|
|
|
| Clinical Efficacy and Safety of Caffeine Citrate Combined with Noninvasive Respiratory Support in the Treatment of Neonatal Severe Aspiration Pneumonia |
| ZHANG Fen-xia, FENG Cheng-hu, WU Xiao-yu, et al |
| Yan'an People's Hospital,Yan'an Shaanxi 716000 |
|
|
|
|
Abstract 【Objective】 To investigate the clinical efficacy and safety of caffeine citrate combined with noninvasive respiratory support in the treatment of neonatal severe aspiration pneumonia. 【Methods】 A total of 70 newborns with severe aspiration pneumonia treated in our hospital from June 2018 to April 2020 were prospectively selected and randomly divided into observation group (caffeine citrate combined with nasal continuous positive airway pressure ventilation,n= 34) and control group (caffeine citrate combined with nasal synchronous intermittent positive pressure ventilation,n= 36). The indexes of pulmonary function, respiratory mechanics and serum insulin-like growth factor binding protein-3 (IGFBP-3) and β- Endorphins(β- EP) were compared between the two groups,and the incidence of complications were also compared. 【Results】 After treatment, tidal volume (TV), peak time ratio (TPTEF/TE), peak volume ratio (VPEF/VE) and peak expiratory flow rate (PEF) in the two groups were higher than those before treatment (P<0.05), respiratory rate (RR), functional residual capacity (FRC) and effective airway resistance were lower than those before treatment (P<0.05), and there were significant differences between the observation group and the control group (P<0.05); The oxygenation index and lung compliance of the two groups were higher than those before treatment (P<0.05), and the inspiratory resistance was lower than that before treatment (P<0.05). There was significant difference between the observation group and the control group (P<0.05); The level of serum IGFBP-3 in the two groups was higher than that before treatment, and the level of β- EP was lower than that before treatment (P<0.05), and there was significant difference between the observation group and the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05).【Conclusion】 Caffeine citrate combined with noninvasive respiratory support model in the treatment of neonatal severe aspiration pneumonia can improve the indexes of pulmonary function and respiratory mechanics, and regulate serum IGFBP-3 and β- EP level, but transnasal synchronous intermittent positive pressure ventilation is better than transnasal continuous positive airway pressure ventilation.
|
|
Received: 06 December 2021
|
|
|
|
|
|
[1] 王新玲,高清.新生儿吸入性肺炎治疗中沐舒坦的应用[J].中国城乡企业卫生,2019,34(11):122-123.
[2] 沙春娜,张海鸿.枸橼酸咖啡因治疗早产儿呼吸暂停及预防支气管肺发育不良的效果[J].医学信息,2020,33(2):142-143.
[3] 黄进洁,马晓利,吴俊,等.无创呼吸支持模式对早产儿支气管肺发育不良及相关生物学指标的影响[J].中国现代药物应用,2019,13(2):16-17.
[4] PADMANABHAN R, PAULA L, TROY D,et al.FIRST-line support for Assistance in Breathing in Children (FIRST-ABC):a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care[J].Crit Care,2018,22(1):144.
[5] 尚彪,董文斌,刘娟,等.枸橼酸咖啡因治疗新生儿呼吸窘迫综合征的临床研究[J].重庆医学,2018,47(24):3155-3157.
[6] 庄方莉.枸橼酸咖啡因治疗早产儿原发性呼吸暂停及对智能发育的影响[J].北方药学,2019,16(3):21-22.
[7] FERMÍN GMR,LOURDES UM,GLORIA GH,et al.Neural breathing patterns in preterm newborns supported with non-invasive neurally adjusted ventilatory assist[J].J Perinatol,2018,38(9):1235-1241.
[8] 梁文英,黄水霞.枸橼酸咖啡因联合俯卧位经鼻持续气道正压通气治疗早产儿频发呼吸暂停56例[J].安徽医药,2020,24(5):1022-1026.
[9] 黄秋生,张伟峰,孙振宏,等.早产儿血清IGF-1、IGFBP-3浓度与孕周、胎龄及体重相关性探讨[J].医学理论与实践,2019,32(18):2984-2986.
[10] 邓演超,李全双,沈红艳,等.不同年龄健康儿童作为对照对IGF-1、IGFBP-3诊断GHD的准确度影响[J].国际检验医学杂志,2020,41(16):2021-2024.
[11] 刘静.神经节苷脂联合高压氧治疗对缺血缺氧性脑病新生儿炎性因子及血清BDNF、NSE、Bcl-2、β-EP水平的影响[J].中国医学工程,2020,28(2):85-87.
[12] 兰芳.经鼻持续气道正压通气对早产儿反复呼吸暂停β-EP、NPY表达的影响[J].中国医学创新,2018,15(6):20-23. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(5): 796-798. |
|
|
|
|
2022, Vol. 39 
