor DOU Li, MIAO Run-yan DOI: 10.3969/j.issn.1671-7171.2022.04.025 【Objective】To investigate the diagnostic value of the detection of anaplastic lymphoma kinase (ALK) in uterine inflammatory myofibroblastic tumor (IMT). 【Methods】A total of 2000 cases of uterine smooth muscle tumor were screened by ALK immunohistochemistry. ALK staining in the cytoplasm and/or cell membrane of tumor cells was considered as ALK positive. The diagnostic value of ALK protein detection in uterine IMT was discussed. 【Results】The positive rate of ALK protein in patients with uterine IMT was significantly higher than that in patients with benign leiomyoma (P<0.05). Using pathological results as gold standard, ALK protein expression was calculated by four grid table to diagnose uterine IMT. Results showed that the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 72.00%, 99.85%, 99.50%, 85.71% and 99.65%, respectively. In 2000 cases of uterine smooth muscle tumor, 25 cases were diagnosed as uterine IMT by pathological examination. Of which, 18 cases were diagnosed with uterine IMT by using ALK protein positive: 14 cases (14/18, 77.78%) were strongly positive for ALK expression (+++), 3 cases (3/18, 16.67%) were moderately positive (++), and 1 case (1/18, 5.56%) was weakly positive (+). In the 18 uterine IMT patients with ALK positive stainning, the FISH results showed that 88.89% (16/18) patients had ALK rearrangement, and 11.11% (2/18) had no ALK rearrangement. 【Conclusion】Immunohistochemical staining of ALK protein expression in uterine smooth muscle tumors has a good diagnostic value for the detection of IMT with high specificity and accuracy. 2022 Vol. 39 (4): 568-571 [Abstract] ( 36 ) HTML (1 KB)  PDF (1622 KB)  ( 54 ) 572 Clinical Effect of Xingpi Yanger Granules Combined with Bifidobacterium Lactobacillus Triple Viable Capsules and Lysine Glucozinc Granules in the Treatment of Infantile Anorexia WANG Ping, XUE Lei DOI: 10.3969/j.issn.1671-7171.2022.04.026 【Objective】To investigate the clinical effect of Xingpi Yanger granules combined with bifid triple viable capsules and lysine glucozinc granules in the treatment of anorexia. 【Methods】A total of 112 children with anorexia who were admitted to Xi'an Gaoxin Hospital from October 2019 to June 2020 were selected and divided into the observation group and the control group by random number table method, with 56 cases in each group. The control group was given bifidobacterium lactobacillus triple viable capsules and lysine glucozinc granules, and the observation group was given Xingpi Yanger Granules on the basis of the control group. The curative effect and the occurrence of adverse reactions were compared between the two groups, and the levels of serum zinc (Zn), appetite regulating factors [motilin (MTL), substance P (SP)], body weight and height before and after treatment were compared between the two groups. 【Results】The total effective rate in the observation group was 96.43% (54/56), which was higher than 82.14% (46/54) in the control group, and the difference was statistically significant (P<0.05). After treatment, the serum levels of Zn, MTL and SP in the two groups were higher than those before treatment; and the observation group was higher than the control group. The differences were statistically significant (P<0.05). There was no significant difference in height between the two groups before treatment (P>0.05). However, the weight of the two groups of children was higher than that before treatment. The weight in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). There were no adverse reactions in the two groups during the treatment, and the children were well tolerated. 【Conclusion】Xingpi Yanger granules combined with bifidobacterium lactobacillus triple viable capsules and lysine glucozinc granules have very good effect in the treatment of children with anorexia, which can effectively regulate the levels of serum Zn and appetite regulating factors, and play an important role in promoting growth and development. 2022 Vol. 39 (4): 572-574 [Abstract] ( 99 ) HTML (1 KB)  PDF (1156 KB)  ( 64 ) 575 Relationship between the Expression of Serum Hep, TRF, SF, Fe and Left Ventricular Structure and Vascular Endothelial Function in Elderly Patients with Chronic Heart Failure Complicated with Iron Deficiency ZHANG Ting, REN Feng DOI: 10.3969/j.issn.1671-7171.2022.04.027 【Objective】 To investigate the correlation between serum ferritin (HEP), transferrin (TRF), ferritin (SF), iron (Fe) and left ventricular structure and vascular endothelial function in elderly patients with chronic heart failure (CHF) complicated with iron deficiency. 