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| Effect of Angiotensin Ⅱ Receptor Inhibitor on the Expression of Gap Connexin Cx43 in Rats with Myocardial Ischemia |
| GAO Yi-kai, ZHANG Li |
| Department of Intensive Care Unit,Shandong Provincial Third Hospital ,Jinan Shandong,250031,China |
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Abstract 【Objective】 To investigate the effect of angiotensin Ⅱ receptor inhibitor valsartan on the expression of gap connexin Cx43 in rats with myocardial ischemia. 【Methods】 Sixty SD rats were randomly divided into blank control group (group A), sham operation group (group B), model group (group C) and valsartan group (group D). The Group D was pretreated with valsartan, and the groups of A, B and C were given equal amount of saline, and 7d was used continuously. The model of myocardial ischemia was established in the group C and the group D, and the rat was killed after the model was set up by 1h. The histopathological changes, expression of Cx43 protein and the gene in myocardium of the 4 groups were observed. 【Results】 The pathological changes of myocardial ischemia in the group D were less than that in the group C. The expression level of Cx43 protein and gene in the C group was significantly lower than that in the group A and the group B (P<0.05), and the expression level of Cx43 protein and gene in the group D was significantly higher than that inthe C group (P<0.05). 【Conclusion】 Valsartan preconditioning can reduce the decrease of Cx43 induced by myocardial ischemia and alleviate the pathological changes of myocardial ischemia tissue, and have protective effect on myocardial ischemia rats.
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Received: 31 October 2019
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2020, Vol. 37 
