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Quick Search     Adv Search 2020 Vol. 37, No. 8 Published: 2020-08-30   1124 Effect of Nurse Led Rehabilitation Training on Mental State, Clinical Symptoms and Quality of Life of Inpatients with Schizophrenia YANG Wei-bo, DAI Jin-jun, YU Jian-ying, et al DOI: 10.3969/j.issn.1671-7171.2020.08.002 【Objective】 To explore the effect of nurse led rehabilitation training on mental state, clinical symptoms and quality of life of inpatients with schizophrenia.【Methods】 Seventy patients with schizophrenia admitted to our hospital from November 2017 to July 2018 were selected and randomly divided into observation group and control group, 35 cases in each group. Both groups were treated with medication and psychological nursing. The control group was given routine rehabilitation training guidance, while the observation group was given rehabilitation training guided by nurses on the basis of the control rehabilitation training guidance. The psychological status, clinical symptoms and quality of life of the two groups before and after the intervention were compared, and their compliance with nursing work was compared.【Results】 After the intervention, HAMA and HAMD scores of the two groups were significantly lower than those before the intervention, and the observation group was lower than the control group, the differences were statistically significant (P<0.05). After the intervention, the scores of lack of vitality, anxiety and depression, activation, thinking disorder and hostile suspicion of the two groups were lower than before intervention, and the observation group was significantly better than the control group, the differences were statistically significant (P<0.05). After the intervention, the scores of psychosocial, dynamic/energetic and symptom/adverse reactions in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The treatment and nursing compliance rate of the observation group was 94.29% (33/35), which was significantly higher than 77.14% (27/35) of the control group, and the difference was statistically significant (χ2=8.018,P=0.025<0.05). 【Conclusion】 The nursing led rehabilitation training intervention for inpatients with schizophrenia can effectively alleviate the bad psychological state of patients, and it is also of great significance in improving the clinical symptoms and quality of life of patients, which is worthy of promotion. 2020 Vol. 37 (8): 1124-1127 [Abstract] ( 200 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 1128 A study of Mismatch Negativity in Schizophrenic Patients with Affective Retardation TANG Pei-xi, SUN Qiao-ling, TAN Li-wen DOI: 10.3969/j.issn.1671-7171.2020.08.003 【Objective】 To investigate the relationship between the symptoms of emotional retardation and mismatch negativity (MMN) in event-related potential (ERP) in schizophrenia.【Methods】 Fifteen schizophrenic patients with and without affective retardation symptoms and 15 healthy subjects were selected as the subjects without medication or withdrawal for more than four weeks. The ERP data of all subjects under the auditory oddball paradigm were recorded, and the differences of MMN latency and amplitude among the three groups were compared. 【Results】 (1) MMN amplitude: in frontal region, the amplitude of MMN in the non affective group was lower than that in the healthy control group, while the MMN amplitude in the frontal region in the emotional retardation group was lower than that in the former two groups. In central area, left side and right side, only the MMN amplitude of patients with affective retardation was lower than that of healthy control group; in the middle, MMN amplitude of patients with and without affective retardation was lower than that of healthy control group, but there was no significant difference between the two groups. (2) There was no significant difference in MMN latency among the three groups.【Conclusions】 This study found that the process of pre attention processing is impaired in schizophrenic patients, and the degree of impairment is more serious in patients with emotional retardation. 2020 Vol. 37 (8): 1128-1132 [Abstract] ( 131 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 1133 Intrauterine Outcome and Clinical Prognosis of Fetus with Isolated Lateral Ventricle Enlargement Diagnosed by Ultrasonography ZHANG Mei-xiang, LUO Ying-chun, HOU Li-qiong, et al DOI: 10.3969/j.issn.1671-7171.2020.08.004 【Objective】 To investigate the intrauterine outcomes and clinical prognosis of fetuses with isolated ventriculomegaly (IVM) diagnosed by ultrasound. 【Methods】 Retrospective analysis of 536 cases of mild to moderate IVM fetuses diagnosed by prenatal ultrasound in our hospital from January 2013 to December 2017 were retrospectively analyzed.【Results】 The prenatal recovery rate of mild IVM was 74.70% (378/506), which was significantly higher than 13.33% (4/30) of moderate IVM (χ2=52.092,P=0.000). There were different degrees of abnormalities in 10 cases of IVM (1.87%, 10/536), including 6 cases of bilateral IVM (6.0%, 6/100) and 4 cases of unilateral (0.92%, 4/436). The risk of abnormal birth in bilateral IVM was significantly higher than that in unilateral IVM (χ2=11.477,P=0.001). There were 8 cases of postnatal neurobehavioral abnormalities (1.58%, 8/506) in mild IVM and 2 cases (6.67%, 2/30) in moderate IVM, but there was no significant difference in mild to moderate mental disorders (χ2=4.001,P=0.103).【Conclusion】 Most of the mild to moderate IVM fetuses have good intrauterine outcome and postnatal prognosis, but there is a certain risk of neurobehavioral abnormalities such as growth and development, language and intelligence development,especially in bilateral IVM. Therefore, attention should be paid to the follow-up after birth. 2020 Vol. 37 (8): 1133-1135 [Abstract] ( 176 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1136 Expression and Significance of Serum IL-4, TNF-α, IL-27 and IFN-γ Levels in Children with Upper Airway Cough Syndrome LI Hao, LIU Xiao-jia, ZHAO Hui, et al DOI: 10.3969/j.issn.1671-7171.2020.08.005 【Objective】 To investigate the changes and clinical significance of serum IL-4 ,TNF-α,IL-27 and IFN-γ levels in children with upper airway cough syndrome (UACS) before and after treatment. 【Methods】 The levels of IL-4 ,TNF-α,IL-27 and IFN-γ in serum of 15 healthy children volunteer (the control group) and 30 children with UACS (the observation group) before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA) and compared between both groups. 【Results】 The levels of IL-4 and TNF-α in serum of 30 children with UACS before treatment were higher than those of the control group, and the levels of IL-27 and IFN-γ were lower than those of the control group (P<0.05). After treatment, the levels of IL-4 and TNF-α in serum of 30 children with UACS were lower than before treatment, while the levels of IL-27 and IFN-γ were higher than before treatment. The differences were statistically significant (P<0.05). There were no significant differences in the levels of the above cytokines between the two groups of children after treatment (P>0.05).【Conclusion】 The expression levels of IL-4 and TNF-α in the serum of children with UACS increase, while the expression levels of IL-27 and IFN-γ decrease. IL-4, TNF-α, IL-27 and IFN-γ may play a role in immunomodulation in the pathogenesis of UACS in children. IL-4, TNF-α, IL-27 and IFN-γ can be used as evaluation indexes for clinical diagnosis and prognosis of UACS in children, which is worthy of clinical application. 