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Quick Search     Adv Search 2019 Vol. 36, No. 12 Published: 2019-12-30   2289 Effect of Qingyi Decoction on Pro-inflammatory and Anti-inflammatory Factors in Rats with Severe Acute Pancreatitis XIAO Yan, LIU Li-lei, LEI Yan-jun, et al DOI: 10.3969/j.issn.1671-7171.2019.12.001 【Objective】To investigate the effect of Qingyi Decoction on serum interleukin-6 (IL-6), IL-10, tumor necrosis factor-α(TNF-α), amylase (Amy), calcium ion (Ca2+) and pancreatic histopathological score in rats with severe acute pancreatitis (SAP). 【Methods】Thirty healthy SD rats were randomly divided into sham operation group (SO Group), SAP Group and SAP Qingyi Decoction treatment group (QYT Group). In the SO Group, the model of sap was established by retrograde injection of 5% sodium taurocholate (1 mg/kg). 24 hours after the model was established, three groups of rats were re opened to observe the ascites, saponification spots in the abdominal cavity and the general morphological changes of the pancreas. The serum levels of Amy, Ca2+, TNF-α, IL-6 and IL-10 were measured, and the pathological scores of the pancreas were made. 【Results】The SAP Group showed hyperemia, edema, necrosis and lamellar hemorrhage of the whole pancreas; the QYT Group showed hyperemia, edema, punctate hemorrhage and necrosis of the whole pancreas, the SO Group did not see the above changes. Serum TNF-α, IL-6, IL-10, Amy and pathological scores in the Qingyi Decoction Group were significantly lower than those in the SAP Group (P<0.05), but higher than those in the so Group (P<0.05). The serum calcium concentration of the Qingyi Decoction Group was significantly higher than that of the SAP Group (P<0.05), and lower than that of the SO Group (P<0.05). 【Conclusion】Qingyi decoction can reduce the release of TNF-α, IL-6, IL-10 inflammatory factors in serum, reduce the hemorrhage and necrosis of pancreatic tissue, and play a certain therapeutic role. 2019 Vol. 36 (12): 2289-2291 [Abstract] ( 259 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2292 Evaluation of Serum Anti-CarP Antibody in Early Diagnosis of Rheumatoid Arthritis and Prediction of Bone Damage WU Gang, TAN Yun-zhi, DUAN Yu-han DOI: 10.3969/j.issn.1671-7171.2019.12.002 【Objective】To explore the value of serum anti-carbamyl protein (anti-CarP) antibody in early diagnosis of rheumatoid arthritis (RA) and prediction of bone damage. 【Methods】A total of 100 patients with RA admitted to our hospital from June 2015 to June 2018 were selected as the observation group whose RA disease activity and bone damage were sub-divided into the active and stable status according to the DAS28 score and X-ray film image. Healthy volunteers in the same period were selected as the control group. Levels of anti-CarP antibody, C-reactive protein (CPR), anti-cyclic citrullinated peptide (CCP), rheumatoid factor (RF) and matrix metalloproteinase 3 (MMP3) plus DAS28 score were measured and compared. The correlations of serum anti-CarP antibody with different serum factors, DAS score and degrees of bone damage were analyzed. 【Results】The expression level and positive rate of serum anti-CarP antibody in the observation group were significantly higher than those in the control group (P<0.05). Levels of serum anti-CarP antibody,CRP, RF, CCP and MMP3 plus DAS28 score in patients with active RA were significantly higher than those in patients with stable RA (P<0.05). The results showed that there were significant differences in serum levels of anti-CarP antibody, CRP, RF, CCP and MMP3 in RA patients with different degrees of bone injury (P<0.05).Of which, values of stage Ⅱ RA patients were significantly higher than those of RA patients in stage Ⅰ and stage 0 (P<0.05); Values of stage I RA patients were significantly higher than those of RA patients in phase 0 (P<0.05). The serum anti-CarP antibody of RA patients showed significant positive correlation with CRP, RF, CCP, MMP3, DAS28 scores and bone injury stages (P<0.05). 【Conclusion】Anti-CarP antibodies are highly expressed in the serum of RA patients, and anti-CarP antibody levels increase with RA activity and bone damage. 2019 Vol. 36 (12): 2292-2294 [Abstract] ( 137 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 2295 Lentivirus-mediated shRNA Vector Targeted Knockout of ZNF217 Gene Expression on Invasion and Apoptosis of Human Neuroblastoma KELLY Cells TANG Xiang-lian, WEN Jia-bing, LI Ming, et al DOI: 10.3969/j.issn.1671-7171.2019.12.003 【Objective】To investigate the effect of targeted knockout of ZNF217 gene expression by shRNA vector on invasion and apoptosis of human neuroblastoma Kelly . 【Methods】The shRNA hairpin structure of ZNF217 gene was constructed by siRNA technology. The human neuroblastoma cell line Kelly cells were divided into blank control group (group A), blank vector virus group (group B) and ZNF217 gene silencing expression vector lentivirus group (Group C). The expression levels of ZNF217, caspase-3 and caspase-9 were detected by RT-PCR and Western blot. Transwell kit was used to detect cell invasion, AV-PI kit to detect apoptosis, CCK-8 kit to detect cell proliferation. 【Results】The transfection titer of lentivirus was 3×107 TU/mL, and the transfection efficiency was over 92%. RT-PCR and Western blot showed that the relative expression of ZNF217 mRNA and protein in the group C was lower than that in the group A and B (P<0.05). However, the relative expression of Caspase-3 and caspase-9 in the group C was higher than that in the group A and B (P<0.05). The cell proliferation rate of the group C was significantly lower than that of the group B and the group A (P<0.05), and the cell invasion ability of the group C was significantly lower than that of the group B and the group A (P<0.05). The apoptosis rate of the group C was significantly higher than that of the group B and the group A (P<0.05). 【Conclusion】Targeted knockout of ZNF217 gene expression by shRNA vector can inhibit the proliferation, invasion and apoptosis of human neuroblastoma cell line Kelly cells, so ZNF217 gene can be used as a potential therapeutic target for neuroblastoma. 2019 Vol. 36 (12): 2295-2298 [Abstract] ( 147 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 2299 Influence of Discharge Preparation Service on Blood Glucose Management and Discharge Guidance Quality of Diabetic Patients WEN Yan-xia, WU Liao-fang, LONG Fan DOI: 10.3969/j.issn.1671-7171.2019.12.004 【Objective】To explore the influence of discharge preparation service on blood glucose management and discharge guidance quality of inpatients with diabetes mellitus. 【Methods】Eighty patients with type 2 diabetes who were hospitalized in the Department of endocrinology of Xiangya Hospital from May to July 2018 were randomly divided into observation group and control group with 40 cases each. The control group received routine nursing, the observation group received discharge preparation service on the basis of the control group, and compared the quality of blood glucose management and discharge guidance between the two groups. 【Results】The rate of blood glucose in the observation group was higher than that in the control group, and the incidence of hyperglycemia and hypoglycemia in the observation group was significantly lower than that in the control group (P<0.05), and the total score of discharge guidance quality in the observation group was significantly higher than that in the control group (P<0.05). 