Abstract 【Objective】 To investigate the expression and clinical significance of miR-133 and epidermal growth factor receptor (EGFR) in colon cancer. 【Methods】 The expressions of miR-133 and EGFR were detected by real-time fluorescent quantitative PCR (RT-PCR); the correlation between miR-133 and EGFR was analyzed by Pearson; the effect of expression level on survival rate was analyzed by Kaplan Meier (K-M) survival curve.【Results】 The expression level of miR-133 in colon cancer tissues was significantly lower than that in normal tissues, while the expression of EGFR was significantly higher than that in normal tissues (P<0.05). There was a negative correlation between the expression of miR-133 and EGFR (r=-0.4941, P<0.01). The expression of miR-133 and EGFR were correlated with clinical stage, lymph node metastasis, TNM stage and pathological grade. The survival rate of patients with high expression of miR-133 was higher than that of the low expression group (P<0.05), while the survival rate of patients with high expression of EGFR was lower than that of the low expression group (P<0.05). 【Conclusion】 The expression of miR-133 and EGFR was increased in colon cancer, and they were negatively correlated with the prognosis of colon cancer. The combined detection of miR-133 and EGFR is expected to be an effective index and method for diagnosis and treatment of colon cancer.
LI Mei-Ling,ZHANG Guang-Ying. Expression and Clinical Significance of miR-133 and EGFR in Colon Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1213-1215.
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2020, Vol. 37 