2020 Vol. 37 (8): 1136-1138 [Abstract] ( 149 ) HTML (1 KB)  PDF  (0 KB)  ( 5 ) 1139 Effect of Dextroimide Combined with Levocarnitine on the Prevention of Cardiac Toxicity Induced by Epirubicin Chemotherapy in Patients with Hepatocellular Carcinoma SU Yan DOI: 10.3969/j.issn.1671-7171.2020.08.006 【Objective】 To study the efficacy and safety of dextroimide combined with levocarnitine for epirubicin-induced cardiotoxicity in patients with hepatocellular carcinoma. 【Methods】 A total of 86 patients with liver cancer received epirubicin chemotherapy in our hospital were selected as study subjects. The patients were randomly divided into two groups with 43 cases in each group. The patients in both groups were treated with epirubicin after admission. One day before chemotherapy, patients in the control group received dexamine injection, while patients in the observation group received both dextromine and levocarnitine. Patients in both groups were routinely given 5 cycles of adjuvant chemotherapy, with 3 weeks as a cycle. The changes of electrocardiogram (sinus tachycardia, premature beat, QRS low voltage, ST-T change, Q-T interval prolongation, atrioventricular block) and myocardial enzyme spectrum markers (LDH,cTnI,CK and CK-MB) were observed. The therapeutic effect and the incidence of non-cardiac toxicity were compared between the two groups as well. 【Results】 ①After treatment, the incidence of abnormal ECG in the two groups increased with the increase of the number of chemotherapy cycles. The incidence of abnormal ECG in the control group after treatment was higher than that before treatment (P<0.05). The incidence of abnormal electrocardiogram in the observation group was higher than that before treatment, however, the difference was not statistically significant (P<0.05). ②The level of myocardial enzyme spectrum in the observation group was not significantly increased after treatment, while the myocardial enzyme level of the control group after treatment was higher than that before treatment; and the difference was significant compared with that of the observation group (P<0.05). ③There was no statistically significant in the incidence of non-cardiac toxicity in both groups during the treatment (P>0.05). 【Conclusion】 Dextroimide combined with levocarnitine has a better protective effect on the occurrence of cardiac toxicity induced by epirubicin than single application of dextroimide. 2020 Vol. 37 (8): 1139-1141 [Abstract] ( 141 ) HTML (1 KB)  PDF  (0 KB)  ( 16 ) 1142 Effect of Different Doses of Dexmedetomidine on Analgesia in Women with Postoperative Cesarean Section GONG Hong-yue DOI: 10.3969/j.issn.1671-7171.2020.08.007 【Objective】 To study the effect of the applied dosage of dexmedetomidine onanalgesia in women with postoperative cesarean section. 【Methods】 A total of 168 patients with Cesarean section in our hospital were selected as the subjects of this study. According to the dose of dexmedetomidine, patients were divided into the control group and group A, B and C of dexmedetomidine, with 42 cases in each group. The control group did not use dexmedetomidine for analgesia, and the applied dosage of dexmedetomidine in group A, B and C was 0.3, 0.4 and 0.5μg/kg, respectively.The effect of different doses of dexmedetomidine on the postoperative analgesia in all groups was observed and compared. 【Results】 There was no significant difference in the operation time and the amount of blood loss among women in each group (P>0.05). Compared to the control group, the dynamic and static VAS scores of patients in group B and C were significantly lower (P<0.05), and those VAS scores in group C was slightly lower than in group B. The incidence of nausea and vomiting in groups A,B and C was lower than that in the control group (P< 0.05). and the incidence of bradycardia and hypotension in group C was higher than that in group A, B and the control group (P<0.05). 【Conclusion】 The application of dexmedetomidine to cesarean section women can effectively relieve postoperative pain, and the right dose of dexmedetomidine at 0.4 μg/kg has the best effect and has fewer side effects. 2020 Vol. 37 (8): 1142-1144 [Abstract] ( 161 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1145 Diagnostic Value of Serum Amino Acid, CEA and CA19-9 in Benign and Malignant Colorectal Space-occupying Lesions MEI Hao-yan, NIU Hui-hui DOI: 10.3969/j.issn.1671-7171.2020.08.008 【Objective】 To explore the application of serum amino acid, CEA and CA19-9 on the differential diagnosis of benign and malignant colorectal space-occupying lesions. 【Methods】 A total of 94 patients with colorectal space-occupying lesions treated in our hospital were selected. According to the examination results, patients were divided into two groups: the control group with benign lesions (n=63) and the observation group with malignant lesions (n=31). The basic clinical data, serum amino acid, CEA and CA19-9 levels were compared between the two groups. Statistically significant indicators were evaluated by multi-factor logistic analysis to explore the risk factors of malignant colorectal space-occupying lesions. 【Results】 The levels of citrulline, ethanolamine, serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) in the observation group were higher than those in the control group, while the levels of valine, serotonin and leucine were lower than the control group, and the differences were statistically significant (P <0.05). Multivariate logistic analysis showed that elevated citrulline, elevated ethanolamine, lowered valine, lowered serotonin, lowered leucine, elevated CEA, and elevated CA19-9 were the risk factors for colorectal malignant mass lesions. 【Conclusion】 Serum amino acids and CEA/CA19-9 are of great significance for the differential diagnosis of colorectal benign and malignant space-occupying lesions. The increased levels of citrulline, ethanolamine, CEA and CA19-9 and the decreased levels of valine, serotonin and leucine in patients may have the risk for colorectal malignant space-occupying lesions. 2020 Vol. 37 (8): 1145-1147 [Abstract] ( 130 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1148 Effect of Serum Uric Acid Level on the Risk of Diabetic Nephropathy in Patients with Diabetic Retinopathy HU Shu-yang, XU Yan, ZHAO Heng-xia DOI: 10.3969/j.issn.1671-7171.2020.08.009 【Objective】 To investigate the effect of serum uric acid level on the risk of diabetic nephropathy (DN) in patients with type 2 diabetic retinopathy (DR). 【Methods】 A total of 100 patients with type 2 diabetes mellitus without diabetic retinopathy in our hospital were enrolled in the study. Serum uric acid level was measured. The patients were followed up for incidence of DR and DN. The correlation between serum uric acid and DN was evaluated and the influencing factors of DN in patients with type 2 diabetes DR were analyzed. 【Results】 The average follow-up time was (33.2±3.1) months. No patients were lost to follow-up. A total of 23 cases (23.0%) of DN occurred, and the no-DN rate was 87.0% (87/100) in 2 years. The uric acid level in patients with DN was higher than that in patients without DN (P<0.05). Kaplan-Meier and Log-rank test showed that patients with elevated blood uric acid levels had shorter DN accumulation time than patients with reduced serum uric acid levels (P<0.05). Cox analysis showed that age, duration of diabetes, carotid atherosclerotic plaque, fundus lesions, fasting blood glucose, and uric acid were independent factors affecting DN in patients with type 2 diabetes (P<0.05). ROC analysis showed that the area under the curve uric acid to predict DN in DR patients with type 2 diabetes was 0.74, the sensitivity was 65.2% and the specificity was 78.9%.【Conclusion】 The risk of DN is significantly increased in type 2 diabetic DR patients with elevated serum uric acid level, and serum uric acid is an effective biomarker for predicting DN in patients with type 2 diabetes. 