【Conclusion】Discharge preparation service can improve the quality of blood glucose management and discharge guidance for diabetic patients, which is worthy of clinical application. 2019 Vol. 36 (12): 2299-2301 [Abstract] ( 146 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2302 Clinical Analysis of Thrombolysis before Transportation for PCI in Patients with Acute ST Segment Elevation Myocardial Infarction Complicated with Pulmonary Infection LI Zhe, MING Hui, LI Feng-jie DOI: 10.3969/j.issn.1671-7171.2019.12.005 【Objective】To investigate the clinical effect of thrombolysis before transporting for PCI in patients with STEMI complicated with pulmonary infection. 【Methods】From January 2016 to December 2018, 200 patients with STEMI and pulmonary infection who were treated by PCI were divided into observation group (n=76, thrombolysis before transport) and control group (n=124, none thrombolysis before transport) according to whether thrombolysis was performed before referral. The changes of left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDd), left ventricular end systolic diameter (LVESD) were observed. The serum levels of procalcitonin (PCT) and C-reactive protein (CRP) were compared before and 7 days after treatment. The patients were followed up for half a year to observe the adverse events of the two groups. 【Results】After treatment, LVEDD and LVESD of the two groups were lower than before treatment, and LVEF was higher than before treatment. LVEDd and LVESD of the observation group were lower than that of the control group, and LVEF was higher than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of PCT and CRP in serum of the two groups were lower than that before treatment, and that in the observation group was lower than that in the control group (P<0.05). After 6 months follow-up, the incidence of cardiovascular adverse events in the observation group was 5.26% (4 / 76) lower than that in the control group (14.52%) (18/124), the difference was statistically significant (χ2=4.121,P=0.042<0.05). 【Conclusion】Thrombolysis before transportation for PCI is helpful for the recovery of heart function and the control of pulmonary infection in patients with STEMI complicated with pulmonary infection, and it can reduce the risk of cardiovascular adverse events, which is worthy of clinical reference. 2019 Vol. 36 (12): 2302-2304 [Abstract] ( 147 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2305 Clinical and Pathological Analysis of 18 Cases of Children with Granuloma Annulare LU Hui, QIAN Hua, LI Wei, et al DOI: 10.3969/j.issn.1671-7171.2019.12.006 【Objective】To summarize the clinical and histopathological features of granuloma annularis in children. 【Methods】The clinical data and histopathological findings of 18 children with granuloma annulare diagnosed and treated in children's Hospital of Soochow University from January 2013 to December 2018 were analyzed retrospectively. 【Results】The skin lesions were mostly characterized by single circular erythema or plaques fused by red papules with clear boundary. Histopathological examination showed palisade granulomatous changes in the dermis with degenerated collagen fibers in the center and palisade arrangement of lymphocytes, histiocytes and a small number of epithelioid cells around the dermis. 【Conclusion】According to the typical skin lesion characteristics and pathological manifestations, the diagnosis of granuloma annular can be confirmed. 2019 Vol. 36 (12): 2305-2306 [Abstract] ( 130 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2307 Relationship between the Changes of Serum TNF-α, 5-HT, E and IL-1β and the Degree of Depression in Patients with Parkinson's Disease Complicated with Depression XU Shu-ping, WANG Yan, LIU Feng-guo, et al DOI: 10.3969/j.issn.1671-7171.2019.12.007 【Objective】To explore the relationship between the changes of serum TNF-α, 5-HT, E and IL-1βin patients with Parkinson's disease (PD) complieted with depression. 【Methods】One hundred and six PD patients (observation group) admitted to our hospital from January 2016 to July 2018 were selected, and 53 healthy subjects in the same period were selected as the control group. The levels of TNF-α, 5-HT, E and IL-1 βin serum of the two groups were measured. The PD group was divided into depression group and non depression group according to the scores of Hamilton Depression Scale (HAMD-24). 【Results】The levels of TNF-α, e, IL-1 β in the serum of the observation group were higher than those of the control group, and the levels of 5-HT in the serum were lower than those of the control group (P<0.05). The levels of TNF-α, E, IL-1βin the depression group were higher than those in the non depression group, and the levels of 5-HT in the depression group were lower than those in the non depression group (P<0.05). The levels of TNF-α, E, IL-1βin serum of PD patients with depression were positively correlated with HAMD-24 scores (rTNF-α= 0.411,rE=0.362, rIL-1β=0.446, all P<0.05), while the levels of 5-HT in serum were negatively correlated with HAMD-24 scores (r5-HT=-0.507, P<0.05). 【Conclusion】The levels of TNF-α, E, IL-1β in the serum of PD patients with depression are higher, and 5-HT are lower than those of PD patients with depression alone. 2019 Vol. 36 (12): 2307-2309 [Abstract] ( 157 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2310 Effect of Fast-track Surgery on Perioperative Rehabilitation and Prognosis of Laparoscopic Cholecystectomy ZHANG Yan-yan, MA Yan DOI: 10.3969/j.issn.1671-7171.2019.12.008 【Objective】To study the effect of rapid rehabilitation surgery called Fast track surgery (FTS) on perioperative rehabilitation and prognosis of cholecystitis/gallstone laparoscopic cholecystectomy. 【Methods】A total of 80 patients with cholecystitis or gallstones undergoing laparoscopic cholecystectomy in Nanjing central hospital from April 2017 to April 2019 were randomly divided into the observation group and the control group, with 40 cases in each group. The control group received routine perioperative intervention, while the observation group received perioperative intervention under the guidance of FTS concept. The status of operation and recovery, the incidence of complications and the changes of quality of life score before surgery and 1 week after operation in the two groups were compared. Effects of FTS on the rehabilitation and prognosis of patients was analyzed. 【Results】The operation time, intraoperative blood loss, postoperative feeding time, time to get out of bed, exhaust time, VAS score and hospitalization time of the observation group were lower than those of the control group. The differences were statistically significant (P<0.05). The incidence of postoperative complications in the observation group was 5.00%,which was lower than 20.00% in the control group (P<0.05). The scores of physiological function, physical pain, general health status, energy, social function and mental health of the two groups were improved 7 days after operation. The scores of physical function, physical pain, general health status, energy and mental health of the observation group were higher than those of the control group at the same time. The differences were statistically significant (P<0.05). 【Conclusion】Fast-track surgery can improve the rehabilitation effect of laparoscopic cholecystectomy and the quality of life after surgery. 