Abstract 【Objective】To investigate the efficacy of omeprazole and lansoprazole in the treatment of chronic gastritis and gastric ulcer and their effects on the levels of serum procalcitonin (PCT) and gastrin (gas). 【Methods】 A total of 72 patients with chronic gastritis and gastric ulcer treated in our hospital from February 2019 to February 2021 were randomly divided into observation group and control group, with 36 cases in each group. The control group was treated with omeprazole and the observation group was treated with lansoprazole. The treatment time of both groups was 14 days. The symptom disappearance time, clinical efficacy, serum PCT and gas levels, HP eradication rate and adverse reactions were compared between the two groups.【Results】The disappearance time of acid reflux, belching, epigastric pain and abdominal distension in the observation group was shorter than that in the control group (P<0.05).The total clinical effective rate in the observation group was 94.44% (34/36), which was significantly higher than 75.00% (27/36) in the control group (P<0.05); Before treatment, there was no significant difference in the levels of serum PCT and GAS between the two groups (P>0.05); After treatment, the levels of serum PCT and GAS in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The eradication rate of HP in the observation group was 94.44% (34/36), which was higher than 77.78% (28/36) in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Lansoprazole in the treatment of patients with chronic gastritis and gastric ulcer can shorten the disappearance time of clinical symptoms and has good curative effect. At the same time, it can reduce the levels of serum PCT and gas and improve the eradication rate of HP. It is safe and reliable.
LIU Ying,GAO Di. Efficacy of Omeprazole and Lansoprazole in the Treatment of Chronic Gastritis and Gastric Ulcer and their Effects on Serum PCT and GAS Levels[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 565-567.
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2022, Vol. 39 