2020 Vol. 37 (8): 1148-1150 [Abstract] ( 141 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1151 Efficacy of Irinotecan Combined with Doxorubicin in Treatment of Nasopharyngeal Carcinoma and Influence on Peripheral Blood T Cell Subsets CHEN Yang DOI: 10.3969/j.issn.1671-7171.2020.08.010 【Objective】 To investigate the clinical effects of irinotecan combined with doxorubicin in patients with nasopharyngeal carcinoma and the influence of T cell subsets in peripheral blood. 【Methods】 A total of 72 patients with nasopharyngeal carcinoma random were divided into the conventional drug group (A group, n=36) and the combination group (B group, n=36). Both groups were treated with radiotherapy. A group was treated with cisplatin plus 5-fluorouracil. B group was treated with irinotecan combined with doxorubicin. A course of treatment contained 21 days and the whole procedure have 4 consecutive courses. The short-term efficacy, levels of peripheral blood T lymphocyte subsets and the incidence of toxic side effects were compared between the two groups. 【Results】 The short-term efficacy rate of the B group was 55.56% (20/36), which was higher than that of the A group 41.67% (15/36, P<0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in the B group after treatment were higher than those in the A group (P<0.05), while CD8+ level was lower in the A group (P<0.05).The incidence of red blood cell reduction, thrombocytopenia, myelosuppression, abnormal electrocardiogram and digestive tract reaction during the treatment in the B group was lower than that in the A group (P<0.05). 【Conclusion】 The combination treatment of irinotecan and doxorubicin in patients with nasopharyngeal carcinoma can obtain higher short-term effects, improve the peripheral blood T-cell subsets, and have a low incidence of side effects. It is worthy of popularization and application. 2020 Vol. 37 (8): 1151-1153 [Abstract] ( 104 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1154 Efficacy of Intravitreal Injection Ranibizumab Combined with Subthreshold Micropulse Laser Photocoagulation Treatment for Macular Edema Secondary to Branch Retinal Vein Occlusion ZENG Feng, LU Ya-mei, ZHOU Yuan-qing, et al DOI: 10.3969/j.issn.1671-7171.2020.08.011 【Objective】 To investigate the clinical efficacy of intravitreal injection ranibizumab combined with 532nm subthreshold micropulse laser photocoagulation treatment for macular edema (ME) secondary to branch retinal vein occlusion (BRVO). 【Methods】 A total of 30 patients (30 eyes) with macular edema secondary to branch retinal vein occlusion were randomly divided into the control group (with ranibizumab therapy) and the observation group (ranibizumab combined with 532nm subthreshold micropulse laser therapy).The best corrected visual acuity(BCVA),central macular thickness(CMT), repeated injection times and complications were compared between the two groups before and after treatment. 【Results】 After treatment, patients' BCVA of the two groups decreased; And the difference was statistically significant compared to that before treatment (P<0.05). However, there was no statistically significant difference in BCVA between the two groups at each time point (P>0.05). The CMT of the two groups gradually decreased after treatment, and the difference was statistically significant compared with that before treatment (P<0.05). There was no significant difference within the observation group only at d7 and 1 month after treatment (t=0.954,P>0.05); The differences at the remaining time points within the observation group showed statistically significant (P<0.05). Patients in the observation group had an average intraocular injection (1.73±0.96) times, which was significantly lower than the control group (3.07±0.70) times. The difference was statistically significant (P<0.05). No serious eye and systemic adverse reactions occurred during follow-up. 【Conclusion】 Intravitreal injection ranibizumab combined with 532nm subthreshold micropulse laser photocoagulation shows effective treatment for macular edema secondary to branch retinal vein occlusion, which can improve condition of macular edema and vision. It also reduces the number of intraocular injection. 2020 Vol. 37 (8): 1154-1157 [Abstract] ( 114 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1158 Effect of Robotic Repair of Atrial Septal Defect in Adults with Secondary Atrial Septal Defect SHAO Ming-xiu, TIAN Li, LI Jian-mei, et al DOI: 10.3969/j.issn.1671-7171.2020.08.012 【Objective】 To investigate the clinical effect of robot repair of atrial septal defect in adult patients. 【Methods】 The clinical data of 110 patients with secondary atrial septal defect admitted to our hospital were retrospectively analyzed. According to the different treatment methods, they were divided into observation group (robot atrial septal defect repair, n=57) and control group (transcatheter closure, n=53). The operation time, hospital stay, postoperative blood transfusion rate and postoperative complications were compared between the two groups. The right atrial diameter (RA), right ventricular diameter (RV), left atrial diameter (LA) and left ventricular diameter (LV) were compared between the two groups before and 6 months after operation.【Results】 The operation time, hospital stay and postoperative blood transfusion in the observation group were significantly higher than those in the control group (P<0.05). 6 months after operation, RA and RV in observation group and control group were lower than those before operation, the difference was statistically significant (P<0.05); LA and LV of two groups were not statistically significant (P>0.05); RA and RV of observation group were significantly lower than those of control group at 6 months after operation, the difference was statistically significant (P<0.05). The incidence of postoperative complications in the observation group was 5.26% (3/57), which was lower than 24.53% (13/53) of the control group, and the difference was statistically significant (χ2=8.200, P=0.004<0.05).【Conclusion】 Robot atrial septal defect repair plays an important role in the treatment of adult secondary atrial septal defect. It can significantly reduce postoperative RA and RV, and has high clinical safety. 2020 Vol. 37 (8): 1158-1160 [Abstract] ( 88 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1161 Novel Coronavirus Pneumonia in Pediatric Emergency Department by 4R Crisis Management Theory JIANG Yan, LIU Ping, LEI Guang-feng DOI: 10.3969/j.issn.1671-7171.2020.08.013 【Objective】 During the epidemic of novel coronavirus pneumonia (COVID-19), 4R crisis management theory was adopted to take positive and effective measures to avoid recurrence and spread of infection.【Methods】 From January 24, 2020 to March 7, 2020, a 4R crisis management method was adopted in the pediatric emergency room of our hospital. The four links of crisis reduction, crisis preparation, crisis response and crisis recovery were taken as nodes to establish and improve the department nursing management system in special period for comprehensive prevention and control. Our mission is to evaluate the situation of suspected cases treated by screening in pediatric emergency room, medical staff's mastery of covid-19 knowledge, pediatric emergency screening process, correct use of masks, standard protection and other knowledge, so as to understand the wearing rate and correct rate of masks of all people in pediatric emergency department, the number of accompanying persons per day, and the incidence of hospital infection. 