【Methods】 A total of 92 elderly patients with CHF complicated with iron deficiency treated in Xi'an International Medical Center Hospital from January 2019 to January 2021 were divided into MACE group (n=25) and no MACE group (n=67) according to whether MACE occurred after 3 months of treatment. The levels of serum Hep, TRF, SF and Fe, left ventricular structural indexes [left atrial diameter (LAD), left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVESD), ventricular septal thickness (IVST), left ventricular mass index (LVMI)] and vascular endothelial function indexes [nitric oxide (NO), endothelin-1 (ET-1)] were compared between the two groups.The correlation between serum Hep, TRF, SF and Fe levels and left ventricular structure and vascular endothelial function was analyzed, and the predictive value of serum Hep, TRF, SF and Fe levels to MACE was evaluated.【Results】The levels of serum Hep in the MACE group were higher than those in non MACE group, and the levels of serum TRF, SF and Fe were lower than those in the non MACE group (P<0.05); Serum Hep levels were positively correlated with LAD, LVEDD, LVESD,IVST , LVMI and ET-1 and negatively correlated with No. Serum TRF, SF and Fe levels were negatively correlated with LAD, LVEDd, LVESD, IVST, LVMI and ET-1 and positively correlated with NO (P<0.05).The area under the curve (AUC) of serum Hep, TRF, SF and Fe in predicting MACE in elderly patients with CHF complicated with iron deficiency was the largest, which was 0.957.【Conclusion】The levels of serum Hep, TRF, SF and Fe are significantly correlated with left ventricular structure and vascular endothelial function in elderly patients with CHF complicated with iron deficiency. The combined detection of the four is of great value in predicting the occurrence of MACE. 2022 Vol. 39 (4): 575-578 [Abstract] ( 41 ) HTML (1 KB)  PDF (1307 KB)  ( 59 ) 579 Value of PGR Combined with Serum Tumor Markers in the Differential Diagnosis of Gastric Benign Diseases and Gastric Cancer TIAN Xiao-hua, JIA Hai-juan DOI: 10.3969/j.issn.1671-7171.2022.04.028 【Objective】To explore the value of serum pepsinogen ratio (PGR) combined with glycoprotein antigen 19-9 (CA19-9) and glycoprotein antigen 72-4 (CA72-4) in the differential diagnosis of benign gastric diseases and gastric cancer.【Methods】The data of 128 patients with suspected gastric cancer were collected and sorted.The levels of PGR and tumor markers (CA19-9 and CA72-4) were analyzed by Logistic regression to explore the related factors affecting gastric cancer. A receiver operating characteristic curve (ROC) was drawn, and the area under the curve (AUC) was used to evaluate the diagnostic value of serum PGR, CA19-9 and CA72-4 levels for gastric cancer. 【Results】Among 128 patients with suspected gastric cancer, 80(62.50%)were diagnosed as the gastric cancer group, and the remaining 48 (37.50%) were the non-gastric cancer group.The gastric cancer group had a lower proportion of previous gastric diseases than the non-gastric cancer group, and the PGR level was lower than that of the non-gastric cancer group, while the levels of CA19-9 and CA72-4 were higher than those in the non-gastric cancer group.The differences were statistically significant (P<0.05). The results of multivariate analysis showed that the existence of past history of gastric disease, high expression levels of CA19-9 and CA72-4, and low expression levels of PGR were all related factors for gastric cancer (P<0.05). ROC analysis showed that the sensitivity of serum PGR, CA19-9, CA72-4 and the combined diagnosis of gastric cancer was 61.25%, 58.75%, 63.75%, and 73.75%, respectively, the specificity was 58.33%, 56.52%, 60.42%, and 75.00%,respectively.The area under curve (AUC) was 0.824, 0.815, 0.894, and 0.916,respectively, and the single diagnostic efficacy of serum PGR, CA19 -9 or CA72-4 was lower than the combined diagnostic efficacy of the three (P<0.05). 【Conclusion】Patients with a history of gastric disease have a higher incidence of gastric cancer.The expression level of PGR in patients with gastric cancer is low, and the expression levels of CA19-9 and CA72-4 are high.Serum PGR, CA19-9 and CA72-4 have clinical diagnostic value for gastric cancer diagnosis, and the combined diagnosis efficiency of the three parameters is even higher. 2022 Vol. 39 (4): 579-581 [Abstract] ( 32 ) HTML (1 KB)  PDF (1267 KB)  ( 99 ) 582 Effect of Total Parathyroidectomy plus Autologous Transplantation on Secondary Hyperparathyroidism in Maintenance Hemodialysis Patients LIU Jun, QIN Jiao, WEN Rui, et al DOI: 10.3969/j.issn.1671-7171.2022.04.029 【Objective】 To observe effect of total parathyroidectomy plus autologous transplantation on secondary hyperparathyroidism in maintenance hemodialysis patients【Methods】 The clinical data of 21 patients with secondary hyperparathyroidism who underwent hemodialysis and surgical treatment (total parathyroidectomy + autologous transplantation) in our hospital from July 2019 to August 2020 were analyzed retrospectively. The blood routine and biochemical test results (including hemoglobin, free calcium, phosphorus, parathyroid hormone, alkaline phosphatase, etc.), clinical symptoms (bone pain, skin pruritus, restless legs syndrome, sleep disorder, etc.) and treatment plan of patients at different stages before and after operation (1 day, 1 week, 1 month, 3 months, 6 months, 12 months) were collected and statistically analyzed. 