2019 Vol. 36 (12): 2310-2312 [Abstract] ( 168 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2313 Clinical Efficacy and Mechanism of Sequential Treatment of Diabetic Nephropathy with Shenkang Injection and Shenkang Suppository LI Gai-xian, LIU Ping, WANG Hao, et al DOI: 10.3969/j.issn.1671-7171.2019.12.009 【Objective】To investigate the clinical efficacy and mechanism of sequential treatment of diabetic nephropathy with Shenkang injection and Shenkang suppository. 【Methods】A total of 180 patients with diabetic nephropathy from October 2017 to January 2018 were divided into the observation group and the control group by random number table method, with 90 case in each group. Patients in the control group received routine treatment for diabetic nephropathy, while patients in the observation group received Chinese medicine (Shenkang Injection sequentialy combined with Shenkang suppository treatment) for 8 weeks. Before and after treatment, serum interleukin-17 (IL-17) and tumor cell necrosis factor-a (TNF-α) were detected by enzyme-linked immunosorbent assay (ELISA); And serum hypersensitive C-reactive protein (hs-CRP) was detected by immunoturbidimetry. The levels of plasma resistin, nitric oxide (NO) and matrix metalloproteinase-9 (MMP-9) were measured by Elisa method. The peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) of renal artery were measured by Doppler ultrasound. Serum homocysteine (Hcy), cystatin-C (Cys-c), β2-microglobulin (β2-MG), twenty-four hours urinary microalbumin (24UAE), serum uric acid and insulin resistance index (HOMA-IR) were compared between the two groups. 【Results】After treatment, the serum Hcy, Cys-C, β 2-MG, 24UAE, UA, HOMA-IR of the two groups were significantly improved compared to those before treatment. The improvement range of the observation group was better than that of the control group; The difference was statistically significant (P<0.05). Compared to before treatment, the levels of IL-17, TNF-α, hs-CRP, resistin, MMP-9 and NO in the two groups decreased; And the changes in the observation group were more significant (P<0.05). After treatment, the PSV speed and RI in the observation group decreased significantly compared to before treatment and the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.67%, which was slightly higher than that in the control group (4.44%), but there was no statistical difference (P>0.05). 【Conclusion】Shenkang injection with sequential Shenkang suppository treatment can significantly reduce the urinary protein content in patients with diabetic nephropathy, improve renal tissue blood perfusion, reduce renal function damage, and improve the clinical efficacy of patients with diabetic nephropathy. Its mechanism is related to the down-regulation of inflammatory response and the improvement of vascular endothelial cell function in patients treated with sequential Chinese medicine. 2019 Vol. 36 (12): 2313-2316 [Abstract] ( 113 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2317 Effect of Uterine Artery Embolization combined with Hysteroscopy in the Treatment of Ectogenic Scar Pregnancy CHEN Jing-ping, LU Yuan-yuan, WEI Ren-ji, et al DOI: 10.3969/j.issn.1671-7171.2019.12.010 【Objective】To investigate the efficacy and safety of uterine artery embolization (UAE) combined with hysteroscopy in the treatment of scar pregnancy (CSP) after cesarean section. 【Methods】The clinical data of 92 patients with exogenous CSP diagnosed in our hospital from March 2015 to December 2018 were collected. According to the treatment, they were divided into two groups: uterine curettage operation group (control group,n=42) and UAE combined with hysteroscopy operation group (observation group,n=50). The intraoperative bleeding volume, the time of first anal exhaust, the time of hospitalization, the time of complete absorption of the mass, the time of conversion of HCG and the time of menstrual recovery were recorded. The incidence of postoperative complications was counted. The visual analogue score (VAS) and the World Health Organization Quality of life scale (WHOQOL-100) were compared between the two groups. 【Results】The amount of bleeding in the observation group was significantly less than that in the control group. The time of the first anal exhaust, the time of hospitalization, the time of hCG turning to negative, the time of complete absorption of the mass and the time of menstrual recovery were all shorter than those in the control group (P<0.05). The total complication rate and VAS score at different time points in the observation group were significantly lower than those in the control group, and the quality of life score was significantly higher than that in the control group (P<0.05). 【Conclusion】UAE combined with hysteroscopic surgery for exogenous CSP can reduce intraoperative bleeding, shorten postoperative recovery time, reduce the incidence of complications, and has high safety, and can reduce postoperative pain, improve the quality of life of patients, which is worthy of clinical application. 2019 Vol. 36 (12): 2317-2319 [Abstract] ( 107 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 2320 Predictive Value of Serum Inhibin A, Activin A and Uterine Artery Blood Flow Resistance in Preeclampsia ZHAO Yi, CAO Dong-ru, LIU Ya-jie, et al DOI: 10.3969/j.issn.1671-7171.2019.12.011 【Objective】To explore the predictive value of serum inhibin A (ACTA), activin A (INHA) combined with uterine artery blood flow resistance in preeclampsia (PE). 【Methods】A total of 192 pregnant women with gestational weeks of 10 to 13+6 undergoing routine Down's screening in the hospital from October 2016 to March 2018 were selected as subjects (92 PE pregnant women were included in the study group, and 100 normal pregnant women were included in the control group). The blood samples were taken to complete the serum test on the day of applying for a card. The whole process was traced to the end of delivery. The levels of serum ACTA and INHA were measured by enzyme-linked immunosorbent assay. The parameters of uterine artery blood flow resistance [ratio of systolic to diastolic flow rates (S/D), pulsation index (PI), resistance index (RI)] were evaluated by color Doppler ultrasound. The differences of the above indicators of patients under different conditions in the study group were compared. The ROC curve was used to analyze the predictive value of ACTA and INHA combined with uterine artery blood flow resistance for PE. 【Results】The levels of serum ACTA and INHA in the study group were higher than those in the control group. The levels of ACTA and INHA in patients with severe illness were higher than those with mild illness in the study group (P<0.05). The S/D, PI and RI in the study group were higher than those in the control group. The above three indexes in patients with severe illness were higher than those with mild illness in the study group (P<0.05). ROC curve analysis showed that the sensitivity, specificity, accuracy and the area under the curve (AUC) for predicting PE by ACTA and INHA combined with uterine artery blood flow resistance detection were 0.85, 0.81, 0.80, and 0.804, respectively, which were higher than those by either of them. 