【Results】 During this period, a total of 20 children who need further evaluation were screened out by pediatric emergency department of our hospital. Among them, 10 cases were confirmed as suspected cases and went to the designated hospital for observation. No confirmed cases were found. The qualified rate of medical staff in mastering covid-19 knowledge, pediatric emergency treatment process and emergency plan, correct use of masks and standard protection increased from 67% to 100%. The rate of wearing masks increased from 45.5% to 96.0% and the correct rate of wearing masks increased from 80.6% to 95.0%. The number of visiting and accompanying persons decreased from 3.1 cases per day before management to 1.8 cases per day per capita per day. No infection was found among medical staff, and the infection rate was 0%. 【Conclusion】 4R crisis management theory and methods are conducive to guide the prevention and control and management of pediatric emergency during the spread of covid-19 epidemic, improve the efficiency of hospital diagnosis and treatment, reduce hospital infection, and ensure the safety of children, family members and medical staff, and control the spread of the epidemic. This study can be used for reference and reference for the management of departments in similar situations. 2020 Vol. 37 (8): 1161-1164 [Abstract] ( 128 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1165 Effect of Total Thoracoscopic Lobectomy on Protein Metabolism and Stress Factors in Elderly Patients with Lung Cancer HE Chun-lei, LIU Ai-lan, LU Ming-lei, et al DOI: 10.3969/j.issn.1671-7171.2020.08.014 【Objective】 To investigate the effect of total thoracoscopic lobectomy on protein metabolism and stress factors in elderly patients with lung cancer.【Methods】 Methods: a total of 120 patients with lung cancer who were treated in our hospital from April 2016 to April 2018 were retrospectively selected and divided into observation group and control group according to different surgical schemes. The observation group was treated with thoracoscopic lobectomy, and the control group was treated with traditional thoracotomy lobectomy. Before and 5 days after operation, the serum protein metabolic reaction indexes such as retinol binding protein (RBP), prealbumin (PA), transferrin (TRF), bradykinin (BK), substance P (SP) and prostaglandin E2 (PGE2) were compared between the two groups. 【Results】 The incision length, blood loss, operation time and hospitalization time in the observation group were significantly less than those in the control group, and the difference was statistically significant (P<0.05). After operation, the decrease range of serum RBP, PA, TRF levels in the observation group was less than that in the control group, and the increase range of serum BK, SP, PGE2 levels was less than that of the control group, the differences were statistically significant (P<0.05).【Conclusion】 Thoracoscopic lobectomy in the treatment of elderly patients with lung cancer can reduce the degree of pain and stress in patients with relatively small impact on metabolic response, which is a safe and effective treatment method, worthy of clinical application. 2020 Vol. 37 (8): 1165-1167 [Abstract] ( 93 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1168 Analgesic Value of Pecs-Ⅱ Guided by Ultrasound in Radical Breast Cancer Surgery QIAN Wei, ZHAO Ying, ZHANG Jing-jing DOI: 10.3969/j.issn.1671-7171.2020.08.015 【Objective】 To explore the sedative value of ultrasound-guided thoracic nerve block Ⅱ (Pecs-Ⅱ) in radical mastectomy of breast cancer . 【Methods】 A total of 84 patients with radical mastectomy due to breast cancer who were treated in our hospital were selected as subjects. All patients were randomly divided into two groups. Among them, 42 patients in the control group received thoracic paravertebral nerve block (TPVB) and 42 patients in the observation group underwent ultrasound-guided thoracic nerve block Ⅱ(Pecs-Ⅱ).The operation time, sufentanil dosage within 24 hours, 24-hour VAS score, heart rate, mean arterial pressure and the incidence of adverse reactions were compared between the two groups. 【Results】 The average operation time of the observation group was 122.14±12.03 min, which was not significantly different from the control group's 135.27±13.26 min (P>0.05). The dosage of sufentanil for PCIA , the VAS score , heart rate and average arterial pressure 24 hours after surgery in the observation group were better than those in the control group. The difference was statistically significant (P<0.05). The incidence of adverse reactions such as nausea, vomiting, excessive analgesia, and respiratory depression in the observation group was lower than that in the control group. The difference between the two groups was statistically significant (P<0.05). 【Conclusion】 Ultrasound-guided Pecs-Ⅱ can effectively improve the analgesic value of women undergoing radical surgery for breast cancer, reduce the dosage of sufentanil, relieve pain, enhance analgesic effect, ensure heart rate and blood pressure well maintained at normal level, and reduce the incidence of adverse reactions. It is worth promoting in clinic. 2020 Vol. 37 (8): 1168-1170 [Abstract] ( 118 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1171 Clinical Effect of Intracranial and External Artery Bypass Grafting in the Treatment of Complex Middle Cerebral Aneurysms YU Li-gang, CUI En-dong, XU Zhen-dong, et al DOI: 10.3969/j.issn.1671-7171.2020.08.016 【Objective】 To investigate the effect of extracranial and intra arterial (IC-EC) artery bypass grafting in the treatment of complex middle cerebral artery aneurysms. 【Methods】 The clinical data of 22 patients with complex middle cerebral aneurysms treated in our hospital from January 2014 to January 2018 were retrospectively analyzed. IC-EC artery bypass grafting was performed. The prognosis of patients was evaluated by mRS score, and the living ability of patients was evaluated by daily living scale (ADL). DSA examination confirmed the patency after vascular reconstruction, including regional cerebral blood volume (rCBV), relative time to peak (RTTP), relative mean transit time (rMTT).【Results】 DSA was reexamined in all patients 1-2 weeks after operation. The results showed that the parent artery was completely occluded, the blood flow was unobstructed, and there was no death case.The mRS score at 7 days and 3 months after operation was significantly lower than that before operation, while the ADL score was significantly higher than that before operation (P<0.05); the mRS score of 3 months after operation was significantly lower than that of 7 days after operation, and the ADL score was significantly higher than that of 7 days after operation, the differences were statistically significant (P<0.05). The rCBV of 7 days and 3 months after operation was significantly higher than that before operation, while rMTT and rTTP were significantly lower than those before operation (P<0.05); rCBV of 3 months after operation was significantly higher than that of 7 days after operation, while rmtt and rTTP were significantly lower than 7 days after operation, the differences were statistically significant (P<0.05).【Conclusion】 IC-EC artery bypass grafting has a good effect in the treatment of MCA aneurysms, which is worthy of clinical use. 2020 Vol. 37 (8): 1171-1173 [Abstract] ( 84 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1174 Effect of Safflower Injection Combined with Limb Rehabilitation Therapy in the Treatment of Cerebral Infarction and its Influence on Serum Inflammatory Factors XIAO Lin-ting, ZHOU Hui, ZHOU Jing-xia DOI: 10.3969/j.issn.1671-7171.2020.08.017 【Objective】 To investigate the curative effect of safflower injection combined with limb rehabilitation therapy in the treatment of cerebral infarction and its influence on serum inflammatory factors.