【Results】Compared with before operation, blood calcium, blood phosphorus, iPTH and ALP decreased significantly in all patients (P<0.05). The symptoms of postoperative patients such as bone pain, skin pruritus, restless legs syndrome and sleep were relieved to varying degrees. The blood pressure of postoperative patients was better controlled than that before operation, and the dose of erythropoietin required to maintain the target hemoglobin level was significantly reduced. 【Conclusion】Total parathyroidectomy plus autotransplantation can significantly improve calcium/ phosphorus metabolism disorder and renal anemia in patients with secondary hyperparathyroidism after hemodialysis, reduce blood pressure, parathyroid hormone and alkaline phosphatase levels, and effectively alleviate clinical symptoms such as bone pain, skin pruritus, restless legs syndrome and sleep disorder. 2022 Vol. 39 (4): 582-585 [Abstract] ( 52 ) HTML (1 KB)  PDF (1184 KB)  ( 79 ) 586 Correlation between Immunoglobulin Level and Vitamin A, hs-CRP and IL-1 in Children with Recurrent Respiratory Tract Infection OU Jing-lin, SUN Yi-juan DOI: 10.3969/j.issn.1671-7171.2022.04.030 【Objective】To investigate the correlation between immunoglobulin level and vitamin A, high-sensitivity C-reactive protein (hs-CRP) and interleukin-1 (IL-1) in children with recurrent respiratory tract infection. 【Methods】 A total of 75 children with recurrent respiratory tract infection (observation group) treated in our hospital from September 2019 to September 2020 were selected, and 75 healthy children with physical examination in the same period were selected as the control group. The levels of immunoglobulin (IGA, IgG, IgM), vitamin A, hs-CRP and IL-1 were compared between the two groups. The value of immunoglobulin and vitamin A, hs-CRP and IL-1 in predicting recurrent respiratory tract infection was analyzed by receiver operating characteristic (ROC) curve, and the correlation between immunoglobulin level and vitamin A, hs CRP and IL-1 was analyzed. 【Results】The levels of IgA, IgM, IgG, vitamin A and IL-1 in the observation group were significantly lower than those in the control group, and the level of hs-CRP was significantly higher than that in the control group (P<0.05). Pearson correlation analysis showed that vitamin A and IL-1 were positively correlated with IgA, IgM and IgG (P<0.05), and hs-CRP was negatively correlated with IgA, IgM and IgG (P<0.05). The AUC of IgA, IgM, IgG, vitamin A, hs-CRP and IL-1 in predicting recurrent respiratory tract infection were 0.881, 0.685, 0.665, 0.832, 0.919 and 0.966 respectively (all P<0.05).【Conclusion】 Recurrent respiratory tract infection is closely related to the levels of immunoglobulin, vitamin A, hs-CRP and IL-1. Vitamin A and IL-1 are positively correlated with immunoglobulin. An appropriate amount of vitamin A can be supplemented according to the specific situation of children. 2022 Vol. 39 (4): 586-588 [Abstract] ( 41 ) HTML (1 KB)  PDF (1251 KB)  ( 105 ) 589 Effect of Wrist Ankle Acupuncture Combined with Patient-controlled Intravenous Analgesia Pump on Pain and Complications in Patients with Mixed Hemorrhoids SHI Zhou-nai, WANG Yong-xiang DOI: 10.3969/j.issn.1671-7171.2022.04.031 【Objective】To investigate the effect of wrist ankle acupuncture combined with patient-controlled intravenous analgesia pump on pain and complications in patients with mixed hemorrhoids. 【Methods】 A total of 80 patients with mixed hemorrhoids who underwent external stripping and internal ligation from February 2019 to January 2020 were divided into control group and observation group, with 40 cases in each group. The dosage of analgesic pump, pain visual analogue scale (VAS), nursing satisfaction and complications were compared between the two groups. 【Results】The dosage of analgesic pump in the observation group was significantly lower than that in the control group at 12 h, 24 h and 48 h after operation (P<0.05); There was no significant difference in VAS score between the two groups on the first day after operation (P>0.05), but the VAS score of the observation group on the third and fifth day after operation was significantly lower than that of the control group; The nursing satisfaction of the observation group was significantly higher than that of the control group (P<0.05); The incidence of complications such as urinary retention, itching and vertigo in the two groups had no significant difference(P>0.05). 【Conclusion】 Wrist ankle acupuncture combined with patient-controlled intravenous analgesia pump can effectively reduce the pain of patients with mixed hemorrhoids, reduce the use of analgesic drugs, improve nursing satisfaction, and will not increase the incidence of complications. 2022 Vol. 39 (4): 589-592 [Abstract] ( 58 ) HTML (1 KB)  PDF (1253 KB)  ( 135 )

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