【Conclusion】The serum of patients with PE is abnormal in ACTA and INHA.The resistance of uterine artery blood flow is increased. The combined detection of ACTA, INHA and uterine arterial blood flow resistance is of great value for predicting PE. 2019 Vol. 36 (12): 2320-2322 [Abstract] ( 98 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2323 Study on CT Image and Clinical Characteristics of Patients with pulmonary tuberculosis Complicated with Asthma YUE Xiao-bo, WU Xian-qing, ZHANG Wen-jun, et al DOI: 10.3969/j.issn.1671-7171.2019.12.012 【Objective】To explore the CT image and clinical characteristics of patients with pulmonary tuberculosis complicated with asthma. 【Methods】From June 2015 to June 2018, 60 patients with pulmonary tuberculosis complicated with asthma were selected as the observation group and 60 patients with simple tuberculosis as the control group. The clinical characteristics, Th1 / Th2 cytokine levels in peripheral blood and CT imaging characteristics of the two groups were compared.. 【Results】The proportion of chest pain and hoarseness in the observation group was significantly higher than that in the control group (P<0.05). The levels of IFN-γ, IL-2, Th1, Th2 and Th1 / Th2 in the observation group were significantly lower than those in the control group, and the levels of IL-6 in the observation group were significantly higher than those in the control group (P<0.05). CT showed that pleural depression sign, bronchial wall thickening, atelectasis, spinous process protrusions, tuberculosis cavity, tree bud sign and bronchiectasis were significantly higher in the observation group than in the control group (P<0.05). 【Conclusion】The CT imaging findings of patients with pulmonary tuberculosis and asthma were patchy blurred high-density image with increased fiber growth and tissue brightness around the lesion. Patients with bronchial wall thickening, pleural depression sign, spinous process, atelectasis, tuberculosis cavity should pay close attention to the occurrence of asthma. 2019 Vol. 36 (12): 2323-2325 [Abstract] ( 133 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 2326 Value of HIF-1a Combined with UA/MCA, RA/MCA and VSCR for Fetal Distress Diagnosis CAO Shuo, MA Zheng-ge, WANG Yuan-Yuan, et al DOI: 10.3969/j.issn.1671-7171.2019.12.013 【Objective】To investigate the diagnostic value of hypoxia-inducible factor-1a (HIF-1a) combined with the ratio of umbilical artery/middle cerebral artery (UA/MCA), ratio of renal artery/middle cerebral artery (RA/MCA)and venous catheter shunt rate (VCSR) in intrauterine distress. 【Methods】A total of 50 pregnant women with intrauterine distress received treatment in our hospital from January 2016 to May 2018 were selected as the observation group, while in the same period 60 normal pregnant women with birth examination were enrolled as the control group. All pregnant women took blood test to measure HIF-1a and received color Doppler ultrasound detection for fetal umbilical artery (UA), renal artery (RA) and middle cerebral artery (MCA). The maximum systolic flow rate/maximum diastolic flow rate (S/D)of MCA, the resistance index (RI), the pulse index (PI) and venous catheter shunt rate (VCSR) were calculated and compared between the two groups. 【Results】The detection value of maternal blood HIF-1a in observation group was higher than that in normal control group; The difference was statistically significant (P<0.05).The resistance ratio (S/D) of MCA and UA (MCA/UA), RI and PI in the observation group were significantly lower than those in the control group (P<0.05). Fetal RA and MCA resistance ratio of RA/MCA S/D, RI and PI in the observation group were significantly higher than those in the control group; The differences were statistically significant (P<0.05).The venous catheter shunt rate (VSCR) in the observation group was significantly higher than that in the control group. The difference was statistically significant (P<0.05).The fetal distress diagnostic sensitivity, specificity, positive predictive value, negative predictive value and the correct diagnosis rate of HIF-1a in combination with MCA/UA,RA/MCA and VCSR were significantly better than HIF-1a, MCA/UA, RA/MCA, VCSR alone. The differences were statistically significant (P<0.05). 【Conclusion】Maternal blood HIF-1a in combination with MCA/UA,RA/MCA and VCSR has higher diagnostic value for intrauterine distress which can provide timely clinical monitoring and intervention. 2019 Vol. 36 (12): 2326-2328 [Abstract] ( 102 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2329 Study on the Mechanism of Metformin in the Treatment of Obese T2DM Rats SHAN Xin-ping, SONG Li-ying, LI Ling DOI: 10.3969/j.issn.1671-7171.2019.12.014 【Objective】To explore the mechanism of metformin in the treatment of obese type 2 diabetes (T2DM) rats. 【Methods】Adult male Wistar rats (90 rats) were fed with high glucose and high fat, and then injected with streptozotocin intraperitoneally to establish diabetes obesity model. They were randomly divided into control group, model group and experimental group. The rats in the model group and the experimental group were fed with high-fat and high sugar diet for 21 days, supplemented with 55 mg / kg intraperitoneal injection of streptozotocin (STZ) to induce T2DM model, while the rats in the control group were fed with ordinary diet as normal control. The rats in the control group and the model group were given the same amount of normal saline by gavage once a day. After 16 weeks of continuous gavage, the rats were killed. The urine urea nitrogen (UUN), urine creatinine (UCr) and 24-hour urine protein content (24hPro) were measured. Serum cholesterol (TC), free fatty acid (FFA), triglyceride (TG), fasting blood glucose (FPG), fasting insulin (FINS), insulin sensitivity index (ISI) and insulin resistance index (HOMA-IR) were measured. HE method was used to detect renal pathological changes;The expression of FoxO 1, Wnt-1 and β-Catenin in serum, pancreas and liver of rats was measured by Western blot. 【Results】Compared with the control group, the 24hPro, UCr, UUN, TC, FFA, TG, FPG, FINS, ISI, HOMA-IR contents of the model group and the experimental group were significantly increased; compared with the model group, the above biochemical indexes contents of the experimental group were significantly reduced, and the differences were statistically significant (P<0.05). In the control group, there was no obvious abnormality in renal tissue morphology, and the cell structure was basically normal. In the model group, a large number of vacuolar degeneration, deformation, abscission and partial necrosis were found in the renal tubular epithelial cells, and the renal tubules were dilated, fibrotic or atrophic, dilated and sparsely arranged. In the experimental group, the symptoms were improved obviously, the cell edema and vacuole were reduced, and the damage and destruction of renal tubule structure were improved. Compared with the control group, the expression of FoxO1, Wnt-1 and β- Catenin protein in serum, pancreas, liver and kidney of rats in the model group and the experimental group was significantly increased; compared with the model group, the expression of FoxO1, Wnt-1 and β- Catenin protein in the experimental group was significantly decreased, and the difference was statistically significant (P<0.05). 【Conclusion】Metformin has renal protective effect on T2DM obese rats. It can inhibit the injury of T2DM obese rats by regulating FoxO1 / Wnt /β- Catenin signal pathway. 