【Methods】 One hundred and twelve patients with cerebral infarction in our hospital from September 2015 to may 2017 were selected and randomly divided into observation group and control group. The control group was given routine rehabilitation treatment, while the observation group was treated with Safflower Injection on the basis of the control group. The clinical efficacy, hemodynamic changes and serum inflammatory factor levels of the two groups were compared.【Results】 The clinical total effective rate of the observation group was 92.86%, significantly higher than 78.57% of the control group, the difference was statistically significant (χ2=4.667, P<0.05); after treatment, the Fugl Meyer Rating Scale (FMA) score and Barthel Index (BI) score of the observation group were significantly higher than those of the control group, and the NIHSS score was significantly lower than that of the control group (P<0.05) The blood high shear viscosity, low shear viscosity and plasma viscosity of the observation group were significantly lower than those of the control group, and the maximum peak flow velocity and vascular resistance index of bilateral middle cerebral arteries were significantly higher than those of the control group, and the difference was statistically significant (P<0.05); after treatment, the levels of serum high-sensitivity C-reactive protein (hs CRP) and central nerve specific protein (S100 β protein) in the observation group were significantly lower than those in the control group The levels of vascular endothelial growth factor (VEGF) and transforming growth factor-β1(TGF-β 1) in the two groups were significantly higher than those in the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 On the basis of conventional rehabilitation therapy, safflower injection can effectively improve the clinical efficacy of patients with cerebral infarction, improve the blood flow status of patients, and reduce the level of serum inflammatory factors, which is worthy of clinical application. 2020 Vol. 37 (8): 1174-1177 [Abstract] ( 82 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1178 Expression and Significance of CA125, CA50 and CEA in Patients with Cardiac Cancer WANG Xiang-jun, TIAN Chuan, ZHANG Jian-she DOI: 10.3969/j.issn.1671-7171.2020.08.018 【Objective】 To investigate the expression and clinical significance of carcinoembryonic antigen (CEA), carbohydrate antigen (CA125 and CA50) in patients with cardiac cancer . 【Methods】 A total of 80 patients with cardiac cancer were selected as the observation group. At the same time period, 80 healthy volunteers were enrolled as the control group. The serum levels of CA125, CA50 and CEA were measured and compared in the two groups. The differences of CA125, CA50 and CEA levels in patients with different staging of cardiac cancer were compared as well. 【Results】 Serum CA125, CA50 and CEA levels in the observation group were 52.35±5.17 U/mL, 7.34±1.32 U/mL, 3.46±0.92 ng/mL, respectively, which were higher than those of the control group (25.46±2.09 U/mL, 5.86. ±1.01 U/mL, 1.85±0.84 ng/mL, respectively). The differences were statistically significant ( P<0.01). The levels of CA125, CA50, and CEA levels were higher in cardiac cancer patients with clinical stage Ⅲ, medium and moderate and poorly differentiated histological grade, and with lymph node metastasis. There were no significant differences in CA125, CA50, and CEA levels between patients with different genders.Regression analysis of CEA level as a dependent variable showed that lymph node metastasis was a factor affecting CA125, CA50, and CEA levels in patients with cardiac cancer. 【Conclusion】 The expression levels of CA125, CA50 and CEA in patients with cardiac cancer are higher and are affected by lymph node metastasis. 2020 Vol. 37 (8): 1178-1180 [Abstract] ( 90 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 1181 Safety and Efficacy of Surgical Treatment of Intracranial Cavernous Hemangioma with Epilepsy GUO Zi-kang, QUAN Tian-long DOI: 10.3969/j.issn.1671-7171.2020.08.019 【Objective】 To investigate the safety and clinical effect of surgical treatment of intracranial cavernous hemangioma with epilepsy. 【Methods】 A total of 76 cases of intracranial cavernous hemangioma with epilepsy in our hospital from January 2013 to August 2017 were selected. The postoperative clinical effect, postoperative neurological function recovery and clinical complications were recorded.【Results】 76 patients were followed up postoperatively. At the last follow-up, Engel classification was grade Ⅰ in 41 cases (53.95%), grade Ⅱ in 19 cases (25.00%), grade Ⅲ in 12 cases (15.79%), grade Ⅳ in 4 cases (5.26%). The proportion of patients with course of disease less than 2 years and surgical method of complete resection + cauterization were 78.79% and 65.91%, respectively, which were significantly higher than those of patients with course of disease ≥ 2 years and complete resection (P<0.05).Logistic regression analysis showed that duration of disease ≥ 2 years was the risk factor of Engel grade Ⅰ (OR=1.956, P<0.05).Complete resection + cauterization were the protective factors of Engel grade Ⅰ (OR=0.643, P<0.05).【Conclusion】 Surgical treatment of intracranial cavernous hemangioma with epilepsy has good effect and safety, worthy of clinical application. 2020 Vol. 37 (8): 1181-1183 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 1184 Relationship between NLR, PLR and Breast Cancer LIU Cong-fang, WANG Bao-xiang, WU Yu-hui, et al DOI: 10.3969/j.issn.1671-7171.2020.08.020 【Objective】 To analyze the correlation between neutrophil count/lymphocyte count (NLR), platelet count/lymphocyte count (PLR) and clinicopathological parameters in patients with breast cancer.【Methods】 Four hundred and thirty-three cases of breast cancer patients (breast cancer group), 631 cases of breast BIRADS class 1 (normal group) and 309 cases of breast BIRADS 2-3 (benign breast disease group) in our hospital from June to December 2018 were selected as the research objects. The age, neutrophil count, lymphocyte count, platelet count of each group were collected, and the clinicopathological data of breast cancer group were collected, including clinical stage, molecular typing, pathological grade, Ki67, lymph node metastasis and other indicators. NLR, platelet count and lymphocyte count were calculated to calculate PLR value. The NLR and PLR of normal group, benign breast disease group and breast cancer group were compared, and the relationship between NLR, PLR and clinicopathological parameters of breast cancer was analyzed.【Results】 There were significant differences in NLR among breast cancer group, benign breast disease group and normal group (P<0.05). There was significant difference in PLR among the three groups (P<0.05), but there was no significant difference between breast cancer and benign breast disease group, between breast cancer and normal group (P>0.05). The area under ROC curve (AUC) was 0.573, 95% CI was 0.54-0.606. NLR and PLR had no significant correlation with pathological grade, Ki67 and molecular typing of breast cancer (P>0.05). However, NLR was correlated with lymph node metastasis of breast cancer (P<0.05), and was positively correlated with NLR (rs=0.103, P=0.033). PLR was positively correlated with PLR (rs=0.188, P=0.00) and clinical stage (rs=0.135, P=0.005).【Conclusion】 The level of NLR and PLR can predict lymph node metastasis to a certain extent. PLR is positively correlated with clinical stage, suggesting that NLR and PLR have certain correlation with prognosis of breast cancer patients. 