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| Effect of Methotrexate Combined with Uterine Artery Embolization on Uterine Curettage in Patients with Scar Pregnancy |
| ZHANG Fu-e, LI Juan |
| Department of Gynecology, Baoji People's Hospital, Baoji Shaanxi 721000 |
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Abstract 【Objective】 To investigate the effect of methotrexate combined with uterine artery embolization on uterine curettage in patients with scar pregnancy.【Methods】 A total of 60 patients with scar pregnancy who were diagnosed and treated in Baoji people's Hospital of Shaanxi Province from March 2018 to may 2021 and planned to undergo uterine curettage were randomly divided into control group and observation group. The control group was pretreated with mifepristone combined with methotrexate before uterine curettage, and the observation group was pretreated with methotrexate combined with uterine artery embolization before uterine curettage. The amount of intraoperative bleeding, menstrual recovery time, serum human chorionic gonadotropin(β- HCG), sex hormone level and occurrence of adverse reactions of the two groups were compared. 【Results】 The amount of bleeding in the observation group was (75.62 ± 28.39) ml, which was significantly less than (106.57±34.86) mL in the control group (P<0.05). The operation time ,the negative time of β-HCG and the recovery time of menstruation were (25.18±5.34) min, (22.39±6.17) d and (38.35±5.76) d, respectively, which were shorter than those of the control group (33.75±7.29) min, (29.84±7.63) d and (49.56±6.84) d (P<0.05); At 1 and 3 months after operation, the levels of sex hormones in the two groups were lower than those before operation (P<0.05); Three months after operation, the levels of sex hormones in both groups were higher than that in one month after operation, and the change range of sex hormone levels in the observation group was smaller (P<0.05); The total incidence of adverse reactions in the observation group was 6.67%, which was lower than 30.00% in the control group (P<0.05).【Conclusion】Methotrexate combined with uterine artery embolization can reduce the bleeding volume of complete curettage of uterine cavity, shorten the time of β-HCG turning negative, promote the recovery of menstruation after operation, and have little effect on sex hormone level and low incidence of adverse reactions.
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Received: 17 December 2021
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2022, Vol. 39 