2019 Vol. 36 (12): 2329-2332 [Abstract] ( 255 ) HTML (1 KB)  PDF  (0 KB)  ( 15 ) 2333 Effect of Fast Track Surgery on Perioperative Period of Children with Hypospadias undergoing Snodgrass Operation CHEN Yao-yao, TANG Yuan-hui, CHEN Yi-fu, et al DOI: 10.3969/j.issn.1671-7171.2019.12.015 【Objective】To investigate the effect of fast track surgery (FTS) on perioperative period of children with hypospadias undergoing Snodgrass operation. 【Methods】From May 2018 to February 2019, 76 children with hypospadias who underwent Snodgrass operation in our hospital were randomly divided into observation group (n=38) and control group (n=38). The patients in the observation group were given FTS comprehensive nursing during the perioperative period. The recovery index, complication rate and nursing satisfaction of patients in the two groups were compared. 【Results】The first defecation time, hospitalization days, average crying time and postoperative incidence of urinary fistula in observation group were significantly lower than those in control group, and the total satisfaction rate of nursing at discharge was significantly higher than that in control group (P<0.05). There were no significant differences on operation time, intraoperative bleeding volume, incidences of incision swelling, bleeding and infection between two groups (P>0.05). 【Conclusion】FTS nursing is satisfactory in children with hypospadias undergoing Snodgrass operation. It could significantly promote postoperative rehabilitation, prevent the occurrence of urinary fistula and improve nursing satisfaction, which is worth popularizing. 2019 Vol. 36 (12): 2333-2335 [Abstract] ( 110 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 2336 Application of ACR TI-RADS Combined with Contrast-enhanced Ultrasound for Diagnosis of Benign and Malignant Thyroid Nodules XUE Rong, LIU Liang, CHEN Hong-tian, et al DOI: 10.3969/j.issn.1671-7171.2019.12.016 【Objective】To explore the diagnostic value of American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) classification combined with contrast-enhanced ultrasound (CEUS) for benign and malignant thyroid nodules. 【Methods】The sonographic images and CEUS imaging data of 105 patients with thyroid nodules (153 nodules in total) were retrospectively analyzed. All thyroid nodules were classified into corresponding categories according to the criteria of ACR TI-RADS (version of year 2017). The diagnostic value of ACR TI-RADS classification combined with CEUS in benign and malignant thyroid nodules was evaluated based on the results of final surgical pathology examination. 【Results】The pathological results showed that there were 94 benign nodules and 59 malignant nodules among total 153 thyroid nodules. The sensitivity, specificity, accuracy, positive and negative predictive value of ACR TI-RADS combined with CEUS for thyroid cancer diagnosis were 93.22%,95.74%,94.77%,93.22%,and 95.74%, respectively, which were significantly higher than those of either ACR TI-RADS alone (71.19%,84.04%,79.08%,73.68% and 82.29%, respectively,) or CEUS alone (79.66%,86.17%,83.66%,78.33% and 87.1%, respectively). The differences were statistically significant (all P<0.05). 【Conclusion】The ACR TI-RADS classification combined with CEUS has a high diagnosis value for benign and malignant thyroid nodules. It is worthy of clinical application. 2019 Vol. 36 (12): 2336-2339 [Abstract] ( 120 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2340 Clinical Effect of Glass Ion Fossa and Sulcus Closure on Prevention of Second Deciduous Molar Dental Caries in Preschool Children YOU Yi, Huang Pei-cheng DOI: 10.3969/j.issn.1671-7171.2019.12.017 【Objective】To investigate the clinical effect of glass ion fossa and sulcus closure on prevention of second deciduous molar dental caries in preschool children. 【Methods】A total of 120 preschool children who underwent oral health examination in our hospital from July to October 2017 were randomly divided into the observation group and the control group, with 60 cases in each group (240 teeth of second deciduous molars in each group). The observation group was treated with ion fossa and sulcus closure technique, while the control group was treated with light-cured resin sealant. Follow-up was conducted at 6 months, 12 months and 18 months after operation. The retention rate of pit and fissure sealants and the incidence of dental caries were compared between the two groups after treatment. 【Results】There was no significant difference in the retention rate of pit and fissure sealants between the two groups at 6 months after operation (P>0.05), while the retention rate of pit and fissure sealants in the observation group at 12 months and 18 months after operation was significantly higher than that in the control group (P<0.05). There was no significant difference in the incidence of dental caries between the two groups at 6 months after operation (P>0.05), while the incidence of dental caries in the observation group at 12 months and 18 months after operation was significantly lower than that in the control group (P<0.05). 【Conclusion】Glass ion fossa and sulcus closure is an effective technique for pit and fissure sealing of deciduous teeth in preschool children, which can effectively improve the retention rate of pit and fissure sealing materials and reduce the incidence of dental caries in preschool children after operation. 2019 Vol. 36 (12): 2340-2342 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2343 Value of Combined Detection of Serum Myo, cTnI and IMA in the Diagnosis and Condition Evaluation of AMI REN Jie, ZHENG Tao, HU Jing-wen, et al DOI: 10.3969/j.issn.1671-7171.2019.12.018 【Objective】To explore the value of combined detection of IMA, cTnI and myo in the diagnosis and condition evaluation of acute myocardial infarction (AMI). 【Methods】One hundred and twenty patients with AMI (observation group) and 120 healthy volunteers (control group) treated in our hospital were selected. The serum Myo,cTnI,IMA levels of the two groups were measured and the changes of serum Myo,cTnI,IMA levels of patients with different coronary artery lesions were compared. The value of differential diagnosis of AMI was analyzed by ROC analysis of the working curve of the subjects. 【Results】The level of serum Myo,cTnI,IMA in the observation group was significantly higher than that in the control group (P<0.05).The level of serum Myo,cTnI,IMA in patients with three-vessel disease and two-vessel disease in the AMI group was higher than that in patients with single-vessel coronary artery disease.The serum levels of myo, cTnI and IMA of the patients with three-vessel deaease in the AMI group were significantly higher than those with two vessel disease (P<0.05).). The diagnosis of AMI by serum Myo, cTnI and IMA showed that the sensitivity was 96.38%, the specificity was 90.11%, the missed diagnosis rate was 3.62%, the misdiagnosis rate was 9.89%, and the AUC value was 0.932. 【Conclusion】The combined detection of serum Myo, cTnI and IMA has a certain clinical value for the early diagnosis of AMI. 2019 Vol. 36 (12): 2343-2345 [Abstract] ( 110 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 2346 Serum Levels and Clinical Significance of CCL20 and HSP70 in Patients with Gastric Cancer MIAO Meng-jun, FANG Zhi-hong, CENG Qing-yi DOI: 10.3969/j.issn.1671-7171.2019.12.019 【Objective】To investigate the serum levels and clinical significance of chemokine L20 (CCL20) and heat shock protein 70 (HSP70) in patients with gastric cancer. 