2020 Vol. 37 (8): 1184-1187 [Abstract] ( 116 ) HTML (1 KB)  PDF  (0 KB)  ( 8 ) 1188 Clinical Analysis of Interventional Embolization in the Treatment of Small Anterior Communicating Artery Aneurysms GONG Yong, FAN Tian-yu, ZHANG Shuai, et al DOI: 10.3969/j.issn.1671-7171.2020.08.021 【Objective】 To investigate the clinical effect of interventional embolization in the treatment of small anterior communicating artery aneurysm.【Methods】 The clinical data of 28 patients with small anterior communicating artery aneurysms treated by interventional embolization in the Department of Neurosurgery of Changsha Central Hospital from January 2011 to June 2017 were collected, and the treatment process was analyzed. The prognosis was evaluated by improved Rankin Scale score 6 months after operation, and the prognosis was considered as good if the score was less than or equal to 2.【Results】 Among the 28 cases, 2 cases died, 8 cases had poor prognosis, 20 cases had good prognosis and no plant survival patients. Six months after operation, 21 patients underwent DSA reexamination, all showed that the parent artery was unobstructed, and no obvious stenosis was found in the stent; 2 cases of aneurysm recurrence, all of them were patients with simple coil embolization. Seven patients failed to undergo DSA reexamination, including 2 dead patients, and 5 patients were followed up by telephone. 【Conclusion】 Interventional embolization for the treatment of small anterior communicating artery aneurysms has good short-term effect and good prognosis, which is worthy of clinical reference. 2020 Vol. 37 (8): 1188-1191 [Abstract] ( 77 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1192 Correlation between Lymphocyte Count and 3-year Mortality in Elderly Patients with Severe COPD WU Jin-song, ZHANG Yan, ZHANG Huai-zhong DOI: 10.3969/j.issn.1671-7171.2020.08.022 【Objective】 To evaluate the correlation between the relative lymphocyte count (L%) and the 3-year mortality in elderly patients with COPD.【Methods】 A total of 69 patients with chronic obstructive pulmonary disease (COPD) in our hospital from August 2015 to August 2016 were selected for the study. Patients were divided into two groups according to the relative lymphocytes count. Group A was the relative lymphocyte count ≤ 20% and the group B was the relative lymphocyte count > 20%. The general data of the two groups were collected, all patients were followed up for 3 years after discharge. Thus the general data of the two groups were compared and the relationship between the relative lymph count and the 3-year mortality rate was analyzed. 【Results】 Among 69 patients, 27 (39.13%) patients had the relative lymphocyte count ≤20% (group A), and 42 (60.87%) patients had the relative lymphocyte count >20% (group B).The 3-year mortality rates of patients in the group A and group B were 81.48%(22/27)and 57.14%(24/42),respectively (P<0.05). The survival curve analysis showed that the mortality of patients with relative lymphocytes count ≤ 20% was higher; And the difference was statistically significant (P<0.05). After adjusting for age and gender the risk of death was 1.88 [95% confidence interval CI:1.21~2.56,P<0.01].【Conclusion】 Lower relative lymphocyte count is associated with higher mortality in elderly patients with severe COPD. This result suggests that relative lymphocyte count can predict the prognosis of elderly patients with severe COPD. 2020 Vol. 37 (8): 1192-1194 [Abstract] ( 88 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1195 Clinical Efficacy of Injured Vertebrae Fixation and Posterior Ligament Complex Reconstruction for Treatment of Thoracolumbar Burst Fractures WANG Shou-gang, YUE Hai-yuan DOI: 10.3969/j.issn.1671-7171.2020.08.023 【Objective】 To investigate the clinical efficacy of fixation of the injured vertebrae and reconstruction of the posterior ligament complex for the treatment of thoracolumbar burst fractures. 【Methods】 From June 2012 to June 2018, 160 patients with thoracolumbar burst fractures were treated with laminectomy, injured vertebrae fixation and reconstruction of the posterior ligament complex. Among them, there were 112 males and 48 females, aged from 18 to 58 (36.10±7.43) years old. The degree of vertebral body reduction and fracture healing were analyzed. 【Results】 The patients were followed up for 8 to 61 months, with an average of (38.40±6.36) months. Among the 160 patients, 153 cases of spinal fracture healed on schedule, accounting for 95.63%; And 6 cases of delayed fracture healing, accounting for 3.75%. The total healing rate was 99.38%. The X-ray results showed that the height of the injured vertebrae recovered and no internal fixation occurred unexpectedly. The ASIA classification of spinal cord function increased by 1 to 3. 【Conclusion】 Fixing and reconstructing the posterior ligament complex through the injured vertebra can effectively avoid spinal instability and internal fixation accidents. The clinical curative effect is excellent and it is an effective method for the treatment of thoracolumbar burst fractures. 2020 Vol. 37 (8): 1195-1197 [Abstract] ( 94 ) HTML (1 KB)  PDF  (0 KB)  ( 22 ) 1198 Clinical Effect of VATS in the Treatment of Elderly snNSCLC Patients ZHANG Ya-nian, ZHONG Ning, ZHANG Lu DOI: 10.3969/j.issn.1671-7171.2020.08.024 【Objective】 To investigate the clinical effect of video-assisted thoracoscopic surgery (VATS) in the treatment of elderly patients with small nodule non-small cell lung cancer (snNSCLC). 【Methods】 A total of 120 elderly patients with snNSCLC treated in our hospital from January 2016 to March 2019 were selected, the patients were divided into observation group (n=62) and observation group (n=58) according to the selected surgical scheme, the observation group was treated with VATS, while the control group was treated with traditional thoracotomy, the operation time and bleeding volume and so on were observed. 【Results】 The operation time, bleeding volume and drainage volume in the observation group were (180.64±23.34) min, (260.51±52.87) mL and (630.03±100.45) mL, which were significantly less than those in the control group (P<0.05); The levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), cortisol and prostaglandin E2 (PGE2) in the observation group at3 days after operation were (40.10±5.54) mg/L, (63.35 ±5.15) pg/mL, (120.05±25.54) ng/mL and (182.26±21.50) ng/mL, which were significantly lower than those in the control group (P<0.05);There were no significant difference in the incidence of complications, recurrence or metastasis between the observation group and the control group (P>0.05). 【Conclusion】 VATS has a good clinical effect in the treatment of elderly patients with snNSCLC, the patients'stress and inflammatory reaction are mild, which is worthy of clinical use. 2020 Vol. 37 (8): 1198-1200 [Abstract] ( 80 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 1201 Clinical Characteristics and Nursing Methods of Patients with Acute Cutaneous Graft-Versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation LU Dan, HU Yan DOI: 10.3969/j.issn.1671-7171.2020.08.025 【Objective】 To investigate the clinical characteristics and nursing methods of patients with acute skin graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. 【Methods】 The clinical characteristics of 42 patients with allogeneic hematopoietic stem cell transplantation who were treated in our hospital from January 2013 to January 2015 were retrospectively analyzed. The incidence, clinical characteristics and nursing methods of acute skin type GVHD were analyzed.