Abstract 【Objective】To investigate the correlation between immunoglobulin level and vitamin A, high-sensitivity C-reactive protein (hs-CRP) and interleukin-1 (IL-1) in children with recurrent respiratory tract infection. 【Methods】 A total of 75 children with recurrent respiratory tract infection (observation group) treated in our hospital from September 2019 to September 2020 were selected, and 75 healthy children with physical examination in the same period were selected as the control group. The levels of immunoglobulin (IGA, IgG, IgM), vitamin A, hs-CRP and IL-1 were compared between the two groups. The value of immunoglobulin and vitamin A, hs-CRP and IL-1 in predicting recurrent respiratory tract infection was analyzed by receiver operating characteristic (ROC) curve, and the correlation between immunoglobulin level and vitamin A, hs CRP and IL-1 was analyzed. 【Results】The levels of IgA, IgM, IgG, vitamin A and IL-1 in the observation group were significantly lower than those in the control group, and the level of hs-CRP was significantly higher than that in the control group (P<0.05). Pearson correlation analysis showed that vitamin A and IL-1 were positively correlated with IgA, IgM and IgG (P<0.05), and hs-CRP was negatively correlated with IgA, IgM and IgG (P<0.05). The AUC of IgA, IgM, IgG, vitamin A, hs-CRP and IL-1 in predicting recurrent respiratory tract infection were 0.881, 0.685, 0.665, 0.832, 0.919 and 0.966 respectively (all P<0.05).【Conclusion】 Recurrent respiratory tract infection is closely related to the levels of immunoglobulin, vitamin A, hs-CRP and IL-1. Vitamin A and IL-1 are positively correlated with immunoglobulin. An appropriate amount of vitamin A can be supplemented according to the specific situation of children.
OU Jing-lin,SUN Yi-juan. Correlation between Immunoglobulin Level and Vitamin A, hs-CRP and IL-1 in Children with Recurrent Respiratory Tract Infection[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(4): 586-588.
[1] LI X N, LIU Y, HUANG N , et al. The association between environmental lead exposure and recurrent respiratory infections in children aged 3-7 years in Shenyang, China[J].Indian Pediatr,2020, 57(11):1023-1025.
[2] JAYAWEERA J A A S. Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis[J].Sci Rep,2021, 11(1):10421.
[3] LEWANDOWICZ-USZYŃSKA A, PASTERNAK G, PENTO K. Immunoglobulin G deficiency in children with recurrent respiratory infections with and without history of allergy[J].Adv Exp Med Biol,2020, 1289(10):63-70.
[4] 刘江海. 免疫球蛋白、血清炎症因子在小儿呼吸道感染诊断中的价值[J].中国妇幼保健, 2019, 34(24):5679-5682.
[5] 卢競. 儿童反复呼吸道感染的诊断与治疗[J].中国医刊, 2007, 42(10):7-9.
[6] CELIKSOY M H, DOGAN C, ERTURK B, et al. The MEFV gene and its association with familial Mediterranean fever, severe atopy, and recurrent respiratory tract infections[J].Allergol Immunopathol,2020, 48(5):430-440.
[7] MUNTEANU A N, SURCEL M, HUIC R, et al. Peripheral immune cell markers in children with recurrent respiratory infections in the absence of primary immunodeficiency[J].Exp Ther Med,2019,18(3):1693-1700.
[8] 李政, 蒋晶晶, 巫波,等. 反复呼吸道感染患儿血清维生素A、E和体液免疫水平变化及临床意义的研究[J].成都医学院学报, 2019, 14(4):463-466.[9] 刘连娜. 维生素A缺乏和炎症因子与小儿呼吸道感染的相关性研究[J].现代医学与健康研究电子杂志, 2019, 3(24):30-32.
[10] 王国玉, 王浩宇, 巴春贺,等. 高流量湿化氧疗对老年下呼吸道感染患者血清IL-6与IL-1水平的影响[J].中国老年学杂志, 2021, 41(7):1418-1421.
[11] 黄瑞勋. 降钙素原与超敏C反应蛋白联合检测对上呼吸道感染早期诊断的临床价值[J].检验医学与临床, 2019, 16(2):227-229.
[12] 刘霞, 薛亦男, 杨慧,等. 维生素A、维生素D、维生素E水平与儿童反复呼吸道感染及免疫功能相关性研究[J].中国临床医生杂志, 2019, 47(9):1094-1097.
[13] 杨晓祥, 覃敏, 庞夏玲,等. 广西地区反复呼吸道感染儿童维生素A、E水平及其与免疫功能的相关性分析[J].浙江医学, 2020, 42(17):1867-1870.
[1]
. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 768-770.
2022, Vol. 39 