【Methods】A total of 92 patients with gastric cancer were selected as the gastric cancer group and 100 healthy volunteers were selected as the control group. Serum levels of CCL20 and HSP70 were measured and compared between the two groups. The correlation between serum CCL20 level and HSP70 level in patients with gastric cancer was also analyzed. 【Results】The serum levels of CCL20 and HSP70 in the gastric cancer group were (44.12±9.47) pg/ml and (2.40±0.65) pg/L, respectively, which were significantly higher than those in control group (P<0.05). The serum CCL20 and HSP70 levels in patients with stage Ⅲ~Ⅳ, lymph node metastasis and HP-positive gastric cancer were significantly higher than those in gastric cancer patients with stage Ⅰ~Ⅱ, no lymph node metastasis and HP-negative infection (P<0.05). The level of serum CCL20 was positively correlated with the level of HSP70 (r=0.433,P<0.05). 【Conclusion】The serum levels of CCL20 and HSP70 are significantly increased in patients with gastric cancer, which are related to clinical stage, lymph node metastasis and HP infection. 2019 Vol. 36 (12): 2346-2348 [Abstract] ( 101 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 2349 Clinical Significance of Cystatin C, High-sensitive C reactive protein and Uric Acid in Cerebral Small Vessel Disease WU Xian-chuan, WANG Yuan-qiao, LI Lin-min, et al DOI: 10.3969/j.issn.1671-7171.2019.12.020 【Objective】To investigate the clinical significance of cystatin C (Cys-C),high-sensitive C reactive protein (hs-CRP) and uric acid (UA) in patients with cerebral small vessel disease (CSVD). 【Methods】A total of 98 patients with CSVD admitted to our hospital from August 2016 to August 2017 were selected as the observation group, while 98 volunteers with normal cerebrovascular examination in our hospital were selected as the control group. All patients underwent MRI examination. Levels of cystatin C, high-sensitive C reactive protein and uric acid in two groups were compared. The patients with CSVD were further divided into the cognitive impairment group (n=54) and normal cognition group (n=44) and levels of cystatin C, high-sensitive C reactive protein and uric acid between two groups were compared. Risk factors and correlation of cognitive impairment were analyzed by Logistic regression analysis and Pearson correlation analysis. 【Results】Levels of cystatin C, high-sensitive C reactive protein and uric acid in the observation group were higher than those in the control group; The differences were statistically significant (P＜0.05).The were no significantly differences of the levels of cystatin C and high-sensitive C reactive protein in the groups of cognitive impairment and normal cognition CSVD patients, however, the level of UA in the cognitive impairment group was higher than that in the cognitively normal group (P＜0.05).Uric acid was an independent risk factor for the occurrence of CSVD and it was negatively correlated with total score of MoCA, executive ability, language capacity and delayed recall. 【Conclusion】The levels of cystatin C, high sensitive C reactive protein and uric acid in the patients with CSVD were elevated. The level of uric acid was a risk factor for cognitive impairment. 2019 Vol. 36 (12): 2349-2351 [Abstract] ( 124 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2352 Clinical Effect and Prognosis of Nasoenternal Nutrition in the Treatment of Severe Traumatic Brain Injury WANG Xiao-lin, LU Jun, JIANG Jian-xin DOI: 10.3969/j.issn.1671-7171.2019.12.021 【Objective】To explore the clinical efficacy and prognosis of enteral nutrition in the treatment of severe traumatic brain injury. 【Methods】Eighty-eight patients with severe traumatic brain injury admitted to our hospital from April 2015 to March 2018 were selected as the study objects. According to the treatment, the patients were divided into nasogastric tube group (n=43) and naso intestinal tube group (n=45). The patients were followed up for 6 months to compare the nutritional status, complications and prognosis of the two groups before and after treatment. Logistic regression was used to analyze the risk factors influencing the prognosis of patients. 【Results】After treatment, the improvement of body mass index, hemoglobin, serum albumin and prealbumin in the naso intestinal tube group was better than that in the nasogastric tube group (P<0.05); the incidence of nausea and vomiting, abdominal distention, gastrointestinal bleeding, pulmonary infection, reflux esophagitis and electrolyte disorder in the nasogastric tube group was significantly higher than that in the naso intestinal tube group (P<0.05). After 6 months follow-up, 32 patients (35.36%) had poor prognosis. Multivariate logistic regression analysis showed that age, GCS score, multiple injury, location of hematoma, and treatment were closely related to the prognosis of patients. 【Conclusions】Nasojejunointestinal nutrition can significantly improve the nutritional status and clinical prognosis of patients with severe traumatic brain injury. 2019 Vol. 36 (12): 2352-2354 [Abstract] ( 87 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2355 Diagnostic Value of Bedside Lung Ultrasound in Neonatal Pulmonary Hyaline Membrane Disease NING Hao-jie, WEI De-zhan, LUO Hu, et al DOI: 10.3969/j.issn.1671-7171.2019.12.022 【Objective】To explore the diagnostic value of bedside lung ultrasound in neonatal pulmonary hyaline membrane disease (HMD). 【Methods】A total of 90 neonatal patients with lung hyaline membrane disease admitted to our hospital from May 2017 to December 2018 were selected as research objects. They were divided into the control group and the observation group by random number table method, with 45 cases in each group. The control group was given bedside computer radiography (CR) for HMD diagnosis, while the observation group was given bedside lung ultrasound (US). Taking the neonatal digital imaging (DR) examination as the gold diagnostic standard, the HMD diagnostic methods of CR and US were compared. Furthermore, bedside lung ultrasound was evaluated to assess the severity of the disease. 【Results】There were no significant differences in the sensitivity and positive predictive value between the observation group (US) and the control group (CR) (P>0.05), while the specificity and negative predictive value of US were significantly higher than those of CR (P<0.05). The total pulmonary ultrasound score of severe HMD children was significantly higher than that of mild HMD children, however, PaO2/FiO2 of the severe group was significantly lower than that of the mild group. The differences were statistically significant (P<0.05). Pearson correlation analysis results showed that there was a negative correlation between pulmonary ultrasound assessment of HMD and PaO2/FiO2 (r=-1.655,P<0.05). 【Conclusion】Bedside lung ultrasound has the advantages of non-invasive and repeatable in the diagnosis of neonatal pulmonary hyaline membrane disease. Its high diagnostic efficiency also reflects the severity of the disease which is worthy of clinical promotion. 2019 Vol. 36 (12): 2355-2357 [Abstract] ( 110 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2358 Value of Monoclonal Bands Detected by Serum Protein Electrophoresis for Multiple Myeloma Diagnosis YAN Xiang-hong, WANG Lin, NI Juan, et al DOI: 10.3969/j.issn.1671-7171.2019.12.023 【Objective】To investigate the clinical value of monoclonal bands detected by serum protein electrophoresis for multiple myeloma(MM)diagnosis. 