【Results】 Among the 42 patients, 15 cases were complicated with acute skin GVHD, the incidence rate was 35.7%, including 5 males and 10 females. There were 5 cases of acute myeloid leukemia (AML) (33.3%), 2 cases of acute lymphoblastic leukemia(ALL) (13.3%), 4 cases of myelodysplastic syndrome (MDS) (26.7%), 2 cases of aplastic anemia (AA)(13.3%), 1 case of chronic myeloid leukemia (CML) (6.7%), 1 case of acute mixed cell leukemia (MAL)(6.7%). There were 13 sibling donors (86.7%) and 2 unrelated donors (13.3%). In this group, 15 cases of acute skin type GVHD rash appeared at the earliest 3 days after stem cell infusion, and the latest time was 38 days; the rash initially manifested as mild diffuse erythema and papules, similar to measles and scarlet fever like drug eruption, with slight pain or pruritus. The most common sites were palms, head and face, and behind ears. The severity of the lesions was grade Ⅰ and grade Ⅱ. All the 15 patients were treated with psychological nursing. After communication, their mood improved significantly, they were able to face the disease positively, and they were able to accept treatment and nursing with the best mentality. No serious infection occurred. The skin involved in 15 patients with acute GVHD was grade Ⅰ to Ⅱ. No skin blister and skin integrity damage occurred, and no medical adhesive related skin lesions occurred.Among the 15 patients, 13 patients' rash subsided and discharged after active treatment and careful nursing. 2 cases occurred after the reduction of methylprednisolone. The range of rash was obviously extended and the color became red obviously. Because the nurses found and handled the rash in time, the rash was quickly controlled, and 2 cases were obviously improved and discharged. Allogeneic hematopoietic stem cell transplantation was successfully performed in 15 patients with acute GVHD.【Conclusion】 Acute skin GVHD has certain clinical characteristics. Observing skin symptoms, early detection and intervention are helpful to improve the prognosis and ensure the successful completion of hematopoietic stem cell transplantation. 2020 Vol. 37 (8): 1201-1203 [Abstract] ( 95 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1204 Serum Levels and Clinical Significance of HIF-α and VEGF in Adult Patients with Sudden Sensorineural Hearing Loss LIU Zi-di, DEN Xiao-wen, SONG Gui-lin DOI: 10.3969/j.issn.1671-7171.2020.08.026 【Objective】 To investigate the clinical significance through measuring serum levels of hypoxia-inducing factor -α(HIF-α) and vascular endothelial growth factor (VEGF) in adult patients with sudden sensorineural hearing loss (SSHL).【Method】 Clinical data of 50 adult patients with SSHL admitted to our hospital were selected as the observation group, and 50 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. Serum HIF-α and VEGF levels in the two groups were detected, then their correlation to SSHL was analyzed. 【Result】 The level of HIF-α in the observation group was significantly higher than that in the control group (P<0.05). In the observation group, there was no significant difference in the HIF-α level among SSHL patients of different ages (P>0.05);The level of VEGF in the observation group was not significantly higher than that in the control group (P>0.05). However, the VEGF level of SSHL patients aged less than or equal to 40 years old was significantly higher than that of patients aged over 40 years old (P<0.05). There were no significant differences in the levels of HIF-α and VEGF in SSHL patients with different genders and deafness degrees (P<0.05). 【Conclusion】 The changes of serum HIF-α and VEGF levels in SSHL patients are related to the pathogenesis of SSHL. These changes and correlations may indicate the severity of the disease, help clinical treatment and evaluate the prognosis. 2020 Vol. 37 (8): 1204-1206 [Abstract] ( 108 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 1207 Effect of Angiotensin Ⅱ Receptor Inhibitor on the Expression of Gap Connexin Cx43 in Rats with Myocardial Ischemia GAO Yi-kai, ZHANG Li DOI: 10.3969/j.issn.1671-7171.2020.08.027 【Objective】 To investigate the effect of angiotensin Ⅱ receptor inhibitor valsartan on the expression of gap connexin Cx43 in rats with myocardial ischemia. 【Methods】 Sixty SD rats were randomly divided into blank control group (group A), sham operation group (group B), model group (group C) and valsartan group (group D). The Group D was pretreated with valsartan, and the groups of A, B and C were given equal amount of saline, and 7d was used continuously. The model of myocardial ischemia was established in the group C and the group D, and the rat was killed after the model was set up by 1h. The histopathological changes, expression of Cx43 protein and the gene in myocardium of the 4 groups were observed. 【Results】 The pathological changes of myocardial ischemia in the group D were less than that in the group C. The expression level of Cx43 protein and gene in the C group was significantly lower than that in the group A and the group B (P<0.05), and the expression level of Cx43 protein and gene in the group D was significantly higher than that inthe C group (P<0.05). 【Conclusion】 Valsartan preconditioning can reduce the decrease of Cx43 induced by myocardial ischemia and alleviate the pathological changes of myocardial ischemia tissue, and have protective effect on myocardial ischemia rats. 2020 Vol. 37 (8): 1207-1209 [Abstract] ( 83 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 1210 Value of Neutrophil Level in Differentiating Diagnosis for Different Types of Interstitial Lung Disease HUANG Ren-yuan, SONG Yuan-yuan, YING Han-qiu DOI: 10.3969/j.issn.1671-7171.2020.08.028 【Objective】 To explore the value of neutrophil level in differential diagnosis for different types of interstitial lung disease (ILD).【Methods】 A total of 98 ILD patients were admitted to our hospital, including 48 cases of idiopathic interstitial pulmonary fibrosis (IPF-ILD,A group )and 50 cases of connective tissue disease-related ILD (CTD-ILD,B group ). In the same time period, 50 healthy volunteers who underwent physical examination were selected as the control group. The levels of neutrophils in three groups were compared. The ROC curve was drawn to analyze the differential value of neutrophils in different types of ILD.Serum levels of human interferon-gamma induced protein-10 (IP-10), human epithelial cell-derived neutrophil activating peptide-78 (ENA-78) and type I procollagen (PCI) were measured in patients with different types of ILD. The correlation of neutrophil level with serum IP-10, ENA-78 and PCI in patients with ILD was analyzed.【Results】 The levels of neutrophils in ILD patients of both A group and B group were significantly higher than that in the control group (P<0.05).The level of neutrophils in A group was significantly higher than that in B group (P<0.05).The area under the curve of differentiating IPF-ILD and CTD-ILD at neutrophil level was 0.657 (P<0.05).The level of serum IP-10 in A group was significantly higher than that in B group (P<0.05). There was no significant difference in serum ENA-78 and PCI between the two groups (P>0.05). Pearson analysis showed that neutrophil level was positively correlated with serum IP-10 ( P<0.05), but not with ENA-78 and PCI ( P>0.05).【Conclusion】 The level of neutrophils has certain value in differentiating IPF-ILD and CTD-ILD, and it is positively correlated with serum IP-10 in patients with ILD. 2020 Vol. 37 (8): 1210-1212 [Abstract] ( 79 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1213 Expression and Clinical Significance of miR-133 and EGFR in Colon Cancer LI Mei-Ling, ZHANG Guang-Ying DOI: 10.3969/j.issn.1671-7171.2020.08.029 【Objective】 To investigate the expression and clinical significance of miR-133 and epidermal growth factor receptor (EGFR) in colon cancer. 【Methods】 The expressions of miR-133 and EGFR were detected by real-time fluorescent quantitative PCR (RT-PCR); the correlation between miR-133 and EGFR was analyzed by Pearson; the effect of expression level on survival rate was analyzed by Kaplan Meier (K-M) survival curve.【Results】 The expression level of miR-133 in colon cancer tissues was significantly lower than that in normal tissues, while the expression of EGFR was significantly higher than that in normal tissues (P<0.05). There was a negative correlation between the expression of miR-133 and EGFR (r=-0.4941, P<0.01). The expression of miR-133 and EGFR were correlated with clinical stage, lymph node metastasis, TNM stage and pathological grade. The survival rate of patients with high expression of miR-133 was higher than that of the low expression group (P<0.05), while the survival rate of patients with high expression of EGFR was lower than that of the low expression group (P<0.05). 【Conclusion】 The expression of miR-133 and EGFR was increased in colon cancer, and they were negatively correlated with the prognosis of colon cancer. The combined detection of miR-133 and EGFR is expected to be an effective index and method for diagnosis and treatment of colon cancer. 2020 Vol. 37 (8): 1213-1215 [Abstract] ( 100 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 1216 Clinical Effect of Xianling Gubao Capsule Combined with Estrogen Replacement Therapy on Perimenopausal Syndrome Patients LI Xiao-wen, ZHANG Wei-tao, XU Jin-ping, et al DOI: 10.3969/j.issn.1671-7171.2020.08.030 【Objective】 To investigate the influences of Xianling Gubao capsule combined with estrogen replacement therapy on the clinical symptoms, bone density and serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) in perimenopausal syndrome patients. 【Methods】 Eighty-two cases of patients with perimenopausal syndrome in our hospital from August 2016 to August 2017 were selected. Patients were divided into the observation group and the control group by random alphabet. The control group was treated with estrogen replacement therapy, while the observation group was treated with Xianling Gubao capsule in addition to estrogen replacement. The therapeutic effect, adverse reactions and clinical symptoms improvement of the two groups were compared The bone mineral density and serum FSH, LH and estradiol (E2) levels were measured and compared before and after treatment. 【Results】 The effective rate of the observation group was 97.56% (40/41), which was significantly higher than 80.49% (33/41) of the control group (P<0.05). Kupperman score of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). Compared to the control group, the mean vertebral bone density and mean femoral neck bone density were higher in the observation group (P<0.05). In comparison with the control group, the serum FSH and LH levels in the observation group were significantly decreased, while serum E2 level increased significantly (P<0.05); the incidence of adverse reactions in the observation group(4.88%) was significantly lower than that in the control group(24.39%), and the difference was statistically significant (P<0.05). 【Conclusion】 The application of Xianling Gubao capsule combined with estrogen replacement therapy has achieved satisfactory clinical effect in the treatment of perimenopausal syndrome, which clinical symptoms are relieved, bone density is increased significantly, the levels of serum FSH and LH are improved. It can promote the effective recovery of ovarian function, at the same time, there was no obvious adverse reaction. 2020 Vol. 37 (8): 1216-1219 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 1220 Correlation between Changes of T Lymphocyte and Inflammatory Factors and Hyperthyroidism Liver Damage LI Qian-jin, DONG Yong-hui, ZHAO Fu-yan DOI: 10.3969/j.issn.1671-7171.2020.08.031 【Objective】 To investigate the correlation between CD4+ T cells, CD4+ CD25+ regulatory T cells, inflammatory factors and hyperthyroidism liver function injury.【Methods】 The clinical data of 132 patients with hyperthyroidism in our hospital from January 2015 to March 2018 were selected, including 70 patients with liver function injury (observation group) and 62 patients with normal liver function (control group). The levels of CD4+ T cells and CD4+ CD25+ regulatory T cells were detected and compared between the two groups. The serum levels of interleukin-6 (IL-6), interleukin-10 (IL-10), thyroid stimulating hormone (TSH), triiodothyronine (T3) and tetraiodothyronine (T4) were compared between the two groups.【Results】 The level of T3 and T4 in the observation group was significantly higher than that in the control group (P<0.05); there was no significant difference in TSH level between the observation group and the control group (P>0.05). The levels of serum IL-6 and IL-10 in the observation group were significantly higher than those in the control group (P<0.05); the levels of CD4+ T cells and CD4+ CD25+ regulatory T cells in the observation group were significantly lower than those in the control group (P<0.05). ALT and AST were (104.38±32.10) U/L and (90.03±24.39) U/L, respectively, ALP was (82.2±17.44) U/L; Pearson correlation analysis of T lymphocytes, inflammatory factors and ALT, AST, ALP and thyroid hormone levels showed that CD4+ CD25+ regulatory T cells were negatively correlated with ALT, AST, ALP, T3 and T4 (r=-0.544, -0.434,-0.414, -0.322, -0.303, all P<0.05).【Conclusion】 The levels of serum IL-6 and IL-10 increased significantly, while the levels of CD4+ T cells and CD4+ CD25+ regulatory T cells decreased significantly in patients with hyperthyroid liver function injury. Meanwhile, the changes of T lymphocyte subsets are closely related to liver function and thyroid hormone levels. 2020 Vol. 37 (8): 1220-1222 [Abstract] ( 86 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 1223 Hyoid Suspension Combined with Uvulopalatopharyngoplasty in the Treatment of Obstructive Sleep Apnea Syndrome ZHAO Hai-jun, TIAN Hong, SONG Jian-tao DOI: 10.3969/j.issn.1671-7171.2020.08.032 【Objective】 To investigate the effect of uvulopalatopharyngoplasty (UPPP) in patients with obstructive sleep apnea syndrome (OSAHS). 【Methods】 Eighty patients with OSAHS in our hospital from January 2016 to may 2017 were randomly divided into observation group and control group, 40 cases in each group. The control group was treated with UPPP, and the observation group was treated with hyoid suspension on the basis of the control group. The apnea hypopnea index (AHI), minimum arterial oxygen saturation (LSaO2), Epworth Sleepiness Scale (ESS) score and sleep apnea quality of life index (SAQLI)were compared between the two groups before and after treatment.【Results】 Before treatment, there was no significant difference in AHI, LSaO2 and ESS scores between the two groups (P>0.05); after 6 months of treatment, the LSaO2 value of the observation group was significantly higher than that of the control group (P<0.05), AHI value and ESS score were significantly lower than those of the control group (P<0.05); before treatment, there was no significant difference in emotion, social life, daily interaction and symptom scores in SAQLI score between the two groups . After 6 months of treatment, the social life, daily interaction and symptom scores of the observation group were significantly higher than those of the control group (P<0.05). 【Conclusion】 Hyoid suspension combined with UPPP in the treatment of OSAHS patients has a significant effect, can improve the sleep and quality of life of OSAHS patients, worthy of clinical application. 2020 Vol. 37 (8): 1223-1225 [Abstract] ( 84 ) HTML (1 KB)  PDF  (0 KB)  ( 8 )

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