【Methods】A total of 103 patients with MM in our hospital were selected as the experimental group and 100 healthy volunteers of physical examination as the control group. Detection of monoclonal bands by serum protein electrophoresis was compared between the two groups. 【Results】The M protein secreted by MM patients was mainly IgG type, followed by IgA type. The albumin level of patients with multiple myeloma was [31.40 (25.80~35.80)] g/L, which was lower than that of the control group [46.00 (44.00~47.00)] g/L. The globulin expression level was [45.44 (30.70~54.30)] g/L, which was higher than that of the control group [26.67 (25.00~29.00)] g/L. The differences of the two protein detection results between the two groups were statistically significant (P＜0.05).The immunoglobulin content of patients with MM is positively correlated with M protein type. In IgG type, 89.58% (43/48) of M protein bands appeared in the γ region. In IgA type, 53.57% (15/28) of M protein bands appeared in the β region. In IgM type, all of M protein bands appeared in the γ zone. The detection rate of the light chain of M protein bands were low. The positive rate of serum protein electrophoresis for M protein bands was 82.52% (85/103),which was higher than that of immunoglobulin quantitative detection for M protein 71.84% (74/103). There was a statistically significant difference in the detection rate of M protein between the two methods (χ2=29.607,P<0.05). 【Conclusion】Detection of M protein bands by serum protein electrophoresis can effectively improve the detection rate of multiple myeloma. Thus it can avoid the burden of diagnosis and treatment caused by ineffective bone marrow puncture. 2019 Vol. 36 (12): 2358-2360 [Abstract] ( 121 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 2361 Effects of Propofol Intravenous Anesthesia on Hemodynamic and Cytokines in Radical Resection of Lung Cancer GE Li, ZHU Mei-hua DOI: 10.3969/j.issn.1671-7171.2019.12.024 【Objective】To investigate the anesthetic effect of total intravenous propofol anesthesia in radical resection of lung cancer and study its effect on serum cytokines. 【Methods】A total of 70 patients who underwent radical surgery for lung cancer were randomly divided into two group, with 35 cases in each group. The control group received sevoflurane inhalation anesthesia, while the observation group received propofol intravenous anesthesia. Hemodynamic parameters, serum cytokines and intraoperative anesthesia were compared between the two groups. 【Results】At the time of admission (T0), the difference of MAP, HR and SpO2 between the two group was not statistically significant (P>0.05). At the time of T1(start of ventilation),T2 (end of ventilation) and T3 (end of surgery), the measured values of MAP and HR in the control group were lower than those in the observation group (P<0.05). Levels of SpO2 from T1～T4 (extubation) were not significant differences between the two group (P>0.05). There were no significant differences in serum IL-6, IL-8 and IL-10 levels between two group before surgery (P>0.05). At 2h after operation, the serum levels of IL-6 and IL-8 in the observation group were lower (P<0.05) than those in the control group; While the serum IL-10 level at 2h after surgery in the observation group were higher than that in the control group (P<0.05). The anesthetic effects of the two groups was no significant difference (P>0.05). 【Conclusion】The effects of total intravenous propofol anesthesia on hemodynamic parameters and cytokine balance in patients undergoing radical resection of lung cancer are less than those of sevoflurane inhalation anesthesia. 2019 Vol. 36 (12): 2361-2363 [Abstract] ( 87 ) HTML (1 KB)  PDF  (0 KB)  ( 14 ) 2364 Expression and Clinical Significance of PAX2, AIB1 and MTDH in Breast Cancer Patients TIAN Ya-li, ZHU Jie-bin, GU Min, et al DOI: 10.3969/j.issn.1671-7171.2019.12.025 【Objective】To investigate the expression and clinical significance of PAX2, AIB1 and MTDH in breast cancer (BC) patients. 【Methods】A total of 200 patients with breast discomfort who underwent pathological examination in our hospital were selected. According to the pathological diagnosis, patients were divided into the breast cancer group and the benign breast lesion group. The expressions of PAX2, AIB1 and MTDH in the two groups were recorded. Furthermore the expression levels of PAX2, AIB1 and MTDH in breast cancer patients with different clinicopathological characteristics were compared. 【Results】The positive expression rate of PAX2 was lower in breast cancer tissue, while the positive expression rates of AIB1 and MTDH were both higher in breast cancer group. The differences were statistically significant (P<0.01). The positive expression rate of PAX2 was lower in breast cancer patients with moderate or low differentiation, lymph node metastasis and infiltration depth staging T3+T4 (P<0.01).The positive expression rates of AIB1 and MTDH in breast cancer patients with moderate or low differentiation, lymph node metastasis and infiltration depth staging T3+T4 were higher (P<0.01). There was no significant difference in the positive expression rates of PAX2, AIB1, and MTDH in breast cancer patients of different ages (P>0.05). Regression analysis results showed that lymph node metastasis and depth of infiltration were the factors affecting the expression of PAX2, AIB1 and MTDH in breast cancer. 【Conclusion】PAX2 positive expression rate is lower in breast cancer patients, while AIB1 and MTDH positive expression rates are higher. Also those expression rates are closely related to lymph node metastasis and depth of infiltration. 2019 Vol. 36 (12): 2364-2366 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 2367 Application Value of Augmented Reality Guided Laparoscopy in Hepatectomy (A Case Report) XIE Wei, LUO Jia, CHEN Pan, et al DOI: 10.3969/j.issn.1671-7171.2019.12.026 【Objective】To explore the value of augmented reality combined with laparoscopy in the resection of hepatocelluar carcinoma. 【Methods】The 3D virtual model of liver cancer patients was constructed with the data obtained by MRI before operation. The 3D image and the image collected by laparoscope were transferred to the video acquisition card of workstation, and the synthetic video was sent to the video display of operating room through workstation processing. Finally, AR construction was completed and the liver tumor was removed with AR. 【Results】The 3D image of liver cancer constructed before operation and the liver image collected during laparoscopic operation are processed by workstation to achieve accurate fusion. The liver tumor was located in the posterior lobe of the right liver, about 5 cm×5 cm. The texture of the tumor was hard, and the boundary was not clear. No metastasis was found in the abdominal cavity and pelvic cavity. The operation time was about 180 minutes, and the hilum of liver was blocked four times during the operation, each time was 15 minutes, the interval was 5 minutes, and the amount of bleeding was about 300 ml. On the day 1, the stomach tube was pulled out and the fluid was fed. On the day 2, the patient got out of bed and had exhaust. On the day 5, the abdominal drainage tube was pulled out. On the day 7, the patient was discharged smoothly. 【Conclusion】The combination of AR and laparoscopy can accurately fuse the image obtained by laparoscopy with the 3D model before operation in real time, so as to guide laparoscopy to carry out accurate resection of liver tumor. 2019 Vol. 36 (12): 2367-2369 [Abstract] ( 112 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 2370 Analysis of Echocardiographic Characteristics of Heart in Patients with Chronic Kidney Disease JIN Ren-bo DOI: 10.3969/j.issn.1671-7171.2019.12.027 【Objective】To analyze the relationship between echocardiographic characteristics and left atrial structure, volume and function in patients with chronic kidney disease (CKD). 【Methods】From January 2016 to February 2019, 50 CKD patients (observation group) and 50 healthy people (control group) were selected for diagnosis and treatment in our hospital. The relationship between the characteristics of echocardiography and the structure, volume and function of left atrium was analyzed by color Doppler ultrasound. 【Results】The velocity of aortic valve in the observation group was significantly higher than that in the control group, and the velocity of pulmonary valve in the observation group was significantly lower than that in the control group (P<0.05). The LVPWd, LVIDd, LAD and IVSd levels in the observation group were significantly higher than those in the control group The left atrial maximum volume index (LAVImax), left atrial minimum volume index (LAVImin), left atrial pre systolic volume index (LAVIp), left atrial total emptying index (LAVItotal), active emptying index (LAVIlact), total emptying fraction (LATEF) and peak velocity of blood flow in early diastolic period / tissue Doppler diastolic period (E/e')level was significantly higher than that of the control group (P<0.05), and the aortic valve velocity and pulmonary valve velocity were positively correlated with LVPWd, LVIDd, LAD, IVSd, LAVImax, LAVImin, LAVIp, LAVItotal , LAVIlact and E/e' (P<0.05). 【Conclusion】There was a significant positive correlation between the velocity of aortic valve and pulmonary valve and the structure, volume and function of left ventricle in CKD patients. 2019 Vol. 36 (12): 2370-2372 [Abstract] ( 91 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 2373 Effect of Intensive Nursing Based on Thermal Insulation Intervention on Intraoperative Temperature Control and Postoperative Rehabilitation of Patients Undergoing Laparoscopic Cholecystectomy REN Jian-lan, ZHANG Dai-ying, PENG Jing-han DOI: 10.3969/j.issn.1671-7171.2019.12.028 【Objective】To explore the effect of intensive nursing based on thermal insulation intervention on intraoperative temperature control and rehabilitation of patients undergoing laparoscopic cholecystectomy. 【Methods】One hundred and eight patients who underwent laparoscopic cholecystectomy in our hospital from January to December 2017 were randomly divided into observation group and control group with 54 cases in each group. The control group was given routine nursing intervention in operating room, and the observation group was combined with the intensive nursing based on the thermal preservation intervention. The body temperature change, gastrointestinal function recovery time, hospitalization time and complications of the two groups were compared. 【Results】There was no significant difference in the body temperature of the observation group at different time points (P>0.05). The body temperature of the control group before and after pneumoperitoneum was significantly lower than that of the same group at admission (P<0.01), and significantly lower than that of the observation group at the same time point(P<0.05);the recovery time, anal exhaust time, defecation time and hospitalization time of the observation group were significantly shorter than those of the control group (P<0.05); the incidence of nausea, vomiting, abdominal pain, shivering and agitation was significantly lower than that of the control group (P<0.05). 【Conclusion】The intensive nursing based on thermal preservation intervention is helpful to maintain the relative stability of body temperature, promote the recovery of gastrointestinal function, shorten the hospitalization time and reduce the occurrence of perioperative complications. 2019 Vol. 36 (12): 2373-2375 [Abstract] ( 92 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 2376 Effect of Shenfu Injection on Heart, Live and Kidney Function of Patients with Multiple Organ Dysfunction Syndrome WANG Yi-ru, RUI Qing-lin DOI: 10.3969/j.issn.1671-7171.2019.12.029 【Objective】To investigate the protective effect of Shenfu injection on the heart, live and kidney function of patients with multiple organ dysfunction syndrome (MODS) after cardiopulmonary resuscitation. 【Methods】A total of 50 patients with MODS after resuscitation were randomly divided into two group with 25 cases each. The basic treatment was consistent between the two groups. Simultaneous administration of Shenfu injection was applied in patients of the observation group. Levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), alanine aminotransferase (ALT), creatine kinase (CK), creatine kinase Isoenzyme (CK-MB), lactate dehydrogenase (LDH), blood creatinine (SCr), pH value, arterial blood oxygen partial pressure (PaO2), arterial blood carbon dioxide partial pressure (PaCO2), oxygenation index (OI) and mortality before and after treatment were compared in the two groups. 【Results】There were no significant differences in all detected parameters between the two groups of patients before treatment (P>0.05). After treatment, the levels of TNF-α, IL-6, ALT, CK, CK-MB and LDH in the observation group were lower than those in the control group (P<0.05). Before treatment, the differences in pH, PaO2, PaCO2 and OI levels between two groups were not statistically significant (P>0.05). However, after treatment, the PaCO2 level of the observation group was lower and the pH value, PaO2 and OI levels in the observation group were higher than those in the control group (P<0.05). The patient survival rate of the observation group was 56.00% (14/25), which was higher than that of the control group (28.00%, 7/25). The difference was statistically significant (P<0.05). 【Conclusion】Shenfu injection for the treatment of patients with MODS after resuscitation has certain protective effects on heart, liver and kidney function. It reduces inflammatory reactive damage and improves blood gas index of patients. 2019 Vol. 36 (12): 2376-2378 [Abstract] ( 84 ) HTML (1 KB)  PDF  (0 KB)  ( 9 ) 2379 A Study on the Relationship between the Control Level of Children's Asthma and Their Parents' Quality of Life ZHANG Xi, DUAN Xiao-jun, LI Lin-rui, et al DOI: 10.3969/j.issn.1671-7171.2019.12.030 【Objective】To explore the correlation between the control level of children's asthma and the quality of life of their parents. 【Methods】From June 2015 to June 2018, 517 hospitalized children with asthma and their parents were selected as the subjects. The asthma control level and parents' quality of life were collected by questionnaire and the correlation analysis was carried out. 【Results】Severe asthma, frequent awakening at night and part of poor control and control were related to function, emotion and social function (P<0.05); part of control was related to function and emotion, and control was related to function, emotion and social function (P<0.05). 【Conclusion】The control level of asthma in children is related to their parents' quality of life, which is an independent factor affecting their parents' quality of life. parents. 2019 Vol. 36 (12): 2379-2380 [Abstract] ( 98 ) HTML (1 KB)  PDF  (0 KB)  ( 9 )

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